적층가공을 이용한 임시의치 제작 및 기존방식의 임시의치와의 비교 증례

김현아,임현필,강현,양홍서,박상원,윤귀덕,Kim, Hyun-Ah,Lim, Hyun-Pil,Kang, Hyeon,Yang, Hongso,Park, Sang-Won,Yun, Kwi-Dug 대한치과보철학회 2019 대한치과보철학회지 Vol.57 No.4

디지털치의학의 발달과 함께 computer-aided design and computer-aided manufacturing (CAD/CAM)을 이용한 3D 제작산업이 최근 급격한 성장을 하고 있다. 디지털 방식을 이용한 의치 제작 또한 최근의 디지털치의학 기술의 발전으로 증가하는 추세에 있다. CAD/CAM 제작방법은 크게 두가지 타입으로 나눌 수 있다: 절삭가공, 적층가공, 밀링과 같은 절삭가공은 블록 형태의 재료를 깎아 제조하는 기술을 토대로 하며, 3D printing과 같은 적층가공은 재료를 적층 방식으로 쌓아 올려 제조하는 기술을 토대로 한다. 적층가공은 밀링이 어려운 복잡한 구조의 제작에 적용할 수 있다. 본 증례에서, 적층가공방법이 레진상 총의치 제작에 이용되었다. 디지털방식을 적용한 의치의 사용기간동안 기능적, 심미적으로 만족할 만한 결과를 보여주었다. With development of digital dentistry, the 3-dimensional (3D) manufacturing industry using computer-aided design and computer-aided manufacturing (CAD/CAM) has grown dramatically in recent years. Denture fabrication using digital method is also increasing due to the recent development of digital technology in dentistry. The 3D manufacturing process can be categorized into 2 types: subtractive manufacturing (SM) and additive manufacturing (AM). SM, such as milling is based on cutting away from a solid block of materal. AM, such as 3D printing, is based on adding the material layer by layer. AM enables the fabrication of complex structures that are difficult to mill. In this case, additive manufacturing method was applied to the fabrication of the resin-based complete denture to a 80 year-old patient. During the follow-up periods, the denture using digital method has provided satisfactory results esthetically and functionally.

시장 내부에서 해소될 수 있는 대책 마련시급

김현아,Kim, Hyeon-A 한국주택협회 2007 주택과 사람들 Vol.210 No.-

미분양 아파트가 정부 통계9만 가구 이상이고, 시장 분위기는 20만 가구가 넘어선 가운데 정부는 미분양 아파트를 임대 주택으로 활용하는 방안을 발표했으나 시장은 냉담하기만 하다. 지방의 미분양 아파트는 적체된 지 오래고, 남양주 진접지구 등 수도권 지역도 미분양에서 더 이상 자유롭지 못하다. 각 지역별 미분양 현황을 살펴보고, 부동산 경기 활성화를 위한 대책에 대해 알아본다

라벤더, 레몬, 유칼립투스 혼합 에센셜오일이 아토피 피부염 동물 모델의 Th2 관련인자에 미치는 영향

김현아,윤미영,송향희,정광조,유화승,Kim, Hyeon-Ah,Yun, Mi-Young,Song, Hyang-Hee,Cheong, Kwang-Jo,Yoo, Hwa-Seung 대한약침학회 2010 Journal of pharmacopuncture Vol.13 No.1

Purpose : To investigate the effects of the lavender, lemon and eucalyptus oil mixture on the atopy dermatitis skin lesions induced on NC/Nga Mice by dinitrochlorobenzene (DNCB). Material and Method : For this purpose, we fabricated the oil mixture blending three essential oils (lavender, lemon, eucalyptus : ELL) with one carrier oil (jojoba) and apply it on the atopic dermatitis skin lesions of NC/Nga Mice. Atopic dermatitis in NC/Nga Mice was induced by DNCB treatment on the dorsal skin of mice for 8 weeks. The mixture of ratio of each essential oil drop was 1 (eucalyptus) : 2 (lemon) : 2 (lavender) and this mixture was blended with jojoba oil 50ml (0.025%). The ELL-ointment was supplied for 8 weeks. We evaluated the effects of ELL on cell viability of mouse lung fibroblast, clinical skin features and severity, the level of serum Immunoglobulin (Ig) E & Ig G1, Interleukin (IL)-4, IL-13 and Interferon (IFN)-$\gamma$. Results : ELL showed safety on the cell viability of mouse lung fibroblast compared with control group. The cell viability was measured by SRB method. The effects of ELL on clinical skin features and severity in DNCB-induced dermatitis model of NC/Nga mice was significant compared with control group. EEL also showed significant effects on clinical symptom score compared with control group. Serum IgE & IgG1 level and development of atopy dermatitis skin lesions were evaluated. Serum IgE & IgG1 production was significantly down-regulated in EEL group compared with control group. ELL also down-regulated the levels of IL-4 and IL-13, and up-regulated the level of IFN-$\gamma$ compared with control group significantly. Conclusion : ELL was effective on atopy dermatitis by modulating Th2 related factors.

