유방 고형 종괴의 출력 도플러 초음파 소견과 병리조직학적 최대 미세혈관수와의 관련성$^1$

국신호,Guk, Sin-Ho 대한영상의학회 2002 대한영상의학회지 Vol.46 No.2

Purpose: To compare the power Doppler ultrasonographic (PDUS) findings of angiogenesis occurring in solid breast with the histopathologic findings. Materials and Methods: Thirty-one cases of pathologically proven solid breast lesions (eight benign, 23 malignant) were retrospectively reviewed, focusing on tumor size (< 3 cm, $\geq$ 3 cm), the amount (none, mild,marked), morphology (none/linear, branching, disordered) and pattern (none/peripheral, central, penetrating), as demonstrated by power Doppler ultrasonography. We compared the PDUS findings with microscopic micro-vessel density (Max-MVD, the number of micro-vessels revealed at pathologic examination after factor - VIII staining). Statistical significance was determined using the x2-test. Results: Max-MVD tended to increase according to fumor size, but the relationship was not statistically significant. In solid breast lesions there was close correlation between the observed increase in the intensity of Doppler signals and increased Max-MVD (P < 0.05). Morphologically, branching and disordered vessels were more often seen in malignant lesions, though the relationship between this finding and increased Max-MVD was not statistically significant. Penetrating and central Doppler signals were more frequent in malignant lesions and showed close correlation with increased Max-MVD (P < 0.05). Conclusion: The increased intensity of Doppler signals and the central and penetrating pattern of solid breast lesions seen at power Doppler sonography were closely related with increases in Max-MVD. 목적: 고형 유방 종괴의 출력 도플러 초음파 소견과 병리조직학적 종양의 신생혈관의 정도를 비교하여 연관성을 알아보고자 하였다. 대상과 방법: 유방 고형 종괴 총 31예 (악성 23예,양성 8예)의 출력 초음파 소견은 종괴의 크기(<3 cm, $\geq$3 cm), 도플러 신호의 양(없음, 소량, 많음), 모양(선형, 분지형, 불규칙한형), 분포 유형 (변연성, 중심성, 침투성)으로 나누어 분석하였다. 신생혈관의 정도는 조직 표본을 Factor VIII으로 특수 염색한 후에 측정한 최대 미세혈관 수(Maximum Micro-Vessel Density; 이하 Max-MVD로 표기함)로 분석하였다. 각각의 초음파 소견이 MVD에 따라 차이가 있는지 에 대해서 알아보았고 이의 통계적 유의성은 x$^2$-test를 이용하여 검증하였다. 결과: Max-MVD와 종괴 크기와의 관계는 크기가 커질수록 Max-MVD의 수치가 증가하는 경향을 보였으나 통계적인 유의성은 없었다. 도플러 신호 양의 증가와 Max-MVD의 증가는 상관관계를 보였고 통계적으로 유의하였다 (p <0.05). Max-MVD와 도플러 신호의 모양과의 관계를 보면 악성에서 비교적 특징적으로 볼 수 있는 분지형이나 불규칙한 모양의 경우 Max-MVD의 증가와 유의적 상관관계가 없었다.Max-MVD와 도플러 신호 분포 유형사이에서는 악성에 특징적인 중심성 및 침투성의 경우 Max-MVD의 증가와 밀접한 상관관계가 있었으며 통계적으로 유의하였다(p <0.05). 결론: 유방 고형 종괴의 출력 도플러 소견에서 도플러 신호 양의 증가와 도플러 신호 분포 유형 중 중심성 및 침투성은 Max-MVD의 증가와 밀접한 연관성이 있었다.

