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윤보라 ( Bo Ra Yun ),이명호 ( Myung Ho Lee ),이혜순 ( Hye Sun Lee ),최윤영 ( Yoon Young Choi ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: Insufficiency fracture (IF) occurs when normal or physiological muscular activity stresses a bone that is deficient in mineral or elastic resistance. We studied clinical characteristics of IF in patients with chronic inflammatory joint diseases in Korea. Methods: Between Aug. 1997 and Feb. 2003, thirty five patients with 77 fractures were studied at the authors` institution when they were being treated for their rheumatic diseases. The clinical and laboratory data were collected by review of medical record retrospectively. Results: All patients except four were postmenopausal women (mean age 63.0±10.0 years) with long disease duration (mean 14.2±11.6 years). Thirty three patients had rheumatoid arthritis, 1 ankylosing spondylitis and 1 systemic lupus erythematosus. Twenty nine patients (85.7%) were receiving regular steroid treatment (mean dose 4.0±2.3 mg/day, mean duration 6.1±4.2 years). Twenty four patients were treated with methotrexate. The significant reduction in their bone mineral density was found 27 patients based on BMD or QCT. Eight patients without osteoporosis were treated with steroid or MTX. Twenty three patients were ever used for osteoporosis treatment. Most patients except four presented with pain in the low back, groin, hip, pelvic, leg and knee. Initial simple radiography was positive in only 7 patients, with vertebral compression fracture in 11 patients and no effect on mobility except ten. Diagnosis was delayed (mean duration of symptom until diagnosis was 45.6±64.5 days). IF was confirmed using the bone scan. Sacrum and pelvic bone was most frequently affected site. The other sites were SI joint, iliac wing, symphysis pubis, acetabulum and femur neck. Twenty nine patients required in-patient stay (mean 17.4 days). All but one patient showed an uneventful recovery with conservative treatment. Conclusion: The low grade nature of symptoms, minimal effect on mobility, absence of significant trauma and missed on initial plain radiography make diagnosis difficult and delayed. IF should be suspected in cases of unexplained pain with local tenderness in patients of chronic inflammatory joint diseases. The technetium-99m diphosphonate bone scintigraphy was valuable diagnostic tool in the early recognition of IF.
국립소방역사박물관의 전시 프로그램과 공간구성에 관한 연구
윤보라(Yun, Bo-Ra),공순구(Kong, Soon-Ku) 한국실내디자인학회 2019 한국실내디자인학회 학술대회논문집 Vol.21 No.1
There have been numerous human casualties caused by various incidents around the world; overcrowding and convenience from urban development are becoming dangerous factors in people"s lives. which leads to the purpose of the study; to plan the National Fire History Museum to enhance people’s safety awareness from education and furthermore, prevent accidents. The study analyzes exhibition programs and spacial compositions of Fire History museums and proposes an exhibition plan for an efficient exhibition program and spatial composition. Fire museum cases overseas were analyzed with an exhibition system of narratives to identify problems from existing exhibition programs and spatial composition and propose a solution. The research methods were analyzing preceding studies, the constructive system of the exhibition, and composing elements of narratives. According to the analysis, fire museum overseas had simple narrative structure and text-oriented education programs—visitors can easily lose interest from the exhibition—lack of narrative characteristics was analyzed. Under the assumption that the museum program and space provides interesting experience to visitors from analysis of visitor’s various sensual experiences and information can lead to a better educational effect than before. This study analyzes the program and spatial composition of fire museums overseas and structure of exhibition narratives to provide guidelines—structural elements of programs, spatial composition, and narratives—designing a Fire History museum. Furthermore, the study focuses on the problems that existing exhibition systems have and provide academic help to the National Fire History museum; Effective education of knowledge and thinking from the exhibition.
김현철,최승경,윤보라,Kim, Hyun-Chul,Choi, Seung-Kyung,Yun, Bo-Ra 한국통계학회 2011 Communications for statistical applications and me Vol.18 No.1
우리는기온의변화와기온변동성을알아보기위해한국의다섯지점에서측정한월평균기온, 일최고기온, 일최저기온에 대한 50년간의 장기시계열을 분석하였다. 그 결과 기온은 1960년대에 비해 2000년대에 월평균기온을 기준으로 울산은 연평균 $1.26^{\circ}C$, 서울은 $1.19^{\circ}C$ 상승하였으나 추풍령은 $0.13^{\circ}C$ 상승하여 지점별로 큰 차이가 있었다. 또 계절별로 다른 현상을 나타내기도 하였다. 그러나 기온변동성에 대한 분석결과, 변동성의 증가는 확인할 수 없었다. We analyzed the observed temperature data for 50 years on 5 representative points in Korea to verify global warming and the increase in climate variability. We found that there was some level of global warming but we could not disregard the effects of urbanization. In addition, we could not find any information for the increase in climate variability.
