Ethylene glycol 중독견의 임상병리학적 소견

성은주,이현범,Sung, Eun-ju,Lee, Hyun-beom 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.4

Present study was undertaken in order to find out the most significant laboratory test for the early diagnosis of ethylene glycol poisoning in dogs. Seven dogs weighing from 5.0kg to 19.3kg were administered orally 6ml or l0ml of ethylene glycol per kilogram of body weight. In addition to clinical observations, blood samples were taken from the jugular vein on 0, 1, 3, 6, 12, 24 and 48 hours or until death after the adminisration and examined for the hematological, blood chemical, venous blood gas and electrolyte changes. Urine samples were simultaneously taken and examined for pH, protein, glucose and calcium oxalate crystals in the sediments. The results were as follows : 1. All dogs showed marked hypothermia in addition to the characteristic signs of ethylene glycol poisoning until death. 2. No significant hematological changes were observable after the administration of ethylene glycol except the secondary dehydration and stress leukogram. 3. Chemical values related to the liver function(serum glutamic pyruvic transaminase, total serum protein, serum albumin, serum total bilirubin) showed no significant changes during the experimental period in all dogs. 4. Chemical values related to the renal function(BUN and creatinine) showed significant(p<0.0l, p<0.001) increase from 24 hours to death in all dogs. 5. All dogs showed significant(p<0.01, p<0.001) decrease in blood pH from 3 hours to death after the ethylene glycol administration. 6. All dogs showed significant(p<0.05, p<0.01, p<0.001) increaes in anion gap from 1 hour to death after the ethylene glycol administration. 7. All dogs showed significant(p<0.05, p<0.01) decrease in urine pH from 1 hour to 6 hours after the administration of ethylene glycol. 8. Characteristic envelope form of calcium oxalate crystals were found in the urinary sediment from 6 hours after the administration of ethylene glycol in all dogs. 9. Histologically calcium oxalate crystals were found in the renal rubles in all dogs. 10. From these results, it may be concluded that the examinations of urinary sediments for the calcium oxalate crystals, blood or urinary pH and blood anion gap are most reliable tests for the early diagnosis of ethylene glycol poisoning in dogs.

부모 양육방식이 자녀의 자아존중감 및 학교생활 적응에 미치는 영향에 관한 연구

성은주(Eun ju Sung) 한국정책개발학회 2014 정책개발연구 Vol.14 No.1

본 연구는 청소년기의 중학교 3학년 학생을 대상으로 부모의 양육방식이 휴대폰 의존도에 미치는 영향을 규명하고, 휴대폰 의존으로 인한 부정적, 긍정적인 효과를 규명하고자 하였다. 이를 위해 부모의 양육방식과 휴대폰 의존도, 자아존중감, 학교생활적응 간의 관계를 규명하기 위하여 2012 아동ㆍ청소년패널 자료를 활용하여 다중회귀분석을 실시하였다. 그 결과 긍정적 양육방식은 청소년의 휴대폰 의존도를 낮추는 효과가 있는 반면, 부정적 양육방식은 휴대폰의존도를 높이는 것으로 밝혀졌다. 또한 휴대폰 의존도는 자아존중감을 낮추고, 학교생활적응에 부정적 영향을 미치는 것으로 밝혀졌다. 이에 본 연구에서는 긍정적 부모양육방식과 청소년의 올바른 휴대폰 사용을 위한 교육프로그램의 필요성을 제시하고자 하였다. The purpose of this study is to investigate the influence of parent rearing methods on mobile phone dependence with subjects being middle school students in their early adolescent age and to investigate the negative effects brought by mobile phones. For this, in order to investigate the relationship among parental rearing method, mobile phone dependence, self-esteem and school adaptation, the 2010 Teenagers panel data was utilized to conduct a multiple regression analysis. As a result, a controlled rearing method which is one of the negative parental rearing methods demonstrated a high dependence on mobile phones while a supervised rearing method which is one of the positive parental rearing methods indicated low mobile phone dependence. In addition, the mobile phone dependence lowered self-esteem and showed to have negative influences on school adaptation. Thus, this study proposes the need for positive parental rearing methods and an educational program targeting the correct use of mobile phones for teenagers.

