애생원(愛生園) 나환자(癩患者) 800명에 대한 나균검사성적보고(癩菌檢査成績報告) : 초록(抄錄)

김중명 대한미생물학회 1958 大韓微生物學會誌 Vol.1 No.1

국방 연구개발사업의 의사결정 지원을 위한 시스템 성숙도 평가 모델 개발

김중명,박영원,Kim, Jung-Myong,Park, Young-Won 한국군사과학기술학회 2010 한국군사과학기술학회지 Vol.13 No.5

This paper proposes a novel appoach which can assess the system technical maturity for use in Defense R&D Program reviews. As the weapon systems become more complicated, the success and effectiveness of R&D outcome heavily depend on the application and tailoring of systems engineering process and methods. It is a difficult task to assess the system readiness level(SRL) of the system being developed. A system-focused approach for managing weapon systems development and making effective and efficient decisions during the development lifecycle is critical to ensure the success of the program. The proposed weighted average SRL can facilitate the system technical maturity assessment without expending heavy work load.

국방 연구개발사업의 시스템 요구사항 개발 프로세스 개선

김중명,박영원,Kim, Jung-Myong,Park, Young-Won 한국군사과학기술학회 2009 한국군사과학기술학회지 Vol.12 No.3

This paper proposes a novel process which can develop the system requirements in defense R&D programs. As the weapon systems become more complicated, the success and effectiveness of R&D outcome heavily depend on the application and tailoring of systems engineering process and methods. And, the accuracy and quality of system requirements are essential prerequisite to leverage the systems engineering process. To produce the artifacts of systems engineering such as OCD, ORD, and the systems requirements, the system user can write out requirement document using the proposed implementation process and templates without expending heavy work loads.

임상 가검물에서 분리된 균(대장균과 황색 포도균)의 약제 내성

김중명,김재식,김경선,김재룡,전동석,최성만,서상철,김인자,김재숭,이건일,김경숙 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1981년 1월에서 12월말까지 임상 제료에서 분리한 Escherichia coli (E. coli)와 Staphylococcus aureus (S. aureus) 중에서 무작위로 각 50주 씩 선택하여 원판 확산법과 평판 희섭법으로 그 내성주를 조사하여 다음과 같은 성적을 얻었다. 전체적으로 볼 때에 Teteracyclin (TET), Chloramphenicol (CM) 및 Ampicillin (AMP)에 대한 내성주가 가장 많았고, Amikacin (AMK)에 대한 내성주는 가장 적어다. 이것을 균종별로 보면 E. coli에 있어서는 TET, AMP 및 CM는 원판 확산법으로서 74∼76%, 평판 희석법으로서는 78∼94%가 내성주임을 나타내었고, 또 Cephalothin(CEP)은 원판 확산법에서는 8%가 내성주로 나타났으나, 평판 의석법에서는 52%가 내성주로 나타났다. S. aureus에 있어서는 TET는 원판 확산법으로 82%, 평판 희석법으로서는 78%가 내성주로 나왔고 Penicillin (P)은 원판 확산법에서는 56% 평판 희석법으로는 22%의 내성주가 나왔으며, GM과 CM은 원판확산법에서는 18∼44%, 평판 희석법에서는 56∼58%가 내성주로 나왔다. Each 50 strains of Escherichia coli and Staphylococcus aureus were selected at random out of the stock cultures which were isolated from the clinical materials in the bacteriological laboratory of the department of clinical pathology. Kyungpook National University Hospital from the first of January to the end of December in 1982, and their resistance against eight antibiotics were as follows; Escherichia coli and Staphylococcus aureus had the most resistant pattern against tetracyclin, chloramphenicol, and ampicillin, while they had the most sensitive pattern against amikacin in general. Escherichia coli revealed resistant pattern to tetracyclin, ampicillin, and chloramphenicol 74-76% by the disk diffusion method and 78-94% by the plate dilution method, and revealed resistant pattern to cephalothin 8% by the disk diffusion and 52% by the plate dilution. Staphylococcs aureus disclosed resistant pattern to tetracyclin 82% by the disk diffusion and 78% by the plate dilution, and disclosed resistant pattern to penicillin 56% by the disk diffusion and 22% by the plate dilution, and to gentamicin and-chloramphenicol 18-44% by the disk diffusion and 56-58% by the plate dilution.

