도시주민 건강진단 수진에 관한 행동변인 연구

문현창,염용태 외1명 한국역학회 1990 Epidemiology and Health Vol.12 No.2

스티렌 暴露 動勞者의 生化學的 監視 및 腎臟障害에 對한 硏究

文顯昌 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.1

여성 외음부 및 질에 발생한 평활근종 2례

문현창(Hyun Chang Moon),이승연(Seung Yun Yi),조유진(Yu Jin Cho),오병찬(Byung Chan Oh) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8

Leiomyomas of vagina and vulva are rare solid tumors, but most common mesenchymal tumors in adult woman. Most of the reported cases have been benign. The tumors were firm, well-defined submucosal masses in a majority of patients. We experienced two cases of vulvar and vaginal leiomyoma, thus it is presented with a brief review of the cases and its literatures.

스티렌 暴露 動勞者의 生物學的 監視 및 腎臟障害에 對한 硏究

文顯昌,李恩一,廉容泰 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.1

Two field studies were conducted on workers exposed to low level of styrene. The objective of first study was evaluation of variations of urinary mandelic acid and phenylgly-oxylic acid on 17 male-workers and 9 female-workers for 2 days, and that of second study was for evaluation of correlation between styrene exposure and urinary metabolites for 73 male-workers and 8 female-workers whose urines were sampled at end-shift and next morning. The results were as follows; 1. The mean values of urinary mandelic acid and phenylglyoxylic acid were increased as working time within 3 hours, between 4-6 hours, and between 7-9 hours elapsed. 2. The regression analysis of the urinary mandelic acid and phenylglyoxylic acid with time showed trend that urinary metabolites incresed more rapidly in higher exposure group. 3. The correlation coefficients between styrene in air and metabolites in next morning urine were higher than those in end-shift urine. But, the correlation coefficients between ,styrene in air and metabolites in end-shift urine of the total samples were higher than those in next morning urine of non-smoking workers or non-drinking workers. 4. Only the stryene in air was independent variable which was statistically significant in multiple regression on urinary metabolites by styrene in air, smoking, and drinking. The slope was steeper in using the sum values of metabolites in end-shift urine as dependent variable than in using others. But the R square value was greater in using phenylglyoxylic acid in next morning urine as dependent variable than in using others. 5. There was no significant correlation between the styrene in air and n-acetyl-β-glucosaminidase activity in urine. The smoking or drinking habit had no significant effect in the correlation. The smoking and drinking habit would be considered in determination of time of urine sampling about urinary mandelic and phenylglyoxylic acid as biological monitoring of workers exposed to styrene. Because the correlations beween air styrene and urinary metabolites in next morning urine were higher than those in end-shift urine in smoking or drinking workers.

포스타 : 산과학 ; Antiphospholipid Syndrome(APS)에 의한 습관성 유산 환자의 치험 1예

진소자,문현창,김정희,김종덕 대한산부인과학회 1997 대한산부인과학회 학술대회 Vol.80 No.-

T Cell Microvilli: Finger-Shaped External Structures Linked to the Fate of T Cells

김혜란,박정수,서원창,김나영,문현윤,이지수,전창덕 대한면역학회 2023 Immune Network Vol.23 No.1

Microvilli are outer membrane organelles that contain cross-linked filamentous actin. Unlike well-characterized epithelial microvilli, T-cell microvilli are dynamic similar to those of filopodia, which grow and shrink intermittently via the alternate actin-assembly and -disassembly. T-cell microvilli are specialized for sensing Ags on the surface of Ag-presenting cells (APCs). Thus, these finger-shaped microprotrusions contain many signaling-related proteins and can serve as a signaling platforms that induce intracellular signals. However, they are not limited to sensing external information but can provide sites for parts of the cell-body to tear away from the cell. Cells are known to produce many types of extracellular vesicles (EVs), such as exosomes, microvesicles, and membrane particles. T cells also produce EVs, but little is known about under what conditions T cells generate EVs and which types of EVs are released. We discovered that T cells produce few exosomes but release large amounsts of microvilli-derived particles during physical interaction with APCs. Although much is unanswered as to why T cells use the same organelles to sense Ags or to produce EVs, these events can significantly affect T cell fate, including clonal expansion and death. Since TCRs are localized at microvilli tips, this membrane event also raises a new question regarding long-standing paradigm in T cell biology; i.e., surface TCR downmodulation following T cell activation. Since T-cell microvilli particles carry T-cell message to their cognate partner, these particles are termed T-cell immunological synaptosomes (TISs). We discuss the potential physiological role of TISs and their application to immunotherapies.

