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탈수초화 동물 모델과 <sup>1</sup>H 자기공명분광영상
조한별,이수지,박신원,강일향,마지영,정현석,김지은,윤수정,류인균,임수미,김정윤,Cho, Han Byul,Lee, Suji,Park, Shinwon,Kang, Ilhyang,Ma, Jiyoung,Jeong, Hyeonseok S.,Kim, Jieun E.,Yoon, Sujung,Lyoo, In Kyoon,Lim, Soo Mee,Kim, Jungyoon 대한생물정신의학회 2017 생물정신의학 Vol.24 No.1
The proton magnetic resonance spectroscopy ($^1H-MRS$) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
유시영,최예지,김상준,정현석,마지영,김영훈,문소현,강일향,정유진,서채원,신경식,김지은,Yu, Si Young,Choi, Yejee,Kim, Sangjoon,Jeong, Hyeonseok S.,Ma, Jiyoung,Kim, Young Hoon,Moon, Sohyeon,Kang, Ilhyang,Jeong, Eujin,Suh, Chae Won,Shin, Kyun 대한생물정신의학회 2016 생물정신의학 Vol.23 No.3
Aggression and aggressive behaviors, often explained as harmful social interaction with the intention of hurting or inflicting damage upon another, have been considered as an adaptive mechanism from the evolutionary psychological point of view. However, various studies on aggression and aggressive behaviors have been done with psychopathological approach as the extreme aggressive behaviors may harm themselves and others at the same time. Recently, researchers have attempted to explain aggression in terms of neurobiological substrates rather than based on traditional psychopathological and/or behavioral concept. In this regard, there have been findings of differences in neurotransmitters and their receptors, and genetic polymorphisms. In this review article, we provide a brief overview of the literature about seven most frequently reported neurotransmitters including neurohormones (serotonin, norepinephrine, dopamine, gamma-aminobutyric acid, nitric oxide, oxytocin and vasopressin) and an associated enzyme (monoamine oxidase A), which are known to be related with aggression and aggressive behaviors.
이정세 ( Lee Jungse ),마지영 ( Ma Jiyoung ),이남수 ( Lee Namsoo ),백경문 ( Baek Koungmoon ),장동헌 ( Jang Dong-heon ) 한국농촌계획학회 2021 농촌계획 Vol.27 No.1
This study analyzed the effect of the farm’s sense of community on participation satisfaction by participating in the contract cultivation of onions. To this end, we investigated the participation satisfaction with the sense of community’s emotional connection, fulfillment of need, membership, and influence. According to the analysis of the sense of community of onion farmers, the definition of need, membership, and influenced participation satisfaction and were statistically significant. It was also shown to affect sense of community in the order of membership, Influence, fulfillment of need, and emotional connection. Therefore, it is necessary to form a continuous relationship with the leader and Nonghyup, to lead to improved farm income, induce pride as a member of participating farmers, and form a positive perception among onion farmers.
소방공무원과 구조대원에서 한국어판 Post-Traumatic Stress Disorder Checklist의 신뢰도와 타당도
박신원,정현석,임주연,전유진,마지영,최예라,반순현,김성은,유시영,이선호,전새롬,강일향,이보라,이수연,손지희,임재호,윤수정,김의정,김지은,류인균,Park, Shinwon,Jeong, Hyeonseok S.,Im, Jooyeon Jamie,Jeon, Yujin,Ma, Jiyoung,Choi, Yera,Ban, Soonhyun,Kim, Sungeun,Yu, Si 대한생물정신의학회 2016 생물정신의학 Vol.23 No.1
Objectives Firefighters and rescue workers are likely to be exposed to a variety of traumatic events; as such, they are vulnerable to the risk of post-traumatic stress disorder (PTSD). The psychometric properties of the Korean version of the PTSD Checklist (PCL), a widely used self-report screening tool for PTSD, were assessed in South Korean firefighters and rescue workers. Methods Data were collected via self-report questionnaires and semi-structured clinical interviews administered to 221 firefighters. Internal consistency, item-total correlation, one-week test-retest reliability, convergent validity, and divergent validity were examined. Content validity of the PCL was evaluated using factor analysis and receiver operating characteristic (ROC) analyses were used to estimate the optimal cutoff point and area under the curve. Results The PCL demonstrated excellent internal consistency (${\alpha}=0.97$), item-total correlation (r = 0.72-0.88), test-retest reliability (r = 0.95), and convergent and divergent validity. The total score of PCL was positively correlated with the number of traumatic events experienced (p < 0.001). Factor analysis revealed two theoretically congruent factors: re-experience/avoidance and numbing/hyperarousal. The optimal cutoff was 45 and the area under the ROC curve was 0.97. Conclusions The Korean version of the PCL may be a useful PTSD screening instrument for firefighters and rescue workers, further maximizing opportunities for accurate PTSD diagnosis and treatment.
