천막상부 원시신경외배엽 종양의 방사선요법

김일한,유형준,조영갑,김대용,Kim Il Han,Yoo Hyung Jun,Cho Young Kan,Kim Dae Yong 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.1

목적 : 원시신경외배엽 종양은 빈번한 국소 재발 및 광범위한 지주막하 전이를 나타내는 종양이기때문에 수술 및 항암 약물요법과 함께 전뇌척수조사를 시행하는 방사선요법으로 치료 성적을 높이고자 꾸준한 노력을 시도하여 왔으며, 이에 저자들은 복합요법을 시행한 환자들의 실패 경향, 장기 생존율과 치료 후유증 등을 분석하고자 한다. 대상 및 방법 : 총 18명의 환자들을 대상으로 분석하였으며, 1세-27세 (중앙값=5세)의 연령분포 로 12명 대 6명의 남녀비를 나타내었다. 수술적 절제범위에 따라 완전절제술이 9명, 부분절제술 이 8명, 단순 조직생검술이 1명이었다. 모든 환자에서 수술후 방사선요법을 시행하였으며 방사선 조사야는 16명에서 전뇌척수조사를, 2명에서는 각각 전뇌조사 및 원발병소조사만을 시행하였고, 조사선량은 원발병소에 3120-5800cGy(중앙값=5460cGy), 전뇌부위에 1500-4200cGy(중앙값=3600cGy), 그리고 전척수부위에 1320-3600cGy(중앙값=2400cy)이었다. 항암약물요법은 13명 의 환자들에 대해서만 실시하였다. 추적관찰기간은 1개월부터 89개월로 중앙값은 45개월이다. 결과 : 치료도중 사망한 1명을 포함 총 9명의 환자에서 0-40개월뒤 재발을 확인하였으며 재발경향은 원발병소 단독 재발이 1명, 두개내의 전이성 재발은 2명, 척수부위 재발은 4명, 광범위한 뇌척수 재발이 1명, 그리고 전신적 다발성 골전이를 나타낸 환자가 1명이었다. 전뇌척수부위 방사선요법을 시행하지않은 2명의 환자중 2명 모두 척수부위 재발을 나타내었으며, 전뇌척수부위 방사선요법을 시행한 IS명의 환자중에서는 3명이 척추부위를 포함한 재발 경향을 보였고, 재발한 9명의 환자는 모두 재발 후 1-13개월내 사망하였다. 전체 환자의 2년 및 5년 생존율은 각각 $61\%,\;49\%$이며, 예후인자 분석에서는 성별, 나이, 종양위치와는 무관하였으나 완전절제술 및 항암 약물요법을 시행한 환자군에서 높은 생존율을 나타내었다. 치료 후 후유증으로는 원발병소에 5580cGy를 조사한 환자 1명에서 40개월 뒤 자기공명영상 및 자기공명분광법으로 방사선괴사로 추정되고 있으며, 생존하는 9명의 환자에서 뇌하수체기능저하증이 2명, 그리고 인지능력저하 1명, 기억장애 2명, 성장저하$(\leq5\%)$는 1명에서 관찰되었다. 결 론 : 천막상부 원시신경외배엽 종양 환자의 치료성적을 높이기 위해서는 가능한한 종양의 완전절제가 필수적이며 수술후 항암 약물요법과 방사선요법의 보조요법이 결과를 향상시킬 수 있을 것으로 기대되며, 방사선치료시 조사부위는 전뇌척수부위를 모두 포함하여 조사하여야 한다. Purpose : To evaluate the efficacy of combined treatment of surgery and chemoradiotherapy for supratentorial primitive neuroectodermal tumors (SPNET) and obtain the Prognostic factors and complications Materials and Methods .The a9e of 18 patients ranged from 1 to 27 years (median=5 years). There were 12 males and 6 females The extents of surgery were gross total (n:9), subtotal (n:8), biopsy only (n: 1). Craniospinal radiotherapy was delivered to all the patients except 2 patients who were treated only with the whole brain and primary lesion. Radiation dose were 3120-5800cGy (median=5460) to primary mass, 1500-4200cGy (median=3600cGy) to the whole brain and 1320-3600cGy (median= 2400 cGy) to the spinal axis. Chemotherapy was done in 13 patients. Median follow-up period was 45 months ranged from 1 to 89 months. Results : Patterns of failure were as follows; local recurrence (1), multiple intracranial recurrence (2), spinal seeding (3), craniospinal seeding (2) and multiple bone metastasis (1). Two of two patients who did not received craniospinal radiotherapy failed at spinal area. All the relapsed cases died at 1 to 13 months after diagnosis of progression. The 2- and 5-rear overall survival rates were $61\%\;and\;49\%$, respectively The a9e, sex, tumor location did not influence the survival but aggressive resection with combined chemotherapy showed better outcome. Among 9 survivors, complications were detected as radiation necrosis (n=1), hypopituitarism (n=2), cognitive defect(n=1), memory deficit (n=1), growth retardation (n=1). Conclusion : To improve the results of treatment of SPNET, maximal surgical resection followed by radiation therapy and chemotherapy is necessary. The extended radiation field including craniospinal axis may reduce the recurrence in spinal axis.

