Nocardia Brain Abscess Mimicking a Metastatic Brain Tumor: A Severe CNS Infection Requiring Aggressive Management

이아름,김희경 대한자기공명의과학회 2013 Investigative Magnetic Resonance Imaging Vol.17 No.1

Nocardiosis is an uncommon Gram-positive bacterial infection caused by aerobic actinomycetes in the genus Nocardia. Nocardia spp. have the ability to cause localized or systemic suppurative disease in humans and animals. Nocardiosis is typically regarded as an opportunistic infection, but approximately one-third of infected patients are immunocompetent. We report a rare case of pulmonary nocardiosis and a brain abscess caused by Nocardia asteroides in an elderly woman with a history of Crohn’s disease. Radiographic imaging revealed a contrast-enhancing lesion with perilesional parenchymal edema that was preoperatively thought to be a neoplasm. The patient experienced aggressive disease progression simulating a metastatic brain tumor. Early diagnosis of norcadiosis, the absence of underlying disease, and the administration of appropriate antibiotics has a positive impact on prognosis. Familiarity with the magnetic resonance and computed tomography findings associated with CNS nocardiosis, such as those presented here, is essential for making an early diagnosis.

증숙 횟수에 따른 천마 추출물의 피부 생리 활성 평가

이아름,김건형,권오준,김수현,김경조,노성수 대한본초학회 2018 大韓本草學會誌 Vol.33 No.1

Objectives : Gastrodiae Rhizoma extract (GE) is possess the various bioactive compounds such as gastrodin, vanilyl alcool and p-hydroxybenzyl alcohol. Various processing methods such as steaming have been widely applied to ease ingestion and enhance the therapeutic effects of plant materials including GE in East-Asia area. The aim of this study was to evaluate the dermal bioactive properties of GE. Methods : First, total phenol, total flavonoid, gastrodin and ergothionein contents of GE were measured. In order to evaluate the dermal bioactive properties of steamed GE compared with not-steamed GE, tyrosinase, collagenase and elastase inhibitory activity were tested. Furthermore, the anti-oxidant activity of GE assessed based on DPPH and ABTS radical scavenging assay. Results : In results, total phenol and total flavonoid contents were increased when 9 times steamed compared to not- steamed GE. Also, GE increased gastrodin contents, in proportion to the number of steaming times and ergothioneine content was abolished in the steaming state. The DPPH radical scavenging activity of GE increased by steaming, but the ABTS radical scavenging activity was not related to the steaming process. In addition, the tyrosinase inhibitory activity was increased as the number of steaming times of GE increased. Collagenase was most inhibited by 4 times steamed GE, and elastase was inhibited by 8 times steamed GE. Conclusion : In conclusion, these results suggest that steamed GE extract has the potential as a cosmetic material which possess anti-oxidant and whitening activities than not steamed GE.

시베리아 산불에 따른 총일차생산량의 시간적 변동

이아름,박창의 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.10

Estimating the Soil Carbon Stocks for a Pinus densiflora Forest Using the Soil Carbon Model, Yasso

이아름,노남진,조용성,이우균,손요환 한국생태학회 2009 Journal of Ecology and Environment Vol.32 No.1

The soil carbon stock for a Pinus densiflora forest at Gwangneung, central Korea was estimated using the soil carbon model, Yasso. The soil carbon stock measured in the forest was 43.73 t C ha-1, and the simulated initial (steady state) soil carbon stock and the simulated current soil carbon stock in 2007 were 39.19 t C ha-1 and 38.90 t C ha-1, respectively. Under the assumption of a 0.1℃ increase in mean annual temperature per year, the decomposition and litter fractionation rates increased from 0.28 to 0.56 % year-1 and the soil carbon stock decreased from 0.03 to 0.12 % year-1. Yasso is a simple and general model that can be applied in cases where there is insufficient input information. However, in order to obtain more accurate estimates in Korea, parameters need to be recalibrated under Korean climatic and vegetation conditions. In addition, the Yasso model needs to be linked to other models to generate better litter input data. The soil carbon stock for a Pinus densiflora forest at Gwangneung, central Korea was estimated using the soil carbon model, Yasso. The soil carbon stock measured in the forest was 43.73 t C ha-1, and the simulated initial (steady state) soil carbon stock and the simulated current soil carbon stock in 2007 were 39.19 t C ha-1 and 38.90 t C ha-1, respectively. Under the assumption of a 0.1℃ increase in mean annual temperature per year, the decomposition and litter fractionation rates increased from 0.28 to 0.56 % year-1 and the soil carbon stock decreased from 0.03 to 0.12 % year-1. Yasso is a simple and general model that can be applied in cases where there is insufficient input information. However, in order to obtain more accurate estimates in Korea, parameters need to be recalibrated under Korean climatic and vegetation conditions. In addition, the Yasso model needs to be linked to other models to generate better litter input data.

