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이상인,김종훈,정미혜,허갑도,손성표,변상준,최세식,배무현 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.2
Myasthenia gravis (MG) is a neuromuscular transmission disorder charaterized by fatigue and weakness of voluntrary muscles. This muscular weakness is intensified by activity and stress, and improved by the use of anticholinesterase compounds. The pathogenesis is known to be an autoimmune related reduction in the number of available acetylcholine receptors at neuromuscular junction. Myasthenia gravis is usually associated with other autoimmune disorders, such as autoimmune thyroid disease, rheumatoid arthritis, SLE, pernicious anemia, Sj grens syndrome, ulcerative colitis, Eaton-Lambert syndrome. In the past reports, there were some case of hyperthyroidism associated with myasthenia gravis. But, hypothyroidism accompaning myasthenia gravis was reported rarely. So, we report a case of myasthenia gravis associated with Hypothyroidism may be due to Hashimoto's thyroiditis. (J Kor Soc Endocrinol 8:217∼220, 1993)
이준호,윤설영,최소진,이창렬,손성표 대한내분비학회 1999 Endocrinology and metabolism Vol.14 No.1
Hypercalcemia is one of the most common paraneoplastic syndromes and believed to occur through two general mechanisms, one humoral and the other local. The former mechanism has been termed humoral hypercalcemia of malignancy (HHM) and has been associated with the secretion of various cytokines, including parathyroid hormone-related protein (PTHrP). PTHrP beats sttuctural and functional similarities to PTH and seems to play a key role in the pathogenesis of HHM. We experienced the case of HHM associated with hepatoma, a rare cause of HHM, in 48 year-old male. We found no evidence of bone metastasis. In this case, contrary to our general acknowledgment, serum 1,25 (OH)D concentration was elevated. We report this case with a brief review of related literatures (J Kor Soc Endocrinol 14:197~202, 1999).
급성 췌장염으로 발현된 낭성 변화를 이릉킨 종격동 부갑상선 선종 1예
이준호,최영식,박진홍,허갑도,윤설영,최소진,권태헌,이창렬,손성표,박영효 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3
Hypercalcemia due to hyperparathyroidism is rarely associated with acute pancreatitis. But, the relationship between hypercalcemia and pancreatitis still remains controvesial. Ectopic parathyroid adenoma with cystic change is one of the rare causes of hyperparathyroidism, and is usually located in neck and mediastinum. We report a case of mediastinal parathyroid adenoma with cystic change associated with acute pancreatitis. A 54-year-old male presented with epigastric pain for 3 days. The serum calcium, phosphate, elastase were 16.8mg/dL, 1.1 mg/dL, 2772.0 ng/mL respectively and his parathyroid hormone level in serum was 651.84 pg/mL. Chest CT showed a mediastinal mass with well defined inhomogenously enhanced density located between SVC and aorta. The patient was diagnosed to hyperparathyroidism with acute pancreatitis due to mediastinal parathyroid adenoma with cystic change, and was surgically removed. The surgical biopsy showed parathyroid adenoma with cystic change. After operation his general condition was improved and serum calcium, phosphate, amylase, lipase level were normalized (J Kor Soc Endocrinol 13:473-479, 1998).