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加減補陽還五湯이 생쥐의 學習과 記憶의 減退 및 Acetylcholinesterase 의 抑制에 미치는 影響
文誠秀,李相龍 대한한방신경정신과학회 2000 동의신경정신과학회지 Vol.11 No.1
Alzheimer's disease(AD) is progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylcholinesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PSI and PS2, and amyloid precursor proteins (APPs) overexpression. The present research is to examine the inhibition effect of KBT on PS1, PS2 and APPs overexpression by detected to Western blotting. To verify the Effects of KBT on cognitive deficits further, we tested it on the scopolamine (1 mg/kg)-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection to scopolamine. KBT only partially blocked the increase in blood serum level of acetylcholinesterase and U ? u acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracellular serum level compared with only scopolamine injection. In conclusion, studies of KBT that has been know as anti-choline and inhibition ablilities of APPs overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.
문성수 전남도립대학교 1999 전남도립대학교 논문집 Vol.S No.-
Smoke is emitted in diesel engines because fuel injected into the high-temperatured and high- pressured combustion chamber bums with its mixture with insufficient oxygen. In consideration of air pollution, above all, it is necessary to predict the quantity of smoke emission in diesel engines In general, the emission of smoke concentration may be expected to be linearly related to premixed mixture quantity and air fuel mixing rate and to be propotional to the amount of fuel injected in the cylinder. The smoke emission, which is characteristic of diffusion combustion in diesel engines, results from pyrolysis of fuel not mixed with air. Therefore the smoke emission is dependent on diffusion combustion quantity, which is in tum controlled by engine parameter The study aims at making experimental characteristic equation of smoke emission in diesel engines with heat released within combustion chamber according to each engine parameter. air fuel ratio, injection timing and engine speed - by the aid of reaction velocity equation of Arrhenious type. The emission of smoke concentration in the single cylinder direct water cooling diesel engine may be computed with the aid of the established empirical equation.
문성수,김종화,강선미,김은숙,오태정,윤재승,조호찬,김대중,박태선 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.1
This report presents the status of diabetic neuropathy (DN) in Korea as determined using a National Health Insurance Service-National Sample Cohort (NHIS-NSC). Annual prevalences of DN were estimated by age and gender using descriptive statistics. Pharmacological treatments for DN were also analyzed. The annual prevalence of DN increased from 24.9% in 2006 to 26.6% in 2007, and thereafter, gradually subsided to 20.8% in 2015. In most cases, pharmacological treatments involved a single drug, which accounted for 91.6% of total prescriptions in 2015. The most commonly used drugs (in decreasing order) were thioctic acid, an anti-convulsive agent, or a tricyclic antidepressant. In conclusion, the prevalence of DN decreased over the 10-year study period. Thioctic acid monotherapy was usually prescribed for DN. To reduce the socio-economic burden of DN, more attention should be paid to the diagnosis of this condition and to the appropriate management of patients.
메탄올 스파크 점화기관의 시동성 향상을 위한 연료 증발장치에 관한 연구
문성수 전남도립대학교 2003 전남도립대학교 논문집 Vol.5 No.-
Methanol is regarded by many experts as the alternative fuel. The reasons are that metanol can be available abundantly extracted from natual gas or through goal processing, that the fuel cost will become competitive with those of current petrolum fuel. For the application of methanol as automotive fuel, basic application and development have been made extensively since the 이crisis and such technology as the neat methanol spark ignition system has been upgrade for practical application. And methanol has defect that latant heat of vaporization is higher than that of gasoline, it could be supposed that the inducted methanol is sufficiently vaprized, in which case the liquided methanol can play a role of solvent, wash off the lubricant film from the cylinder wall. leak out of the piston gap Due to its high liquid film flow, methanol engine requires additional heating. Therefore, in order to improve vaporiztion of methanol, the author have made the fuel vaporizing device which can eliminate which can eliminate the fuel film flow and heat the mixture.