첨가 방법을 달리하여 제조한 아로니아 막걸리의 이화학적 특성 및 항산화 활성

이아름,오은영,정연정,노재관,윤향식,이기열,김이기,엄현주,Lee, A Reum,Oh, Eun Young,Jeong, Yeon Jeong,Noh, Jae-Gwan,Yoon, Hyang-Sik,Lee, Ki Yeol,Kim, Yee Gi,Eom, Hyun-Ju 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

Aronia melanocarpa (Rosaceae family), black chokeberry, has significantly higher anthocyanin, phenolic compounds, and antioxidant activity than other berries. The aim of this study is to characterize the content of aronia makgeolli prepared with the additive method such as fresh-type and crushed-type and to investigate the effect of aronia on the quality of makgeolli at $25^{\circ}C$ for 8 days. The changes in pH, total acidity, ethanol content, color, antioxidant activity, total polyphenol content, and sensory testing were determined. The pH values were 3.9~4.2 in fresh aronia makgeolli (the fresh group), and 3.6~3.9 in crushed aronia makgeolli (the crushed group). The total acidity of all samples gradually increased during the fermentation period. The ethanol content was 10~15% after the second stage of fermentation, and was reduced followed by an increase in the addition rate of aronia, showing the lowest values in 50% crushed aronia makgeolli. As the aronia content increased, both the antioxidant activity and the total polyphenol content significantly increased. In the fresh group, low values were seen in early fermentation, which significantly increased according to the progress of fermentation, while the crushed group showed high values for 6 days. In the sensory evaluation, the color, flavor, bitterness, and overall acceptance of the makgeolli with 30% fresh aronia showed higher values than the control and other samples. In conclusion, the present study suggests that fresh aronia without undergoing the breaking process is a more suitable additive method than the crushed type for antioxidant activity and palatability of aronia makgeolli. 본 연구는 막걸리 제조 시 아로니아의 첨가 방법을 달리하여 제조한 후, 발효하면서 항산화 활성 및 이화학적 품질특성을 분석하였다. 아로니아는 생과와 마쇄한 형태로 첨가하였고, 쌀 함량의 10%, 30% 그리고 50%로 하였다. 막걸리의 pH는 발효 초기에 생과를 첨가한 시료가 3.9~4.2로, 마쇄하여 첨가한 시료(3.6~3.9)보다 높았고, 발효가 진행되면서 생과로 첨가한 경우는 pH가 낮아지다가 다시 증가하는 경향성을 보였다. 총산의 경우는 초기 발효에는 생과보다 마쇄한 시료에서 더 높게 나타났고, 발효가 진행될수록 총산의 함량이 증가하였다. 환원당 함량은 발효가 진행되며 대부분의 시료에서 감소하였다. 에탄올 함량은 1단 담금 시 11.4%로 나타났고, 2단 담금 6일 후에는 10~15%였으며, 특히, 아로니아를 50% 첨가한 실험구는 1단 담금 시 보다 낮은 에탄올 함량을 보였으며, 마쇄하여 첨가할수록 더 낮은 알코올함량을 보였다. 색도 중 a값(적색도)을 비교했을 때 생과 사용 시 천천히 a값이 높아져 마지막 날에는 생과 처리구 간 유의적으로 차이가 났지만, 마쇄한 경우는 처음부터 마지막 발효까지 높은 a값을 가져 생과를 처리한 경우보다 높게 나타났다. 총 폴리페놀함량 측정과 DPPH radical 소거능 측정 결과는 아로니아 첨가량이 증가할수록 함께 증가하였는데, 생과첨가군의 경우 초기에는 낮은 값을 가지다가 발효가 진행하며 급속히 증가하였고, 마쇄첨가군에서는 초기에서부터 높은 값을 가졌다. 또한 아로니아를 30% 첨가하여도 50%를 첨가한 것과 같이 뛰어난 항산화 활성을 나타내었다. 관능검사는 생과 30%를 첨가한 시료가 색, 쓴맛, 전체적 기호도에서 높아 관능적 만족도가 우수한 것으로 나타났다. 이상의 결과로 아로니아를 첨가한 기능성 막걸리의 특성을 보았을 때 아로니아를 마쇄한 형태보다 생과 형태로 30%를 첨가하는 것이 관능적 특성과 항산화 활성을 고려하였을 때 가장 적합한 것으로 나타났다.

