원발성 알도스테론증과 본태성 고혈압에서의 표적장기 손상 빈도 비교

박주리,김동진,양세정,김혜숙,박수연,류혜진,이윤정,김희영,류옥현,이계원,서지아,김신곤,최경묵,백세현,최동섭 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.1

Background: A number of recent clinical studies have reported marked target organ damages in patients with primary aldosteronism. The aim of this study was to compare the incidence of target organ damages in patients with primary aldosteronism (PA) and essential hypertension (EHT). Methods: The clinical records of 41 PA patients, over a 20-year period, were retrospectively analyzed. The clinical characteristics and incidence of target organ damages of 33 of the patients in this group were compared with those of 66 patients with essential hypertension, directly matched for age, gender and mean blood pressure. 8 of the PA patients could not be matched with EHT patients for age, gender and mean blood pressure, so were excluded from the comparison. The patients with essential hypertension were sampled from patients who visited for the evaluation of hypertension. Results: Ischemic heart diseases were found in 18.2 and 10.6% of patients with PA and EHT, respectively (P = 0.22). From echocardiograms, left ventricular hypertrophy was found in 93.3% and 61.4% of patients with PA and EHT, respectively (P = 0.017). The degrees of left ventricular hypertrophy were correlated with the levels of serum aldosterone, with an r value of 0.490 (P < 0.005). Cerebrovascular attack was found in 18.2% and 1.5% of patients with PA and EHT, respectively (P = 0.005). Hypertensive retinopathy was found in 50% and 33.3% of patients with PA and EHT (P = 0.255), and nephropathy was found in 42.4% and 25.8% of patients with PA and EHT, respectively (P = 0.074). Conclusion: Patients with primary aldosteronism had target organ damages more frequently than with those with essential hypertension, which was independent of blood pressure. (J Kor Endocrinol Soc 22:11~18, 2007) 배경: 최근 원발성 알도스테론증은 전체 고혈압의 5~13%를 차지하며 표적 장기 손상 빈도도 적지 않게 나타나는 것으로 보고되고 있다. 이번 연구에서는 원발성 알도스테론증의 표적 장기 손상 빈도를 조사하고 이것을 원발성 고혈압 환자와 비교해 보고자 하였다. 방법: 1986년부터 2005년까지 고려대학교 병원을 방문하여 원발성 알도스테론증을 진단받은 41명의 환자를 의무기록을 통해 후향적으로 분석하였다. 이들 중 33명의 환자와 나이, 성별, 평균 혈압을 짝짓기한 원발성 고혈압 환자 66명을 임상적 특성 및 표적 장기 손상 빈도에 대해 비교하였다. 나이, 성별, 평균 혈압을 짝짓기한 원발성 고혈압 환자를 찾을 수 없는 8명의 원발성 알도스테론증 환자는 비교대상에서 제외되었다. 결과: 허혈성 심질환의 과거력을 가진 환자는 원발성 알도스테론증 환자군에서는 6명, 본태성 고혈압 환자군에서는 7명이었다(18.2% 대 10.6%; odds ratio 1.8; 95% CI 0.6 ~6.1, P = 0.22). 심초음파로 진단된 좌심실비대는 원발성 알도스테론증 환자군에서는 14명, 본태성 고혈압 환자군에서는 27명이었다(93.3% 대 61.4%; OR 8.8; 95% CI 1.06 ~73.2). 좌심실비대의 정도는 혈장 알도스테론 수치와 통계적으로 유의한 양의 상관관계를 보였다(r = 0.490). 뇌경색의 과거력을 가진 사람은 원발성 알도스테론증 환자군에서는 6명, 본태성 고혈압 환자군에서는 1명으로 원발성 알도스테론증 환자군에서 통계적으로 유의하게 더 높은 빈도를 나타내었다(18.2% 대 1.5%; odds ratio 14.4; 95% CI 1.65~127.5). 고혈압성 망막질환이나 신질환도 통계적으로 유의하지는 않았으나 각각의 위험도가 2.0, 2.1로 원발성 알도스테론증 환자군에서 더 높은 빈도를 나타내는 경향성을 보였다.

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

박주리,이민정,안국영,윤태훈,최인성,이은성,이현숙,최성욱 한국고분자학회 2019 Macromolecular Research Vol.27 No.9

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing.