유방암의 고해상 역동적 자기공명영상 소견과 예후인자의 상관성

이신호,조나리야,정혜경,김승자,차주희,조경수,문우경 대한영상의학회 2005 대한영상의학회지 Vol.52 No.5

Purpose: We wanted to correlate the kinetic and morphologic MR findings of invasive breast cancer with the classical and molecular prognostic factors. Materials and Methods: Eighty-seven patients with invasive ductal carcinoma NOS underwent dynamic MR imaging at 1.5 T, and with using the T1-weighted 3D FLASH technique. The morphologic findings (shape, margin, internal enhancement of the mass or the enhancement distribution and the internal enhancement of any non-mass lesion) and the kinetic findings (the initial phase and the delayed phase of the time-signal Intensity curve) were interpreted using a ACR BI-RADSⓡ-MRI lexicon. We correlate MR findings with histopathologic prognostic factors (tumor size, lymph node status and tumor grade) and the immunohistochemically detected biomarkers (ER, PR, p53, c-erbB-2, EGFR and Ki-67). Univariate and multivariate statistical analyses were then performed. Results: Among the MR findings, a spiculated margin, rim enhancement and washout were significantly correlated with the prognostic factors. A spiculated margin was independently associated with the established predictors of a good prognosis (a lower histologic and nuclear grade, positive ER and PR) and rim enhancement was associated with a poor prognosis (a higher histologic and nuclear grade, negative ER and PR). Wash out was a independent predictor of Ki-67 activity. Conclusion: Some of the findings of high resolution dynamic MR imaging were associated with the prognostic factors, and these findings may predict the prognosis of breast cancer. 목적: 침습성 유방암의 동역학적, 형태학적 자기공명영상(MR) 소견과 전통적, 분자생물학적 예후인자들과의 상관성을 알아보았다. 대상과 방법: 침윤성 선관 암종으로 확진된 87예를 대상으로 하였으며, 1.5 T 기종으로, T1강조 삼차원 FLASH(Fast low angle shot) 기법으로 역동적 자기공명영상을 얻었다. 자기공명영상에서 형태학적 소견인 종양 조영증강의 모양, 변연, 내부 조영증강 특성 또는 비종양 조영증강(Non-Mass-Like enhancement) 의 분포, 내부 조영증강 특성 그리고, 동역학적 소견인 시간에 따른 신호강도 변화 곡선(Time-Signal Intensity curve) 의 초기 유형, 지연기 유형을 ACR BIRADS-MRI lexicon(American College of Radiology Breast Imaging Reporting and Data Systems - Magnetic Resonance Image)으로 해석하였다. 자기공명영상소견과 조직병리학적 예후인자인 종양의 크기, 액와림프절 전이의 수와 종양의 핵 분화도, 조직학적 분화도 그리고, 면역조직화학 염색법 표식자인 에스트로겐 수용체, 프로게스테론 수용체, p53,c-erbB-2, EGFR, Ki-67를 단변량, 다변량 분석으로 비교하였다. 결과: MR 소견 중 침상변연, 테두리조영증강, 조영증강의 빠른 감소가 예후인자와 유의한 관계가 있었다. 침상변연은 좋은 예후가 예상되는 인자인 낮은 조직학적 분화도와 핵 분화도, 양성 에스트로겐과 프로게스테론 수용체와 독립적으로 관련이 있었으며, 테두리조영증강은 나쁜 예후인자인 높은 조직학적 분화도와 핵 분화도, 음성 에스트로겐과 프로게스테론 수용체와 관련이 있었다. 조영증강의 빠른 감소는 Ki-67 활성도와 독립적으로 관련이 있었다. 결론: 역동적 고해상 자기공명영상의 일부 형태학적, 동역학적 소견들은 유방암의 예후인자와 상관관계가 있는 바 유방암의 예후 예측인자로 이용될 수 있을 것이다.

