한국인에서 자궁경관임신의 치료에 관한 연구

고지환(Jee Hwan Ko),이종범(Jong Bum Lee),오영균(Young Kun Oh),손성경(Song Kyong Son),서영석(Young Seok Seo),이기환(Ki Hwan Lee),남상륜(Sang Lyun Nam),노흥태(Heung Tae Noh),강길전(Kil Chun Kang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8

N/A Objective : The study was designed to find out current state of conservative treatment modalities for cervical pregnancies in korean. Method : 64 cases of cervical pregnancies reported by the joining of The Korean Society of Obstetrics & Gynecology from 1960 to 2000 and the 10 cases at Chungnam National University Hospital were analyzed retrospectively. Results : The average age of the 74 cases was 31.7±6.6 years, and the average gestational age at the time of diagnosis was 8.3±3.4 weeks. The average duration of hospitalization was 8.2±4.8 days. Most (67/74) of the patients had previously experienced delivery or abortion. Out of the 74 cases, 36 had total hysterectomy; 4 cases had curettage; 12 were used only methotrexate; 11 had combined curettage and methotrexate; 10 cases had Foley catheter ballooning after curettage. From the 1960's to the end of 1980's, 33 (84.6%) cases out of 39 were performed hysterectomy. Whereas mainly conservative methods, in particular methotrexate treatment, were performed in the 1990's. Among the conservative modalities, Foley catheter ballooning after curettage had the shortest length of hospitalization with 4.3 days. Conclusion : After comparing the conservative methods for treating cervical pregnancies, it was found that methotrexate treatment was performed the most; however, Foley catheter ballooning after curettage seems to be an excellent treatment option.

배양액의 에너지원 조성이 생쥐 초기배 발달에 미치는 효과에 관한 연구

이종범(Jong Bum Lee),김주환(Ju Hwan Kim),고지환(Jee Hwan Ko),오영균(Young Kun Oh),손성경(Song Kyong Son),서영석(Young Seok Seo),노흥태(Heung Tae Noh),강길전(Kil Chun Kang),송해범(Hai Bum Song),이기환(Ki Hwan Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3

N/A Objective: The objective of this study was to examine the effect on development of mouse preimplantation embryos in culture media with different composition of energy sources in vitro culture. Methods: Two hundred and seventy one two-cell embryos were cultured in four different culture system for 96 hours. Group I (n=61)was cultured in DMEM-G (DMEM with glutamine) only, group II (n=64)was cultured in DMEM-GGP (DMEM with glutamine, glucose and pyruvate) only, group III(n=72) was cultured for 48hoursinDMEM-G and then transferred to DMEM-GGP and group IV (n=74)was cultured for 48 hours in DMEM-GGP and then transferred to DMEM-G. Development of embryos in each group was observed every 24 hours. Results: After 24 hours, the rate of development ≥3-cell was significantly higher in group II(87.5%) and IV(86.5%)compared with group I(59.0%)and III(62.5%).After 48 hours, the rate of development into ≥morula stage was significantly higher in Group II(79.7%)and IV(86.5%)compared with group I(34.4%) and III(37.5%).After 72 hours, the rate of development into blastocyst was significantly higher in group IV(74.3%)compared with group I (49.2%)and III (45.8%).After 96 hours, the rate of development into ≥expanded blastocyst was significantly higher in group IV(70.3%)compared with group I (32.8%), II ( 53.1%), and group III (40.3%) Conclusion: Mouse preimplantation embryos development was the most effective in culture system with DMEM-GGP for 48 hours and then transferred to DMEM-G.

폐경기 증후군 환자에서 홍삼 복방 제품의 임상적 유용성

노흥태(Heung Tae Noh),손성경(Sung Kyong Son),고지환(Jee Hwan Ko),오영균(Young Kyun Oh),김용일(Yong Il Kim),박명한(Myung Han Park),김나미(Na Mi Kim),전병선(Byeong Seon Jeon) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1

