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한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
Instrumentation Failure after Partial Corpectomy with Instrumentation of a Metastatic Spine
Park, Sung Bae,Kim, Ki Jeong,Han, Sanghyun,Oh, Sohee,Kim, Chi Heon,Chung, Chun Kee The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.3
Objective : To identify the perioperative factors associated with instrument failure in patients undergoing a partial corpectomy with instrumentation (PCI) for spinal metastasis. Methods : We assessed the one hundred twenty-four patients with who underwent PCI for a metastatic spine from 1987 to 2011. Outcome measure was the risk factor related to implantation failure. The preoperative factors analyzed were age, sex, ambulation, American Spinal Injury Association grade, bone mineral density, use of steroid, primary tumor site, number of vertebrae with metastasis, extra-bone metastasis, preoperative adjuvant chemotherapy, and preoperative spinal radiotherapy. The intraoperative factors were the number of fixed vertebrae, fixation in osteolytic vertebrae, bone grafting, and type of surgical approach. The postoperative factors included postoperative adjuvant chemotherapy and spinal radiotherapy. This study was supported by the National Research Foundation grant funded by government. There were no study-specific biases related to conflicts of interest. Results : There were 15 instrumentation failures (15/124, 12.1%). Preoperative ambulatory status and primary tumor site were not significantly related to the development of implant failure. There were no significant associations between insertion of a bone graft into the partial corpectomy site and instrumentation failure. The preoperative and operative factors analyzed were not significantly related to instrumentation failure. In univariable and multivariable analyses, postoperative spinal radiotherapy was the only significant variable related to instrumentation failure (p=0.049 and 0.050, respectively). Conclusion : When performing PCI in patients with spinal metastasis followed by postoperative spinal radiotherapy, the surgeon may consider the possibility of instrumentation failure and find other strategies for augmentation than the use of a bone graft for fusion.
EFFECTS OF PROACTIVE PERSONALITIES AND PSYCHOLOGICAL CONTRACTS ON TOUR GUIDES’ SUBJECTIVE WELL-BEING
Sung Hee Park,Chi-Ming Hsieh 한국호텔외식관광경영학회 2015 한국호텔외식경영학회 학술발표논문집 Vol.- No.-
Tour guides play active and critical roles in group package tours and are frontline employees who interact closely with tourists. A proactive personality can affect the way a tour guide behaves, leading a tour to succeed or fail and potentially establishing tourists’ loyalty. This study examines how proactive personalities and psychological contracts affect tour guides’ subjective well-being. Data were collected from 359 licensed tour guides working in registered travel agencies in Taiwan. The structural equation modeling results support the notion that tour guides’ proactive personalities and psychological contracts, including transactional and relational psychological contracts, play concurrent positive roles in determining tour guides’ subjective well-being. Managerial implications and future research are discussed.
( Sang Ho Park ),( Dong Hun Lee ),( Kye Heon Oh ),( Kyoung Lee ),( Chi Kyung Kim ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.3
Gene fusions were constructed by the transcriptional fusion of the dnaK promoter of Pseudomonas sp. DJ-12 or E. coli to the lux or luc marker gene. The dnaKp-DJ::luxCDABE bioluminescent fusion in the biosensor using the Pseudomonas sp. DJ-12 dnaK promoter exhibited about 5-fold more extensive response to ethanol than that of dnaKp-EC::luxCDABE. The bioluminescent response of the dnaK-DJ::luc fusion to ethanol was much weaker than those of the other fusions. The biosensor harboring the dnaKp-DJ::luxCDABE fusion was examined for its bioluminescence production based on exposure to aromatic compounds, such as biphenyl, 4-chlorobiphenyl (4CB), 4-hydroxybenzoate (4HBA), and catechol. In particular, the bioluminescence produced by the dnaKp-DJ::luxCDABE fusion was most sensitive to 1 mM biphenyl and 4CB when exposed for 80 min, and the responses were also very strong to other aromatics. Therefore, the biosensor bearing the dnaKp-DJ:: luxCDABE fusion would appear to be the most useful for the detection of aromatics and other pollutants.