노인들의 낙상 예방 활동에 관한 고찰

이재갑,김명준,김성은,김진 한국지역사회건강관리협회 대한건강과학학회 2014 대한건강과학학회지 Vol.11 No.2

Purpose : A Study on the falls and prevent falls through the study of literature from the necessity and the prevention of procedure is designed to find a way. Method : Analyze the related papers. Result : (1)Percentage falls is ① Somewhere in 30 to 50 % of older adults, experienced the falls. ② Community appeared higher than in the fall rate is 40 to 80 percent of hospitals or nursing agencies. ③ Women there is a high occurrence of falls than men. ④ The occurrence of the more difficult economic situation, fall is high. ⑤ There is a higher occurrence of cases that have experienced in falls. ⑥ If there is a disease, have a higher occurrence of falls. ⑦ The environmental problem is happening to increase the occurrence (2)Fall cause classification ; Should be categorized into groups to control of the causes of falls. Therefore, physical, psychological, environmental, classified by environmental factors. (3)The problems caused by falls : 65 percent of the fall an old man's suffered a cerebral hemorrhage, fractures, sprains, contusions, lacerations, abrasions, damaged. (5)Prevention methods : It was exercise and music, rhythm, education programs, a combination of effective. Conclusion : Evaluation of the possible fall on a regular basis. And the development of any program that combines rhythmic movements and interesting education enhances its effectiveness.

신설 사회복지학과의 정착과 지속적인 발전전략 수립 연구

고성환, 라선아, 유범상, 김영빈, 신용갑, 김석권, 임광민, 이다림, 김용수, 노지영 한국방송통신대학교 원격교육연구소 2017 정책과제 Vol.2017 No.-

ㅇ 신설과정 - 사회복지학과 신설 논의는 2000년대 초부터 진행되어 왔지만, 본격적인 논의는 2009년임. 학과신설을 논의했던 2009년 TF/T는 사회복지학과 신설은 모든 측면에서 긍정적이나 다른 학과에 미치는 영향의 측면에서 문제가 있다고 판단함. - 대안으로 사회복지연계전공이 2010년에 시작되었음. 연계전공은 사회복지에 대한 교육기회를 제공했다는 점에서 긍정적인 기여를 했음. 특히 사회복지학과 신설의 징검다리가 되었다는 점도 결과론적으로 중요한 기여로 기록될 것임. - 하지만 사회복지연계전공의 책임주체가 불분명하고, 입학부터 졸업까지 학생들의 어려움이 존재하고, 사회복지학의 정체성 확보의 어려움 등의 문제점이 노출되어 옴. 결국 사회복지학과에 대한 논의가 본격적으로 진행되었고, 2016년 학과신설이 결정됨.