D.D.S의 血中 濃度에 對하여

金重明,河柱子 大韓癩學會 1960 癩學 會誌 Vol.1 No.1

癩에 施行한 四年前後의 Lepromin reaction 과 Tuberculin reaction의 比較

金重明 大韓癩學會 1960 癩學 會誌 Vol.1 No.1

病的資料에서의 病原菌의 分離

金重明,楊聖基,禹成九,金在植,李健一,金慶淑 慶北大學校 醫科大學 1977 慶北醫大誌 Vol.18 No.2

1976年 9月 1日에서 1977年 8月 31日까지 滿 1年間 血液外 29種目의 病的資料 2846例中 Micro-coccus外 25種目의 細菌 1763株를 分離하여 그 中 1757株를 同定하였는데 그 結果는 다음과 같다. 血液에서는 Staphylococcus epidermidis (Step.ep.) 41株(36.6%), Staphyloccus aureus (Stap.au.) 7株(6.3%), Alpha Streptococcus (Alpra Str.) 6株(5.4%), Streptococcus pneumoniae(St-r.pneu.) 2株(1.8%), Neisseria meningitidis(N.meningi.) 1株(0.9%), Salmonella group A(Sal.GG.A) 8株(7.1%), Salmonella group D (Sal.G.D.) 13株(11.6%), Escherichia coli (Esch.coli)17株(15.2%), Enterobacter aerogenes (Ente.aero.) 4株(3.5%), Enterobactes cloacae (Ente.cloa.) 2株(1.8%), Serratia marcescens (Serr.marc.) 4株(3.5%), Proteus mirabilis (Prot.mira.) 2株(1.8%), Pseudomonas aeruginosa(Ps-eu. aeru.) 3株(2.7%) 및 未同定 2株(1.8%), 都合 112株를 分離하였다. 裵髓液에서는 總 28株를 分離하였는데, 卽 Stap.ep. 7株(25.0%), Stap. au. 1株(3.6%), Apha Str. 8株(28.6%), Str. pneu. 6株(21.4%), N.me-nigi. 1株(3.6%), Esch.coli 3株(10.8) 및 Proteusvulgaris(Prot. vulg.)와 未同定菌 各 一株(3.6%)였다. 心??液에서는 3株가 分離되었는데 Stap.ep.,Alpha Str. 및 Serr. marc.의 各 1株였고, 肋膜液에서는 23株가 分離되었는데, Stap. ep. 5株(21. 7%), Stap. au.와 Ente. aero. 各 3株(13.0%), Alpha Str. 6株(26.1%), Salmonella arizonae(Sal. ariz.)와 Esch. coli 各 2株(8.7%), Prot.vulg.와 Pseu.aeru. 各 1株(4.3%)였다. 胸廓液에서는 Srap. ep. 3株(50.0%), Srap.au. 2株(33.3%), Prot. vulg. 1株(16.7%), 都合 6株가 分離되었고, 腹水 腹膜液 및 腹腔液에서는 Stap ep. 와 Alpha Str. 各 2株(13.3%), Str. pneu. 3株(20.0%), Esxh. coli 8株(53.3%), 都合 15株가, 關節囊液, 穿刺液 및 囊腫液에서는 Stap. au. 2株(50.0%), Alpha Str.와 Prot. mira. 各 1株(25.0%), 都合 4株가 分離되었다. 尿에서는 Microco., Sal.ariz., Klebsiella pneumoniae (Kleb. pneu.),Ente. cloa., Serr. marc. 및 Serratia liquefa-ciens (Sess. liqu.) 各 1株(0.4%), Stap. ep. 80株(32.9%), Stap. au. 17株(7.0%), Alpha Str.30株(12.3%), Esch. coli 66株(27.2%), Ente. aero. 21株(8.6%), Hafnia 2株(0.8%), Prot.vulg. 13株(5.3%), Pseu. aeru. 8株(3.3%), 都合 243株가, 咽喉에서는 Microco. 62株(24.1%), Stap ep. 28株(10.9%), Stap. au. 13株(5.1%),Alpha Str. 49株(19.1%), Beta Streptococcus(Beta Str.), Str. pneu., Hafnia 및 Serr. ma-rc. 各 1株(0.4%), Esch. coli 33株(12.8%), Ente, aero. 1株(8.2%), Prot. vulg. 3株(1.2%),Conynebacterium diphtheriae (Cory. diph.) 36株(14.0%), Candida albicans (Cand. albi.) 8株(3.1%), 都合 257株가 分離되었다. 鼻에서는 Mi-croco.와 Prot. mira. 各 2株(2.8%), Stap. ep.26株(36.6%), Stap. au. 14株(19.7%), Alpha Str. 5株(7.0%), Esch. coli 19株(26.8%), Ente. aero. 3株(4.2%), 都合 71株가, 喀痰에서는 Micro co. 201株(39.8%), Stap. ep. 25株(5.0%), Stap.au. 9株(1.8%), Alpha Str. 115株(22.8%), Str.pneu. 22株(4.4%), Sal. ariz., Kleb.pneu. 및 Serr. marc. 各 3株(0.6%), Esch. coli 50株(9.9%), Ente.aerc.와 Prot. vulg. 各 13株(2.6%), Ente. cloa., Hafnia 및 Serr. liqu. 各 1株(0.2%), Pseu. aeru. 8株(1.6%), Cand. albi. 37株(7.3%), 都合 505株가, ??에서는 Stap. ep., Stap.au., Sal.G.A., Sal.G.B., Sal.G.C. 및 Serr. liqu. 各 1株(2.1%), Alpha Str. 4株(8.5%), Esch. coli 30株(63.8%), Ente. acro. 2株(4.3%), Prot. mira. 5株(10.6%), 都合 47株가 分離되었다. 膿에서는 Microco.와 Kleb. pneu. 各 2株(0.7%), Stap. ep. 41株(15.2%), Stap. au. 55株(20.4%), Alpha Str. 28株(10.4%), Beta Str.4株(1.5%), Str. pneu., Sal. ariz. 및 Ente. cloa. 各 1株(0.4%), Esch. coli 50株(18.6%), Ente. aero.