한의학적 치료를 받은 자폐 스펙트럼 장애 환아 63례에 대한 후향적 차트리뷰

박소현,김예지,박슬기,이선행,이지홍,박용석,김재현,장규태,이진용,Park, So Hyun,Kim, Ye Ji,Park, Sul Gi,Lee, Sun Haeng,Lee, Jihong,Park, Yong Seok,Kim, Jae Hyun,Chang, Gyu Tae,Lee, Jin Yong 대한한방소아과학회 2021 대한한방소아과학회지 Vol.35 No.3

Objectives This study aimed to analyze the clinical characteristics of 63 patients with autism spectrum disorder (ASD) who received Korean medicine treatment. Methods This study identified and retrospectively reviewed the first visit records and clinical characteristics of all of the patients who visited the Kyung Hee University Korean Medicine Hospital and Kyung Hee University Korean Medicine Hospital at Gangdong in South Korea with ASD as their chief complaints. The herbal medicines that were prescribed according to the patient's symptoms were analyzed by separating them into categories. Results The data of 83 children with ASD were collected. Among them, the primary medical record charts of 63 patients were reviewed. Additional analysis was performed for 56 patients who were treated with herbal medicine. Through a retrospective chart review, the patients' clinical characteristics and the tendency of the prescribed herbal medicine was identified. Conclusions This study was conducted to provide preliminary data that proposes Korean medicine as a new alternative medical treatment. Our study is meaningful as it used the demographic and clinical records of 63 patients with ASD in Korea who visited an Korean medicine hospital in the last 11 years to identify tendencies and analyzed the prescriptions of two or more Korean medicine pediatricians.

참당귀 초임계 이산화탄소 선택 추출물의 항염 효능

박소현,이광원,박신성,신문삼,박수인,Park, So Hyeon,Lee, Kwang Won,Park, Shinsung,Shin, Moon Sam,Park, Su In 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

본 연구에서는 참당귀(Angelica gigas Nakai)의 핵심 유효 성분인 decursin과 decursinol angelate를 높은 수율로 추출한 초임계 이산화탄소 선택 추출물의 항염증 효능을 에탄올 추출물과 비교하여 측정하였다. 항염증 효능을 측정하기 위해 염증 매개 인자인 nitric oxide(NO), 염증성 사이토카인인 interleukin(IL)-6, IL-8 생성량을 측정하였다. NO 생성량은 lipopolysaccharide(LPS)로 염증 반응을 유도한 Raw 264.7 세포를 대상으로 Griess assay를 통해 측정하였고, IL-6 및 IL-8 생성량은 tumor necrosis factor(TNF)-α로 염증 반응을 유도한 human keratinocyte cell line(HaCaT) 세포를 대상으로 enzyme-linked immunoadsorbent assay(ELISA)를 통해 측정하였다. NO 생성량은 초임계 이산화탄소 추출물이 에탄올 추출물에 비해 뛰어나게 억제하였다. IL-6 및 IL-8 생성량 또한 에탄올 추출물은 오히려 증가시키는 반면, 초임계 이산화탄소 추출물은 6.25 ㎍/mL의 농도에서 통계적으로 유의하게 억제하였다(P<0.01). 우리는 이러한 결과를 통해 참당귀 초임계 이산화탄소 선택 추출물이 아토피 피부염을 완화시키는 항염증 코스메슈티컬 소재로써 활용 가능함을 확인하였다.

가미서경탕(加味舒經湯)을 이용한 상부관절와순파열로 진단받은 견비통 환자 치험 2례

박소현,노해린,Park, So-Hyun,Ro, Hae-Rin 척추신경추나의학회 2011 척추신경추나의학회지 Vol.6 No.1

Objectives : The propose of this study is to find out the clinical application of conservative treatment for SLAP lesion. Methods : We examined 2 patients with SLAP lesion who admitted Jaseng Hospital of Oriental Medicine. The patients were treated by conservative treatments including herbal mixture, acupuncture, pharmacupuncture. Results : In this study, in the end of continuous conservative treatment, patient's shoulder pain has improved. Visual Analog Score(VAS) were also decreased. Conclusions : A conservative treatment for SLAP lesion was effective in restore of functional activities, but usefulness of this treatment needs more study.

