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이상인,김종훈,정미혜,허갑도,손성표,변상준,최세식,배무현 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.2
Myasthenia gravis (MG) is a neuromuscular transmission disorder charaterized by fatigue and weakness of voluntrary muscles. This muscular weakness is intensified by activity and stress, and improved by the use of anticholinesterase compounds. The pathogenesis is known to be an autoimmune related reduction in the number of available acetylcholine receptors at neuromuscular junction. Myasthenia gravis is usually associated with other autoimmune disorders, such as autoimmune thyroid disease, rheumatoid arthritis, SLE, pernicious anemia, Sj grens syndrome, ulcerative colitis, Eaton-Lambert syndrome. In the past reports, there were some case of hyperthyroidism associated with myasthenia gravis. But, hypothyroidism accompaning myasthenia gravis was reported rarely. So, we report a case of myasthenia gravis associated with Hypothyroidism may be due to Hashimoto's thyroiditis. (J Kor Soc Endocrinol 8:217∼220, 1993)
Young Adult 의 직장에 발생된 광범위한 혈관이형성증과 그로 인한 대량 출혈 1 예
이상인,김종훈,최익수,나산균,조성락,변상준,지정희,최세식,배무현,정미혜,김천환,구호성 대한내과학회 1995 대한내과학회지 Vol.48 No.2
Angiodysplasia as a cause of gastrointestinal bleeding is increasingly recognized with the advancement of diagnostic technique. Most cases of angiodysplasia occur in old age and their sizes rarely exceed a few millimeters in diameter. We experienced a case of bleeding angiodysplasia in the rectum of 22-year old woman. The lesion was located at the submucosa of nearly all the rectum. This patient had a history of repeated hematochezia for several years. Diagnosis could be done easily by the colonoscopy with biopsy only. This report summarized our case and review of literature.
이상인(Sang In Lee),최세식(Se Seek Chol),배무현(Mu Hyun Bae),김종훈(Jong Hoon Kim),최익수(Ik Su Choi),김천환(Chun Whan Kim),구호성(Ho Sung Goo),이민기(Min Ki Lee),나산균(San Gyun Rha),허갑도(Gap Do Hur) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2
Primary malignant melanoma of esophagus is rare and its symptoms are similar to those of squamous cell carcinoma. In general, this tumor tends to be polypoid with smooth intact overlying mucosa or be pediculated and irregular. Microscopically, characteristic features are junctional lenti- ginous growth pattern and tendency to expand and fill the submucosa without invading the muscularis. Primary malignant melanoma should be radiologically differentiated with unusual esophageal tumor, particularly if the lesion is polypoid. Because of the patentially widespread intramural component, surgical treatment requires a radical procedures with a far greater margin than for the usual squamous cell carcinoma. Despite these measures, however the prognosis is poor, with a 5 year survival of 4.2%. It is usually fatal within one year. The case of a 64-year-old man with esophageal malignant melanoma is described, and review of the llterature in presented related studies. (Korean J Gastroenterol 1995;27:245 - 250)
이상인(Sang In Lee),문성수(Sung Soo Moon),변상준(Sang Jun Byun),배무현(Mu Hyun Bae),김종훈(Jong Hun Kim),정미혜(Mi Hae Jung),나산균(San Kyun Nah),조성락(Sung Lak Cho) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Lynch syndrome I is rare hereditary disease characterized by appearance, early in life, of multiple and primary cancer in the colon and rectum. This syndnome appears to be inherited in autosomal dominant f ashion with lack of antecedent polyposis. Individual with Lynch syndrome .I has a high risk of second carcinoma either synchronous or metachronous. So, it is noted that careful follow up as well as early diagnosis and managernnit is very important. We reported a case of metachronous Lynch Syndrome I with review of the literatures.