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이진탕가미방(二陳湯加味方)과 침치료를 병행한 비미란성 위식도역류질환 환자 7인 증례보고
임희용,오중한,김동우,최빈혜,허진일,김대준,변준석,김봉석,Lim, Hee-Yong,Oh, Jung-Han,Kim, Dong-Woo,Choi, Bin-Hye,Hur, Jin-Il,Kim, Dae-Joon,Byun, Joon-Seok,Kim, Bong-Suk 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4
It is well known that NERD(Non-erosive gastroesophageal reflux disease) is a well known esophageal disease. Symptoms of NERD may be divided into two classes. Important symptoms are acid regurgitation and heartburn. Secondary symptoms are noncardiac chest pain, dysphagia, chronic coughing, hoarseness, sore throat, globus, halitosis, epigastric pain or discomfort and abdominal pain or discomfort related to bowel movement. The relationship between NERD and Tan-San(呑酸) is complex. But the most common symptoms of NERD are acid regurgitation and heartburn. These symptoms arc similar to Tan-San and can be treated with oriental medical herb and acupuncture. Ljintang-Gamibang(二陳湯加味方) mentioned in the Donguibogam(東醫寶鑑) is one of these oriental medical herbs. Therefore, this comparative study between first medical examination and end of medical treatment with Ljintang-Gamibang and acupuncture was made. The clinical progress of NERD was investigated. After treatment, all seven patients showed improvement in all symptoms associated with NERD, including general condition. The results of this study suggest that Ljintang-Gamibang and acupuncture are an effective treatment for NERD and progressive research to develop a practical treatment of NERD are needed.
가성담낭종물(假性膽囊腫物)을 동반한 복통(腹痛)환자 1례(例) 보고(報告)
임희용,오중한,김동우,최빈혜,박송기,변준석,김봉석,Lim, Hee-Yong,Oh, Jung-Han,Kim, Dong-Woo,Choi, Bin-Hye,Park, Song-Ki,Byun, Joon-Seok,Shim, Yun-Seub,Kim, Guk-Bum,Han, Jong-Hyun,Kim, Sun-Hong,Kim, Eun-Gon,Kim, Sang-Uk,Seon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
There are different kinds of the pseudo-mass of the gallbladder(GB) such as GB stones, GB polyps, GB sludge, and these can be differentiated by simple-ultrasonogram(USG). The most common symptoms of GB polyps are abdominal pain(RUQ), dyspepsia, jaundice, but usually there are no symptoms. GB polyps are commonly treated with a cholecystectomy if 10 mm or more in diameter. Pseudo-mass of the GB is regarded as products of stagnation of the Liver Ki in Oriental Medicine. The patient suffered from mild fever. abdominal pain(RUQ), and jaundice. He was diagnosed with a GB polyp(10 mm), liver cyst(12 mm) by simple USG. We treated him with Acupuncture, Herbal Medicine(Hoinsamgum-tang). After three days of treatment, the symptoms improved, and after one month the GB polyp was removed on the follow up of USG.
핵성(核性) 안면신경마비(顔面神經麻痺) 환자 증례 1례(例)
김봉석,임희용,김승모,박재현,이태현,Kim Bong-Suk,Lim Hee-Yong,Kim Seong-Mo,Park Jae-Hyun,Lee Tae-Hyun 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
Facial nerver paralysis is classified as Supranuclear, Peripheral and Nuclear. It is mostly Spontaneous Peripheral Facial Paralysis(Bell's palsy) or Supranuclear Paralysis by C.V.A, but Nuclear Facial Nerve Paralysis is rarely reported. We treated a 64-years-old female patient who had 7-years history of C.V.A with hypertension and heart disease, and complained of these symptoms; left facial palsy, ocular dysmetria, diplopia, and right extremity weakness. We diagnosed as direct attack from the wind pathogen(風邪入中) with deficiency of both Gi(Qi, vital energy) and blood(氣血雨虛), and employed Oriental medical treatments; herb-medication, acupuncture and moxa therapy. The result was relatively acceptable. So We report this case with a brief review of related literatures.