척추 마취 후 발생한 마미증후군 환자 1례에 대한 임상적 고찰

박소현,노해린,이재영,한상엽,신동재,박재영,김창연,Park, So-Hyun,Ro, Hae-Rin,Lee, Jae-Young,Han, Sang-Yup,Shin, Dong-Jae,Park, Jae-Young,Kim, Chang-Yeon 척추신경추나의학회 2012 척추신경추나의학회지 Vol.7 No.2

Objective : The purpose of this study is to report clinical effect of oriental meical treatments for Cauda Equina Syndrome Patient induced spinal anesthesia. Methods : The patient was treated by Oriental medical treatments including acupuncture, ShinBaro pharmacopuncture treatment, herbal medication. The improvement of the clinical symptoms was observed by Visual analog scale(VAS) and Oswestry disability index(ODI). Results : After treatments, VAS and ODI. were improved in case. Conclusions : Oriental medical treatment might be an effective method to improve the clinical symptoms of Cauda Equina Syndrome Patient induced spinal anesthesia.

만성 요통 및 하지방사통 환자에서 감압치료(KNX $7000^{(R)}$)와 견인치료의 단기 치료 효과

박소현,김철승,이동규,안상호,Park, So-Hyun,Kim, Chul-Seoung,Lee, Dong-Gyu,Ahn, Sang-Ho 대한물리치료학회 2011 대한물리치료학회지 Vol.23 No.5

Purpose: The purpose of this study is to evaluate the short term effects of the traction and decompression device, which is a newly developed domestic medical device, on pain and functional activity in patients with chronic low back pain with or without radicular pain. Methods: Forty patients with chronic low back pain were included and allocated to decompression (n=20) and traction groups (n=20). They received decompression or traction therapy for 20 minutes a day, 3 days per week for two weeks. For evaluating pain and functional activity, a visual analogue scale (VAS) for low back pain and the Oswestry back pain disability index (ODI) were obtained on pre-treatment, and at 6, 12 and 15 days after treatment. Patients'satisfaction levels were measured 15 days after treatment. Results: VAS was significantly decreased at 12 days and 15 days post-treatment compared to pre-treatment in both groups (p<0.05). ODI was significantly decreased at 12 days and 15 days post-treatment compared to pre-treatment in the decompression group (p<0.05). However, there was no significant difference between the two groups in the VAS and ODI scales (p>0.05). Patients' satisfaction levels were significantly higher in the decompression group than in the traction group (p<0.05). Conclusion: These findings suggest that decompression therapy might be effective for increasing functional activity in patients with low back pain and could provide patients with higher satisfaction than traction therapy. This study provided validity data for the therapeutic effects of the decompression device in patients with low back pain and it will be useful for medical cost development and patient education of this device.

순차 적응 최근접 이웃을 활용한 결측값 대치법

박소현,방성완,전명식,Park, So-Hyun,Bang, Sung-Wan,Jhun, Myoung-Shic 한국통계학회 2011 응용통계연구 Vol.24 No.6

비모수적 결측치 대치법인 k-최근접 이웃(k-Nearest Neighbors; KNN) 대치법을 개선한 적응 최근접 이웃(Adaptive Nearest Neighbor; ANN) 대치법과 순차 k-최근접 이웃(Sequential k-Nearest Neighbor; SKNN) 대치법의 장점들을 결합한 순차 적응 최근접 이웃(Sequential Adaptive Nearest Neighbor; SANN) 대치법을 제안하고자 한다. 이 방법은 ANN 대치법의 장점인 자료의 국소적 특징을 반영할 뿐 아니라, SKNN 대치법과 같이 결측값 대치가 이루어진 개체를 다음 결측값을 대치할 때 사용함으로써 효율성에 개선이 있을 것으로 기대한다. In this paper, we propose a Sequential Adaptive Nearest Neighbor(SANN) imputation method that combines the Adaptive Nearest Neighbor(ANN) method and the Sequential k-Nearest Neighbor(SKNN) method. When choosing the nearest neighbors of missing observations, the proposed SANN method takes the local feature of the missing observations into account as well as reutilizes the imputed observations in a sequential manner. By using a Monte Carlo study and a real data example, we demonstrate the characteristics of the SANN method and its potential performance.

