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신호문(HM Shin),유중배(JB Yoo),신영우(YW Shin),한영호(YH Han),김문신(MS Kim),김두상(DS Kim),이태형(TH Lee) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.1
조직학적으로 확진된 4기 악성 Brenner 종양 1예에 수술 및 화학치료를 가하고 이와 병행하여 second-look Laparotomy로서 debulking하고 third-look laparotomy로서 완치를 확인하였기 보고한다. Malignant Brenner tumor is a relatively rare tumor of the obary. We had experienced a rare case of malignant Brenner tumor, Stage Ⅳ. A Brief review of the litertures and a discussion concerning malignant Brenner tumor are presented in this paper.
소목(Caesalpina sappan L.)추출물의 항균성과 분쇄육의 저장에 미치는 영향
이신호(Shin-Ho Lee),문원석(Won-Suk Moon),박경남(Kyung-Nam Park) 한국식품영양과학회 2000 한국식품영양과학회지 Vol.29 No.5
소목 추출물의 식품보존제로서의 사용 가능성을 검토 하고자 추출물의 항미생물 활성을 조사한 결과 소목 추출물은 공시 균주에 대해 뚜렷한 clear zone이 생성되어 항균활성을 나타내었으며, 추출물 1% 함유한 TSB에서 B.subtilis KCTC 1021, V. parahaemolyticus ATCC 17802는 배양 12시간동안 성장을 거의 관찰할 수 없었으며, 그외 L. monocytogenes Brie 1, E. coli ATCC 11775, S. aureus ATCC 11775, P. fluorescens ATCC 11775 등은 4~5log10 cycle 성장 억제 현상을 나타내었다. 추출물 1%를 첨가한 분쇄육의 4℃에서 30일간 저장 중 pH 변화는 대조구의 경우 저장기간 동안 pH 5.2에서 6.0으로 변화하였으나, 첨가구의 경우 pH 5.0~5.2의 범위를 유지하였다. 미생물의 변화는 대조구의 경우 저장 15일이 지나면서 10^6/g 이상을 나타낸 반면 첨가구의 경우 저장 25일째 10^6/g을 나타내었다. Coliform bacteria의 변화는 대조구는 저장 30일 동안 10³/g에서 10^6/g까지 증가하였으나, 첨가구는 저장 20일째까지 10³/g을 나타내었다. 백색도(lightness)는 저장 중 대조구와 첨가구간의 차이는 나타나지 않았다. 적색도(redness)는 대조구의 경우 저장 10일 이후 급격하게 감소한 반면, 첨가구는 저장 20일째까지 뚜렷한 변화는 관찰되지 않았으나 저장 25일 이후 급격하게 감소였다. Hamburger patty를 제조한 다음 소목 추출물을 1%, 3%의 비율로 첨가하여 대조구와 기호성을 비교한 결과는 대조구와 추출물 1% 첨가구간의 기호성은 맛, 향, 종합적 기호도면에서 뚜렷한 차이는 나타나지 않았다. Antimicrobial activity of Caesalpina sappan L. extract (CS extract) against 6 kinds of food spoilage and pathogenic organisms was studied. The growth of Listeria monocytogenes Brie 1, Escherichia coli ATCC 11775, Staphylococcus aureus ATCC 11775, and Pseudomonas fluorescens ATCC 11775 was inhibited about 4 to 5 log_(10) cycle in Tryptic Soy Broth (TSB) containing 1% CS extract. Bacillus subtilis KCTC 102 and Vibrio parahaemolyticus ATCC 17802 did not show apparant growth in the same medium. Effect of CS extract on preservation of ground meat was also investigated. The range of pH change was 5.0~5.2 in CS extract added ground meat, 5.2~6.0 in CS extract not added ground meat (control) during storage at 4℃ for 30 days. Number of total bacteria after 15 days storage was 10^6/g in CS extract added ground meat, 10³/g in control. Redness of ground meats was improved significantly by addition of 1% CS extract during storage at 4℃ for 30 days. The sensory quality of 1% CS extract added hamburger patty was similar to that of the control in taste, flavor, and overall acceptability.
