감염 ; 우리나라 사람면역결핍바이러스 감염 환자에서 악성종양 발생 양상

설영미 ( Young Mi Seol ),송무곤 ( Moo Gon Song ),최영진 ( Young Jin Choi ),이선희 ( Sun Hee Lee ),김성일 ( Sung Il Kim ),정주섭 ( Joo Seop Chung ),곽임수 ( Ihm Soo Kwak ),조군제 ( Goon Jae Cho ),이혁 ( Hyuck Lee ),정동식 ( Dong S 대한내과학회 2009 대한내과학회지 Vol.76 No.5

목적: 항HIV 치료의 발전으로 HIV 환자가 장기간 생존하게 되면서 악성종양은 HIV 환자에서 중요한 사망원인으로 대두되고 있다. 본 연구는 국내 HIV 환자에서 암 발생양상을 알아보고 이전에 발표된 국내의 연구들과 비교해봄으로서 우리나라 HIV 환자에서 발생하는 암 발생 특성을 파악하는데 도움이 되는 자료를 제시하고자 하였다. 방법: 1990년 1월부터 2008년까지 6월까지 부산지역 4개 대학 병원(고신대병원, 동아대병원, 부산대병원, 인제대병원)에 내원하였던 HIV 감염 환자들을 대상으로 의무기록을 후향적으로 분석하였다. 결과: 대상 환자 683명 중 27명(4%)에서 악성종양이 발생하였다. 27명 중에서 남자는 25명(93%)이었고, 악성종양 진단 시점 연령의 중앙값(범위) 48세(24~76세)였다. 진단 당시 평균 CD4+ 세포수의 중앙값(범위)은 42/uL (3~399)이었다. 비에이즈 정의 악성종양이 14예(52%), 에이즈 정의 악성종양 13예(48%)였다. 시기별로는 Pre-HAART 기간에는 에이즈 정의 악성종양과 비이에즈 정의 악성종양이 각각 2예씩 발생하였고, HAART 기간에는 비에이즈 정의 악성종양이 12예(52%)로 에이즈 정의 악성종양 11예(48%)가 발생하였다. 에이즈 정의 악성종양 중에서는 비호지킨 림프종(9/13)이 가장 많았고, 카포시육종(4/13)의 순이었다. 비호지킨 림프종 중에서는 미만성 B형 대세포 림프종이 가장 많았으며(5/9) 중추신경계 미만성 B형 대세포 림프종 (3/9), 버킷 림프종 (1/9)의 순이었다. 비에이즈 정의 악성종양 중에서는 위암, 직장암, 간세포암이 가장 많았으며(각각 3/14) 그 외 갑상선암, 편도암, 식도암, 혈관육종, 에크린 땀샘암종(eccrine carcinoma)이 각각 1예로, 위장관 기원 악성종양이 50% (7/14)를 차지하였다. 에이즈 정의 악성종양과 비에이즈 정의악성종양 발생 환자의 사이에는 내원 시점 CD4+ 세포수 중앙값은 각각 18, 114/uL로 비에이즈 정의 악성종양 환자에서 의미있게 높았다(p=0.001). 그 외에 성별, 전파경로, HBsAg 양성, 진단 시점 연령, 사망여부, HIV 감염에서 악성종양 진단까지 및 첫 내원부터 악성종양 진단까지 기간은 양 군 간에 의미있는 차이가 없었다. 결론: 국내 HIV 감염 환자의 악성 종양 발병률은 4%였다. 항HIV 치료에 의한 생존율의 향상에 따른 에이즈 악성종양의 감소와 비에이즈 정의 악성종양의 상대적 증가 양상은 관찰되지 않았다. 가장 흔한 악성종양은 비호지킨 림프종이었으며 비에이즈 악성종양 중에서는 소화기계통의 악성종양과 간암이 흔히 발생하였다. Background/Aims: The prevalence of malignancies associated with human immunodeficiency virus (HIV) is rapidly increasing. The aim of the present study was to identify clinical features associated with malignancies in South Korean patients infected with HIV. Methods: From January 1990 to June 2007, we reviewed an electronic database containing pathological reports obtained from HIV-infected patients and then retrospectively analyzed a total of 27 malignancy cases treated at four different institutions. Results: Among 683 patients infected with HIV, malignant diseases were diagnosed in 27 cases (4.0%). Twenty-five of these patients were male, and the median age was 48 (range; 24-76). At the time of diagnosis, the median CD4+ lymphocyte count was 42/uL (range 3-339). Acquired immune deficiency syndrome (AIDS)-defining malignancies were diagnosed in 13 patients (48%) and non-AIDS-defining malignancies were diagnosed in 14 patients (52%). Two patients each were diagnosed with AIDS-defining and non-AIDS-defining malignancies during the pre-highly active anti-retroviral therapy (HARRT) period. In contrast, 11 patients (48%) and 12 patients (52%) were diagnosed with AIDS-defining and non-AIDS-defining malignancies during the HARRT period, respectively. Among AIDS-defining malignancies, non-Hodgkins lymphoma was the most frequently observed (9/13), followed by Kaposi`s sarcoma (4/13). Among the 9 patients with non-Hodgkins lymphoma, diffuse large B-cell lymphoma was most common (5/9), followed by primary CNS lymphoma (3/9) and Burkitt`s lymphoma (1/9). Gastrointestinal (GI) malignancies [i.e., gastric cancer (3/14), rectal cancer (3/14), and esophageal cancer (1/14)] and hepatocellular carcinoma (3/14) were the most commonly observed among the non-AIDS-defining malignancies. Other observed non-AIDS-defining malignancies were thyroid cancer (1/14), tonsillar cancer (1/14), angiosarcoma (1/14), and eccrine cancer (1/14). Finally, median CD4+ lymphocyte counts at the time of diagnosis were significantly different (18 vs. 114/uL, p=0.001) between AIDS-defining malignancies and non-AIDS-defining malignancies. Conclusions: Malignancies were diagnosed in 4.0% of patients infected with HIV. This study showed similar rates of incidence between AIDS-defining and non-AIDS-defining malignancies. Non-Hodgkins lymphoma was the most frequently observed malignancy, whereas GI malignancies and hepatocellular carcinoma were common among non-AIDS-defining malignancies. (Korean J Med 76:554-563, 2009)

