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다낭난소증후군에서 인슐린수용체기질 유전자다형성과 인슐린 저항성의 관련성에 관한 연구
오지영,오지영,성연아,이혜진,정혜원 대한내분비학회 2009 Endocrinology and metabolism Vol.24 No.2
Background: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS), and several candidate genes involved in insulin action such as insulin receptor or insulin recpetor substrate (IRS) have been investigated. In this study, we examined the genetic effects of the IRS-1 and IRS-2 genes on the metabolic and reproductive features in women with PCOS. Methods: 125 patients with PCOS and 344 regular cycling controls were enrolled. Analysis of the polymorphisms of Gly972Arg in the IRS-1 gene and Gly1057Asp in the IRS-2 gene was performed and oral glucose tolerance tests and hyperinsulinemic euglycemic clamp tests were done. Results: The genotype frequencies of the Gly972Arg polymorphism in the IRS-1 gene and the Gly1057Asp polymorphism in the IRS-2 gene were not significantly different between the women with PCOS and the controls. Gly972Arg polymorphism of the IRS-1 gene was extremely rare in both groups. PCOS women with the IRS-2 Asp1057Asp genotype showed significantly higher hirsutism scores, higher levels of free testosterone and higher post-load 60, 90, and 120 min plasma glucose levels compared to those women with the Gly1057Gly or Gly1057Asp genotype. In contrast, the control women with the Asp1057Asp genotype showed significantly lower post-load 60, 90, and 120 min plasma glucose levels compared with those women with the Gly1057Gly or Gly1057Asp genotype. Conclusion: Gly972Arg polymorphism of the IRS-1 gene was extremely rare in Korean women. Gly1057Asp polymorphism of the IRS-2 gene was associated with the phenotypic features of PCOS such as hirsutism, hyperandrogenemia and hyperglycemia, but it was not associated with the insulin sensitivity index. In conclusion, Gly1057Asp polymorphism of the IRS-2 gene may not have a significant impact on insulin resistance in Korean women with PCOS. Background: Insulin resistance is a key factor in the pathogenesis of polycystic ovary syndrome (PCOS), and several candidate genes involved in insulin action such as insulin receptor or insulin recpetor substrate (IRS) have been investigated. In this study, we examined the genetic effects of the IRS-1 and IRS-2 genes on the metabolic and reproductive features in women with PCOS. Methods: 125 patients with PCOS and 344 regular cycling controls were enrolled. Analysis of the polymorphisms of Gly972Arg in the IRS-1 gene and Gly1057Asp in the IRS-2 gene was performed and oral glucose tolerance tests and hyperinsulinemic euglycemic clamp tests were done. Results: The genotype frequencies of the Gly972Arg polymorphism in the IRS-1 gene and the Gly1057Asp polymorphism in the IRS-2 gene were not significantly different between the women with PCOS and the controls. Gly972Arg polymorphism of the IRS-1 gene was extremely rare in both groups. PCOS women with the IRS-2 Asp1057Asp genotype showed significantly higher hirsutism scores, higher levels of free testosterone and higher post-load 60, 90, and 120 min plasma glucose levels compared to those women with the Gly1057Gly or Gly1057Asp genotype. In contrast, the control women with the Asp1057Asp genotype showed significantly lower post-load 60, 90, and 120 min plasma glucose levels compared with those women with the Gly1057Gly or Gly1057Asp genotype. Conclusion: Gly972Arg polymorphism of the IRS-1 gene was extremely rare in Korean women. Gly1057Asp polymorphism of the IRS-2 gene was associated with the phenotypic features of PCOS such as hirsutism, hyperandrogenemia and hyperglycemia, but it was not associated with the insulin sensitivity index. In conclusion, Gly1057Asp polymorphism of the IRS-2 gene may not have a significant impact on insulin resistance in Korean women with PCOS.