컴퓨터 사용시간에 따른 중학생의 식행동, 영양지식 및 영양소섭취 상태 비교

이아름,안홍석 誠信女子大學校 生活文化硏究所 2012 生活文化硏究 Vol.26 No.2

This study investigates whether the number of hours of computer use affects the physical development, food patterns, nutrition knowledge, dietary intakes and acquisition of food information in middle school students. 291 middle school students were surveyed using questionnaires in December of 2009 and January of 2010. The respondents were divided into two groups: computer users of long hours (≥2hrs/day) and computer users of short hours (<2hrs/day). In conducting the survey, the 24-hour recall method was employed. The students with longer hours of computer use showed higher numbers in physical weight and height as well as a higher BMI (p<0.05) compared to those with short hours of computer use. The main reason for the long hours of computer use was found to be computer games (p<0.001). As for changes incurred by computer use, the computer users of longer hours had inferior dietary habits and related side-effects: skipping meals, eating faster, loss of appetite, acute indigestion, eating snacks, drinking caffeinated beverages, sleeping trouble (p<0.001). The dietary habit score of computer users of long hours (55.9 points) was lower than that of computer users of short hours (58.7 points). The computer users of long hours also scored lower in nutrition knowledge. They tended to have higher intakes of Na, Niacin and lower intakes of Potassium (p<0.05). From these findings, it can be concluded that long hour computer use has negative effects on the physical development, eating habits and dietary intakes in middle school students.

화학사고 발생 시 오염퇴적토 원위치 thin-layer capping 에 의한 페놀 용출 차단율 평가

이아름,권현아,최용주 한국퇴적환경준설학회(구 한국환경준설학회) 2021 한국환경준설학회 학술대회논문집 Vol.2021 No.06

솔방울 메탄올 추출물의 항산화 및 멜라닌 생성 억제 효과

이아름,노성수,이은숙,민유홍 한국피부과학연구원 2016 아시안뷰티화장품학술지 Vol.14 No.3

Purpose: This study was conducted to evaluate anti-oxidant and anti-melanogenic activities of pine cone extract from Pinus densiflora. Methods: Pine cone extract used in this experiment was extracted with methanol at room temperature for 24 h. Anti-oxidant activities were measured by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and nitro blue tetrazolium chloride (NBT) assay. Moreover, the inhibitory effects of pine cone methanol extract on tyrosinase and melanin synthesis in murine B16-F10 melanoma cells were studied. In addition, cell viability was investigated by MTT assay. Results: The results showed that the pine cone methanol extract strongly reduced the DPPH free radical activity (IC50=9.57±1.24 μg/mL). However, its activity was lower than the activity of L-ascorbic acid (positive control, IC50=1.28±0.03 μg/mL). In NBT assay, the pine cone methanol extract exhibited more superoxide anion radical scavenging activity (IC50=3.33±0.28 μg/mL), compared with L-ascorbic acid (IC50=73.25±1.02 μg/mL). When treated with 3,4-Dihydroxy-L-phenylalanine (L-DOPA) as the substrate of tyrosinase, the extract inhibited the tyrosinase activity with an IC50 value of 106.15±1.69 μg/mL, lower effect than that of kojic acid (IC50=3.12±0.68 μg/mL). In murine B16-F10 cells, the pine cone methanol extract significantly suppressed melanogenesis in a concentration-dependent manner without cytotoxicity. Conclusion: The results indicated that pine cone extract could be potentially valuable as a new potent depigmentation agent. 목적: 본 논문의 목적은 솔방울 메탄올 추출물의 항산화 효과 및 항멜라닌 활성을 평가하는 것이다. 방법: 솔방울 메탄올추출물의 항산화 활성을 알아보기 위하여 2,2-Diphenyl-1-picrylhydrazyl (DPPH) 및 슈퍼옥사이드 음이온 라디칼 소거능(superoxide anion radical scavenging activity)을 측정하였을 뿐 아니라, 미백효능을 평가하기 위하여 티로시나아제에3,4-Dihydroxy-L-phenylalanine (L-DOPA)를 가하여 티로시나아제 활성 저해효능을 측정하였다. 또한 멜라닌 생합성 억제효과는 α-MSH를 가한 B16-F10 세포를 활용하여 확인하였고, Thiazolyl blue tetrazolium bromide (MTT)를 활용하여세포독성을 측정하였다. 결과: 솔방울 메탄올 추출물은 높은 항산화 활성을 가지고 있고, 농도의존적으로 티로시나아제를 억제하였을 뿐 아니라, B16-F10 세포에서 농도의존적으로 멜라닌 형성을 저해하였다. B16-F10 및 CCD-1064SK 세포에서 솔방울 메탄올 추출물은 세포독성을 나타내지 않았다. 결론: 솔방울 메탄올 추출물은 세포독성을 나타내지 않으며 멜라닌 형성을 저해하고 항산화 효과 또한 뛰어나므로 미백 및 항산화 소재로 충분히 활용될 수 있다고 사료된다.

