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Network Analysis을 이용한 류마티스관절염 활액 대식세포에서 유전자 발현 연구
지종대 ( Jong Dae Ji ),김태환 ( Tae Hwan Kim ),이빛나라 ( Bit Na Ra Lee ),최성재 ( Sung Jae Choi ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2
Objective. We wanted to investigate the mechanisms that could account for the pathogenesis of rheumatoid arthritis, so we examined the different expressions of the genes in rheumatoid arthritis (RA) synovial fluid macrophages as compared with that of normal peripheral blood (PB) monocyte-derived macrophages using microarray and bioinformatic analysis. Methods. We examined the expression of genes by using a gene expression oligonucleotide microarray. The differences of the gene expressions between the RA synovial macrophages and the normal PB monocytes-derived macrophages were analyzed using bioinformatic tools, including cytoscape and its plugin. Results. In this study, we found that 899 genes (464 genes up-regulated and 435 genes down-regulated) were differentially expressed between the two groups. Among the 899 genes, 552 genes were included for gene ontology analysis and network analysis. Based on biological process ontology, they were categorised mainly into immune response processes, responses to stimulus and signaling and regulation of biological processes. In addition to the genes related with STAT1 and AP-1 signaling, we found that the genes involved in the antigen processing and the cell cycle are abundantly expressed in RA synovial macrophages, suggesting that these genes may play an important role in the pathogenesis of RA. Conclusion. Our study suggest that this approach using integration of the gene expression profile with the protein interaction data may help to find several important pathogenic mechanisms in RA.
건강 검진 환자에서 만성 피로 증후군의 발생 빈도와 임상양상
지종대(Jong Dae Ji),천병철(Byung Chul Chun),최윤선(Youn Seon Choi),최성재(Seong Jae Choi),이영호(Young Ho Lee),송관규(Gwan Gyu Song) 대한내과학회 2000 대한내과학회지 Vol.59 No.5
N/A Background : To determine the prevalence of chronic fatigue syndrome and idiopathic chronic fatigue in Korea and to describe demographic, clinical, and psychological differences among those with chronic fatigue syndrome (CFS), those with idiopathic chronic fatigue, and healthy controls. Methods : 1,526 persons aged 18-76 years who visited Korea university hospital health management center for general check-up between December 1998 and August 1999 were participated in the study. The questionnaire made according to the Centers for Disease Control and Prevention criteria was administered to the recruited persons and patients with chronic fatigue syndrome were diagnosed by questionnaire, physical examination and laboratory tests. The Korean version of the Center for Epidemiological Studies-Depression Scale (CES-D) was used to assess depression. Results : Of the 1,526 persons studied, 433 (29.4 %) reported severe fatigue lasting at least 6 months. Of the 202 persons with unexplained chronic fatigue, 31 persons (2.0% of the study population) were classified as CFS cases. The prevalence of CFS was 2.81% in women, 1.49% in men respectively (p<0.05). When CES-D cut-off score of 25 was used, 30.43% of persons with CFS and 5.93% of persons without chronic fatigue had scores suggestive of depression. CFS patients had higher mean scores on CES-D than persons without chronic fatigue (p<0.05). Conclusion : Persons who met the criteria for chronic fatigue syndrome were found in 2.0%. The prevalence of chronic fatigue syndrome in our study were high, compared with previous studies in other countries. CFS patients had higher mean scores on CES-D than persons without chronic fatigue.(Korean J Med 59:529-534, 2000)
Prostaglandin E2 면역 및 염증반응에서의 역할
지종대 ( Jong Dae Ji ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.4
Prostaglandins have numerous biologic effects on a variety of physiological and pathological activities such as inflammation, platelet aggregation, neurotransmitter release, smooth muscle contraction, and so forth. PGE2 is one of the well-studied inflammatory prostaglandins and causes vasodilatation, edema, fever and pain. Also PGE2 induces the production of matrix metalloproteinases (MMPs) which involve in destruction of tissue. In rheumatoid arthritis, macrophages isolated from patients secrete large amounts of PGE2 and PGE2 promote inflammation and participate in destructive mechanisms of the rheumatoid joint. In addition to its proinflammatory effects, PGE2 acts also as an immunomodulator, promote humoral and Th2-type immune responses and inhibit Th1-type immune responses. Also PGE2 inhibits the production of tumor necrosis factor (TNF-α), IL-1β, IL-8 and IL-12 and stimulates the production of IL-10 by macrophages. Thus PGE2 should be regarded not as proinflammatory molecule but as modulator of immune responses. In this review, we will focus on the current knowledge about PGE2 as the modulator of immune responses and summarize the effects of PGE2 on the immune systems and inflammation.
섬유 조직염환자에서 만성피로 증후군이 동반되는 빈도와 임상양상
지종대(Jong Dae Ji),이영호(Young Ho Lee),송관규(Gwan Gyu Song) 대한내과학회 1998 대한내과학회지 Vol.55 No.5
N/A Objectives: Fibromyalgia is a common rheumatologic disease characterized by chronic myalgia, fatigue, and sleeq disturbance. Chronic fatigue syndrome is chracterized by debilitating fatigue of at least 6 months duration accompenied by other symptoms such as fever, pharyngitis, painful lymph nodes, headache, myalgia, sleep disturbances, neurocognitive complaints, and depression. There has reported that 70% of patients with fibromyalgia met the centers for Disease Control and Prevention symptom criteria for chronic fatigue syndrome. The objectives of this study were to determine how frequently patients with fibromyalgia met the criteria for and chronic fatigue syndrome and what syndrome were manifested. Methods: 34 patients diagnosed with fibromyalgia were participated in the study. The questionnaire made according to the Centers for Disease Control and Prevention criteria was administerd and patients with chronic fatigue syndrome were diagnosed by this questionnaire, physical examination and laboratory tests. Results: 21%(7 patients) of patients with fibromyalgia met the criteria for chronic fatigue syndrome. The symptoms in patients with chronic fatigue syndrome were memory loss/forgetfullness(100%), sore throat(57%), painful lymph node(29%), myalgia(100%), multiple arthralgia(57%), headache(57%), unrefreshing sleep(86%), postexertional malaise(86%). Conclusion: 21% of patients diagnosed with fibromyalgia met the criteria for chronic fatigue syndrome, The incidence of chronic fatigue syndrome in our study is low as compared with the previous study(70%) in 1996.