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오지영 한국산업식품공학회 2018 학술대회 및 심포지엄 Vol.2018 No.04
전체 김치시장 규모는 2조 3,886억으로 자가제조 1조 2,300억, 상품김치 1조 1,586억 규모이며, 그 중 상품김치는 업소용을 제외하고 가정용의 경우 약 3,000억 규모로 이중 리테일은 2,098억으로 추산된다. 현재의 시장규모에서 2025년까지 상품김치 시장은 어떤 규모로 변화될지 몇가지 지표를 바탕으로 예측해 보면 아래와 같다. 대한민국 가구 구조변화, HMR 취식트렌드 등의 식생활 패턴 변화, 김치조달방식 변화등으로 자가제조 김치시장에서 매년 약 1.9%씩 포장김치로 수요가 전이될 때 2017년 16%에서 2020년 19.6%, 2025년 25.6%로 성장될 것으로 전망되며 김치시장은 B2C기준 2020년 5,158억, 2025년 7,863억으로 예측된다. 인구감소와 1인당 김치취식량 변화에 따라 김치시장의 성장이 둔화, 축소되는 것이 아니라 식생활의 패턴과 김치조달 방식의 변화로 자가제조 시장에서 전이되면서 포장김치 시장의 성장율은 더 빠르고 클 것으로 예측된다. 반면, 2032년을 기점으로 인구 증가율이 마이너스로 전환되고, 노령화에 따른 15세~64세 인구가 빠르게 감소되어 가용 노동인구의 감소가 예상된다. 또한 근로자의 노동시간은 단축되는 반면 노동임금은 증가되고 있으며 노동환경 역시 빠르게 변화되고 있다. 김치의 경우 김치가 상품화 되기 시작하였던 1980년대 대비 상당부분 설비를 이용한 기계화, 자동화가 부분적으로 도입되어 수작업 의존도가 많이 낮아졌다. 그러나 포장김치 시장으로는 한국의 약 3배에 이르는 일본과의 제조경쟁력을 비교하였을 때에는 아직도 해결해야 되는 숙제들이 많은 것이 현실이다. 그럼에도 김치세계화를 위해 세계김치연구소와 기업을 중심으로 제조공정 자동화에 대한 연구가 활발히 진행되고 있으며, 일부 자동화 설비가 제조현장에 도입/상용화 되고 있는 것은 바람직하다고 할 수 있겠다. 향후 성장하는 김치시장에 대응하고 김치세계화를 위해서 제조경쟁력은 더 이상 선택이 아닌 필수요건임에는 의심의 여지가 없는 부분이다.
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오지영,김진우,김용수,정우경,송순영 대한영상의학회 2010 대한영상의학회지 Vol.62 No.3
Pancreatic arteriovenous malformation and isolated spontaneous dissection of the superior mesenteric artery are both rare maladies, and now they can be easily diagnosed due to the development of such noninvasive modalities as multi-detector computed tomography and magnetic resonance imaging. We report here on the multi-detector computed tomography and magnetic resonance imaging findings of a rare case of pancreatic arteriovenous malformation combined with isolated dissection of the superior mesenteric artery.
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Peppermint Oil Promotes Hair Growth without Toxic Signs
오지영,김영철,박민아 한국독성학회 2014 Toxicological Research Vol.30 No.4
Peppermint (Mentha piperita) is a plant native to Europe and has been widely used as a carminative and gastric stimulant worldwide. This plant also has been used in cosmetic formulations as a fragrance component and skin conditioning agent. This study investigated the effect of peppermint oil on hair growth in C57BL/6 mice. The animals were randomized into 4 groups based on different topical applications: saline (SA), jojoba oil (JO), 3% minoxidil (MXD), and 3% peppermint oil (PEO). The hair growth effects of the 4-week topical applications were evaluated in terms of hair growth, histological analysis, enzymatic activity of alkaline phosphatase (ALP), and gene expression of insulin-like growth factor-1 (IGF-1), known bio-markers for the enhanced hair growth. Of the 4 experimental groups, PEO group showed the most prominent hair growth effects; a significant increase in dermal thickness, follicle number, and follicle depth. ALP activity and IGF-1 expression also significantly increased in PEO group. Body weight gain and food efficiency were not significantly different between groups. These results suggest that PEO induces a rapid anagen stage and could be used for a practical agent for hair growth without change of body weight gain and food efficiency.
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