배란유도제가 생쥐 미성숙난자의 성숙에 미치는 영향 및 여러 배양액내에서 생쥐 2세포기의 배아 발달에 관한 연구

이종진,양춘모,문현창,이호성,이기숙,류철희,김종덕,Lee, Jong-Jin,Yang, Chun-Mo,Moon, Hyun-Chang,Lee, Ho-Seong,Lee, Ky-Sook,Rheu, Cheul-Hee,Kim, Jong-Duk 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2

Purpose of the present study was to find the optimal ovulation induction medicine for the maturation and development of immature oocytes and culture media for 2-cell embryos in the mouse model. ICR female mouse aged 6 to 8 weeks, were stimulated with 5 IU PMSG injection. At 47 to 50 hour post-PMSG injection, ovaries were dissected out and oocytes-cumulus complexes were punctured. The oocyte-cumulus complexes were cultured in media containing various ovulation induction medicine, CC, HMG and Metrodin for 18 hours. Female ICR mice were stimulated with 5 IU PMSG and 48 hours later were injected 5 IU of hCG, then female and male mice were mated. At 48 hour post-hCG injection, oviducts were dissected out and 2-cell embryos were flushed. The 2-cell embryos were cultured in various media, Ham's F-10 media of milli-Q water $(3^{\circ})$, Ham's F-10 media of HPLC (high performance liquid chromatography, Baxter) water, Medicult media, HTF (human tubal fluid) media for 96 hours. The results were as follows. 1. When the oocytes-cumulus complexes were cultured in $10^{-9}{\mu}g/ml{\sim}10^{-8}{\mu}g/ml$ of CC, those were suppressed in meiotic maturation $(28.2{\sim}33.7%)$. Whereas the oocytes-cumulus complexes were cultured in $10^{-7}{\mu}g/ml{\sim}10^{-4}{\mu}g/ml$, these were not effected in meiotic maturation $(54.5{\sim}72.7%)$. 2. When the oocytes-cumulus complexes were cultured in $10^{-4}{\mu}g/ml{\sim}10^{-1}{\mu}g/ml$ of Metrodin, those were suppressed in meiotic maturation $(35.7{\sim}41.5%)$. Meanwhile the oocytes-cumulus complexes were cultured in $10^{-7}{\mu}g/ml{\sim}10^{-5}{\mu}g/ml$, those were not effected in meiotic maturation $(54.2{\sim}70.3%)$. 3. When the oocytes-cumulus complexes were cultured in $10^{-5}{\mu}g/ml{\sim}10^{-4}{\mu}g/ml$ of HMG, those were suppressed in meiotic maturation $(48.2{\sim}50.4%)$. As being cultured in $10^{-7}{\mu}g/ml{\sim}10^{-6}{\mu}g/ml$, increased in meiotic maturation $(75.8{\sim}80.7%)$. 4. When the 2-cell embryos were cultured in Ham's F-10 media of milli-Q water $(3^{\circ})$, Ham's F-10 media of HPLC (high performance liquid chromatograpy, Baxter) water, Medicult media, HTF (human tubal fluid) media, developmental rates to blastocyst and hatching for 96 hour were 50.0%, 45.2%, 71.5% and 95.6%, respectively.