신경범죄학 : 뇌영상을 활용한 공격성 및 범죄 행동의 이해
유시영,최예지,김상준,정현석,마지영,정유진,문소현,김영은,강일향,김영훈,신경식,김지은,Yu, Si Young,Choi, Yejee,Kim, Sangjoon,Jeong, Hyeonseok S.,Ma, Jiyoung,Jeong, Eujin,Moon, Sohyeon,Kim, Nicole Y.,Kang, Ilhyang,Kim, Young Hoon,Shin, Kyu 대한생물정신의학회 2016 생물정신의학 Vol.23 No.2
Criminology has been understood within a sociological framework until the emergence of neurocriminology, which describes, understands and predicts criminal behaviors from a neurobiological point of view. Not only using biological factors including genes and hormones to understand criminal behaviors, but also using neuroimaging techniques, the field of neurocriminology aims to delve into both structural and functional differences in the brain of individuals with aggression, antisocial personalities, and even the criminals. Various studies have been conducted based on this idea, however, there still are limitations for the knowledge from these studies to be used in the court. In this review article, we provide an overview of the various research in neurocriminology, and provide insight into the future direction and implication of the field.
인지 및 행동영역에서 교대 근무의 유해적인 영향 : 비판적 고찰
이수지,박창현,하은지,박신원,홍혜진,박수현,마지영,강일향,강한,송병훈,김정윤,김지은,Lee, Suji L.,Park, Chang-hyun,Ha, Eunji,Park, Shinwon,Hong, Haejin,Park, Su Hyun,Ma, Jiyoung,Kang, Ilhyang,Kang, Hahn,Song, William Byunghoon,Kim, Jungyo 대한생물정신의학회 2017 생물정신의학 Vol.24 No.2
Shift workers experience a disruption in the circadian sleep-wake rhythm, which brings upon adverse health effects such as fatigue, insomnia and decreased sleep quality. Moreover, shift work has deleterious effects on both work productivity and safety. In this review, we present a brief overview of the current literature on the consequences of shift work, especially focusing on attention-associated cognitive decline and related behavioral changes. We searched two electronic databases, PubMed and RISS, using key search terms related to cognitive domains, deleterious effects, and shift work. Twenty studies were eligible for the final review. The consequences of shift work can be classified into the following three categories extracted from the literature review : 1) work accidents ; 2) commuting accidents such as car accidents that occur on the way to and from work ; and 3) attendance management at work (i.e., absenteeism, tardiness, and unscheduled early departure). These cognitive and behavioral consequences of shift work were also found to be associated with sleep disorders in shift workers. Thus, improvements in the shift work system are necessary in order to enhance workers' health conditions, work productivity, and safety.
신경항법을 이용한 반복적 경두개자기자극의 적용 위치 선정 방법과 우울증 치료 효과 고찰
김명주(Myeongju Kim),송유미(Yumi Song),서채원(Chaewon Suh),마지영(Jiyoung Ma),홍가혜(Gahae Hong),김정윤(Jungyoon Kim) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.2
Repetitive transcranial magnetic stimulation (rTMS) is widely recognized as an effective and noninvasive neuromodulation for treating depression, and has been applied in a wide range of clinical settings. However, previous studies often reported inconsistent antidepressant effects that may be due to differences in the rTMS protocols such as coil placement. The typical simulation site for rTMS depression protocol is the left dorsolateral prefrontal cortex (DLPFC). Targeting the exact site of the left DLPFC while considering individual brain structure has been challenging due to the non-invasive nature of rTMS. Several researchers have applied various targeting methods to overcome the abovementioned issue. Most of the previous studies have applied the “5-cm rule” or the “international 10-20 system,” which is easily applicable. Recently, researchers started to apply a neuronavigation system that targets the stimulation site based on neuroimaging of each individual. Pros and cons of targeting methods have been discussed in terms of validity and reliability of targeting stimulation sites, differences in treatment responses, as well as considerations of individual characteristics. Therefore, the current review focuses on the targeting methods of stimulation site and the treatment effects of depression in previous studies. For discussion, we divided neuronavigation methods into using fixed coordinates and using individualized targets. Furthermore, the limitations of each targeting method are discussed that may potentially contribute to the development of the optimal rTMS protocol for depression treatment.
산화물계 촉매 적용을 통한 Li-CO₂ 전지 성능개선 연구
송정환(Jeong-hwan Song),서준교(Joon Kyo Seo),마지영(Jiyoung Ma),우중제(Jung-je Woo),송진주(Jinju Song),장일찬(Il Chan Jang) 한국전지학회 2023 한국전지학회지 Vol.3 No.2
Li-CO₂전지 성능은 반응생성물 형성과 밀접한 관련이 있다. L₂2CO₃는 약 5 nm에서 결정을 형성하고, MnO₂는 Li을 포함한 탄소종과 결합력이 강한 것으로 알려져있다. 이번 연구에서 mesopore silica을 이용해 10wt% mesoporous Beta-MnO2 촉매를 Li-CO₂ 양극에 적용하여 성능개선 하였다. Li-CO₂ battery performance is closely related to the formation of reaction products. Li₂CO₃ forms crystals at about 5 nm and MnO₂ is known to have a strong anchoring force with a Li-containing carbonaceous species. In this study, the performance of Li-CO₂ battery was improved by applying a 10wt% mesoporous Beta-MnO₂ catalyst by a hard template method using mesopore silica.