N/A The most dramatic endocrine event associated with aging in women is the cessation of normal, cyclic ovarian activity. The loss of ovarian function is reflected by alterations in ovarian steroid secretion, which result in the discontinuation of menstruation. This process appears to be related to some of the classic features of the climacteric, such as hot flushes, altered reproductive tract histology, and accelerated bone loss. Oral estrogen therapy can cause endometrial hyperplasia and carcinoma, in addition to systemic side effects. Therefore, alternative therapeutic agents are currently being developed. Korean Red Ginseng has been used in the Orient as an elixer for hundred of years. However, the demonstrable actions of Korean Red Ginseng components have not been fully explored and knowledge concerning the mode of action is fragmented. Recent data has shown that Korean Red Ginseng is effective in treating various perimenopausal symptoms. We investigated the clinical efficacy and safety of Korean Red Ginseng in 30 patients who suffered postmenopausal symptoms. The drug was administered orally at a dose of 6 capsules daily for 12 consecutive weeks between April and July 2001. Data were analyzed using the student's t test with p<0.05 considered valid. The result were as follows: 1. The distribution of clinical symptoms in the studied patients prior to treatment was: fatigue, 63.3%; arthralgia, 56.7%; sweating and dry mouth, 53.3%; palpitation, 46.7%; followed by urinary symptoms, insomnia, headache, hot flushes. 2. The efficacy rate after treatment with Korean Red Ginseng was 100.0% for gastrointestinal symptoms, 91.6% for hot flush, 85.6% for palpitation, 76.4% for arthralgia, followed by fatigue, sweating and dry mouth, insomnia, neuropsychological symptoms. 3. The average level of estradiol was 9.16pg/ml prior to the treatment. The level increased to 11.76pg/ml, 15.60pg/ml, and 21.30pg/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). The FSH level changed from 46.24 mIU/ml, pre-treatment, to 51.08 mIU/ml, 48.52 mIU/ml, and 48.55 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p>0.05). The LH levels increased from 21.30 mIU/ml, pre-treatment, to 22.16 mIU/ml, 22.48 mIU/ml, and 23.01 mIU/ml at 4, 8, and 12 weeks post-treatment, respectively (p<0.05). 4. Most patients suffered mild symptoms that were below 20 on the menopausal index scale. The index value was 14.36 prior to the treatment, which dropped to 8.60 after 4weeks, 8.30 after 8weeks, and 5.46 after 12 weeks of treatment. These values were statistically significant. (p<0.05) 5. No definite evidence of side effects was observed during the study. 6. There were no differences in vital signs, body weight, and body mass index between before and after the treatment.

자궁경부종양에서 p53 단백발현과 맥관형성의 의의

고지환,서광선,노흥태 대한부인종양 콜포스코피학회 2001 Journal of Gynecologic Oncology Vol.12 No.4

자궁경부암 Ia기의 임상적 고찰

노흥태,고지환 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

In 1995, The Cancer Committee of the International Federation of Gynecology and Obstetrics(FIGO) subdivided stage Ia cervical cancer into stage Ia1, tumor which invades the cervical stroma to a depth of 3.0 mm or less, and stage Ia2, tumor which invades the cervical stroma to a depth of 3.0 - 5.0 mm and a horizontal spread of 7 mm or less. We conducted this retrospective study in order to evaluate the result of therapeutic approach in patient with stage Ia cervical cancer. To investigate the clinical and pathological aspect of cervical cancer Ia1, a retrospective study was made on 62 cases, histological reconfirmed surgical specimen, which had been treated during the period from January, 1995 to October, 1999 at department of Obstetrics and Gynecology, Chungnam National University, Daejeon, Korea. The age ranged from 25 to 64 years and median age 41.8 years. In 62 cases, mean parity was 2.34. In 42 cases (67.8%) incidentally found through the routine Pap smear, in symptomatic group most frequently initiating symptom was vaginal bleeding (19.4%). Pap smear was done in all cases, the results reveals CIN Ⅲ in 51.5% and carcinoma in 32.3%. The corresponding rate of Pap smear was done 39.8%. The type Ⅰ hysterectomy was performed in 34 cases, and the type Ⅱ hysterectomy wan done in 24 cases of stage Ia1 disease and the type Ⅲ hysterectomy was done in 4 cases of stage Ia2 disease. Postoperative complication was in 6 cases, in which was bladder dysfunction in 2 cases, wound hematoma in 2 cases, wound infection in 2 cases. In conclusion, preoperative correct diagnosis of stage Ia cervical cancer was not easy. Based upon meticulous analysis of Pap smear, colposcopy and biopsy finding, more liberal use of diagnostic conization should be done for correct diagnosis.

난소에 발생한 원발성 이행세포암 1 예

오영균,이석수,고지환,남상륜,서광선 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11

Primary ovarian transitional cell carcinoma is extremely rare tumor. The histologic subtype was divided from malignant Brenner tumor due to it's own histologic characteristics and chemosensitive nature. Most of recent studies revealed that transitional cell carcinoma has a good response to chemotherapy and long-term survival. Recent histopathologic reports show that transitional cell carcinoma of the bladder and of the ovary are immunophenotypically different. We experienced a case of primary ovarian transitional cell carcinoma, and report this case with a brief review of the concerned literatures.