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TNFα and TNFR2 Immunohistochemistry During Ovarian Follicular Development and Atresia in the Rat
한승로(Seung Ro Han),손성경(Sung Kyong Son),양윤석(Yun Seok Yang),김원식(Won Sik Kim) 대한해부학회 2005 Anatomy & Cell Biology Vol.38 No.6
TNFα는 난소의 발생과 기능에 있어서 중요한 역할을 하는 사이토카인(cytokine)으로 알려져 있다. 그리고 TNFα 수용체의 확인은 TNFα의 역할을 입증하는데 기여하였다. TNFα는 TNF 수용체 1 (TNFR1) 또는 TNF 수용체 2 (TNFR2)와 결합함으로써 기능을 발휘하게 된다. TNFα가 TNFR2와 결합시에는 과립층세포의 증식을 초래하게 된다. 본 연구를 통해 흰쥐 난소에서, 건강한 난포에서는 과립층의 바깥층에서 TNFα와 TNFR2에 강한 반응이 관찰되었고 아울러 많은 증식세포를 관찰했으며 세포자멸사는 관찰되지 않았다. 반면 폐쇄난포에서는 TNFα와 TNFR2의 발현이 과립층에서 급격히 감소하였고 이곳에서 많은 세포자멸사를 볼 수 있었다. 이같은 결과로 볼 때 TNFα는 흰쥐 난소에서 난포폐쇄시 과립층세포의 생존요소로서 작용할 것으로 생각된다. Tumor necrosis factor alpha (TNFα) is an intraovarian cytokine that may play a role in ovarian development and function. Identification of ovarian TNFα receptors provides support for establishing a role of TNFα in ovarian development and function. TNFα exerts its effects by binding to either TNF receptor 1 or 2 (TNFR1 or TNFR2). When TNFα binds with TNFR2, expression of survival genes is up-regulated, resulting in proliferation of granulosa cells. In the present study, the authors identified the changes in localization of TNFα and the expression of TNFR2 in granulosa cells during follicular atresia in rat ovaries. In healthy follicles, intense signals for TNFα and TNFR2 were found in the outer surface of the granulosa layer, where many proliferating cells and no apoptotic cells were observed. In atretic follicles, decreased expression of TNFα and TNFR2 was observed in the granulosa layer, where many apoptotic cells were seen. These findings suggested that TNFα acts as a survival factor in granulosa cells during follicular atresia in rat ovaries.
폐경기 증후군 환자에서 홍삼 복방 제품의 임상적 유용성
노흥태(Heung Tae Noh),손성경(Sung Kyong Son),고지환(Jee Hwan Ko),오영균(Young Kyun Oh),김용일(Yong Il Kim),박명한(Myung Han Park),김나미(Na Mi Kim),전병선(Byeong Seon Jeon) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A The most dramatic endocrine event associated with aging in women is the cessation of normal, cyclic ovarian activity. The loss of ovarian function is reflected by alterations in ovarian steroid secretion, which result in the discontinuation of menstruation. This process appears to be related to some of the classic features of the climacteric, such as hot flushes, altered reproductive tract histology, and accelerated bone loss. Oral estrogen therapy can cause endometrial hyperplasia and carcinoma, in addition to systemic side effects. Therefore, alternative therapeutic agents are currently being developed. Korean Red Ginseng has been used in the Orient as an elixer for hundred of years. However, the demonstrable actions of Korean Red Ginseng components have not been fully explored and knowledge concerning the mode of action is fragmented. Recent data has shown that Korean Red Ginseng is effective in treating various perimenopausal symptoms. We investigated the clinical efficacy and safety of Korean Red Ginseng in 30 patients who suffered postmenopausal symptoms. The drug was administered orally at a dose of 6 capsules daily for 12 consecutive weeks between April and July 2001. Data were analyzed using the student's t test with p<0.05 considered valid. The result were as follows: 1. The distribution of clinical symptoms in the studied patients prior to treatment was: fatigue, 63.3%; arthralgia, 56.7%; sweating and dry mouth, 53.3%; palpitation, 46.7%; followed by urinary symptoms, insomnia, headache, hot flushes. 2. The efficacy rate after treatment with Korean Red Ginseng was 100.0% for gastrointestinal symptoms, 91.6% for hot flush, 85.6% for palpitation, 76.4% for arthralgia, followed by fatigue, sweating and dry mouth, insomnia, neuropsychological symptoms. 3. The average level of estradiol was 9.16pg/ml prior to the treatment. The level increased to 11.76pg/ml, 15.60pg/ml, and 21.30pg/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). The FSH level changed from 46.24 mIU/ml, pre-treatment, to 51.08 mIU/ml, 48.52 mIU/ml, and 48.55 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p>0.05). The LH levels increased from 21.30 mIU/ml, pre-treatment, to 22.16 mIU/ml, 22.48 mIU/ml, and 23.01 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). 4. Most patients suffered mild symptoms that were below 20 on the menopausal index scale. The index value was 14.36 prior to the treatment, which dropped to 8.60 after 4weeks, 8.30 after 8weeks, and 5.46 after 12 weeks of treatment. These values were statistically significant. (p<0.05) 5. No definite evidence of side effects was observed during the study. 6. There were no differences in vital signs, body weight, and body mass index between before and after the treatment.
