국립중앙도서관 귀중서고 내 알데히드류 및 휘발성유기화합물(VOCs)에 대한 건강위해성평가

이혜원,임희빈,이귀복,박소연,전정인,이철민,Lee, Hye-Won,Lim, Hui Been,Lee, Kwi-Bok,Park, So Yeon,Jeon, Jeong In,Lee, Cheol Min 한국환경과학회 2020 한국환경과학회지 Vol.29 No.6

This study investigates the concentration distribution of aldehydes and volatile organic compounds (VOCs) in the archive of the National Library in Korea and evaluates the health risks to workers from hazardous chemicals. Acetaldehyde had the highest concentration among the nine species of aldehydes present in the archive and the concentration of toluene was the highest among the six species of VOCs. Most of the detected substances showed that their indoor concentrations were higher than the outdoor ones, suggesting the possibility of indoor sources of aldehydes and VOCs. The evaluation of health risks for workers based on these measurement results showed that not all substances were hazardous to the human body. However, considering the possibility of the presence of indoor sources and the potential limits of our study owing its short period, it is necessary to conduct long-term studies on the concentration distribution of indoor pollutants in the archive environment.

가토 간내 선택적 담관결찰후 간부피의 변화에 대한 실험적 연구

이혜원,윤엽,고영태,최우석,임주원,오주형,임형택,김윤화,이석환,Lee, Hye Won,Yoon, Yup,Ko, Young Tae,Choi, Woo Suk,Lim, Joo Won,Oh, Joo Hyeong,Rim, Heyong Teck,Kim, Youn Wha,Lee, Seok Hwan 대한영상의학회 1998 대한영상의학회지 Vol.39 No.6

Purpose : To evaluate the role of bile duct obstuction in the development of atrophy of the liver, using ananimal model. Materials and Methods : Seven rabbits were divided into two groups : group 1(n=5), in which therewas selective bile duct ligation, and group 2(n=2), which underwent a sham operation. Each group was evaluatedusing CT for changes in hepatic volume after selective bile duct ligation or a sham operation. In group I, thediameter of dilated bile duct was measured 2, 4, 8, 12 and 16 weeks after bile duct ligation, while gross andhistologic change were evaluated in all cases. Results : In group 1, bile duct dilatation was seen on CT two weeksafter selective bile duct ligation, and did not change significantly during follow-up. In four of five cases, CTrevealed no evidence of significant atrophy of the involved segment. Pathologic specimens, however, revealeddilatation of the bile duct, periductal fibrosis, infiltration of chronic inflammatory cells, and periportalfibrosis. One of five cases showed segmental liver atrophy after selective bile duct ligation. In addion to theabove pathologic findings, there was obstruction of the portal vein by foreign body reaction. In group 2, noevidence of dilated bile duct or liver atrophy was revealed by CT or pathologic specimen after a sham operation.Conclusion : During long-term follow-up of 16 weeks, obstruction of the bile duct did not play a major role in thedevelopment of lobar atrophy in the rabbit.