대승기탕(大承氣湯) 투여 후 편폐(便閉 ), 번조(煩燥), 불면(不眠)호전된 중풍 환자 치험 1례
김봉석,임희용,최빈혜,김대준,전연이,조종관,변준석,오중한,Kim, Bong-Suk,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Kim, Dae-Joon,Jun, Yeon-I,Cho, Chong-Kwan,Byun, Joon-Seok,Oh, Jung-Han 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
In the early stage of stroke, the symptoms of constipation, chest discomfort and insomnia may appear in addition to the general symptoms such as specific limb weakness, dysphasia, headache, dizziness etc.. We administered Daeseungkitang(大承氣湯) to the patient diagnosed with cerebral infarction by MRI. He clearly displayed the usual syndromes of stroke(實證), endogenous wind stirring in the liver(肝風內動) and acceleration of upper chest functions(上焦火盛), ascertainned by Oriental Medical methods. After treatment with Daeseungkitang(大承氣湯), the constipation, chest discomfort and insomnia improved along with improvement of general symptoms of stroke.
이진탕(二陳湯) 가미방(加味方) 투여 후 호전된 기능성 소화불량 환자 3례에 대한 증례보고
김봉석,임희용,김동우,최빈혜,허진일,김대준,조종관,변준석,오중한,Kim, Bong-Suk,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Hur, Jin-Il,Kim, Dae-Joon,Cho, Chong-Kwan,Byun, Joon-Seok,Oh, Jung-Han 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3
It is well known that functional dyspepsia is one of the most common diseases. Functional dyspepsia, as defined by Rome I and II criteria, is a known and important gastrointestinal disorder. Symptoms of functional dyspepsia are postprandial fullness, postprandial discomfort, epigastric bloating, epigastric lump sensation, early satiety, nausea, vomiting, regurgitation, eruction, hunger pain, postprandial epigastric pain, heartburn, soreness and anorexia. Treatment of these symptoms are recorded in the Donguibogam(東醫寶鑑). This study is a comparative study between initial medical examination and end of medical treatment with LJTG mentioned in the Donguibogam. After treatment with LJTG, patients showed improvement in all symptoms associated with functional dyspepsia, including general condition. The results of this study suggest that LJTG is an effective treatment for functional dyspepsia.
반하백출천마탕(半夏白朮天麻湯)이 Doxorubicin에 의해 유발(誘發)된 독성(毒性)에 미치는 영향(影響)
김봉석,오중환,임희용,백정한,박치상,김상찬,변준석,황희정,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Beak Jung-Han,Park Chi-Sang,Kim Sang-Chan,Byun Joon-Seok,Hwang Hui-Jeung 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2
Object : The effect of Banhabakchulchunma-tang extracts on the hepatic, splenic and cardiac toxicity induced by Doxorubicin administration(Three injection protocol) were monitored using male ICR mice. Methods : The changes of body weight, clinical signs, necropsy findings and organ weights of liver, spleen and heart were observed with blood GOT and GPT levels. Results : 1. Decrease of body weight and The degrees of anorexia, ataxia and dehydration after Doxorubicin treatment were dose-dependently inhibited by Banhabakchulchunma-tang extracts. 2. Increase of absolute and relative liver and heart weight observed in Doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of liver congestion necrotic spot and the degrees of heart congestion enlargement were dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. It is also demonstrated that elevated serum GOT and GPT levels in doxorubicin treatment group were significantly decreased in Banhabakchulchunma-tang extracts dosing groups. 3. Decrease of absolute and relative spleen weight observed in doxorubicin treatment group were dose-dependently inhibited by Banhabakchulchunma-tang extracts. In addition, the degrees of splenic atrophy were significantly and dose-dependently decreased after Banhabakchulchunma-tang extracts dosing groups compared to that of doxorubicin treatment group. Conclusion : the toxicity of doxorubicin treatment(decrease of body weights, clinical signs such as anorexia, ataxia and dehydration, changes of organ weights of liver, spleen and heart, elevation of serum GOT and GPT levels) was inhibited and/or prevented by Banhabakchulchunma-tang extracts. According to these results, it is considered that Banhabakchulchunma-tang has some preventive effect against to doxorubicin induced toxicity.