Population Structure and Genetic Diversity of Garlic in Korea by ISSR Marker

허만규,성정숙,최주수,정영기,류은주,정경태,Huh Man-Kyu,Sung Jung-Sook,Choi Joo-Soo,Jeong Young-Kee,Rhu Eun-Ju,Chung Kyung-Tae Korean Society of Life Science 2006 생명과학회지 Vol.16 No.2

마늘은 전 세계적으로 분포하는 다년생 초본이다. 마늘은 약리적, 경제적으로 중요한 작물이다. 야생종과 재배종의 유전관계를 ISSR 마커로 조사하였다. 또 ISSR 분석으로 이들 종의 유전적 다양도와 집단구조를 실시하였다. 한국의 세 야생 집단은 분리되어 있고 패치 분포를 보이지만 재배종에 비해 높은 유전적 다양성을 유지하고 있었다. ISS5R 마커로 야생종과 재배종의 계통관계는 잘 분리되었다. 비록 한국내 재배종 마늘이 산마늘에서 진화하였 다는 직접적 증거는 없지만 본 연구 결과 그런 가능성은 시사된다. 또한 야생종 산마늘 집단은 생식질 동정과 재배종 마늘의 진화과정에서 유익하게 쓰일 수 있다. Garlic is a perennial herb primarily distributed throughout the world. These plants are regarded as a medically and agricultural important crop in the world. The genetic relationships between cultivated and wild species were investigated at the population levels by constructing tree based on ISSR (inter-simple sequence repeats) markers. In addition, ISSR analysis was also conducted to estimate genetic diversity and population structure of these species. Three wild garlic populations in Korea were found to have more alleles per locus (mean 1.672 vs. 1.510) higher percent polymorphic locus (67.2 vs. 51.0), and higher diversity (0.250 vs. 0.198) than three cultivated populations. The cultivated and wild species in Korea are well separated from each other at phylogenetic trees. Although there is not direct evidence that A. victorialis is an ancestor of Korean A. sativum, there is a possibility that cultivated A. sativum in Korea has evolved from wild A. victorialis in Korea. Populations of A. victorialis may be useful in germ-plasm classification and evolutionary process.

마늘이 개의 조직내 카드뮴축적 및 혈액상에 미치는 영향

이병제,성은주,이미순,장인호,이현범,Lee, Byung-je,Sung, Eun-ju,Lee, Mi-soon,Jang, In-ho,Lee, Hyun-beom 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.3

The environmental pollution by heavy metals has become a significant hygenic problem. Recently it is said the garlic supplementation in diet have protective effect on the heavy metal accumulation in tissue of rat by a researcher. In this study two experiments were undertaken. Firstly, dogs were fed diet supplemented with cadmium of cadmium plus 7% of raw garlic for 50 days. on the 50th day of experiment all dogs were euthanasied and the cadmium content of various tissue were measured by atomic absorption spectrophotometeric method. Secondly, in order to find out the toxic effect of garlic dogs were fed diet supplemented with 7% of raw garlic for 50 days and hematological or hematochemical observations were undertaken at 10 day intervals. The results obtained from these experiments were summarized as follows; 1. In dogs treated with cadmium and cadmium plus garlic cadmium was accumulated in renal cortex, liver, and muscle. However the concentrations of cadmium showed no significant between the two group. 2. In dogs fed diets supplemented with 7% of raw garlic significant decrease of erythrocyte count, packed cell volume and hemoglobin content and significant increase of Heinz body erythrocyte and reticulocyte count were recognized. 3. The garlic-treated dogs and control dogs had normal asparate aminotransferase, alanine aminotransferase, alkaline phosphotase, blood urea nitrogen value. The value showed no significant difference between the two group. 4. From these results it may be concluded that the garlic have protective effect for cadmium accmulation in tissue and excess garlic in diet could induce hemolytic anemia in dogs.

CO2와 수온 증가에 대한 봄철 저수온기 팔당호 식물플랑크톤군집 변화

이가람 ( Ka Ram Lee ),성은주 ( Eun Ju Sung ),박혜진 ( Hye Jin Park ),박채홍 ( Chae Hong Park ),박명환 ( Myung Hwan Park ),황순진 ( Soon Jin Hwang ) 한국하천호수학회(구 한국육수학회) 2013 생태와 환경 Vol.46 No.4