이기환(Ki Hwan Lee),남상륜(Sang Lyun Nam),서영석(Young Seok Seo),이석수(Seok Soo Lee),손성경(Sung Kyong Son),강길전(Kil Chun Kang),노흥태(Heung Tae Noh) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1
N/A Objective : Hysterectomy is one of the most common gynecological operations. The objective of this study was to introduce a new uterine elevator for total laparoscopic hysterectomy. Methods : Bae's uterine elevator was modified for laparoscopic hysterectomy. Modified Bae's uterine elevator was 5 cm longer than original one and handle was modified to vertical position and stopper, silicon tube and silicon adapter for colpotomizer was installed on the shaft. Three hundred and fifty seven cases of total laparoscopic hysterectomies using modified Bae's uterine elevator were performed from Jan 1999 to Jun 2000. Results : Mean age of the patients was 41.8, operation time was 48.3 minutes and uterine weight was 245.5 gm. Leiomyoma was the most common cause of hysterectomies (70.9%), and followed by adenomyosis (16.2%), endometriosis (7.6%). There were no major operative complications such as vascular, bladder, ureter or intestinal injuries. Conclusions : Three hundred and fifty seven cases of total laparoscopic hysterectomies using modified Bae's uterine elevator were performed successfully without any major complications. Modified Bae's uterine elevator was very convenient for uterine manipulation during total laparoscopic hysterectomy.
방사선에 의한 난포 퇴축과 난포 대식세포에 관한 형태학적 연구
송근일 ( Keun Il Song ),노흥태 ( Heung Tae Noh ),이윤이 ( Yun Ee Rhee ),손성경 ( Sung Kyong Son ),김원식 ( Won Sik Kim ),김수일 ( Su Il Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 방사선이 난포 퇴축을 일으키는 난포과립층세포들에 미치는 영향과 난포내 대식세포의 일부역할을 형태학적으로 살펴보기 위해 본 연구를 수행하였다. 연구 방법 : 3주령의 Sprague-Dawley계 흰쥐를 실험동물로 8 Gy의 방사선을 조사하고, 조사 후 6시간, 12시간 및 24시간에 각각 희생하여 난소를 채취하고 통상적인 방법으로 처리한 후 광학현미경적 및 투과전자현미경적 관찰, TUNEL 및 대식세포 면역조직화학을 실시하였다. 결과 : 1) 방 Objective : It is well known that X-ray induces follicular atresia, but the exact mechanism of atresia is not still unveiled completely. In addition, the role of macrophage related with clean-up the dead granulosa cells and other functions within the ovar
흰쥐에서 황체발달과 큰포식세포와의 관계에 관한 면역조직화학적 연구
김원식(Won-Sik Kim),김수일(Soo-Il Kim),손성경(Sung-Kyong Son),양윤석(Yun-Seok Yang),조근자(Geun-Ja Cho) 대한해부학회 2007 Anatomy & Cell Biology Vol.40 No.3
황체는 프로게스테론을 생산하여 난포발달의 마지막 단계와 배란을 억제함으로써, 발정주기의 생리적 기간을 결정하고, 성공적인 임신을 달성하는데 결정적으로 기여한다. 큰포식세포는 자신이 분비하는 TNF-α를 통해 황체 발달시기에는 황체발달을 자극하고 용해시기에는 용해를 개시, 촉진시키는 작용을 하는 것으로 알려져 있다. 그러나 아직 임신황체와 비임신황체의 발달과 유지에 대한 TNF-α의 작용기전은 확실히 알려져 있지 않다. 흰쥐를 실험동물로 비임신황체와 임신황체에서 TUNEL, 큰포식세포 및 그것으로부터 분비되는 TNF-α에 대한 면역조직화학을 실시한 본 실험의 결과, 비임신황체에서는 큰포식세포가 주로 세포자멸사 소체의 탐식에 관여하지만 임신황체에서는 황체의 유지과정에 주로 관여하는 것으로 나타났다. Within the corpus luteum, macrophages exert luteotropic and luteolytic actions through secretion of TNF-α. However, the mechanisms of luteotropic actions on the development and maintenance of pregnant and nonpregnant corpora lutea are thoroughly unknown.In this experiment, TUNEL, macrophage, and TNF-α immunohistochemistry on the corpora lutea of pregnant and nonpregnant rats (Sprague-Dawley strain) were carried out to reveal the role of macrophages in the developing corpora lutea. The results were as follows; 1) In the nonpregnant corpora lutea, the number of macrophages was increased significantly, and the degree of ED1-immunoreactivity of macrophages was increased moderately. But lutein cells showed low-degree TNF-α-immunoreactivity. 