만삭임신 시 조기파수 환자에서 진통유발을 위한 Prostaglandin E2의 평가

조성남,서성진,이종진,조유진,문현창 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.7

목적: 만삭임신에서 진통발현 전 자연파수 시 그 처치는 산과의에게 가장 어려운 문제점 중의 하나입니다. 이에 저자들은 만삭임신에서 조기파수 된 환자들에 대한 세가지 처치방법들을 후향적 비교 분석하고자 하였습니다. 연구방법: 본 연구에서는 1996년 1월 1일부터 1997년 12월 31일까지 전북대학교병원 산부인과를 방문한 임신 38주에서 41주사이의 두위의 단태임신으로 파막후 3시간까지 진통이 없는 건강한 140명의 산모를 대상으로 하여 무작위로 3군으로 분류하여 조사하였습니다. 결과: 분만경과시간은 프로스타글란딘E2를 사용한 군과 옥시토신을 사용한 군에서 대조군에 비해 짧았고[P$lt;0.05], 모성감염은 프로스타글란딘E2를 사용한 군에서 옥시토신을 사용한 군과 기대요법을 이용한 대조군에 비해 적었으며[P$lt;0.05], 제왕절개율은 3군에서 차이가 없었고, 또한 프로스타글란딘E2를 사용한 군에서 심한 부작용은 없었다. 결론: 프로스타글란딘E2를 이용한 만삭임신에서 조기파수 된 환자의 분만유도는 옥시토신을 사용하는 것보다 안전하고 간편하다고 볼 수 있다. Objective: The management of premature rupture of the membranes in healthy pregnancy women at term without uterine activity is a matter of debate. A retrospective study comparing three management methods for patients at term with premature rupture of membranes was performed. Methods: This study was undertaken to compare the effectiveness of intravaginal prostaglandin E2 [PGE2] of term labor with oxytocin induction and expectant management in healthy 140 pregnant women with spontaneous rupture of membranes before the onset of labor from Jan. 1, 1996 to Dec. 31, 1997 at the Department of Obstetrics and Gynecology, Chonbuk National University, Medical School. Results: The time interval to delivery was shorter in prostaglandin and oxytocin groups versus control group with statistical significance[P$lt;0.05]. The incidence of maternal infection was lowest in prostaglandin group versus oxytocin and control groups with statistical significance[P$lt;0.05]. Overall cesarean section rate was low in prostaglandin group versus oxytocin and control groups without statistical significance. No adverse effects were observed in prostaglandin group. Conclusion: Vaginal PGE2 suppository can be used successfully to induce labor after premature rupture of membranes at term with greater ease of adminstration when compared with oxytocin.

재사용 투석막이 혈액투석중의 합병증에 미치는 영향

이홍순,유병희,하기수,문성수,문현창,장규만 대한신장학회 1988 Kidney Research and Clinical Practice Vol.7 No.2

It has been known but not widely that there is no difference in efficacy and incidence of complications during hemodialysis between with first use membrane and with reuse membrane. So we examined symptoms and incidence of complications during hemodialysis in 1st use 2392 numbers and reuse 2515 numbers on 34 patients with chronic renal failure who had taken regu- lar hemodialysis at National Medical Center. The results were as follows; 1) The incidence of complications during hemodialysis was 1072 episodes (44.8%) in first use group and 1262 episodes (50.2%) in reuse group, but there was no significant difference. 2) The incidence of chest pain was significantly high in first use group (p$lt;0.05), but others had no significant difference. 3) The most frequent complication during hemodialysis was hypertension,' 392 episodes (16. 4%) in first use group and 447 episodes (17. 5%) in reuse group, but there was no significant difference 4) Weight loss after hemodialysis was 2. 8±1. 0 kg in first use group and 2.7±1.0 kg in reuse group, but there was no significant difference. So we concluded that there was no difference in effect on intradialytic complications between first use of dialyzers and multiple use of dialyzers.

출혈위험이 있는 신부전 환자에서의 혈액투석

조성욱,유병희,하기수,이학중,문성수,문현창 대한신장학회 1989 Kidney Research and Clinical Practice Vol.8 No.2

Anticoagulation during hemodialysis is necessary to prevent coltting of the blood on contact with the dialysis membrane. But systemic heparinization can produce hemorrhagic complications in those patients who are at high risk of bleeding. To solve this dilemma we compared heparin free hemodialysis with systemic heparinization, regional heparinization, intermittent saline flushes and constant saline infusion in 13 chronic patients. After that, we prospectively studied 10 patients with high risk of bleeding usiog heparin free dialysis. The following results were obtained: 1) The percent of fiber-bundle volum loss was increased significantly in the saline infusion and heparin free groups compared to the systemic heparinization gl Oup. 2) The five groups did not differ significantly with regard to weight loss, changes in BUN and serum creatinine, or changes in dialyzer urea or crestinine clearance. 3) All heparin free hemodialyses on 10 patients with high risk of bleeding were performed successfully, but moderate clotting occurred in 15 treatments. 4) There were no significant differences in blood flow, blood pressure, hematocrit and blood transfusion according to the severity of clotting in patients with heparin free dialysis. In conclusion, heparin free hemodialysis is considered as a safe, simple and effective therapeutic strategy in patients with high risk of bleeding.