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- 저자 : 문현창(Hyun Chang Moon) (검색결과 4 건)
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장규만(Kyu Man Jang),하기수(Ki Soo Ha),문현창(Hyun Chang Moon),이문철(Moon Chul Lee),유병희(Byung Hee Yu),이홍순(Hong Soon Lee),문성수(Seong Soo Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.6
N/A Plasma atrial natriuretic peptide (ANP) has been known to be a kind of peptide hormone and to have actions of natriuresis, diuresis and vasodilatation. It has been suggested that plasma ANP may be secreted from the cardiac atrium in response to extracellular fluid volume expansion to maintain blood volume homeostasis, and its level may be raised in volume overloaded conditions, such as congestive heart failure, chronic renal failure and the syndrome of inappropriate antidiuretic hormone secretion. We investigated the effect of fluid removal by sequential ultrafiltration and hemodialysis on circulating plasma ANP in 14 volume overloaded patients with chronic renal failure. The results were as follows: 1) The mean dry weight of patients was 58.3±0.4 kg and the predialytic weight gain was 3.4±0.9 kg. The amount of fluid removal by sequential ultrafilt-ration was 1176±31.7 ml (about 2% of predialytic body weight) and postdialytic weight loss was 3.1±0.3 kg. Systolic and diastolic blood pressures were not significantly changed during sequential ultrafiltration and hemodialysis, Plasma osmolality, BUN and K+ levels were not significantly changed after ultrafiltration but were significantly decreased after hemodialysis. 2) Plasma ANP levels were raised in all patients (mean±SE 205.3±30.7pg/ml, n=l4) compared with healthy contro1s (40.9±4.4 pg/ml, n=16), but showed considerable interpatient variability. 3) Plasma ANP levels fell with fluid removal during ultrafiltration (123.4±4.2 pg/ml, p<0.025) and again as fluid was removed during hemodialysis (88.7±3.1 pg/ml, p<0.05). 4) There was no significant correlation between predialytic weight gain and plasma ANP levels, and between postdialytic weight loss and plasma ANP levels. In conclusion, this study showed that the plasma ANP level was raised as body fluid volume increased in patients with chronic renal failure and fell with fluid removal after dialysis. These findings suggest that changes in body fluid volume play an important role in the regulation of ANP secretion.
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문현창(Hyun Chang Moon),이승연(Seung Yun Yi),조유진(Yu Jin Cho),오병찬(Byung Chan Oh) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8
Leiomyomas of vagina and vulva are rare solid tumors, but most common mesenchymal tumors in adult woman. Most of the reported cases have been benign. The tumors were firm, well-defined submucosal masses in a majority of patients. We experienced two cases of vulvar and vaginal leiomyoma, thus it is presented with a brief review of the cases and its literatures.