2) In the pregnant corpora lutea, the number of macrophages was decreased significantly, and the degree of ED1- immunoreactivity of macrophages was low. But lutein cells showed moderate-degree TNF-α-immunoreactivity. Based on the above results, it was considered that macrophages in the nonpregnant corpora lutea exert phagocytic action mainly, and the macrophages in the pregnant corpora lutea exert TNF-α-secreting action to maintain the structure and function of lutein cells.
고지환(Jee Hwan Ko),이종범(Jong Bum Lee),오영균(Young Kun Oh),손성경(Song Kyong Son),서영석(Young Seok Seo),이기환(Ki Hwan Lee),남상륜(Sang Lyun Nam),노흥태(Heung Tae Noh),강길전(Kil Chun Kang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : The study was designed to find out current state of conservative treatment modalities for cervical pregnancies in korean. Method : 64 cases of cervical pregnancies reported by the joining of The Korean Society of Obstetrics & Gynecology from 1960 to 2000 and the 10 cases at Chungnam National University Hospital were analyzed retrospectively. Results : The average age of the 74 cases was 31.7±6.6 years, and the average gestational age at the time of diagnosis was 8.3±3.4 weeks. The average duration of hospitalization was 8.2±4.8 days. Most (67/74) of the patients had previously experienced delivery or abortion. Out of the 74 cases, 36 had total hysterectomy; 4 cases had curettage; 12 were used only methotrexate; 11 had combined curettage and methotrexate; 10 cases had Foley catheter ballooning after curettage. From the 1960's to the end of 1980's, 33 (84.6%) cases out of 39 were performed hysterectomy. Whereas mainly conservative methods, in particular methotrexate treatment, were performed in the 1990's. Among the conservative modalities, Foley catheter ballooning after curettage had the shortest length of hospitalization with 4.3 days. Conclusion : After comparing the conservative methods for treating cervical pregnancies, it was found that methotrexate treatment was performed the most; however, Foley catheter ballooning after curettage seems to be an excellent treatment option.
이민아 ( Min A Lee ),현석환 ( Suk Whan Hyun ),황순호 ( Soon Ho Hwang ),신관섭 ( Kwan Seop Shin ),양정보 ( Jung Bo Yang ),이진구 ( Jin Goo Lee ),손성경 ( Sung Kyong Son ),이윤이 ( Yun Ee Rhee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.10
Meckel Gruber syndrome consisting of an occipital encephalocele, polycystic kidney disease and polydactyly is a rare autosomal recessive disorder with a recurrence risk of 25%. Targeted ultrasonography in late embryonic or early fetal stages of pregnancy has great importance in diagnosis and management of affected pregnancy in high risk groups due to incomplete genetic mapping of meckel syndrome gene (MKS). We present a case of prenatal diagnosis at 14 weeks` gestational age of Meckel Gruber syndrome in a woman, who experienced same disorder in her previous pregnancy.