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허윤(Yoon Huh),서영도(Yeong Do Suh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A To evaluate the alteration nf the purine nucleoside phosphorylase (PNP) acivity of lymphocytes and helper / inducer and suppressor/ cytotoxic T cells of peripheral blood in gastric cancer patients, we examined PNP activity and CD4 + and CD5 + cells of the peripheral blood in 51 cases of gastric cancer as well as 28 cases of adult healthy subjects as controls in Pusan National University Hospital from January to August, 1990. Of 51 cases of gastric cancer who were confirmed histopathologically, 29 cases were before operation (preoperative cases) and 22 cases underwent operation (gastrectomy cases). The results obtained were summarized as follows: 1) The PNP activity was significantly increased in all the preoperative patients and the stage II to IV as compared with controls, and tended to be increased as the stage advanced in gastric cancer. 2) The PNP activity tended to be increased on the postoperative second week in the gastrectomy patients as compared with preoperative patients with gastric cancer. 3) The percentage of CD4 + cells and CD4/CD6 ratio were significantly decreased in the stage IV of the preoperative patients as compared with control subjects and the stage II and the stage III in gastric cancer, respectively. 4) The percentage of CD8 + cells was significanly increased in the stage IV of the preoperative patients as compared with control subjects and the stage II and the stage III in gastric cancer, respectively. 5) The percentage of CD4+ and CD8+ cells and CD4/CD8 ratio were not different between the preoperative and the gastrectomy patients. 6) There were no significant correlation between the percentage of CD4+ cells, CD8+ cells or CD4/ CD8 ratio and PNP activity in control subjects and the preoperative and gastrectomy patients with gastric cancer. On the basis of this results, it can be suggested that the cellular immunosuppression in the patients with advanced gastric cancer is due to decreased helperginducer T cell and increared suppressorg cytotoxic T cells, and the PNP activity of lymphocyte is increased in all the patients with the early and advanced gastric cancer. This evidence can be suggested that the estimation of PNP activity is
만성 활동성 간염에 있어 생화학적 , 혈청학적 및 조직학적 소견의 비교 관찰
문한규(Han Kyu Moon),심원보(Won Bo Shim),서영도(Yeong Do Suh),윤명순(Myeong Soon Yoon),김영훈(Ywong Hoon Kim),박형구(Hyung Koo Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A The authors have evaluated thirty-two patients of chronic active hepatitis ccnfirmed by needle biopsy of liver to compare the biochemical values in the group of HBeAg with those in the group of HBeAg(-), and to compare the biochemical values according to histologic severity. The patients were composed of male 26, female 6, and the mean age was 35. 5 years. There was not any significant difference of age between male and female. The incidences of HBV markers were 75% in HBsAg, 19% in Anti-HBs, 97% in Anti-HBc, 47% in HBeAg, and 16% in Anti-Hbe by radioimmunoassay, but there was not any significant difference of the incidences of HBV markers according to histologic severity. The activity of aminotransferase was elevated more in the group of HBeAg(+) compared to the group of HBeAg(-), but there was not any significant difference between the two groups. The activity of aminotransferase and the value of globulin were elevated more in the group having bridging necrosis compared to the group having piecemeal necrosis only or with focal necrosis without bridging necrosis, but there was not any significant difference between the two groups. The authors conclude that it is absurd to predict the histologic severity of chronic active hepatitis with the persistence of HBsAg or HBeAg, or with the values of biochemical test.
허윤(Yoon Huh),양웅석(Ung Suk Yang),심원보(Won Bo Shim),조몽(Mong Cho),서영도(Yeong Do Suh) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A Clinical observations were done on 140 cases of bleeding gastric ulcers diagnosed by emergency endoscopy over a period of 6 years, from June 1978 to Mlay 1984 The following results were obtained; 1) Sex incidence showed male predominance with a ratio of 4. 2: 1 and peak age group was 6 th decade. 2) The most common bleeding site was the body of stomach(59.2%) along the lesser curvature(50.3%). Age related difference was not noted in bleeding sites. 3) In elderly over 60 years of age, giant ulcers(over 2.0 cm in diameter) were more frequently observed than younger age group. 4) According to Hamiltons criteria, the severity of bleeding showed massive in 45.0% moderate in 33.6% and mild in 21.4% 5)The 10g patients(72. 9%) were rewverd by treatment and 24 patients(17.1%), including 9 of 10 cases with endoscopically visible vessel, were treated surgically. The patients over 60 years of age showed higher mortality rate than other age group. 6) Among the probable precipitating factors, analgesics was the most frequently involved and the remaining were alcohol, stress and steroid, etc.