기업 간 거래망에 기초한 기능적 경제권의 설정

박소현,권규상,박소영,Park, Sohyun,Kwon, Kyusang,Park, Soyoung 한국경제지리학회 2020 한국경제지리학회지 Vol.23 No.1

본 연구는 기업 간 거래망을 활용하여 지역 간 경제적 연계를 확인하고 경제적 상호의존성에 기초한 기능적 경제권을 설정하는데 그 목적이 있다. 기존의 경제권은 이미 알려진 행정도 경계나 문화적 동질성을 기준으로만 설정되거나 실증자료를 활용하더라도 통근, 인구이동, 화물흐름 등 경제활동을 충분히 설명하지 못하는 자료에만 의존하였다. 본 연구는 이러한 한계를 극복하기 위해 한국기업데이터의 CRETOP+ 데이터베이스를 활용하여 실제 기업 간 거래망을 구축하고, 커뮤니티 발견법을 적용해 우리나라의 기능적 경제권을 파악하였다. 분석결과 거래망에 따라 6~7개의 경제권이 도출되었다. 특히 수도권, 충청권, 강원권을 통합한 하나의 거대한 경제권역이 형성되어 있었으며, 전북, 전남은 서로 간의 기업 간 거래빈도가 매우 낮아 호남권으로 묶이기보다 별도의 경제권을 형성하고 있는 것으로 나타났다. 대구, 경북의 경제권과 부산, 경남의 경제권이 각각 존재하는 것으로 나타났지만 울산, 경주, 포항은 도 경계를 넘어서 별도의 권역을 형성하고 있는 것으로 나타났다. 이를 통해 본 연구는 향후 국가균형발전정책에서 실증 자료에 기반한 정책공간의 설정이 필요함을 주장한다. The study aims to identify economic interdependencies between regions and define functional economic areas of Korea by analyzing inter-firm transaction networks. Previous research has relied on pre-given administrative boundaries or cultural homogeneity and used data such as commuting, population movement, and cargo flows which could not fully explain economic activities. To overcome the limitations, this study applies a community detection method to inter-firm transaction networks derived from the CRETOP+ database of Korean corporate data. The novel dataset and the network analysis enables us to identify Korea's functional economic areas based on actual inter-firm linkages. The result shows that there are six to seven economic blocs in the networks as of 2018. In particular, one huge economic bloc is formed integrating the Seoul metropolitan area, Chungcheong, and Gangwon provinces. Meanwhile, North Jeolla and South Jeolla provinces form two economic blocs separately rather than being tied up in one bloc due to the low frequency of transactions between each other. The two big economic blocs of Daegu-Gyeongbuk and Busan-Gyeongnam exist, and interestingly, Ulsan, Gyeongju, and Pohang form a separate middle-sized bloc across the administrative boundaries. The results reveal that the future balanced national development policies should be implemented based on functional economic areas derived from empirical data.

SOA와 WOA의 통합 아키텍처 설계에 관한 연구

박소현,유해영,Park, So-Hyun,Yoo, Hae-Young 한국정보처리학회 2010 정보처리학회논문지D Vol.17 No.5

IT 자원의 상호운용성 및 재활용성 등의 장점을 지니고 있는 서비스 지향 아키텍처(SOA : Service Oriented Architecture)는 새로운 비즈니스 환경변화에 가장 빠르게 대응할 수 있는 최적의 대안으로 각광받고 있다. 그러나 SOA는 구현의 복잡성 및 그에 따른 높은 비용 등의 문제점들을 갖고 있다. 이러한 문제점들의 보완을 위해 웹 지향 아키텍처(WOA: Web Oriented Architecture)가 제안되어 각광받고 있지만, 이 또한 보안 및 안정적인 메시지 전달 등의 문제점들을 안고 있다. 이에 본 논문에서는 SOA와 WOA의 핵심 개념인 서비스를 내 외부 서비스로 분류후 각각을 SOA와 WOA에 적용하고, SOA와 WOA가 지닌 장점을 바탕으로 유연성이 강조된 통합 아키텍처 설계하였다. 제안한 아키텍처는 구현이 보다 간편하고, 서비스 지향적이며, 고객의 요구사항을 충분히 만족시킬 수 있다. 이를 검증하기 위해 AHP (Analytic Hierarchy Process) 기법을 통하여 제안한 아키텍처 설계의 유용성을 평가하였다. Service Oriented Architecture (SOA), which supports various features such as interoperability and reusability of IT resources, comes into the spotlight as an effective approach for adapting new business environmental changes. SOA, however, has some problems including the high realization complexity and low Return on Investment (ROI). To solve these problems, Web Oriented Architecture (WOA) has gained attention. However, it also has some drawbacks about security concerns and unstable message transmissions. In this paper, we design a novel integrated architecture that classifies services into inside and outside ones and applies SOA for the former and WOA for the latter, respectively. By converging the advantages of SOA and WOA simultaneously, the proposed architecture becomes more simple and service-oriented, and can satisfy diverse requirements of customers. The usefulness evaluation of the proposed architecture is conducted through the Analytic Hierarchy Process (AHP) scheme.