梅毒血淸反應의 比較檢討 : 第1報 MHA-TP法, FTA-ABS法의 術式과 一部成績 Ⅰ. TPHA and FTA-ABS Test, and Results in Part

金在植,楊聖基,禹成九,金重明,金榮泰,楊順甲 慶北大學校 醫科大學 1977 慶北醫大誌 Vol.18 No.2

VDRL陽性血淸 24例와 VDRL陰性血淸 3例 總 27例를 對象으로 TPHA 및 FTA-ABS法을 倂行 實施하여 成績을 比較하여 보았다. VDRL陽性血淸 24例中 21例(87.8%)가 三者 共히 陽性을 나타내었으며 3例는 TPHA陰性으로서 이 中 FTA-ABS陽性이 1例(33.3%)로서 이는 만성화농성좌창을 가진 4歲의 女兒이었고 나머지 2例(66.7%)는 健康人採用身檢例에서의 FTA-ABS陰性으로서 BFP로 判定하였다. 이들 3가지 方法間의 同意率은 約 93.8%로서 FTA-ABS, TPHA 및 VDRL順으로 높은 特異度를 나타내었고 FTA-ABS, VDRL 및 TPHA順으로 높은 銳敏度를 나타내었다. 앞으로 TPHA와 FTA-ABS法을 VDRL이나 R-PR card法과 잘 組合하므로서 梅毒의 診斷에 正確을 期할 수 있다고 期待된다. Treponema pallidum hemagglutinatign (TPHA) and fluorescent treponemal antibody-absorption (FTA-ABS) tests were performed on 24 VDRL positive and 3 VDRL negative sera. Twenty-one sera (87.5%) of 24 VDRL positive sera revealed "reactive" in TPHA and FTA-ABS, and these sera were related to clinical syphilis. Among the remainder 3 sera shown nonreactive TPHA, one serum disclosed reactive FTA-ABS which cases was having chronic pyogenic acne, and two sera revealed non-reactive FTA-ABS which cases were considered to be biological false positive (BFP) in healthy adult. Agreement between, TPHA and FTA were almost 100%. The combined tests in syphilis were thought to be successful screening and confirmation.

Candida glabrata 감염에 의해 발생한 엉덩허리근 농양 1예

김미,정창수,장주현,안병무,송원근,이재갑 대한감염학회 2010 Infection and Chemotherapy Vol.42 No.1

Infections due to Candida species are becoming more frequent in several patient population and settings. The proportion of non-albicans Candida spp. causing candidemia has increased during the recent decades. Especially, fungaemia due to Candida glabrata has reduced susceptibility to azoles. We report a case of iliopsoas abscess caused by Candida glabrata. A 51-year-old male diabetic patient was admitted with fever and both hip joint pain. Abdominal CT scan revealed huge left iliopsoas intramuscular abscess and left perinephric abscess. The abscess was drained percutaneously. Cultures of the pus were positive for Candida glabrata. The patient’s condition improved after abscess drainage and was discharged with oral antifungal agent.

Changes in Prostate Cancer Aggressiveness over a 12-Year Period in Korea

김도정,최대헌,임주현,윤종현,정인갑,유달산,홍준혁,안한종,김청수 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.10

Purpose: To investigate whether tumor aggressiveness in patients with prostate cancer has changed in Korea since the introduction of prostate-specific antigen (PSA) testing. Materials and Methods: The data from 2,508 patients with pathologically confirmed prostate cancer who underwent radical prostatectomy at Asan Medical Center between 2000 and 2011 were reviewed. The patients were divided into four 3-year time series, and the changes between the groups in terms of serum PSA levels, pathological Gleason score (GS), and pathological stage were assessed. The change in GS over time in organ-confined disease and in patients whose PSA was below 10 ng/ml was also analyzed. Results: The mean PSA levels dropped significantly over the 12-year period (p<0.001). The frequency of organ-confined disease increased (55.7% vs. 64.7% vs. 62.9% vs. 63.5%, p=0.043). The frequency of patients with a GS of 8 or more decreased (38.9% vs. 25.7% vs. 18.2% vs. 19.7%) and the frequency of patients with a GS of 6 or less increased (15.0% vs. 18.9% vs. 26.7% vs. 18.2%, p=0.003). However, the vast majority (more than 70%) of all cases had a high GS (7 or greater) at all time points. The GS distribution did not change over time in patients whose PSA levels were below 10 ng/ml or in those who had organ-confined disease. Conclusions: In 2000 to 2011, the preoperative PSA, pathological stage, and pathological GS dropped. However, the majority of the prostate cancers in Korean men were poorly differentiated, even when the patients had organ-confined disease or their PSA levels were less than 10 ng/ml.