포트 재배에 의한 화약물질 오염토양 정화용 내오염성 식물 선정

이아름,배범한,Lee, Ahreum,Bae, Bumhan 한국지하수토양환경학회 2015 지하수토양환경 Vol.20 No.6

Nine plant species were selected through vegetation survey at three military shooting ranges at northern Gyeonggi Province. Plants were germinated in normal soil and three seedlings were transplanted to a bottom sealed pot containing sandy loam soils contaminated with either RDX (291 mg/kg) or TNT (207 mg/kg). Planted, blank (without plant), and control (without explosive compound) pots were grown in triplicate at a green house for 134 days. During cultivation, transplanted plants exhibited chlorosis and necrosis in flower and leaf by explosive toxicity and stress. Only three plants, Wild soybean, Amur silver grass, Reed canary grass, survived in TNT treated pot, while seven plant species except for field penny cress and jimson weed, thrived in RDX treated pot. Appreciable amount of TNT (61.6~241.2 mg/g-D.W.) was detected only in plant roots. Up to 763.3 mg/g-D.W. along with 4-amino-2,6-dinitrotoluene, an intermediate of TNT, accumulated in the root of wild soybean. In addition, azoxy compounds, abiotic intermediates of TNT, were detected in TNT treated soils. RDX absorbed average 1,839.95 mg/kg in shoot and 204.83 mg/kg in root. Most of TNT in plant was accumulated in underground part whereas RDX was localized in aerial part. Material balance calculation showed that more than 95% of the initial TNT was removed in the planted pots whereas only 60% was removed in the blank pot. The amount of RDX removed from soil was in the order of Amur Silver Grass (51%) > Chickweed (43%) > Evening primrose (38%). Based on the results of pot cultures, Amur silver grass and Reed canary grass are selected as tolerant remedial plants for explosive toxicity.

연속적인 위치기반 서비스를 지원하는 그리드 기반 Cloaking 영역 설정 기법

이아름,김형일,장재우,Lee, Ah-Reum,Kim, Hyeong-Il,Chang, Jae-Woo 대한공간정보학회 2009 한국공간정보시스템학회 논문지 Vol.11 No.3

최근 PDA, 휴대폰, GPS와 같은 모바일 기기 및 무선 통신 기술의 발달로 인하여 위치 기반 서비스의 이용이 확산되었다. 하지만 이러한 서비스는 사용자의 정확한 위치정보를 가지고 LBS 서버에 연속적으로 서비스를 요청하기 때문에, 심각한 개인 정보 누출의 위협이 될 수 있다. 따라서 모바일 사용자의 안전하고 편리한 위치기반 서비스 사용을 위한 개인 정보 보호 방법이 필요하다. 이를 위해 본 논문에서는 연속적인 위치기반 서비스를 지원하는 그리드 기반 Cloaking 영역 설정 기법을 제안한다. 제안하는 기법은 연속적인 위치기반 서비스를 효율적으로 지원하기 위하여 그리드 기반의 셀 확장을 통해 빠르게 Cloaking 영역을 설정한다. 아울러, 모바일 사용자의 위치 노출 확률을 최소로 하는 Cloaking 영역 설정을 위하여, 가중치를 부여하여 프라이버시 보호 수준을 계산한다. 마지막으로 성능평가를 통해서 제안하는 기법이 서비스 시간, 프라이버시 보호 수준에서 기존 연구보다 우수함을 보인다. Recent development in wireless communication technology and mobile equipment like PDA, cellular phone and GPS makes location-based services (LBSs) popular. However, because, in the LBSs, users continuously request a query to LBS servers by using their exact locations, privacy information could be in danger. Therefore, a mechanism for users' privacy protection is required for the safe and comfortable use of LBSs by mobile users. For this, this paper propose a grid-based cloaking area creation scheme supporting continuous LBSs. The proposed scheme creates a cloaking area rapidly by using grid-based cell expansion to efficiently support the continuous LBSs. In addition, to generate a cloaking area which makes the exposure probability of a mobile user to a minimum, we compute a privacy protection degree by granting weights to mobile users. Finally, we show from a performance analysis that our cloaking scheme outperforms the existing cloaking schemes, in terms of service time, privacy protection degree.