This study investigated the influence of temperature and CO2 increase on phytoplankton growth and community structure during cold water season (spring) in Lake Paldang, Korea. Four experimental treatments of temperature and CO2 manipulation were prepared in the laboratory batch culture: (1) Control; ambient low temperature (6±2.C) and low CO2 (air level, 400 mg L-1), (2) T1; low temperature and high CO2 (800 mg L-1), (3) T2; high temperature (20±2.C) and low CO2, (4) T3; high temperature and high CO2. Algal growth experiment was carried out for 10 days under the light intensity of 70 μmol m-2 s-1 (L:D=24 : 0). The level of pH decreased in both T1 and T3, due to dissolution of added CO2. The dominant phytoplankton species of ambient water, Cyclotella meneghiniana succeeded to Fragilaria capucina var. gracilis in high-temperature treatment groups (T2 and T3). Cyanobacteria were very rare at the beginning of the experiment, while Oscillatoria limnetica appeared in only high-temperature groups (T2 and T3) at 6~7th day. CO2 addition in ambient temperature (T1) induced the highest phytoplankton growth, and thereby producing the highest average cell density of 3.27±0.33 104 cells mL-1, followed by T2 (2.65±0.26 104 cells mL-1), T3 (2.09±0.16 104 cells mL-1), and Control (1.86±0.13 104 cells mL-1) (F=7.167, p=0.000). In summary, temperature increase changed the phytoplankton community structure and CO2 increase promoted the phytoplankton growth during the cold spring season in Lake Paldang, suggesting a potential effect of climate change on freshwater phytoplankton.

가정의학과 외래 우울증환자에서 moclobemide의 안전성 및 유효성 평가를 위한 시판후조사

김영식,이근미,김병성,신호철,성은주,이상엽,문유선,송상욱,김철환,선우성,Kim, Young-Sik,Lee, Keun-Mi,Kim, Byung-Sung,Shin, Ho-Cheol,Sung, Eun-Ju,Lee, Sang-Yeoup,Moon, Yoo-Sun,Song, Sang-Wook,Kim, Cheol-Hwan,Sunwoo, Sung 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.1

Background : Depression is quite a common disease in primary care however, studies for the safety and effectiveness of antidepressants in primary care setting are rare in Korea. Objectives : This multi-centered post-marketing study was performed to evaluate the safety and effectiveness of Moclobemide and to find out the factors related to the adherence among patients with depression in family practice. Methods : A total of 386 patients were enrolled from July 1999 to January 2000 by twenty family doctors from fifteen family practice centers. They were prescribed Moclobemide and were reevaluated at the 4th, 8th, and l2th week. Evaluation of compliance, safety and effectiveness were performed with pre-made, structured self-reported questionnaires. Evaluation of effectiveness was also performed utilizing self-rating depression scale (SDS). Results : Among 386 patients, safety was evaluated in 310 patients and effectiveness was evaluated in 239 patients. During the first 12 weeks, the number of subjects continuing with Mocclobemide was 136(37.1%). 141 subjects (38.4%) discontinued taking the drug and 90 subjects (24.5%) dropped out at the 12th week. Considering drop-out patients as ineffective cases, overall effectiveness was estimated to be 84.5%. Symptoms improved with time in patients whose follow-up were completed (P<0.01). The SDS score decreased by an average of ${6.8{\pm}9.1(12.2{\pm}19.1%)}$ after 12 weeks(p<0.01). During the study, 33(10.6%) subjects reported adverse events. The most commonly reported adverse events, in descending order, were dizziness(2.3%), headache(1.6%), insomnia(1.3%), facial edema(1.3%), constipation(1.0%), nausea(1.0%) and tremor(1.0%). The main reasons for discontinuing antidepressants were attributed to improvement of symptoms and manifestation of adverse events. Conclusion : The percentage of adherence at 12th week of Moclobemire among patients suffering from depression in the family practice outpatient clinic was shown to be 49%. The antidepressant effect and safety of Moclobemide was relatively superior.

목맴 후 발생한 양측 팔신경얼기손상: 증례보고

윤병남 ( Byung Nam Yoon ),최성혜 ( Seong Hye Choi ),나정호 ( Joung Ho Rha ),성정준 ( Jung Joon Sung ),마은주 ( Eun Ju Ma ),이광우 ( Kwang Woo Lee ) 대한외상학회 2014 大韓外傷學會誌 Vol.27 No.3