참개구리(Rana nigromaculata) 유생기 상피 세포사의 미세구조

이혜원,문명진,Lee, Hye-Won,Moon, Myung-Jin 한국현미경학회 2010 Applied microscopy Vol.40 No.2

변태중인 참개구리(Rana nigromaculata) 유생의 상피에서 세포자멸사가 초래된 세포를 확인하고 이들의 핵과 세포질에서 나타나는 퇴행과정의 미세구조 변화를 TUNEL 염색법과 투과전자현미경 관찰을 통해 분석하였다. 꼬리의 퇴화가 진행되는 Shumway 발생단계 31기부터 33기까지의 유생 상피는 다층의 입방형세포로 이루어져 있었고, TUNEL 염색으로 관찰한 결과, 상피 전역에 걸쳐 광범위한 세포자멸사가 진행되고 있음을 확인할 수 있었다. 자멸사에 의해 초래되는 상피세포의 초기 변형은 먼저 핵에서 관찰되었는데, 염색질이 응축되어 핵막 주변부로 편재되었고 핵의 분절과 세포질의 응축, 그리고 세포막의 변형이 뒤따르는 것으로 확인되었다. 이어서 세포질의 분절에 의해 자멸소체가 형성되었는데 막으로 둘러싸인 소체 내부에서는 비교적 잘 보존된 형태의 세포소기관들이 관찰되었다. 자멸사가 초래된 세포들은 상피내 대식세포(intraepithelial macrophage)로 추정되는 인접 세포들에 의해 탐식되어 잔여소체를 형성하였으며, 급속한 퇴화과정을 거쳐 층판구조를 지닌 소포의 형태로 변형된 후 세포질에서 소멸됨이 확인되었다. The fine structural characteristics of the apoptotic cells in the cutaneous epithelium of the anuran tadpole of the black-spotted frog, Rana nigromaculata was examined using the TUNEL (Terminal deoxynucleotidyl transferase-mediated biotinylated d-Uridine triphosphate Nick End Labeling) staining technique and TEM (transmission electron microscopy) observations. The cutaneous epithelium of the tadpole was composed of stratified cuboidal cells and the apoptotic cell death was observed continuously during the tail degeneration stages from the Shumway stage number 31 to 33. The early apoptotic cells shown in the epithelium demonstrated condensation and margination of the chromatin material at the nuclear periphery, and nuclear breakdown and cytoplasmic condensation were followed. Subsequent cytoplasmic degeneration of the apoptotic cell were produced by membrane-bounded cell fragments with relatively well preserved organelles. Following the processes of autophagic degradation, the late apoptotic cells being phagocytosed by other surrounding cells. These nearby cells, presumptive intraepithelial macrophages, contain a variety of lysosomal residual bodies which fuses with other cell organelles or other cytoplasmatic material to form secondary lysosomes. They are soon transformed into lamellar shaped vesicles and finally disappeared during the process of degradation.

이벤트 - 2005서울국제도서전

이혜원,Lee, Hye-Won 대한출판문화협회 2005 출판저널 Vol.356 No.-

서울국제도서전 결산과 과제

이혜원,Lee, Hye-Won 대한출판문화협회 2004 출판저널 Vol.344 No.-

온톨로지 구조로 표현된 FRSAD 모형에 관한 연구

이혜원,Lee, Hye-Won 한국비블리아학회 2012 한국비블리아학회지 Vol.23 No.1

FRSAD과 온톨로지 모형간의 연계는 어떠한 정보구현시스템이나 특정 상황에서도 독립적인 상위 계층의 지식구조를 제안하고, 의미 연결, 지식구조, 주제접근, 상호운용성 등을 확보하기 위한 노력이다. FRSAD 모형을 현실적인 정보환경에 적용하고, 도서관 안팎 어디서나 자유롭게 정보를 확인하고 공유하기 위해서는 지식표현 인코딩 체계가 필요하다. 본 연구에서는 웹 온톨로지 언어인 OWL를 사용하여 FRSAD 모형을 온톨로지 구조로 표현하였으며, 이를 확인하기 위해 Prot$\acute{e}$g$\acute{e}$를 사용하여 FRSAD 온톨로지 모형을 시범적으로 구축하였다. Mapping FRSAD and other ontology models intends to suggest a higher knowledge level that is independent of any information implementation system or specific context, and to endeavor to focus on the semantics, knowledge structures, subject access, and interoperability. Providing an application of FRSAD model to information environment and representing and sharing the information within the library sector and beyond, there needs encoding scheme for knowledge representation. This study suggested an OWL based ontology architecture for FRSAD model and demonstrated the pilot FRSAD ontology model using Prot$\acute{e}$g$\acute{e}$ software.

Nut류의 항산화 및 항균효과

이혜원,최무영,차배천,Lee, Hye-Won,Choi, Moo-Young,Cha, Bae-Cheon 한국생약학회 1998 생약학회지 Vol.29 No.1

It has been known that diseases related with aging or cancer result, at least in part, from free radicals, and antioxidants may reduce or prevent the abnormalities associated with free radical formation via its scavenging action. Thus, this study was carried out to investigate the antioxidative and antimicrobial activities of nut species for the purpose of developing antioxidant from natural products. Antioxidant activities of four kinds of nuts such as chestnut, groundnut, walnut and acorn were examined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The extracts from chestnut hull and acorn barnyard millet showed strong antioxidative activities among 10 samples tested. Because of their highest antioxidative activity among 10 samples, radical scavenging effects of 4 different extract compartments (Hexane, EtOAc, BuOH and $H_2O$ extracts) from chestnut hull and acorn barnyard millet, were further examined by DPPH method. EtOAc and BuOH extracts exhibited antioxidative activities similar to those of natural, tocopherol or synthetic antioxidants, BHA. These findings demonstrates that major fraction of the antioxidative activity of chestnut hull or acorn barnyard millet was the EtOAc and BuOH extract compartments. However, antimicrobial activities against food-related bacteria and yeasts was relatively weak.