3축 제어용 시뮬레이터의 로드 프로파일 재현 소프트웨어 개발

정상화,이규태,장완식,류신호 朝鮮大學校 機械技術硏究所 2001 機械技術硏究 Vol.4 No.2

실제 운동조건과 같은 환경을 제공하는 다축 제어용 시뮬레이터는 설계나 평가에 있어 대단히 편리하면서도 경제적인 이점을 제공하여 준다. 일반적으로 완성차의 경우 설계에서부터 개발, 실험에 이르기까지 시간과 개발과정에 막대한 비용이 소모되고 있다. 그리고 자동차 부품업체에서는 완성차업체의 부품 검사서의 요구에 의해 시뮬레이터를 구비하고자 노력하고 있으나, 재현소프트웨어의 미비로 어려움을 겪고 있는 실정이다. 본 논문은 개발된 프로그램을 이용하여 기아자동차의 내구로(belgian road), 대우자동차의 도시로(city road), 고속도로(highway), 자갈로(gravel road)등의 신호를 입력하여 실제 실험을 수행함으로서 로드 프로파일 재현 소프트웨어의 타당성을 검증하였다. 이 과정에서 실험차량의 현가장치와 타이어가 비선형이기 때문에 초기 구동화일에 대한 응답신호는 요구되는 신호와 차이가 발생하였는데 이 오차는 반복 개선작업을 통하여 최소화시키면서 응답신호가 요구신호에 일치하도록 반복작업을 되풀이하였다. Full scale durability test in the laboratory is an essential of any fatigue life evaluation of components or structures of the automotive vehicle. Component testing is particularly important in today's highly competitive industries where the design to reduce weight and production costs must be balanced with the necessity to avoid expensive service failure. Generally, Hydraulic road simulator is used to carry out the fatigue test and the vibration test. In this paper, the algorithm and software to realize the real road profile are developed. The operation software for simultaneously controlled 3-axial simulator is developed and the input and output data are displayed window based PC controller in the real time. Futhermore, the software to generate the real road profile are developed. The validity of the software are verified by applying the belgian road, the city road the highway, and the gravel road. The results of the above experiment show that the real road profiles are realized well after 10th iteration. .

Streptococcus lactis IFO 12007 이 생성하는 항생물질 Nisin 에 관한 연구 2 . Nisin 의 생육형 세포와 포자 발아에 미치는 영향

이신호,김현욱 ( Shin Ho Lee,Hyun UK Kim ) 한국축산학회 1985 한국축산학회지 Vol.27 No.7

The growth of Lactobacillus plantarum, L. bulgaricus, L. casei, L. acidophilus, L. Helveticus, Streptococcus thermophilus, Staphylococcus aureus, Bacillus subtilis, B. coagulans and B. megaterium was inhibitec by 200 IU/㎖ of raisin. In the Presence of various germinants, such as alanine, valine, leucine, isoleucine, methionine, asparagine, glucose and fructose, germination of B. subtilis LDTM1 spore was inhibited by 50㎍/㎖ of raisin at 37℃. The germination of B. subtilis LDTM1 spores was delayed and their outgrowth was inhibited by raisin in the presence of alanine (10mM/㎖) and glucose (10mM/㎖) in the PCA(plate count agar) borth. Heat resistance of B. subtilis LDTM1 spores was decreased by raisin in the sterilized milk.

의료기관 신임제도

이신호 대한영양사회 2000 國民營養 Vol.218 No.-

Validity of the Wii Balance Board for Evaluation of Medial Patellar Luxation in Small Sized Dog

이신호,이주명,박현정,차유리,정종태 한국임상수의학회 2019 한국임상수의학회지 Vol.36 No.6

Wii® balance board (WBB) is a device that can measure and record body sway. This study was conducted to evaluate the reliability of WBB in small sized dog as inexpensive, portable and convenient tool. The center of pressure path length (CPPL) and 95% confidence ellipse area (Area 95) were evaluated with only two plates of WBB. The parameters were evaluated between no load (0 kg) and mass group (0.25-4 kg on each one plate). 23 dogs (2.3- 7.3 kg) were evaluated for with hindlimb standing for 10 seconds. The mass group showed a significant value in comparison to the no load during the measurement. And intra-class correlation coefficients (ICCs) between CPPL and Area 95 revealed very high both mass and dog group. In the evaluation of medial patellar luxation (MPL) as a diagnostic tool, 80 dogs with MPL and 23 non-affected dogs were used. In studies of CPPL and Area 95, significant differences were found between non-affected and MPL groups for 10 and 30 seconds, respectively. The WBB can be used as a valid tool for evaluating hind limb standing balance and can be useful as an objective tool to present clinical results in small sized dog with MPL.