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배란유도제가 생쥐 미성숙난자의 성숙에 미치는 영향 및 여러 배양액내에서 생쥐 2세포기의 배아 발달에 관한 연구
이종진,양춘모,문현창,이호성,이기숙,류철희,김종덕,Lee, Jong-Jin,Yang, Chun-Mo,Moon, Hyun-Chang,Lee, Ho-Seong,Lee, Ky-Sook,Rheu, Cheul-Hee,Kim, Jong-Duk 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2
Purpose of the present study was to find the optimal ovulation induction medicine for the maturation and development of immature oocytes and culture media for 2-cell embryos in the mouse model. ICR female mouse aged 6 to 8 weeks, were stimulated with 5 IU PMSG injection. At 47 to 50 hour post-PMSG injection, ovaries were dissected out and oocytes-cumulus complexes were punctured. The oocyte-cumulus complexes were cultured in media containing various ovulation induction medicine, CC, HMG and Metrodin for 18 hours. Female ICR mice were stimulated with 5 IU PMSG and 48 hours later were injected 5 IU of hCG, then female and male mice were mated. At 48 hour post-hCG injection, oviducts were dissected out and 2-cell embryos were flushed. The 2-cell embryos were cultured in various media, Ham's F-10 media of milli-Q water $(3^{\circ})$, Ham's F-10 media of HPLC (high performance liquid chromatography, Baxter) water, Medicult media, HTF (human tubal fluid) media for 96 hours. The results were as follows. 1. When the oocytes-cumulus complexes were cultured in $10^{-9}{\mu}g/ml{\sim}10^{-8}{\mu}g/ml$ of CC, those were suppressed in meiotic maturation $(28.2{\sim}33.7%)$. Whereas the oocytes-cumulus complexes were cultured in $10^{-7}{\mu}g/ml{\sim}10^{-4}{\mu}g/ml$, these were not effected in meiotic maturation $(54.5{\sim}72.7%)$. 2. When the oocytes-cumulus complexes were cultured in $10^{-4}{\mu}g/ml{\sim}10^{-1}{\mu}g/ml$ of Metrodin, those were suppressed in meiotic maturation $(35.7{\sim}41.5%)$. Meanwhile the oocytes-cumulus complexes were cultured in $10^{-7}{\mu}g/ml{\sim}10^{-5}{\mu}g/ml$, those were not effected in meiotic maturation $(54.2{\sim}70.3%)$. 3. When the oocytes-cumulus complexes were cultured in $10^{-5}{\mu}g/ml{\sim}10^{-4}{\mu}g/ml$ of HMG, those were suppressed in meiotic maturation $(48.2{\sim}50.4%)$. As being cultured in $10^{-7}{\mu}g/ml{\sim}10^{-6}{\mu}g/ml$, increased in meiotic maturation $(75.8{\sim}80.7%)$. 4. When the 2-cell embryos were cultured in Ham's F-10 media of milli-Q water $(3^{\circ})$, Ham's F-10 media of HPLC (high performance liquid chromatograpy, Baxter) water, Medicult media, HTF (human tubal fluid) media, developmental rates to blastocyst and hatching for 96 hour were 50.0%, 45.2%, 71.5% and 95.6%, respectively.
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스티렌 暴露 動勞者의 生物學的 監視 및 腎臟障害에 對한 硏究
文顯昌,李恩一,廉容泰 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.1
Two field studies were conducted on workers exposed to low level of styrene. The objective of first study was evaluation of variations of urinary mandelic acid and phenylgly-oxylic acid on 17 male-workers and 9 female-workers for 2 days, and that of second study was for evaluation of correlation between styrene exposure and urinary metabolites for 73 male-workers and 8 female-workers whose urines were sampled at end-shift and next morning. The results were as follows; 1. The mean values of urinary mandelic acid and phenylglyoxylic acid were increased as working time within 3 hours, between 4-6 hours, and between 7-9 hours elapsed. 2. The regression analysis of the urinary mandelic acid and phenylglyoxylic acid with time showed trend that urinary metabolites incresed more rapidly in higher exposure group. 3. The correlation coefficients between styrene in air and metabolites in next morning urine were higher than those in end-shift urine. But, the correlation coefficients between ,styrene in air and metabolites in end-shift urine of the total samples were higher than those in next morning urine of non-smoking workers or non-drinking workers. 4. Only the stryene in air was independent variable which was statistically significant in multiple regression on urinary metabolites by styrene in air, smoking, and drinking. The slope was steeper in using the sum values of metabolites in end-shift urine as dependent variable than in using others. But the R square value was greater in using phenylglyoxylic acid in next morning urine as dependent variable than in using others. 5. There was no significant correlation between the styrene in air and n-acetyl-β-glucosaminidase activity in urine. The smoking or drinking habit had no significant effect in the correlation. The smoking and drinking habit would be considered in determination of time of urine sampling about urinary mandelic and phenylglyoxylic acid as biological monitoring of workers exposed to styrene. Because the correlations beween air styrene and urinary metabolites in next morning urine were higher than those in end-shift urine in smoking or drinking workers.
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