압박 벨트와 비탄력 테이프를 이용한 골반압박이 엎드려 고관절 신전 시 체간과 고관절 신전근의 근 작용에 미치는 영향: 요통 경험군과 요통 비경험군 비교 연구

박소현,김선엽,Park, So-hyun,Kim, Suhn-yeop 대한정형도수물리치료학회 2021 대한정형도수물리치료학회지 Vol.27 No.2

Background : Prone hip extension (PHE) is commonly used for exercises and tests in patients with low back pain. Previous studies have shown that pelvic compression belts (PCB) and non-elastic taping (NET) contribute greatly to improvements in lumbopelvic stability. This study aimed to compare the effect of two lumbopelvic stability methods such as PCB and NET on the trunk and hip extensor muscle activities during PHE tests. Methods: Subjects who experienced low back pain (low back pain group, LBPG; n=20) and those who did not experience low back pain (non-LBPG; n=20) participated in this study. The subjects were instructed to perform PHE with and without a PCB and NET. PHE tests were performed in the condition wherein the two stabilization methods were applied, and the actions of the muscles at that time were measured using surface electromyography (EMG). EMG data were collected from the hamstring, gluteus maximus, erector spine (ES), and multifidus (MF) muscles. The data were collected three times for 5 s with a 1-min rest between each of the three sets. Results: In the LBPG, EMG of the ES muscle was significantly reduced when NET or a PCB was applied (p<.05). There was no difference in the change in the ES muscle activity when NET and a PCB were applied. The ratio of MF/ES muscleactivity showed a significant increase in the LBPG with NET (p<.05). Conclusion: Both NET and PCB applied to subjects who experienced low back pain significantly reduced the ES muscle activity during PHE exercises and helped control the balance of the superficial and deep trunk extensor muscles.

통영연안의 패류양식장 중단 이후 다모류 군집구조의 변화

박소현,김선영,심보람,박세진,김형철,윤상필,Park, Sohyun,Kim, Sunyoung,Sim, Bo-Ram,Park, Se-jin,Kim, Hyung Chul,Yoon, Sang-Pil 해양환경안전학회 2021 海洋環境安全學會誌 Vol.27 No.5

The recovery of the sedimentary environment around a fallowing shellfish farm during its rest period after 20 years of long-running operation, was explored in Tongyeong Bay of Korea. Seasonal survey on macrobenthos community was conducted from July 2016 to September 2018 at five stations, which included the fallowing shellfish farm after 20-year operation (FF), a newly installed shellfish farm (NF), a shellfish farm for comparison around the closed shellfish farm (CF), and control stations with no farming activities (Con1, Con2). The total number of species and the density of macrobenthos were higher at the shellfish farm stations than the non-shellfish farm station, and their seasonal changes were significant. The dominant species at the shellfish farm stations was Capitella capitata while Paraprionospio patiens was dominant at the non-shellfish farm stations. The two dominant species were potential organic contamination indicators usually inhabiting the areas with dense organic matter. This suggests that the overall survey area was highly polluted with organic matters. Multivariate analysis showed that the macrobenthic community of CF changed to a level similar to that of Con1 immediately after the investigation, but not to a state above the Con1 level. Furthermore, the changes in NF were not significant when compared to those in CF. 본 연구에서는 장기간 운영된 양식장에 휴지기가 주어졌을 때, 양식장 주변 퇴적 환경에서 나타나는 회복상태를 규명하고자 하였으며, 이를 위해 경남 통영의 수하식 굴양식장 일대에서 대형저서다모류 군집을 조사하였다. 2016년 7월부터 2018년 9월까지 20년간 운영된 후 폐쇄된 양식장(FF), 양식장의 이동으로 새롭게 설치된 양식장(NF), NF와 인접한 비교대상의 굴양식장(CF), 그리고 양식시설이 없는 두 개의 대조지역(Con1, Con2) 등 5개 정점에서 현장조사를 수행하였다. 출현종수와 서식밀도는 여름철에 감소하고 늦가을철 부터 증가하는 계절 변동을 보였으며, 양식장 정점들이 비양식장 정점들에 비해 높았다. 출현종의 상위우점종은 비양식장 정점에서는 Paraprionospio patiens, 양식장 정점에서는 Capitella capitata로 차이를 보였으나, 두 종 모두 유기물이 심한 지역에서 출현하는 잠재적 유기물 오염지시종으로 조사지역 저서환경의 유기물 오염이 상당히 진행되었음을 나타내었다. 다변량분석 결과, FF가 Con1과 군집구조가 유사한 수준으로 변화하였지만 Con1 이상의 상태로 회복을 나타내지 않았다.