아동 실행 기능(executive function) 결함에 대한 연구 현황 및 향후 방향 제시

박주리,송현주 서울여자대학교 특수치료전문대학원 2009 심리치료: 다학제적 접근 Vol.9 No.2

포스터발표 : 근시안에서 안경과 소프트콘택트렌즈 착용 시 입체시력의 변화

박주리,이병용,최진영,김현정 한국안광학회 2008 논문집 Vol.2008 No.1

Core-Shell Microcapsules Using Coacervation in a Fluidic Device

박주리,최성욱 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0

2-Octyldodecanol(ODD) has been encapsulated using complex coacervation of biopolymers, gelatin and gum arabic. Gelatin-gum arabic microcapsules have been formed through direct homogenization which generally have a non-uniform size, low encapsulation efficiency. These drawbacks led to controlling the structure of microcapsules difficult, which remains unsolved. Herein, we introduce fluidic device process with triple nozzles. Uniform sized gelatin-gum arabic capsules with one core-one shell were fabricated in oil-in-water-in-oil (O-W-O) double emulsion system. With presented system, size of O-W-O emulsion, diameter of core, and thickness of shell can be controlled with adjusting middle phase flowrate.

상향비교가 SNS 중독경향성에 미치는 영향과 소외에 대한 두려움(FoMO)의 매개효과: 개방형 SNS와 폐쇄형 SNS의 차이를 중심으로

박주리,이주영 한국정서행동장애학회 2022 정서ㆍ행동장애연구 Vol.38 No.4

본 연구는 SNS를 사용하는 성인을 대상으로 개방형 SNS 집단과 폐쇄형 SNS 집단을 구분한 후 상향비교가 SNS 중독경향성에 미치는 영향을 확인하고 둘 간의 관계에서 소외에 대한 두려움(FoMO)의 매개효과를 검증하고자 하였다. 이를 위해 SNS를 가장 많이 사용하는 계층인 20대와 30대 322명(남 117명, 여 205명)에게 상향비교, FoMO, SNS 중독경향성 척도를 사용하여 온라인 설문조사를 실시하였다. 분석 결과는 다음과 같다. 첫째, 개방형 SNS 집단과 폐쇄형 SNS 집단에서 상향비교, FoMO, SNS 중독경향성 간에 유의한 정적 상관이 나타났다. 둘째, 개방형 SNS 집단과 폐쇄형 SNS 집단을 비교했을 때, 개방형 집단이 SNS 중독경향성에서 유의하게 높은 수준을 보였다. 셋째, 상향비교, FoMO, SNS 중독경향성에서 여성이 남성에 비해 유의하게 높은 수준을 보였다. 넷째, 구조방정식 모형 검증에서 두 집단 모두에서 상향비교가 SNS 중독경향성에 미치는 영향이 유의함을 확인하였고, 이 관계에서 FoMO가 완전 매개함을 확인하였다. 본 연구결과는 상향비교 경향이 소외에 대한 두려움(FoMO)을 강화시켜 SNS 중독경향성을 높인다는 것을 보여준다. 이러한 결과는 SNS 중독으로 인한 문제에서 상향비교와 FoMO에 대한 개입이 필요함을 시사하며, 특히 개방형 SNS 집단과 여성이 SNS 중독경향성 문제에 취약함을 보여준다.

아동용 실행 기능(Executive Function) 결함 질문지 개발 및 타당화 연구

박주리,송현주 한국임상심리학회 2012 Korean Journal of Clinical Psychology Vol.31 No.1

The purpose of this study was to develop a Children's Executive Function Deficits Inventory(CEFDI), and examine its reliability and validity. In the first part of the study, the factors of CEFDI were categorized based on a review of both the literature and a number of existing inventories, and then CEFDI was developed through content and face validity. The CEFDI was then conducted for 1022 students in fourth, fifth, and sixth grades at four elementary schools in Seoul and Gyeonggi-do, Republic of Korea, the inventories of 931 of these children were subsequently analyzed. The item validity of CEFDI was proved by exploratory and confirmatory factor analyses. In the second part of the study, the internal consistency reliability and concurrent validity were analyzed. In order to verify convergent validity, self-report scales, such as ‘Self Regulation Scale, Barratt Impulsiveness Scale Ⅱ, and ADHD Children's Scale’, and neuropsychological tests, such as ‘Tower of Hanoi Test, Stroop Color and Word Test, Children's Color Trails Test, and Digit Span’, were executed. Subjects for the second part of the study included 159 students in fourth, fifth, and sixth grades in elementary school in Seoul. The CEFDI consisted of 29 questions and was confirmed to be a reliable and valid assessment tool to measure executive function deficits in children.