와 Pseu. aeru. 各 23株(8.6%), Haf-nia 5株(1.9%), Serr. marc. 10株(3.7%), Pr-ot. vulg. 20株(7.4%), Colstridium welchii(Cl-os. welch.) 3株(1.1%), 都合 269株가 傷處排出物에서는 Microco. 와 Hafnia 各 1株(1.9%), Stap. ep. 6株(11.1%), Stap. au.와 Ente. aero. 各 2株(5.6%), Alpha Str. 8株(14.8%), Esch. coli 13株(24.1%), Prot. vulg. 9株(16.7%), Pseu. aeru. 10株(18.5%), 都合 54株가 分離되었으며, 組織片에서는 Stap. ep. 7株(38.9%), Stap. au., Esch. coli 및 , Ente. aero. 各 3株(16.7%), Alpha Str. 2株(11.1%), 都合 18株가, 直腸塗抹物에서는 Stap. ep.와 Alpha Str. 各 7株(10.3%), Esch. coli 34株(50.0%), Ente. aero. 5株(7.4%), Serr. marc. 1株(1.5%), Prot. vulg. 4株(5.9%), Prot. mira. 10株(14.7%), 都合 68株가, 臍帶에서는 Stap. ep. 15株(37.5%), Stap. au.와 Alpha Str. 各 3株(7.5%), Esch. coli 11株(27.5%), Kleb.pneu., Prot. vulg. 및 Prot. mira. 各 1株(2.5%), Ente. aero. 2株(5.0%) 및 未同靜菌 3株(7.5%), 都合40株가 分離되었다. 2種細菌이 同時에 分離된 것이 37例였는데 이 中에서 Microco. 와 Alpha Str.의 混合이 가장 많았고, 3種細菌이 同時에 分離된 것은 8例가 있었는데, M-icroco.와 Alpha Str. 와 Esch. coli의 混合이 가장 많았다. During one year, from 1st of September 1976 to 31st of August 1977, 1757 strains of microorganisms that were consisted of two genera, four groups of Salmonella and 20 species of microorganisms were isolated form cultures of the 2846 cases of the pathogenic specimens that were contained 30 kinds of the clincial materials which were the blood, C.S.F., pericardial fluid, pleural fluid, thoracic fluid, ascitic, peritoneal and abdominal fluids, synovial, aspirated and cystic fluids, urine, throat specimens, nasal specimens, sputum, stool, pus, wound discharges, tissue specimens, rectal swabs and umbilical cords. The results were as follows; 41 strains (86.6%) of Staphylococcus epidermidis (Stap. ep.), 7 strains (6.3%) of Staphylococcus aureus (Stap. au.), 6 strains (5.4%) of alpha Streptococcus (Alpha Str.)., 2 strains (1.8%) of Streptococcus pneumoniae (Str. pneu.), 1 strain (0.9%) of Neisseria meningitidis (N. meningi.)., 8 strains (7.1%) of Salmonella group A (Sal. G.A.), 13 strains (11.6%) of Samonella groupd D (Sal. G.D.), 17 strains (15.2%) of Escherichia coli (Esch. coli), 4 strains (3.5%) of Enterobacter aerogenes (Ente. aero.), 2 strains (1.8%) of Enterobacter cloacase (Ente. cloa.), 4 strains (3.5%) of Serratia marcescens(Serr. marc.). 2 strains (1.8%) of Proteus mirabilis(prot. mira.), 3 strains(2.7%) of Pseudomonas aeruginosa (Pseu. aeru.) and 2 strains (1.8%) of undetermined organisms (Undetermin.), total 112 strains, were siolasted from 845 cases of the blood cultures. In the C.S.F. 28 strains were isolated from 239 cases of the cultures, they were 7 strains (2.5%) of Stap. ep., 1 strain (3.6%) of Stap. au., 8 strains (28.6%) of Alpha Str., 6 strains(21.4%) of Str. pneu., 1 strain (3.6%) of N. meningi., 3 strains (10.7%) of Esch. coli, 1 strain(3.6%) of Proteus vulgaris( Prot. vulg.) and Undetermin. In the pleural fluid, 23 strains were isolated from 85 case of the cultures, they were 5 Stap. ep. (21.7%), 3 Stap. au. and Pseu.Prot.(13.0%), 6 Alpha Str.(26.1%) 2 Salmonella arizonae(Sal. ariz.)and Esch. coli (8.7%), 1 Prot. vulg. and Pseu. aeru. ( 4.3%). In the thoracic fluid, 6 strains of 17 cases were isolated, they were 3 Stap. ep. (50.0%) 2 Stap. au. (33.3%) and 1 Prot. vulg. (16.7%). 