한약(韓藥)을 이용(利用)한 항암(抗癌) 실험연구(實驗硏究)의 경향(傾向)에 관(關)한 고찰(考察)

김현아,임성우,이원철,Kim, Hyung-A,Lim, Sung-Woo,Lee, Won-Chul 대한암한의학회 1998 大韓癌韓醫學會誌 Vol.4 No.1

Because there were lots of side effects and tolerances to the existing anticancer therapeutics, the experiment extracting the anticancer effect from medicinal herbs is in progress liviely. Therefore the purpose of this study were to research the tendency and the course of anticancer studies. To research the tendency of anticancer studies, medicinal herbs of fifty three experimental papers were analyzed and to examine the course of studies, anticancer papers in the medical world were used. The obtained results were as follows: Methods of herbal medicinal treatments were elimination the pathogenic factor(祛邪) and supporting healthy energy(扶正) method used. In this study, immediately tumor bearing and immune response were the most important point. The subject of immediately tumor bearing was not in the specific cancer but in the influence on the life span of general cencerous cells. In the experimental study of immune response, the effect on NK cell activity of medicinal herbs most studied. The combined usage of medicinal herbs and anticancer agent mostly intended to know whether it inhibits the tumor cell growth. The serum test and blood cell number test show if medicinal herbs inhibit side effect of anticancer agent. More than 80 percents of used medicinal herbs, there were anticancer activities. However anticancer experimental studies using medicinal herbs two weak points. The one, it was difficult to choose a prescription according to differentiation of symptoms and signs(辨證論) of the Oriental Medicine, because we put to the test not a man but a mouse. The other, as we observed the indirect effect of the whole physiological regulation caused by synergic effects of the complex prescription, we don't understand the detailed mechanism of the herb. Therefore, if the anticancer effect of the herb is proved the experiment, we should research the concrete medical action of medicinal herbs and immunological analysis of herbal medicines to the body.

실수요자 중심의 청약 제도 개편의 실과 득

김현아,Kim, Hyeon-A 한국주택협회 2007 주택과 사람들 Vol.208 No.-

9월부터 분양가 상한제와 청약 가점제가 도입된다. 이는 주택 구입 능력이 없는 계층에게 과도한 인센티브를 부여했다는 점과 상대적으로 실수요자가 많은 1주택자들, 핵가족 도시 근로자나 이혼 가구, 신혼부부에게는 불리할 수 밖에 없어 현실성이 떨어진다는 지적이다.

양측 선천성 누루 환자에서 누루절제술 시행 후 반복된 감염과 염증

김현아,최혜선,장선영,Hyun A Kim,Hye Sun Choi,Sun Young Jang 대한안과학회 2013 대한안과학회지 Vol.54 No.11

Purpose: To report a case of bilateral congenital lacrimal fistula that presented with repeated infection and inflammation after complete fistulectomy, which required an incision and drainage of pus from the operation site. Case summary: A 22-year-old male without any medical history presented with repeated erythematous swelling and inflammation, resulting in tenderness around the opening of congenital lacrimal fistula. The lacrimal fistula opening was located approximately 12 mm inferiorly apart from the medial canthus. The complete excision of lacrimal fistula was performed without any inter-operative events. However, 4 days postoperatively, the patient complained of discomfort and swelling, with purulent discharge from the bilateral operation site. There was no improvement although treatment with antibiotics, incision and drainage was performed. After 1 month, an additional incision and drainage was necessary due to inflammation in the left operation site. One month later, pus and purulent discharge were occurring from the right operation site, requiring an additional incision and drainage. At that time, Actinomyces israelli was identified on wound culture examination. One month later, an additional incision and drainage was performed due to repeated inflammation in the left operation site. In the present case, we hypothesized the opening site of congenital lacrimal fistula was relatively far apart from the medial canthus and played a role in atypical repeated inflammation and infection on the operation site. Conclusions: In surgical treatment of congenital lacrimal fistula, careful preoperative observation of the location of the lacrimal fistula’s opening site would be helpful in prediction of postoperative complication, such as wound infection and inflammation, as well as in educating and informing the patient. J Korean Ophthalmol Soc 2013;54(11):1778-1782