호흡부전 환자에서 비침습적 양압환기법의 적용

설영미 ( Young Mi Seol ),박영은 ( Young Eun Park ),김서린 ( Seo Rin Kim ),이재형 ( Jae Hyung Lee ),이수진 ( Su Jin Lee ),김기욱 ( Ki Uk Kim ),조진훈 ( Jin Hoon Cho ),박혜경 ( Hye Kyung Park ),김윤성 ( Yun Seong Kim ),이민기 ( Min 대한결핵 및 호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.61 No.1

연구배경: 다양한 원인에 의한 호흡부전증에서 중환자실뿐만 아니라, 응급실, 일반병실에서 호흡보조와 이탈방법으로 NPPV를 사용한 환자에 대해서 임상상을 조사하고, 유용성 및 예후를 조사하고자 하였다. 방법: 2003년 6월부터 2005년 5월까지 부산대학교병원에서 NPPV로 치료한 34명(남자 16명, 여자 18명, 평균연령 58세)을 대상으로 하였다. 모든 환자의 원인질환, 치료기간, 적응 유무, 합병증 및 치료에 대한 성공 여부, NPPV 적용 전과 적용 후 2시간과 24시간 후에 생체징후, 동맥혈 가스검사를 조사하였다. 결과: 성공 군은 24명(71%), 실패 군은 10명(29%)이었다. 성공 군은 실패 군에 비해 평균 연령, 성별, 치료기간, 생체 징후, PaO2, PaCO2, SaO2는 큰 차이가 없었으나, 적용 전의 pH는 유의하게 높았다. 만성폐쇄성 폐질환환자의 성공률이 비만성폐쇄성 폐질환환자보다 높았으며(86% vs 53%), 2시간후 동맥혈 가스검사도 유의하게 향상하였다. 비만성폐쇄성 폐질환환자에서도 기계환기 이탈 후 NPPV를 적용하였을 때 2시간후 동맥혈검사가 유의하게 향상되었다. 합병증은 총 5건으로 안면 피부 발적 3건, 복부팽만 1건, 구강 건조가 1건이 있었으나 이로 인한 중단 예는 없었다. 결론: 다양한 원인에 의한 호흡부전증 환자에서 호흡보조와 이탈방법으로 NPPV의 적용은 유용한 방법으로 생각되며, 적용 전의 pH와 적용 2시간 후 분당 호흡수, 동맥혈 이산화탄소 분압, 동맥혈 산소 분압, 산소포화도의 향상이 성공 여부에 중요한 인자로 생각된다. NPPV 적용의 성공률을 높이기 위해 적절한 기준 및 기계를 다루는 기술과 경험, 성공 인자에 대한 평가가 필요하다. Background: Noninvasive positive pressure ventilation(NPPV) has been increasingly used over the past decade in the management of acute or chronic respiratory failure and weaning of mechanical ventilation. We performed this clinical study to evaluate the usefulness of NPPV in patients who developed acute respiratory failure or post-extubation respiratory failure. Methods: We analysed thirty four patients(sixteen males and eighteen females, mean ages 58 years) who applied NPPV(BIPAP S/T, Respironics co., USA) for respiratory failure or weaning difficulty at medical intensive care unit(MICU), emergency room and general ward of a tertiary hospital. We evaluated the underlying causes of respiratory failure, duration of treatment, the degree of adaptation, complication and predictive parameters of successful outcome. Results: The overall success rate of NPPV was seventy-one percent. The duration of NPPV applying time, baseline blood pressure, pulse rate, respiration rate, PaO2, PaCO2, SaO2 were not different between success group and failure group. But, the baseline pH was higher in the success group. Predictors of success were higher baseline pH, patients with underlying disease of COPD, improvement of vital sign and arterial blood gas value after NPPV application. The success rate in patients with post-extubation respiratory failure was eighty percent. There were no serious complication on applying NPPV except minor complications such as facial skin erythema, abdominal distension & dry mouth. Conclusion: NPPV may be effective treatment in patients with acute respiratory failure or post-extubation respiratory failure in selected cases. (Tuberc Respir Dis 2006; 61: 26-33)