Preliminary PINC(Program for the Inspection of Nickel Alloy Components) RRT(Round Robin Test) - Pressurizer Dissimilar Metal Weld -

김경조,강성식,신호상,정구갑,송명호,정해동 한국비파괴검사학회 2009 한국비파괴검사학회지 Vol.29 No.3

After several damages by PWSCC were found in the world, USNRC and PNNL(Pacific Northwest National Laboratory) started the research on PWSCC under the project name of PINC. The aim of the project was 1) to fabricate representative NDE mock-ups with flaws to simulate PWSCCs, 2) to identify and quantitatively assess NDE methods for accurately detecting, sizing and characterizing PWSCCs, 3) to document the range of locations and morphologies of PWSCCs and 4) to incorporate results with other results of ongoing PWSCC research programs, as appropriate. Korea nuclear industries have also been participating in the project. Thermally and mechanically cracked-four mockups were prepared and phased array and manual ultrasonic testing(UT) techniques were applied. The results and lessons learned from the preliminary RRT are summarized as follows: 1) Korea RRT teams performed the RRT successfully. 2) Crack detection probability of the participating organizations was an average 87%, 80% and 80% respectively. 3) RMS error of the crack sizing showed comparatively good results. 4) The lessons learned may be helpful to perform the PINC RRT and PSI /ISI in Korea in the future.

BEAMnrc code를 이용한 Varian 21Ex 선형가속기 모델링

김정인,박종민,박양균,최창헌,김희정,최윤석,조운갑,예성준 대한방사선방어학회 2009 대한방사선방어학회 학술발표회 논문요약집 Vol.2009 No.11

內頸動脈-海線精脈洞瘻를 同伴한 Persistent Primitive Hypoglossal Artery 1例

金潔,李勳甲,李基燦,朱正和 中央醫學社 1973 中央醫學 Vol.24 No.3

In early embryonic development there are three vessels joining the carotid and basilar arterial system, namely the primitive trigeminal, acoustic and hypoglossal arteries. These vascular channels are usually obliterated by the time of embryo is -14mm in length. One of these channels may rarely persist into adult life, the result is referred to as a persistent primitive anastomstic vessel. About 15.8y, of persistent primitive hypoglossal arteries are associated with vascular anomalies. We are reporting one case of persistent primitine hypoglossal artery associated with carotid-cavernous fistula and the literature reviewed.

번식우에 대한 rBST투여가 포유기 송아지의 비육과 설사 예방에 미치는 영향

이경갑,류경표,이영재,정종태,김희석,김남중,장병선 한국임상수의학회 1999 한국임상수의학회지 Vol.16 No.2

This study was carried out to investigate weight gain and prevention of diarrhea in suckling calves which were injected with recombinant bovine somatopropin (rBST). A total of 101 breeding cows were assigned to the six groups according to the administered dosage and injected time, respectively. Groups T-1, T-3, T-4 and T-6 were injected starting 1 week before calving and groups T-2 and T-5 were injected on the calving day. The six groups were injected five times at two week intervals. Groups T-1 and T-2 were injected with 250mg composite rBST, Group T-3 was injected with 375 mg composite rBST. Groups T-4 and T-5 were injected with 500mg composite rBST, And group T-6 was injected with 500mg rBST-S. The control group was not injected with BST. The groups injected with 500 mg BrST had a lower rate of morbidity from diarrhea than the control group or the groups injected with 250 mg rBST (T-1 and T-2). Weight gain was higher in group T-4 than in the control group or groups T-1 and T-2. In Korean Native Cattle, the total weight gain was greater in group T-4 than in the control group (p<0.05). In crossbred cows, total weight gain was the highest in group T-4, and the total weight gain rate was greater than in group T-4 and the control group (p<0.05). The results of the hematological values showed that injections of rBST did not affect the level of the RBC, TP and BUN in the breeding cows at 9 weeks after postpartum or the neonatal calves. The results of this study indicate that injecting breeding cows with 500 mg rBST before calving would be effective in the preventing of diarrhea and in increasing weight gain of calves from birth to weaning.