말기암 환자 가족에 대한 호스피스 팀의 정보적 지지 제공 효과

이혜원,Lee, Hye-Won 한국호스피스협회 2001 호스피스 학술지 Vol.1 No.1

To evaluate the effect of informational support by hospice team on family caregivers of terminally ill cancer patients, 22 family caregivers of D University Hospital in Daegu city were participated. The research was conducted from Aug. 16th to Oct. 28th 2000 by using self-reported questionnaires. The instruments used in this study were the Weinert's scale of perceived social support, Spielberger's state anxiety inventory, CES-D, and Ellison and Paloutzian's spiritual well-being scale. The intervention was designed to give educational and counselling program up to 7 times within 4 weeks. Educational and counselling booklets which made by the researcher were used step by step by hospice team. The data were analysed frequency, percentage, Wilcoxon Singed Ranks Test Test with SPSS Win 10.0/PC. The results obtained from this study were as follows: 1.The perceived social support of family caregivers was significantly increased after ready planned informational support was applied by hospice team(z=-3.045, p=0.002). 2.The anxiety of family caregivers was significantly reduced after ready planned informational support was applied by hospice team(z=-3.348, p=0.001). 3.The depression of family caregivers was significantly reduced after ready planned informational support was applied by hospice team(z=-3.641, p=0.000). 4.The spiritual well-being score of family caregivers was not significantly improved after ready planned informational support was applied by hospice team(z=-0.422, p=0.673). In conclusion, the results of this study clearly suggests that the informational support provided by hospice team not only increased the family caregivers' who are caring for terminally ill cancer patients. Therefor the informational support program designed by researcher for family caregivers who are caring for terminally ill cancer patients should be utilized and expended.

유지 치주치료에 대한 환자 협조도 분석

이혜원,박진우,서조영,이재목,Lee, Hye-Won,Park, Jin-Woo,Suh, Jo-Young,Lee, Jae-Mok 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.2

Purpose: The purpose of this study was to evaluate the compliance to maintenance schedules recommended supportive periodontal therapy(SPT) and to determine differences in the characteristics of compliant and non-compliant patients. Methods: 414 patients commencing SPT after active periodontal treatment from 2003 to 2005 were included in this study. Based on their compliance with the suggested maintenance schedule, patients were classified as compliant and non-compliant groups. Also patients classified by gender, age, degree of alveolar bone loss and treatment rendered. The association between compliance and patient characteristics was assessed by odds ratio in logistic regression analyses. Results: Only 47% of the initial patient was found to be compliant at the end of August 2008 and 20.8% patients were lost in the first year of SPT. There were significant differences between compliant and non-compliant regard to age, degree of alveolar bone loss and treatment rendered. Conclusions: In conclusion, compliance with SPT generally poor and patients who were older, treated surgical therapy and with mild alveolar bone loss are more compliant to SPT.

목록의 집중기능을 향상시키는 '원형' 개념에 관한 연구

이혜원,Lee, Hye-Won 한국비블리아학회 2011 한국비블리아학회지 Vol.22 No.3

저작은 목록의 집중기능에 중요한 역할을 하는 서지 개체이다. 본 연구에서는 저작의 개념을 재분석하고, 이미 공표된 FRBR 저작의 개념을 보완할 수 있는 새로운 방안을 모색하고자 하였다. 저작의 집중기능을 향상시킬 수 있는 방안으로 저작보다 한 차원 높은 '원형' 개체를 선언하였고, 원형과 관련된 속성 및 관계를 FRBR 모형과 연결하여 설명하였다. Work is a bibliographic entity serving a key role for the collocation function of catalog. This study analyzed the concept of work, provided a new device to complement conventional FRBR work. The 'prototype' was suggested to enhance the collocation function of catalog, the highest level in FRBR. This study explained the definition, attributes of prototype, and relationships between prototype and work within FRBR model.