만삭임신 및 만삭전 임신에서 음향자극후 태아심박동 각 변수의 변화
이재억,신호문,박문일,문형,김두상 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1
Various fetal heart rate (FHR) tests including nonstress test (NST) have been used for antepartum fetal surveillance. The test using FHR response to externally applied sound, namely acoustic stimulation test (AST), is currently being used as an alternative tool of NST. However, there were only few reports regarding computerized FHR analysis in the AST. Individual subjective analysis of FHR tracings can be replaced with an automated computerized objective nalysis system and the accurate recording and analysis of FHR records is now possible using personal computers. In this study, the author prospectively analyzed the FHR response after acoustic stimulation using computerized FHR analysis system, HYFM-1. Sixty five normal term and preterm pregnancies entered to this study. After coustic stimulation with 90 Decibedl and 500 Hertz using programmable acoustic stimulator (8031-CPU, 70-120 Decibel of sound intensity level range, 10-10,000 Hertz of frequency range), the changes of baseline FHR, variability, number of fetal movements and loss of signal were analyzed using HYFM-1. In normal term pregnancies, the baseline FHR, variability, and number of fetal movements were significantly increased after acoustic stimulation. In preterm pregnancies, the baseline FHR and variability were also increased significantly exceptnumber of fetal movements, although absolute value of fetal movement was somewhat increased after acoustic stimulation. Using qualitative analysis of baseline FHR, 15 of 43term pregnancies (34.9%) revealed FHR increments more than 15bpm, however there were only 13.6% (3 of 22 patients)FHR increment over 15 bpm in preterm pregnancies. This difference was statistically significant. It would be suggested that the increment of baseline FHR reflect the central nervous system maturation of fetus at least in term pregnancies.
난소암 환자에 대한 복합 화학요법 ( PAC Regimen ) 의 독성에 관한 연구
김두상(DS Kim),김문신(MS Kim),김용철(YC Kim),박형무(HM Park),유명숙(MS Yoo),신호문(HM Shin),김동명(DM Kim),조수현(SH Cho),조태승(TS Cho),환윤영(YY Hwang),심재철(JC Sim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.2
한양의대 산부인과학교실에서 1978년 10월부터 1982년 9월까지 PAC regimen(제1일에 adriamycin 50mg/㎡, 제2일에 cis-platinum 50mg/㎡, 제3~7일에 cyclophosphamide 150mg/ ㎡)으 로 화학치료를 받은 상피성난소암환자 16예를 대상으로 그 독성을 조사 분석하여 타 보고 자들의 성적과 비교 관찰한 바 다음과 같은 결론을 얻었다. 1. 혈액학적 독성은 총 16예중 10예(62.5%)에서 발생하였으며 혈소판 감소증은 3예 (18.8%), 백 혈구감소증 6예(37.5%), 빈혈 6예(37.5%)로 나타났으며 수혈은 1예(6.3%)에 실시하였다. 2. 신장에 대한 독성은 총 16예중 7예(43.8%)에서 각각 BUN증가 4예(25%) 혈청 creatinine 증 가 3예(18.8%)로 나타났으나, 전예가 경증이었다. 3. 가장 빈발하고 고통스러운 독성은 오심 구토로 전예에서 발생하였으며 perphenazine과 diazepam으로 어느정도 극복할 수 있었다. 4. 기타 말초신경독성은 5예(31.3%), 청력장애 1예(25%), 주관적인 시력장애 3예(18/8%), 간장 독성 1예(6.3%)였고 탈모증은 전예(100%)에서 발생하였다. The toxicity of PAC regimen was evaluated in 17 patients of ovarian epithelial carcinoma at the Edpartmane of Obstet. Nad Gynecol., Hanyang University Hospiatal from October, 1978 through september 1982. The PAC regimen consists of adriamycin 50mg/㎡ on the first day, cis-platinum 50mg/㎡ on the second day, and cyclophos-phanide 150mg/㎡ on the third to seventh day. It was repeated every 4 weeks. The results were as follow: 1. The hematologic toxicity occurred in 62.5%(10/16) of the patients, including thrombocytenia 18.8%(3/16), leukipenia 37.5%(6/16), and anemia 37.5%(6/16). For only one case, transfusion was require. 2. Nephrotoxicity occurred in 43.8%(7/160), including an elevation of BUN 25.0%(4/16) and an elevation of serum creatinine 18.8%(3/16). But all were in mild degree. 3. For the symptoms of gastrointestinal tract were nausea and vomiting which occurred in all cases and most distressing problems. All patients, however, were well tolerated with perphenazine and diazepam. 4. Peripheral neurotoxicity occurred in 31.3%(5/16), ototoxicity in 25.0%(1/4), blurred vision in 18.8%(3/16), hepatotoxicity in 6.3%(1/16) and alopecia in 100%.