15 strains of 34 cases were isolated form the ascitc, peritoneal and abdominal fluids, they were 2 Stap. au. and Alpha Str. (13.3%), 3 Str. pneu. (20.0%), 8 Esch. coli (53.3%). 4 strains of 17 cases were isolated from the synovial, aspirated and abdominal fluids, they were 2 Stap. au. (50.0%), 1 Alpha Str. and Prot. mira (25.0%). In the urine, 243 strains were isolated from 280 cases, they were 1 Micrococcus (Microco.), Sal. ariz., Klebsiella pneumoniae (Kleb. pneu.), Ente. cloa., Serr. marc. and Serratia liquefaciens (Serr. liqu.) (0.4%), 80 Stap. 데. (32.9%), 17 Stap. au. (7.0%), 30 Alpha Str. (12.3%), 66 Esch, coli (27.2%), 21 Ente. aero. (8.6%), 2 Hafnia (0.8%), 13 Prot. vulg. (5.3%) and 8 Pseu. aeru. (3.3%). 2 Microco. and Prot. mira. (2.8%), 25 Stap. au. (36.6%), 14 Stap. au.(19.7%), 5 Alpha Str. (7.0%), 19 Esch coli (26.8%) and 3 Ente. cloa. (4.2%), total 71 strains were isolated form 64 cases of the nasal specimen cultures. In the Sputum, 505 strains were isolated form 298 cases of cultures, they were 201 Micrco. (39.8%), 25 Stap. ep. (5.0%), 9 Stap. au. (1.8%), 115 Alpha Str. (22.8%), 22 Str. pneu. (4.4%), 3 Sal. ariz., Kleb pneu. and Serr. marc. (0.6%), 50 Esch. coli (9.9%), 13 Ente. aero. and Prot. vulg. (2.6%), 1 Ente. cloa., Hafnia and Serr. liqu.(0.2%), 8 Pesu. aeru. (1.6%) and 37 Cand. albi. (7.3%). In the stool, 57 strains were isolated from 181 cases of the cultures, they were 1 Stap. ep., Stap. aul, Sal. G.A., Sal. G.B., Sal. G.C. and Serr liqu.(2.1%), 4 AlphaStr. (8.5%), 30 Esch coli (63.8%), 2 Ente. aero. (4.3%) and 5 Prot. mira. (10.6%). Int he pus, 269 strains were isolated form 300 cases of the cultures, they were 2 Microco. and Kleb. pneu. (0.7%), 41 Stap. ep. (15.2%), 55 Stap. au. (20.4%), 28 Alpha Str. (10.4%), 4 Beta Str. (1.5%), 1 Str. penu., Sal. ariz. and Ente. cloa. (0.4%), 50 Esch. coli (18.6%), 5 Hafnia (1.9%), 10 Serr. marc. (3.7%), 20 Prot. vulg. (7.4%) and 3 clostridium welchii (Clos. welch.) (1.1%). In the wound discharge, 52 strains were isolated form 54 cases of the cultures, they were 1 MIcroco. and Hafnia (1.9%), 6 Stap. ep. (11.1%), 3 Stap. au. and Ente. aero. (5.6%), 8 Aphla Str. (14.8%), 13 Esch. coli (24.1%), 9 Prot. vulg. (16.7%) and 10 Pseu. aeru. (18.5%). In tip and tissue specimesna, 18 strains were isolated from 21 cases of the cultures, they were 7 Stap. ep. (38.9%), 3 Stap. au. Esch. coli and Ente. aero. (16.7%), and 2 Alpha Str. (11.1%). In rectal swabs, 68 strains were isolated from 60 cases of the cultures, they were 7 Stap. ep. and Aphla Str. (10.3%), 34 Esch. coli (50.0%), 5 Ente. aero. (7.4%), 1 Serr. marc. (1.5%), 4 Prot. vulg. (5.9%), and 10 Prot. mira. (14.7%). In the umbilical cord, 40 strains were isolated form 34 cases of the clutres, the were 15 Stap. ep. (37.5%), 3 Stap. au. and Aphla Str. (7.5%), 11 Esch. coli (27.5%), 1 Kleb. pneu. Prot. vulg. and Prot. mira. (2.5%), 2 Ente. aero. (5.0%) and 3 Undetermin. (7.5%). There were 37 cases that two kinds of microorganisms were isolated at the same time and synchronous isolation of the Alpha Str. and Microco. was the most, and were 8 cases that three kinds of microorgainsms were simultaneously isolated and synchronous isolation of Micrco., Alpha Str. and Esch. coli was the most.