아그로박테리움을 이용한 Actinobacillus pleuropneumoniae ApxIIA (ApxII toxin) 유전자 발현 옥수수 형질전환체 개발

김현아,유한상,양문식,권석윤,김진석,최필선,Kim, Hyun-A,Yoo, Han-Sang,Yang, Moon-Sik,Kwon, Suk-Yoon,Kim, Jin-Seog,Choi, Pil-Son 한국식물생명공학회 2010 식물생명공학회지 Vol.37 No.3

To develop edible vaccines for swine, the embryogenic calli (type II) derived from HiII genotype were inoculated with A. tumefaciens strain C58C1 containing the binary vector pMYV611, 613, 616, and V621, 622 and 623 respectively. Six of those vectors carry nptII gene which confers resistance to paromomycin and apxIIA gene producing ApxII toxin which is generated in various serum types of A. pleuropneumoniae as a target gene. The 4,120 callus clones for pMYV611, 5,959 callus clones for pMYV613, 7,581 callus clones for pMYV616, 52,329 callus clones for V621, 48,948 callus clones for V622, and 56,188 callus clones for V623 were inoculated. The frequency of positive response clone was confirmed into range of 2.3% - 4.4% for each vectors by NPTII ELISA kit assay, and the selected callus clones of them were finally 3 callus clones from pMYV611 (0.07%), 4 callus clones from pMYV613 (0.07%), 2 callus clones from pMYV616 (0.03%), 51 callus clones from V621 (0.1%), 72 callus clones from V622 (0.15%), and 102 callus clones from V623 (0.18%) respectively. From the selected callus clones of each binary vector, the integration of the apxIIA gene into maize genome was detected from 2 plants of pMYV613 and 2 plants of V623 by Southern blot analysis. 돼지 흉막폐렴백신을 개발하기 위해 옥수수 HiII genotype 으로부터 유도한 type II형의 배발생캘러스를 식물발현벡터 pMYV611, pMYV613, pMYV616, V621, V622 및 V623로 형질전환시킨 Agrobacterium (C58C1)과 공동배양 하였다. 이들 식물발현벡터는 paromomycin 항생제 저항 유전자인 NPTII 선발마커와 표적 유전자로서 흉막폐렴균의 여러 가지 혈청을 생산하는 apxIIA유전자로 재조합하여 구축하였다. 식물발현벡터pMYV611, pMYV613, pMYV616, V621, V622 및V623의 경우 각각 4,120개, 5,959개, 7,581개, 52,329개, 48,948개 및 56,188개의 캘러스 클론을 Agrobacterium과 공동한 후 NPTII assay kit에 의해 nptII유전자의 발현빈도를 조사한 결과 각 벡터별로 2.3-4.4%의 캘러스 클론에서 항체결합 양성반응을 보였고, 이들 중 최종적으로 선발된 형질전환 캘러스 클론은 pMYV611에서 3개 (0.07%), pMYV613에서 4개 (0.07%), pMYV616에서 2개 (0.02%), V621에서 51개 (0.1%), V622에서 72개 (0.15%) 및 V623에서 102개 (0.18%)를 각각 얻었다. 형질전환된 캘러스 클론으로부터 재분화된 식물체에서 유전자 도입여부를 Southern 분석으로 통해 확인한 결과 pMYV613에서 2개 식물체 및 V623에서 얻은 2개 식물체에서 각각 확인되었다.

아메드 방수유출장치 삽입수술과 병합수술의 효과

김현아,박가희,박태관,온영훈,Hyun A Kim,Ka Hee Park,Tae Kwann Park,Young Hoon Ohn 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To evaluate surgical results after combined operation associated with Ahmed glaucoma valve (AGV) implantation. Methods: A retrospective review was performed for 71 eyes of 67 patients who underwent combined operation associated with AGV implantation from June 2003 to August 2012. Results: Pars plana vitrectomy or phacoemulsification combined with AGV implantation were performed for 16 eyes and AGV implantation alone was performed in 55 eyes. Mean IOP (mm Hg) and the number of antigluacoma agents for both the combined and single groups showed a statistically significant decrease (combined/single; <em>p</em> = 0.008/0.000, 0.002/ 0.000). Visual acuity (log MAR) was improved, but these differences were not statistically significant (combined/single; <em>p</em> = 0.309/0.052). Conclusions: Combined vitrectomy or phacoemulsification and AGV implantation for intractable glaucoma with vitreoretinal disease or cataract is considered to be the primary procedure because of its equivalent efficacy in lowering IOP, improving visual acuity and decreasing the number of glaucoma agents. J Korean Ophthalmol Soc 2014;55(4):578-584

Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis

김현아,Jung Da Young,이승환,조재형,임현우,Kim Hun-Sung 대한의학회 2023 Journal of Korean medical science Vol.38 No.4

Background: It remains unclear whether a combination of glycemic variability and glycated hemoglobin (HbA1c) status leads to a higher incidence of cardiovascular disease (CVD). Therefore, to investigate CVD risk according to the glucose control status during early diabetes, we examined visit-to-visit HbA1c variability among patients with type 2 diabetes (T2DM). Methods: In this 9-year retrospective study, we measured HbA1c levels at each visit and tracked the change in HbA1c levels for 3 years after the first presentation (observation window) in newly diagnosed T2DM patients. We later assessed the occurrence of CVD in the last 3 years (target outcome window) of the study period after allowing a 3-year buffering window. The HbA1c variability score (HVS; divided into quartiles, HVS_Q1–4) was used to determine visit-to-visit HbA1c variability. Results: Among 4,817 enrolled T2DM patients, the mean HbA1c level was < 7% for the first 3 years. The group with the lowest HVS had the lowest rate of CVD (9.4%; 104/1,109 patients). The highest incidence of CVD of 26.7% (8/30 patients) was found in HVS [≥ 9.0%]_Q3, which was significantly higher than that in HVS [6.0–6.9%]_Q1 (P = 0.006), HVS [6.0–6.9%]_Q2 (P = 0.013), HVS [6.0–6.9%]_Q3 (P = 0.018), and HVS [7.0–7.9%]_Q3 (P = 0.040). Conclusion: To our knowledge, this is the first long-term study to analyze the importance of both HbA1c change and visit-to-visit HbA1c variability during outpatient visits within the first 3 years. Lowering glucose levels during early diabetes may be more critical than reducing visit-to-visit HbA1c variability.

동복호 (同福湖) 유입하천의 조류증식능에 (藻類增植能) 관한 연구

김현아,이나나,유춘만,위성욱,주현수,이종빈,위인선 ( Hyun Ah Kim,Na Na Lee,Chun Man Yu,Seong Uk Wui,Hyun Soo Joo,Jong Bin Lee,In Sun Wui ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.1

On filtered and autoclaved water samples from the upper stream of Lake Tong-Bok, physico-chemical analysis and algal growth potential (AGP) test using Selenastrum capricornutum Printz were performed from October, 1991 to July, 1992 in order to assess fertility potential of the lake and to identify possible limiting nutrients. Water temperature of the lake was fluctuated from 3.8℃ to 30.7℃, the range of pH was 6.0 to 8.0, the level of dissolved oxygen ranged from 5.5㎎/ℓ to 14.4㎎/ℓ, biochemical oxygen demand varied from 0.3㎎/ℓ to 7.6㎎/ℓ, and suspended solides was fluctuated from 0.7 ㎎/ℓ to 24.5㎎/ℓ. Results of nutrient analysis were as followings. The level ammonia was from ND(<0.01㎎/ℓ) to 0.74㎎/ℓ, nitrite and nitrate were ND(<0.01㎎/ℓ) - 0.06 ㎎/ℓ, 0.09㎎/ℓ - 1.33㎎/ℓ respectively. The range of phosphate level varied from ND(<0. 01㎎/ℓ) -0.24㎎/ℓ, and total phosphorus was fluctuated 0.04㎎/ℓ - 0.63㎎/ℓ. Algal growth potentials of the filtered and filtered after autoclaved samples were 0.1 ㎎/ℓ - 21.0㎎/ℓ and 2.9㎎/ℓ - 13.9㎎/ℓ respectively during surveyed period. AGP of the filtered after autoclaved were higer than those of the filtered only except some specific sites. The points of maximum growth were measured after addition of N, P, Fe and EDTA each in comparison with unenriched (control) samples. Phosphate appeared to be the major limiting element in AGP test for a tested organism throuhgout the year, especially during spring and summer. According to trophic level by Sudo(1980), it was estimated that Tong-Bok stream was eutrophic, Nae-Puk stream was oligo-mesotrophic, and all other streams of Lake Tong-Bok were mesotropic.