소건중탕가 용골,모려의 항산화효과, 세포활성 및 유전자 발현에 미치는 영향
김태중 ( Tae Joong Kim ),임희용 ( Hee Yong Lim ),관민아 ( Min Ah Kwak ),변준석 ( Joon Seok Byun ),서정철 ( Jung Chul Seo ),한상원 ( Sang Won Han ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.2
N/A Objectives : The purpose of this study was to determine the effect of SG-YM on antioxidant effect, cell viability and the expression of genes in human stomach cancer cells. Methods : Antioxidant effect of SG-YM was compared with that of vitamin C on DPPH radical, respectively. Cell viability was determiend by MTT assay. Finally, gene expression was evaluated by cDNA microarray assay. Results : 1. Scavenging effect of SG-YM on DPPH treated cells were demonstrated by differential antioxidant effect in SG-YM-treated group at the dose of 10 and lmg/ml. 2. Cell viability was increased in SG-YM-treated group at the dose of lmg/ml. 3. Among 8000 unigenes, 208 genes were upregulated while 90 genes were downregulated by SG-YM treatment on human stomach cancer cell line. Conclusions : Collectively, these results can be used as basic data for development of new anticancer drugs or treatment.
평위산(平胃散)과 보화환(保和丸)으로 호전된 연하장애 환자 2례
김동우,오중한,김봉석,임희용,최빈혜,허진일,변준석,김대준,Kim, Dong woo,Oh, Jung-hwan,Kim, Bong-seok,Lim, Hee-yong,Choi, Bin-hye,Heo, Jin-il,Byeon, Jun-seok,Kim, Dae-jun 대한중풍순환신경학회 2005 대한중풍.순환신경학회지 Vol.6 No.1
Dysphagia is an important complication for the rehabilitative treatment and life quality of stroke patients. This report is about two patients with dysphagia after stroke who were treated with Pyungwesan and Bowhawhan. The severity of the patient's dysphagia was evaluated with stage of dysphagia according to severity. After treatment, dysphagia were remarkably improved(from stage 5 to 2, 5 to 1). This result shows that Pyungwesan and Bowhawhan could be effective against dysphagia after stroke.
보중익기합대칠기탕(補中益氣合大七氣湯)과 Doxorubicin의 병용이 MKN-45의 항암효과에 미치는 영향
이윤희,김봉석,오중한,임희용,김동우,최빈혜,변준석,Lee Yun-Hee,Kim Bong-Suk,Oh Jung-Han,Lim Hee-Yong,Kim Dong-Woo,Choi Bin-Hye,Byun Joon-Seok 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1
In order to evaluate the anti-tumor and synergic effect of BoJungIkKeeHapDaeChilKi-Tang on doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and BoJungIkKeeHapDaeChilKi-Tang with their concomitant treatment against MKN-45(Human stomach carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst MKN-45 cell lines. BoJungIkKeeHapDaeChilKi-Tang has only mimic direct anti-tumor effect against to MKN-45 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that BoJungIkKeeHapDaeChilKi-Tang extracts were reduced by the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and BoJungIkKeeHapDaeChilKi-Tang extracts.
순기화중탕(順氣和中湯)과 Doxorubicin의 병용이 Colon-26의 항암효과에 미치는 영향
신민규,김봉석,오중한,임희용,김동우,최빈혜,변준석,Shin, Min-Kyu,Kim, Bong-Suk,Oh, Jung-Han,Lim, Hee-Yong,Kim, Dong-Woo,Choi, Bin-Hye,Byun, Joon-Seok 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2
In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), IC50 and IC90 of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models against 3LL cell lines. Soonkiwhajungtang may only mimic direct anti-tumor effects against 3LL cell lines, but signs of worsening induced by implantation of tumor cell lines generally decreased, while the total WBC and lymphocyte numbers increased. Therefore, experimentation suggests that Soonkiwhajungtang extracts reduced the critical toxicity of doxorubicin, and that Soonkiwhajungtang extracts have favorable synergic effects when combined with doxorubicin.