The brachial plexus is a network of nerves that provides movement and feeling to the shoulder, armand hand. The majority of acute brachial plexus injuries occur when the plexus is stretched violently or torn. This happens as result of the shoulder being pressed down forcefully while the head is pushed up and away from that shoulder. Such injuries frequently result from automobile or motor-cycle accidents or from falls and usually affect one side. Nerve injuries vary in severity from a mild stretching of the nerve to a tearing of the nerve root away from the spinal cord. We experienced a 50-year-old woman with weakness in both upper extremities after an attempted hanging. A consecutive workup revealed bilateral brachial plexus injuries. Six months after the incident, she had fully recovered. This is a very rare case of bilateral brachial plexus injuries after an attempted hanging. [ J Trauma Inj 2014;27:79-83 ]

폐경여성에서 무증상 갑상선 기능 저하증과 심혈관계 위험인자와의 관련성

조수현 ( Soo Hyun Cho ),김진희 ( Jin Hee Kim ),권오성 ( Oh Sung Kwon ),성은주 ( Eun Ju Sung ),박형무 ( Hyoung Moo Park ) 대한폐경학회 2012 대한폐경학회지 Vol.18 No.3

Objectives: The relationship between subclinical hypothyroidism and cardiovascular disease has not yet been clearly defined. This study will investigate whether or not there is a difference in the prevalence of subclinical hypothyroidism in menopausal women with respect to cardiovascular risk factors, and will furthermore analyze the relationship between cardiovascular diseases and subclinical hypothyroidism, in order to establish a foundation for subclinical hypothyroidism research. Methods: The study subjects consisted of 713 post-menopausal women, who visited the hospital for a health check-up in 2006-2010. They were divided into a subclinical hypothyroidism group and a normal group. This study analyzed the difference in blood pressure, serum lipid, body mass index (BMI) and blood glucose level between the two groups. The data was analyzed using a two-sample t-test. Results: The prevalence of subclinical hypothyroidism for menopausal women was 6.7%. The results showed no significant differences between the normal and subclinical hypothyroidism patient groups, in regards to blood pressure, BMI, and blood glucose levels (P > 0.05). However the triglyceride of serum lipid was significantly higher in the subclinical hypothyroidism group (P = 0.003). Conclusion: It has been confirmed that the triglyceride of the subclinical hypothyroidism group was higher than that of the normal group, and so serum lipid maintenance and caution towards cardiovascular disease is necessary for the subclinical hypothyroidism group. (J Korean Soc Menopause 2012;18:193-198)

일차의료에서 주요우울장애 선별을 위한 PHQ-2/PHQ-9 연속선별검사의 유용성

김성래(Seong-Rai Kim),신호철(Ho-Cheol Shin),이덕철(Duk-Chul Lee),김철환(Cheol-Hwan Kim),성은주(Eun-Ju Sung),이계화(Kye-Hwa Lee),김자영(Ja-Young Kim) 대한스트레스학회 2011 스트레스硏究 Vol.19 No.4