Sucrose 첨가가 L.bulgaricus FR1025 로 제조한 요구르트의 점도에 미치는 효과

이신호,한준표,김순동 대구효성가톨릭대학교 자연과학연구소 1987 基礎科學硏究論集 Vol.1 No.-

The effects of sucrose on the viscosity of yogurt were investigated. The viscosity of yogurt manufactured by L. bulgαricus FRI025 was enhanced by addition of sucrose. Changes of pH and titratable acidity during manufacture of yogurt did not show significant difference according to concentration of sucrose. .The optimum sucrose concentration of sucrose and incubation time were 6% and 10 hour to enhance the viscosity of yogurt at 40°C, respectively. The growth of L. bulgaricus FHI025 was enhanced by addition of sucrose.

식육의 처리 단계별 미생물 오염실태와 병원성 미생물의 분포

이신호,오영숙 한국식품위생안전성학회 2001 한국식품위생안전성학회지 Vol.16 No.2

Bacteriological quality of beef carcass and distributions of pathogens in beef processing environments were investigated to improve the hygienic quality of fresh beef. Total bacterial contamination of carcass surface in slaughtering process and cutting board in cut-meat process showed 10^5-10^6CFU/㎠ and l0^5CFU/㎠ in summer, respectively. The viable bacterial count of cotton glove was similar to that of cutting board during and entire period of year. Microbial contamination of carcass surface, cutting board, cotton glove and deboned meat showed the highest in summer and the lowest in winter during the year. Escherichia coli O157, Pseudomonas aeruginosa, Klebsiella. ornithinolytica, Staphylococcus aureus, E. coli, Tatumella. ptyseos, Serratia odorifera, Aeromonas sobria, Enterobacter cloacae and Flavimonas oryzihabitans were isolated from carcass surface during slaughter treatments. S. aureus, Listeria grayi and L. monocytogenes were isolated from cutting board and L. grayi, Erwinia spp. Salmonella spp. and S. aureus were isolated from cotton glove in cut-meat process environments. Citrobacter freundii, L. monocytogenes, and S. aureus were isolated from deboned meat.

Balance Evaluation after Reconstruction of Medial Patellar Luxation in Small-Sized Dogs with Wii Balance Board

이신호,이주명,박현정,차유리,정종태 한국임상수의학회 2019 한국임상수의학회지 Vol.36 No.6

Wii® balance board (WBB, Nintendo, Japan) is a device that can measure and record the center of pressure path length (CPPL) and 95% confidence ellipse area (Area 95) in relation to body sway. For evaluating measure of improvement after reconstruction of medial patellar luxation (MPL) in small sized dogs, A total of 6 dogs with limping and lameness gait attributed to Grade II, III or IV MPL were evaluated. Dogs were measured for difference of extension and flexion range of motion in the stifle (dROM), muscle mass, lameness, willingness to bear weight on the affected limb while standing, and willingness to lift the contralateral limb scores, CPPL and Area 95 of WBB on pre-surgery, post-surgery 4, 8 weeks. CPPL was significantly different on pre-surgery compared with post-surgery 8 weeks (p < 0.05). Except for CPPL, measured variables were significantly different on pre-surgery compared with post-surgery 4 and post-surgery 8 weeks (p < 0.01).

전기차 파우치형 배터리 내부발화 감식기법에 관한 연구

이신호,이호범,김지혜,이상규,최익한,한재영,서성민,옥병철,권희규 한국화재감식학회 2019 한국화재감식학회 학회지 Vol.10 No.3

In this study, we focused on understanding the fire behavior of electric vehicles which became an issue recently among the undeveloped fire investigation area. Pouch-type Li-ion batteries were examined for the different conditions, exposed to fire and overcharged. As a result, we revealed that there existed the evidence to distinguish the internal fault and external fire. Therefore, it is promising that the application of this study makes it clear to decide the origin of the fire.