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증례 : 혈액종양 ; 일차성 중추신경계 림프종의 경막 내 Rituximab 치료 2예
장용호 ( Yong Ho Jang ),하태환 ( Tae Hwan Ha ),김덕희 ( Deok Hee Kim ),김성록 ( Sung Rok Kim ),유영진 ( Young Jin Yuh ),손병석 ( Byeong Seok Sohn ),이혜란 ( Hye Ran Lee ) 대한내과학회 2014 대한내과학회지 Vol.87 No.2
일차성 중추 신경계 림프종(PCNSL)은 완전 관해 이후에도 재발이 흔하고 대부분 뇌연수막 전이에 의해 불량한 예후를 나타내는데 rituximab 경막 내 투여를 통해 PCNSL의 안정 병변 기간 연장 및 부작용은 거의 나타나지 않은 임상증례 2례를 경험하여 보고하며 rituximab 경막 내 투여에 대한 임상 시험 및 연구가 좀 더 필요할 수 있겠다. Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin`s lymphoma (NHL), usually composed of diffuse large B-cells. Although rituximab is known for its curative effect on B-cell NHL, data on the use of intrathecal rituximab for PCNSL are limited. In this report, we present two patients showing relapsed PCNSL with lymphomatous meningitis. Both patients were refractory to conventional methotrexate-based intrathecal chemotherapy. However, after intrathecal rituximab with or without conventional intrathecal chemotherapy, both patients showed stable disease on magnetic resonance brain imaging and cerebrospinal fluid analysis. There were no serious adverse events during each of 3 and 6 cycles with intrathecal rituximab immunotherapy. (Korean J Med 2014;87:224-228)
장용호 ( Yong Ho Jang ),임도형 ( Do Hyoung Lim ),김요한 ( Yo Han Kim ),서원용 ( Won Yong Suh ),박건우 ( Keon Woo Park ),송일한 ( Il Han Song ),이순일 ( Soon Il Lee ) 대한소화기학회 2014 대한소화기학회지 Vol.63 No.1
Skin metastasis from internal carcinoma rarely occurs and it has an incidence of 0.7% to 9%. Although the prognosis of the skin metastases varies considerably depending on the type of the primary malignancy, presence of metastatic skin cancer usually implies a widespread systemic disease and a high mortality. A 50-year-old Korean male patient visited Dankook University Hospital for evaluation of skin rash on his whole abdomen of about 1 month`s duration. He had undergone laparoscopy-assisted distal gastrectomy due to early gastric cancer about 3 months ago. He did not complain of any noticeable symptoms like febrile sense or pruritus. Skin biopsy was performed on the periumbilical area at previous port site and around the scar. Microscopic examination revealed multiple malignant cells in lymphatic spaces, consistent with metastatic carcinoma. He was therefore diagnosed with isolated skin metastasis from early gastic cancer. Because of patient`s poor liver function, systemic chemotherapy could not be performed and only best supportive care was provided. Herein, we report a rare case of cellulitis-like skin metastasis from early gastric cancer with a brief review of the literature. (Korean J Gastroenterol 2014;63:39-41)
열증착법으로 성장된 ZnO 나노구조물의 산소유량 변화에 대한 성장 변화
김경범,장용호,김창일,정영훈,이영진,조정호,백종후,남산,Kim, Kyoung-Bum,Jang, Yong-Ho,Kim, Chang-Il,Jeong, Young-Hun,Lee, Young-Jin,Jo, Jeong-Ho,Paik, Jong-Hoo,Nahm, Sahn 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.10
ZnO nanostructures were developed on a Si (100) substrate from powder mixture of ZnO and 5 mol% Pd (ZP-5) as reactants by ${\times}$ sccm oxygen pressures(x= 0, 10, 20, 40). DTA (differential thermal analysis) result shows the Pd(5 mol%)+ZnO mixtured powder(PZ-5) is easily evaporated than pure ZnO powder. The PZ-5 mixtured powder was characterized by DTA to determine the thermal decomposition which was found to be at $800^{\circ}C$, $1,100^{\circ}C$. Weight loss(%) and ICP (inductively coupled plasma) analysis reveal that Zn vaporization is decreased by increased oxygen pressures from the PZ-5 at $1,100^{\circ}C$ for 30 mins. Needle-like ZnO nanostructures array developed from 10 sccm oxygen pressure, was well aligned vertically on the Si substrate at $1,100^{\circ}C$ for 30 mins. The lengths of the Needle-like ZnO nanostructures is about 2 ${\mu}m$ with diameters of about 65 nm. The developed ZnO nanostructures exhibited growth direction along [001] with defect-free high crystallinity. It is considered that Zn vaporization is responsible for the growth of Needle-like ZnO nanostructures by controlling the oxygen pressures. The photoluminescence spectra of ZnO nanostructures exhibited stronger 376.7 nm NBE (near band-edge emission) peak and 529.3 nm DLE (deep level energy) peak.