各種 植物의 抗菌作用에 關한 硏究(第二報) : 一般植物의 스크리닝檢査에 依한 抗菌作用에 關한 硏究 Report II: Screening Test for Determining Antibiotic Activity of Various Plants

金重明,金在植,金鍾律 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.1

山野에 흔히 있는 120種의 植物을 5月~11月까지 任意로 採取하여 얻은 잎, 꽃, 줄기, 뿌리 및 열매 等 309例의 材料를 가지고 Petroleum ether, (P.ether) 蒸溜水(W.dist) 1%HCl液 및 10%Na_2CO_3液의 4種이 溶媒로 各各 所定의 方法에 依해서 溶出處理해서 얻은 推出液 1236例를 가지고 Staphylococcus aureus 209P(S.aureus)와 Escherichia Coli O111(E.coli)을 對象으로 disk 方法에 依한 Screening test를 하여 다음과 같은 要約을 얻을수 있었다. 1. 全般的으로 1236例中 837例(67.7%)에서 抗菌作用을 볼 수 있었는데 卽 S.aureus에만 있는 것이 96例(7.8%), E.coli에만 있는것이 157例(12.7%), S.aureus와 E.coli의 兩者에 함께 있는것이 584例(47.2%)이었다. 2. 溶出 處理한 推出液別로 그 抗菌作用을 나타낸 것을 보면 P.ether 推出液의 96例(31.0%), n=309), W.dist 推出液이 107例(34.6%, n=309), 1%HCl液 推出液이 181例(58.6%, n=309), 10%Na_2CO_3液 推出液이 453例(146.7%, n=309)었는데 이것을 供試菌別로 보면 P.ether 推出液에서 S.aureus에만 作用한것이 33例(10.7%, n=309), E.coli에만 作用한것이 19例(6.1%, n=309), 兩供試菌에 같이 作用하는 것이 44例(14.2%, n=309)이었고 W.dist.推出液에 S.aureus에만 作用한것이 28例(9.1%, n=309), E.coli에만 作用한것이 19例(6.1%, n=6.1%), 兩菌에 같이 作用한 것이 60例(19.4%, n=309), 1%HCl 推出液에서 S.aureus에만 作用한것이 23例(7.4%, n=309), E.coli 만 作用한것이 40例(13.0%, n=309), 兩菌에 같이 作用한 것이 118例(38.2%, n=309), 10%Na_2CO_3 推出液에서 S.aureus에만 作用한것이 12例(3.9%, n=309), E.coli에만 作用한것이 79例(25.6%, n=309), 兩菌에 같이 作用한 것이 362例(117%, n=309)이었다. 3. 5~11月까지 月別로 나타난 抗菌作用을 보면 S.aureus에서는 5月에 144例中 58例(40.2%), 6月에 284例中 122例(43.0%), 7月에 272例中 119例(43.8%), 8月에 172例中 40例(23.2%), 9月에 172例中 25例(14.5%), 10月에 60例中 15例(25.1%), 11月에 132例中 9例(6.9%)었고, E.coli에서는 5月에 144例中 50例(34.8%), 6月에 284例中 121例(42.7%), 7月에 272例中 135例(49.7%), 8月에 172例中 54例(31.4%), 9月에 172例中 48例(27.9%), 10月에 60例中 17例(28.4%), 11月에 132例中 24例(18.2%)로서 兩供試菌에 있어서 모두 5,6 및 7月에 採取한 植物材料에 抗菌作用이 많이 나왔으며 同時에 月別變動도 볼 수 있었다. 4. 120種의 植物에서 얻은 309例의 植物材料中에서 가장 强한 抗菌作用을 나타낸 것은 S.aureus에 對해서는 Commelins communis L의 잎을 W.dist.로 溶出한 推出液이었는데 ??었고, E.coli에 對해서는 Pinus densiflora Sieb. et Zucc.의 잎과 樹皮를 10%Na_2CO_3 液으로 溶出한 推出液이었는데 ??었다. 5. 以上의 結實로서 一般植物을 資源으로한 抗菌作用物質이 存在할 可能性이 있다고 본다. (實驗을 實行하는데 本敎室 金慶淑孃의 誠心이 가득찬 協助에 크게 힘입어 여기 謝意로 表한다) It is the purpose this report to observe the potential antibiotic activities of the various plants which are chiefly growing and populary finding on the fields and mountains in Korea. The plants for the samples which are 309plant specimens that are conrained the leave, flowers, stems, roots, fruits and seeds etc. or whole grasses from the 120 kinds of plant from May to November 1974. These plant specimenes were extracted with the petroleum ether, water distilled, 1%HCL and 10% Na_2CO_3 solution, and the authers obtained 1236 extracts by the method. The extracts of 1236 were screened for the presence of thier potential antibiotic activities against the Staphylococcus aureus 209 P(S. aureus) and Escherichia coli O111(E.coli) and the results are as follows: 1. Generally the 837 extracts (67.7%) have the potential antibiotic effects against the S.aureus and E.coli, 96 extracts (7.8%) have the antibiotic effects against the S.aureus only and 157 extraets (12.7%) have the effects against the E.coli only and 584 extracts (47.2%) have the effects against the both microorganisms tested. 