대전 대덕테크노밸리 지구 아파트 색채계획

이진숙(Lee Jin Sook),이미진(Lee Mi Jin),오도석(Oh Do Suk),설영미(Sul Young Mi) 한국색채학회 2005 한국색채학회 학술대회 Vol.2005 No.-

유도화학요법 및 국소 치료 후 원격전이를 보인 국소 진행성 두경부암 환자군의 임상 특징 및 위험인자에 관한 연구

이혜원(Hye Won Lee),백동훈(Dong Hoon Baek),이경남(Kyung Nam Lee),조은정(Eun Jung Cho),김효정(Hyo Jeong Kim),설영미(Young Mi Seol),송무곤(Moo Kon Song),최영진(Young Jin Choi),신호진(Ho Jin Shin),정주섭(Joo Seop Chung),조군제(Goon Jae 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.2

Backgrounds:Head and neck cancer is one of the most prevalent cancers in the world. It tends to remain lo-calized at the primary site and regional lymph nodes, but if distant metastasis occurs, it has a poor prognosis. This study was performed to evaluate the prevalence of distant metastasis and to determine the risk factor in local-ly advanced head and neck cancer after induction chemotherapy followed locoregional control therapy. Meth-ods:A retrospective review was performed in 420 patients with locally advanced head and neck cancer who treated with induction chemotherapy followed locoregional control therapy from January 2001 to December 2010. Among them, 31 patients who had distant metastasis as first relapse within 2 years after termination of therapy were analyzed for clinical features and the risk factors of distant metastasis. Results : The overall incidence of distant metastasis was 7.3%. The bone, lung, and liver were the most frequent metastatic organs. In univariate analysis, nodal stage, nasopharyngeal cancer, laryngeal cancer, G3/G4 neutropenia during induction chemother-apy, and concurrent chemoradiotherapy were the influencing factors for distant metastasis. In multivariate analy-sis, advanced N stage and nasopharynx were the risk factors of distant metastasis, and grade 3/4 neutropenia during induction chemotherapy was considered to decrease distant metastasis. Conclusion:This study sug-gests that the advanced N stage is the risk factor of distant metastasis and Grade 3/4 neutropenia during induction chemotherapy can be beneficial against distant metastasis in locally advanced head and neck cancer patients treat-ed with induction chemotherapy followed locoregional control therapy.

유기 박막 트랜지스터의 전기적-열적 성질에 관한 연구

이승찬(S.-C. Lee),이덕규(D.-K. Lee),설영국(Y.-G. Seol),안종현(J.-H. Kim),이내응(N.-E. Lee),김윤제(Y.-J. Kim) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5

The Organic Thin Film Transistor (OTFT) on flexible substrate electroplated electrodes has many advantages in the fabrication of low cost sensors, e-paper, smart cards, and flexible displays. In this study, we simulated 3-D OTFT with various voltage conditions by using COMSOL commercial package. Analysis model was limited with channel, gate, source and drain for research of thermal distribution. The channel interval is 40 urn and the voltage ranged between -20 and -40V. The OTFT was fabricated using pentacene as a semiconducting layer and electroplated Ni as a gate electrode. Electric properties of fabricated OTFT were characterized by I-V measurements and heat flux was predicted with the result of thermal distribution.