Clinical proteomic analysis of scrub typhus infection
Park, Edmond Changkyun,Lee, Sang-Yeop,Yun, Sung Ho,Choi, Chi-Won,Lee, Hayoung,Song, Hyun Seok,Jun, Sangmi,Kim, Gun-Hwa,Lee, Chang-Seop,Kim, Seung Il BioMed Central 2018 Clinical proteomics Vol.15 No.1
<P><B>Background</B></P><P> Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium <I>Orientia tsutsugamushi</I> from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection.</P><P><B>Methods</B></P><P>Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects. One-dimensional sodium dodecyl sulphate–polyacrylamide gel electrophoresis followed by liquid chromatography-tandem mass spectrometry was performed to identify differentially abundant proteins using quantitative proteomic approaches. Bioinformatic analysis was then performed using Ingenuity Pathway Analysis.</P><P><B>Results</B></P><P>Proteomic analysis identified 236 serum proteins, of which 32 were differentially expressed in normal subjects, naive scrub typhus patients and patients treated with antibiotics. Comparative bioinformatic analysis of the identified proteins revealed up-regulation of proteins involved in immune responses, especially complement system, following infection with <I>O. tsutsugamushi</I>, and normal expression was largely rescued by antibiotic treatment.</P><P><B>Conclusions</B></P><P>This is the first proteomic study of clinical serum samples from scrub typhus patients. Proteomic analysis identified changes in protein expression upon infection with <I>O. tsutsugamushi</I> and following antibiotic treatment. Our results provide valuable information for further investigation of scrub typhus therapy and diagnosis.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12014-018-9181-5) contains supplementary material, which is available to authorized users.</P>
Park, Chul-Hong,Son, Hyeong-U,Yoo, Chi-Yeol,Lee, Sang-Han TaylorFrancis 2017 Pharmaceutical biology Vol.55 No.1
<P><B>Abstract</B></P><P><B>Context:</B><I>Aloe</I> has been used for the prevention and cure of various diseases and symptoms including burns, injuries, oedema and pain.</P><P><B>Objective:</B> This study determines the specific inhibitory activity of matrix metalloproteinase (MMP)-9 induced by the low molecular-weight gel fraction of <I>Aloe vera</I> (L.) Burm.f. (lgfAv) on alcohol-induced acute gastric lesions.</P><P><B>Materials and methods:</B> We examined the protective effects of oral (p.o.) administration of lgfAv (molecular weight cutoff <50.0 kDa, 150.0 mg/kg body weight) in a Balb/c mouse model of alcohol-induced acute gastritis for 1 h exposure. By measuring ulcer index, we compared the antiulcerative activity of the fraction. mRNA expression and immunohistochemical analysis of various biomarkers were performed.</P><P><B>Results:</B> The lgfAv-treated mice exhibited drastically fewer ulcer lesions than the untreated control mice did. It featured that lgfAv lessened the ulcer lesions than their relevant controls. Moreover, the transcriptional level of MMP-9 was completely alleviated by lgfAv treatment in alcohol-treated gastritis-induced mice.</P><P><B>Discussion:</B> The transcriptional level of MMP-9 was significantly alleviated by lgfAv treatment of the model. However, reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry experiments revealed that lgfAv treatment in mucosal tissues had the potential to inhibit the mRNA and protein expression levels of MMP-9, respectively. The protein expression of MMP-9 was closely associated with lgfAv-induced gastroprotection against alcohol-induced gastric lesions.</P><P><B>Conclusions:</B> The present findings suggest that lgfAv has the potential to alleviate alcohol-induced acute gastric lesions, which is mediated in part, mainly by the suppression of the mRNA expression of MMP-9.</P>
Enhancement of mass transport in fuel cells using three-dimensional graphene foam as flow field
Park, Ji Eun,Lim, Jongkoo,Kim, Sungjun,Choi, Insoo,Ahn, Chi-Yeong,Hwang, Wonchan,Lim, Myung Su,Cho, Yong-Hun,Sung, Yung-Eun Elsevier 2018 ELECTROCHIMICA ACTA Vol.265 No.-
<P><B>Abstract</B></P> <P>Graphene foam is a three-dimensional graphene-based material with interconnected macropores and it combines the advantage of graphene and structural characteristics of metal foam. Various kinds of metal foam have been developed as flow fields because their high porosity distributes reactants in an entire area and removes generated water. However, metal foam is highly susceptible to corrosion under the operating conditions of polymer-electrolyte-membrane fuel cells. In this work, we proposed using graphene foam as a flow field to investigate its effect on enhancing mass transport of reactants and products. Single-cell tests of the graphene-foam flow field showed the enhancement of mass transport, which led to increased performance at high current densities. Measurements of the oxygen gain (i.e., the difference in voltage under O<SUB>2</SUB> and air atmospheres), electrochemical impedance spectra, and simulation results also revealed that the graphene-foam membrane-electrode assembly (MEA) exhibited lower mass-transport resistance than a conventional MEA because graphene foam is advantageous for the mass transport of reactants and water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A graphene foam MEA using graphene foam as flow field is proposed. </LI> <LI> The graphene foam MEA exhibits high cell performance, especially at high current densities. </LI> <LI> The graphene foam as flow field can decrease mass transport resistance. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>