서장경으로부터 분리한 Homosyringaldehyde의 뇌신경세포 보호 활성
원진배(Jin Bae Weon),이보형(Bohyoung Lee),윤보라(Bo-Ra Yun),이지우(Jiwoo Lee),마충제(Choong Je Ma) 대한약학회 2012 약학회지 Vol.56 No.5
Homosyringaldehyde was isolated and identified from the 80% methanol extract of roots of Cynanchum paniculatum. C. paniculatum has been widely used for the treatment of various diseases such as neurasthenia, insomnia, dysmenorrheal and toothache. This compound exerted significant neuroprotective activities against glutamate-induced neurotoxicity in hippocampal HT22 cell line by 37.53% (at the concentration of 100 μM). We investigated mode of action of this compound. Homosyringaldehyde (100 μM) significantly decreased the ROS level and Ca2+ concentration in the oxidative stress induced HT22 cells by oxidative glutamate toxicity. Thus, our results suggest that homosyringaldehyde significantly protect HT22 cells against glutamate-induced oxidative stress, via antioxidative activities. As the results, we suggest that homosyringaldehyde may be useful in the treatment of neurogenerative disorders.
증숙 과정을 통한 소청룡탕의 뇌신경세포 보호 활성 변화에 관한 연구
원진배(Jin Bae Weon),양혜진(Hye Jin Yang),이보형(Bohyoung Lee),윤보라(Bo-Ra Yun),마진열(Jin Yeul Ma),마충제(Choong Je Ma) 대한약학회 2011 약학회지 Vol.55 No.6
So Cheong Ryong Tang (SCRT) has been used as a traditional herbal medicine for the treatment of the bronchial asthma. In this study, the effect of steaming process on changes in 11 major compounds (homogentisic acid, ephedrine HCl, paeoniflorin, cinnamic acid, cinnam aldehyde, glycyrrhizin, 6-gingerol, schizandrin, methyleugenol, gomisin A and gomisin N) content and neuroprotective activity of SCRT were evaluated. Major compound content was slightly different with steaming produce. The contents of paeoniflorin, cinnamic acid, cinnam aldehyde, 6-gingerol and methyleugenol were decreased and homogentisic acid, ephedrine HCl, glycyrrhizin, schizandrin and gomisin A were increased by steaming process. The neuroprotective activity of steaming SCRT was determined in mouse hippocampal HT22 cells by MTT assay. As a result, neuroprotective activity of a steaming SCRT was higher than that of a non steaming SCRT. This study demonstrated that neuroprotective activity of SCRT can be improved through steaming process.
굴곡성 기관지 내시경과 바스켓을 이용한 기관지 이물 제거 2예
김영철,윤보라,안전옥,백만순,나문준 중앙대학교 의과대학 의과학연구소 1999 中央醫大誌 Vol.24 No.1
저자들은 식사중 부주의로 흡인된 우측 중간 기관지 이물과 우상엽 기관지 내에 생긴 기관지 결석을 굴곡성 내시경과 바스켓을 이용하여 제가한 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다 We have experienced two cases of foreign body in the tracheobronchial tree which removed by fiberoptic bronchoscopy with basket. Traditionally, rigid bronchoscopy has been the treatment for endobronchial foreign body in adults. Recent some reports have suggested that the fiberoptic bronchoscopy may be a valuable therapeutic option for adults. Of our case was aspirated bean in the right intermediate bronchus and the other one was broncholith in the orifice of the anterior segmental bronchus of the right upper lobar bronchus, Removal of this endobronchial foreign bodies would be accomplished by fiberoptic bronchoscope with basket successfully. They are didn't experience any complication and the complete resolution of pneumonia was followed after removal of foreign bodies.
이영환,정진영,나문준,김영철,윤보라,안전옥,백만순,강동욱 대한내과학회 2000 대한내과학회지 Vol.59 No.2
It is very rare for the primary lung cancer to metastasize to gastrointestinal tract, which has poor prognosis. A 72-year-old man admitted with dyspnea and a mass lesion in the left lower lobe on chest roentgenogram and chest computed tomogram(CT). Large cell carcinoma of the lung was diagnosed by percutaneous needle biopsy. Also gastroduodenoscopy was conducted for evaluation of gastrointestinal symptoms, such as indigestion and epigastric discomfort. Large cell carcinoma of duodenum was diagnosed by biopsy of duodenal polyp, which was considered to be metastasized from the primary lung cancer. Palliative radiation therapy was performed, but he died 2 months after diagnosis. We report a rare case of large cell carcinoma of the lung with metastasis to uodenum. (Korean J Med 59:240-244, 2000)