유연성 유기물 transistor를 제작을 위한 고유전 박막 위에서의 Pentacene의 특성

이순우,이상설,박정호,박인성,설영국,이내응,안진호,Lee Sun-Woo,Lee Sang-Seol,Park Jung-Ho,Park In-Sung,Seol Young-Gug,Lee Nae-Eung,Ahn Jin-Ho 한국마이크로전자및패키징학회 2006 마이크로전자 및 패키징학회지 Vol.13 No.2

본 연구는 OTS 표면 처리 유무에 따른 $HfO_2$ 위에서의 pentacene의 grain growth를 비교 연구하였다. OTS 처리에 의해 $HfO_2$의 표면은 hydrophilic에서 hydrophobic으로 변화되었으며, pentacene의 grain size는 50 nm 에서 90 nm으로 증가되었다. 이러한 pentacene의 크기 증가와 더불어 pentacene은 3-dimensional island 구조를 가지며, bulk phase 없이 thin film phase만의 출현으로 인해 OTS/$HfO_2$ 박막 위에서 pentacene은 보다 방향성을 가지며 정렬되었다. We reported the grain growth of pentacone on $HfO_2$ film depending on OTS treatment. The hydrophilic $HfO_2$ thin film was changed into hydrophobic with less interface energy by OTS treatment. The grain size of pentacene on OTS/$HfO_2$ film was increased from 50 nm to 90 nm with the variation of surface energy and the structure was maintained 3-dimensional island structure. Pentacene on OTS/$HfO_2$ surface was directionally arrayed due to appearance of the only thin film phase without bulk phase by OTS treatment.

혈청 항중성구세포질항체 (ANCA) 양성인 반월상 IgA신증 1예

박영은 ( Young Eun Park ),설영미 ( Young Mi Seol ),이혜정 ( Hye Jeong Lee ),안승재 ( Seoung Jae An ),송상헌 ( Sang Heon Song ),이동원 ( Dong Won Lee ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm Soo Kwak ),설미영 ( Mi Young Seol ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.4

특별강연 및 학술연구 발표요지 : 제1분야: 잡초방제 ; 화본과 식물 간 수중 산소 조건에 따른 혐기 대사산물 발생 차이

설영미 ( Y. M. Seol ),김성은 ( S. E. Kim ),조광민 ( K. M. Cho ),신광미 ( K. M. Shin ),손민 ( M. Son ),이진호 ( J. H. Lee ),전재철 ( J. C. Chun ) 한국잡초학회 2006 한국잡초학회 별책(학술대회 초록집) Vol.26 No.2

무역경영자의 정보화 혁신정도가 전자무역에 미치는 실증적 연구

설영기(Young-ki Sul),이제홍(Je-hong Lee) 한국국제상학회 2005 國際商學 Vol.20 No.2

The competitive environments of the 2001's appears to demand not only information technology (IT). but also practical use of internet network in all business areas. Accordingly, Trader's CEO are recognizing that these objectives can only be achieved through conscious mind and business mind in digital management. To make a successful organizational innovation. CEO needs to have the conscious mind for change of human resource management. The underlying theories such as Technology Acceptance Model. examined in the process of deriving the research model. Research methodology used in this study was mainly survey and questionnaire. Structural equation model is used in the hypotheses test. the results support all hypotheses involving hypothesis 1 and 6. The major finding of this paper would be summarized as followed: 1) Perceived information innovations of Trade company CEO's is positively related to the activity level and activity range of trade practical 2) Perceived electronic trade acceptance of trade company CEO's is positively related to the activity achievement of electronic trade. CEO Information attitudes of trade information and knowledge have significant influences on the adoption of hypothesis. There is direct successful factors of Electronic Trade firm, it is they got the notion that for trade information. an appropriate manager which is as important as the technical leadership itself. also they employed the people who are very good at skilled management.

전기-열 유동-구조 연성해석을 이용한 합금철 전기로의 온도 분포 고찰

이하민(Hamin Lee),박석준,설영진(Youngjin Seol),윤장혁(Janghyeok Yoon),김창완(Chang-Wan Kim) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11