일차의료에서 우울증을 조기에 진단하기 위해 많은 선별검사도구들이 사용되고 있다. 두 가지 설문을 이용한 연속 선별검사가 한 가지 설문을 이용하는 것보다 우울증 선별에 있어서 더 효율적인 방법이지만, 아직까지 국내에서는 이를 비교한 연구가 없다. 본 연구는 PHQ-2/PHQ-9 연속선별검사가 현재 일차진료에서 많이 사용하고 있는 BDI 및 PHQ-2, PHQ-9 각각의 단독 시행보다 효율적인 선별도구임을 확인해 보고자 하였다. 본 연구는 2010년 2월부터 6월까지 5개월 동안 일개 대학병원을 대상으로 5개월간 실시되었다. 환자들에게 PHQ-2, PHQ-9, BDI 설문조사를 시행하고 각각 소요되는 시간을 측정하였다. 이후 주치의가 면담을 통하여 DSM-IV 진단기준으로 우울증을 진단하였다. 각 설문도구들에 대한 신뢰도 및 타당도를 측정하였고, PHQ-2/PHQ-9 연속선별검사와 다른 선별검사도구의 진단 정확도 및 소요시간을 비교하였다. 연구대상자 201명 중 우울증 환자군을 27명(13.4%), 비우울증 환자군은 174명(86.6%)이었다. PHQ-2, PHQ-9, BDI의 Cronbach’s alpha 값은 각각 0.730, 0.863, 0.905이었다. PHQ-2/PHQ-9 연속선별검사의 진단 정확도는 87.06%로 PHQ-2 (69.2%), PHQ-9 (81.6%), BDI (72.7%)보다 높았다. 평균소요시간은 PHQ-2가 30초 미만, PHQ-9는 102.9±6.1초로 측정되었고, 따라서 PHQ-2/PHQ-9 연속선별검사가 BDI (224.17±11.9초)보다 소요되는 시간이 적었다. PHQ-2/PHQ-9 연속선별검사는 PHQ-2, PHQ-9의 단독 시행 및 BDI 보다 진단 정확도가 높고 시간이 적게 소요되므로, 일차진료에서 우울증에 대한 매우 유용한 선별검사도구이다. In Primary care, many screening tools to detect depression are used. Patient health questionnaires (PHQ)-2/PHQ-9 serial screening is reported to be more efficient than other questionnaires in primary setting in western country. Therefore, we identified the efficacy of PHQ-2/PHQ-9 serial screening in primary care setting in Korea. We compared PHQ-2/PHQ-9 serial screening with other screening tools in terms of diagnostic accuracy and time required to detect Major depressive disorder (MDD). Total 201 ambulatory patients completed questionnaires in a family practice center at one university hospital. Then, the subjects were interviewed by family doctors according to DSM-IV criteria. The reliability, sensitivity, specificity and the time required to finish PHQ-2/PHQ-9 serial screening were examined and compared to other screening tools (PHQ-2, PHQ-9, BDI). There were 27 patients in the MDD group and 174 in the non-MDD group. The Cronbach’s alpha of PHQ-2, PHQ-9, and BDI was 0.730, 0.863, and 0.905, respectively. The diagnostic accuracy of PHQ-2/PHQ-9 serial screening was 87.0%, which is superior to those of PHQ-2, PHQ-9, and BDI (69.2%, 81.6% and 72.6%, respectively) The estimated time required of PHQ-2/PHQ-9 serial screening, about 132.9±6.1 seconds, was less than those of BDI, about 224.17±11.9 seconds. PHQ-2/PHQ-9 serial screening had a better diagnostic accuracy and took less time than the other screening tools for depression. Therefore, PHQ-2/PHQ-9 serial screening is the most useful measure for detecting depression in primary care. (Korean J Str Res 2011;19:405∼410)

국립공원 관리를 위한 해양생태계 장기 모니터링 프로그램의 발전 방향

이채린(Chae-Lin Lee),유재원(Jae-Won Yoo),정병관(Byungkwan Jeoung),김창수(Chang-Soo Kim),안동식(Dong-Sik Ahn),김성태(Sungtae Kim),성은주(Eun-Ju Sung),김성현(Sung-Hyun Kim),정수영(Su-Yeoung Jeong),박영석(Young-Seuk Park) 국립공원연구원 2021 국립공원연구지 Vol.12 No.2

생태계 변화의 모니터링은 효율적 생태계 관리를 위한 기초 정보 수집을 위해 중요한 과정이다. 많은 생태 현상과 그 과정은 오랜 시간에 걸쳐 진행되므로 국립공원의 지속적인 보전 및 효율적 관리를 위해 생태계 모니터링은 장기적으로 이루어질 필요가 있다. 본 연구는 국내외 장기 모니터링 프로그램 사례 분석을 통해 성공적인 장기 모니터링을 위한 방법으로써, 최적화된 모니터링 설계, 표준화된 운용방안 마련, 인적 자원 및 DATA 관리 체계 수립, 안정적인 재정 마련 및 후속지원 등을 제시하였다. 이를 바탕으로, 현재 10년 넘게 수행되고 있는 ‘HS호 유류유출 사고 해역 장기 모니터링 프로그램’의 발전 방향으로 적응형 모니터링 방식이 적용된 표준화된 프로토콜의 정립, QA/QC와 지속적인 자료 관리, 조사 항목의 연계성 강화 등의 구체적 방안을 제안한다. Monitoring ecosystem changes is an important process for collecting basic information for ecosystem management. Since many ecological phenomena and their processes take place over a long period of time, it is necessary to conduct long-term monitoring of ecosystems for the continuous conservation and efficient management of national parks. This study suggested an optimized monitoring design, standardized operation plan, human resource and data management system, stable financial preparation and follow-up support as methods for successful long-term monitoring through case analysis of domestic and foreign long-term monitoring programs. Based on this, it proposes specific measures such as establishing a standardized protocol with adaptive monitoring methods, continuous data management with QA/QC, and strengthening the linkage of investigation items in the development direction of the “HS oil spill accident long-term monitoring program” that has been conducted for more than a decade.