항Ro/SSA, 항La/SSB 항체 양성인 Cogan’s Syndrome 1예

박주리,노영희,최성재,임기정,장학현,이영호,지종대,송관규 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.1

Cogan's syndrome is a rare chronic inflammatory disease of unknown origin, characterized by nonsyphilitic interstitial keratitis, vestibuloauditory dysfunction and vasculitis. Cogan's syndrome is uncommon and few cases have been published. A case of Cogan's syndrome in a patient with anti-Ro and anti-La positivity is described. A 24-year-old woman visited to department of rheumatology with dry mouth, dry eye, and vertigo on August 2004, and interstitial keratitis had developed on October 2004. She was admitted to the otolaryngology department with rapidly progressive hearing loss on December 2004. The patient's audiogram revealed severe sensorineural deafness. The patient was treated with systemic corticosteroid and methotrexate. This case is the first to report a case of Cogan's syndrome associated with anti-Ro and anti-La positivity.

합리적 행위이론에 기반한 인터넷 사용자의 건강지식 공유의도에 관한 연구

박주리 ( Joo Lee Park ),강민철 ( Min Cheol Kang ),강주영 ( Ju Young Kang ) 경희대학교 경영연구원 2012 의료경영학연구 Vol.6 No.2

This study tries to uncover the relationships of factors influencing the intention and the behavior of health knowledge sharing on the Internet under the Web 2.0 environment based on Theory of Reasoned Action (TRA), intrinsic motivation, and Technology Acceptance Model (TAM). To this end, factors reflecting personal characteristics (i.e., attitude, subjective norm, self-efficacy, and enjoyment of help) and factors reflecting system characteristics (i.e., perceived usefulness, perceived ease of use) are selected as variables of the intention and the behavior of health knowledge sharing on the Internet. In this study, the research model was tested by using structural equation modeling approach was used to analyze collected data. Results of the study show that factors such as subjective norm, enjoyment of help, and perceived usefulness are significantly associated with intention and behaviors of sharing health knowledge on the internet. However, the results reveal that attitude, self-efficacy, and perceived ease of use do not affect the intention and the behavior of sharing health knowledge on the internet.

게슈탈트 시지각 이론을 기반으로 디지털 영상 제작 연구

박주리(Park Juri),권향아(Kwon Hyang-a),김형기(Kim Hyungy) 한국디지털디자인학회 2010 디지털디자인학연구 Vol.10 No.2

시각 예술에 있어 점과 선 그리고 면은 모든 요소의 기본이 되는 표현 수단이다. 이들은 서로 다른 성격과 특징으로 인해 어떻게 조합 하느냐에 따라 시각적 표현이 달라지며 시지각 조합에 따라 작품 분위기가 달라진다. 본 논문은 게슈탈트 시지각 법칙 중 집단성의 원리를 바탕으로 실험적 영상을 제작하여 각각의 요소들 (유사성 근접성 연속성 폐쇄성의 법칙)을 적용하여 작품으로 어떻게 적용 되었는지 연구하고자 한다. 게슈탈트 시지각 법칙의 원리가 적용된 작품의 표현 방법들을 이론적 고찰을 통해 탐구했으며 또한 사례작품을 통해 게슈탈트 원리 적용 방법을 분석하였다. 작품에서는 색의 삼원색(Red Yellow Blue)과 빛의 삼원색(Red Green Blue)을 도형으로 이용하여 표현했으며 도형의 색 모양 크기에 변화를 주어 움직임을 이용하여 게슈탈트의 집단성 원리를 기본 전제 원리로 삼고자 한다. 감상자가 프레임 상에 존재하는 도형의 변화를 자의적으로 해석하고 주관적으로 재해석을 통해 작품을 이해한다는 시지각 원리에 대한 논리적으로 규명한 게슈탈트의 지각원리에 속한다. 결론적으로 잡단성의 원리가 적용된 작품으로 표현할 수 있는 방법적 가능성을 엿볼 수 있다. In the visual arts point line and area are the most basic elements of expression means. They create various visual images by their different characters and affect atmosphere of work according to their combination. In this study the experimental videos based on the principle of collectivity that is one of the gestalt visual perception theory are analyzed how the principles such as the raws of similarity proximity continuity and closedness are applied to them. This study seeks the expression methods in the digital video applied the principle of the gestalt visual perception through the theoretically concepts and also analyzes how the principle is applied to the digital video. In the examples the three primary colors(Red Yellow Blue) and the three primary colors of light(Red Green Blue) are used as figures and the principle of gestalt collectivity is the basic premise principles through the movement of their colors shapes sizes. This principle is one of the gestalt perception principles logically explains that the change of shape in a frame can be subjectively reinterpreted through viewer's individual view and imagination. In conclusion the digital video applied the principle of collectivity are studied in order to find the methodological possibility of the expression methods.