2. The antibiotic effects of the plant extracts by the solvents against the S.aureus and E.coli are as follows: 96 extracts (31.0%, n=309) have the effects in the solvent of the petroleum ether, 107 extracts (34.6%, n=309) in the water distilled, 181 extracts (58.6%, n=309) in the 1%HCL solution and 453 extracts (146.7%, n=309) in the 10%Na_2CO_3 solution. The effects of the plant extracts against the both microorganisms are as follows: 33 extracts (10.7%, n=309) have the effects against S.aureus, 19 extracts (6.1%, n=309) against the E.coli, and 44 extracts (14.2%, n=309) have the effects against S.aureus, 19 extracts (6.1%, n=309) against E.coli, and 60 extracts (19.4%, n=309) against the both in water distilled extraction 23 extracts (7.4%, n=309) against the S.aureus, 40 extracts (13.0%, n=309) against the E.coli, and 118 extracts (38.2%, n=309) against the both in the 1%HCL extraction. 12 extracts (3.9%, n=309) against the S. aureus, 79 extracts (25.6%, n=309) against E.coli, and 362 extracts (117.2%, n=309) have the effects against the both in the 10%Na_2CO_3 extraction. 3. The antibiotic effects of the plant specimens which were collected for the samples from May to November, 1974 are as follows: Against the S.aureus, 58 (40.2%) of 144 plant extracts in May, 122 (43.0%) of 284 plant extracts in June, 119 (43.8%) of 272 plant extracts in July, 40(23.2%) of 172 plant extracts in August, 25(14.5%) of 172 plant extracts in September, 15(25.1%) of 60 plant extracts in October and 9 (6.9%) of 132 plant extracts in November have the effects. Against the E.coli, 50(34.8%) of 144 plant extracts in May, 121 (42.7%) of 244 plant extracts in June, 135 (49.7%) of 272 plant extracts in July, 54(31.4%) of 172 plant extracts in August, 42 (27.9%) of 172 plant extracts in September, 17 (28.4%) of 60 plant extracts in October and 24 (18.2%) of 132 plant extracts in November have the effects. The plant specimens obtained in May, June and July have more the antibiotic effects than the other specimens collected in August, September, October and November. The antibiotic effects of the plants are changeable by the month or season. 4. The leave of the Commelins communis L.extracted with water distilled have the strogest antibiotic effects (??) against the S.aureus, and the leave and cutis of the Pinus densiflora Sieb. et Zucc. extracted with 10%Na_2CO_3 solution have the strongest effects (??) against the E.coli in the all of plant specieses, 120 kinds tested. 5. The existence of the antibiotic effective substances in the various plants may be possioble to foretold by the above results.

癩腫性癩의 血流中에 癩菌檢索에 關한 硏究

金重明,申先伊,徐城鐸,徐治均 慶北大學校 1964 論文集 Vol.8 No.-

Although It was Introduced that the Mycobacterium leprae was investigated in circulatory blood of leprosy patients. In recent, Naniwa(1938) had depicted that there were intimate relationship between the grade of disease and bacillary number in the blood stream, Nagata (1953) had described that the humber of leprosy bacilli in circulatory blood were diminshed by the appropriate leprocy treatment, and Obshima(1957) have suggested that leprosy bacilli in blood stream were closely related with the fundamental problem of pracental infection and onset of untainted children from leprosy patients. In order to investigate this point further, we have tested 211 cases of lepromatous leprosy patients and this observation gave us as following results' 1. We could find out the Mycobacterium leprae in 0,08㎖ of circulatory blood from lepromatous leprosy patient. 2. The bacilli positives were more than 90% in the case of untreated patients and most of them were presented in the monocyte and polymorphonuclear cell. 3. The bacillary numbers were greatly decreased by the treatment, and after 9 months more over begining trearment, it was turned to be complete negative. 4. There were close relation between the bacillary number and grade of disease, but no relation in lepromin and tuberculin reaction. 5. In E.N.L. the bacillus was negative, and 1 of 4 cases was positive in acute infiltration. 6. we think that the bacilli in blood stream of leprosy patient will be a new aspect in the study of the pracental infecton and untained children of leprosy patient.

병적재료에서의 분리균과 그 균의 약제 감수성

김중명,신경호,김재식 慶北大學校 醫科大學 1978 慶北醫大雜誌 Vol.19 No.2