광섬유 다발과 Gradient-index Lens가 결합된 고 분해능 및 최소침습 직경의 공초점 내시 현미경 대물렌즈의 설계

장선영,임천석,Jang, Sun-Young,Rim, Cheon-Seog 한국광학회 2008 한국광학회지 Vol.19 No.2

공초점 내시 현미경의 경우 살아있는(in vivo) 동물체들의 뇌 속에서의 암세포나 특정 세포를 분석할 수 있으며, 비 침습적으로 얻을 수 있는 기술과 동시에 실시간으로 암을 검출할 수 있는 장점이 있다. 공초점 내시 현미경의 경우 최소 직경과 고 분해능을 요하게 된다. 본 논문은 최소 직경을 가지는 GRIN 렌즈와 유동적으로 움직일 수 있는 광섬유 다발을 연결시킴으로써 보다 측정에 용이하도록 하였다. 직경이 1 mm이고 수치구경이 0.5이며 pitch가 0.25인 GRIN렌즈를 사용하였으며, 광섬유 다발은 30,000개의 코어로 구성된 유동적인 광섬유 다발을 사용하였다. 본 논문은 GRIN 렌즈에 의해서 발생되었던 구면수차는 광학보상자를 이용하여 보정하였다. 그 결과 설계되어진 공초점 내시 현미경 대물렌즈의 경우 종 분해능은 $1.63\;{\mu}m$이고 축상물점과 비축물점에서의 에너지 분포가 100%일 때 각각의 spot size는 축상물점에서 $0.3\;{\mu}m$ 비축물점에서 $0.83\;{\mu}m$의 결과를 얻었으며 보다 값싸고 제작에 용이한 양산 비구면 렌즈로 대체 구현된 결과에서는 종 분해능이 $1.74\;{\mu}m$이고, 축상 물점에 대한 spot size는 $1.1\;{\mu}m$이고 비축물점에서는 spot size가 $2.94\;{\mu}m$로 설계되었다. We present a new design for an endoscope objective lens composed of a lexible fiber bundle with 30,000 core, and a gradient-index (GRIN) objective lens with an optical adaptor. The characteristic of this objective lens is to be minimally-invasive to be able to insert easily in the internal organs of live animals. The GRIN lens has a small diameter and a very simple construction, which is selected with the diameter of 1.0 mm and numerical aperture of 0.5 to achieve a minimally-invasive outer diameter and a high resolution. The resultant designed lens shows the performance as follows; a lateral resolution of 1.63 um and diameters of 100% encircled energy of $0.3\;{\mu}m$ and $0.83\;{\mu}m$ for the on-axis and the off-axis image point, respectively. Also, we can present a cheap solution with a lateral resolution of 1.74 um and diameters of 100% encircled energy of $1.10\;{\mu}m$ and $2.84\;{\mu}m$ for the on-axis and the off-axis image point, respectively.

Mucosal dendritic cells shape mucosal immunity

장선영,고현정,권미나 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-

Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs forthe development of efficient mucosal vaccines to protect against infectious diseases.

Generalized Toeplitz algebra of a certain non-amenable semigroup

장선영 대한수학회 2006 대한수학회보 Vol.43 No.2

We analyze a detailed picture of the algebraic struc-ture ofC-algebras generated by isometric representations of thenon-amenable semigroup P = f0;2;3;:;n;: g.

WIENER-HOPF C*-ALGEBRAS OF STRONGLY PERFORATED SEMIGROUPS

장선영 대한수학회 2010 대한수학회보 Vol.47 No.6

If the Wiener-Hopf C*-algebra W(G, M) for a discrete group G with a semigroup M has the uniqueness property, then the structure of it is to some extent independent of the choice of isometries on a Hilbert space. In this paper we show that if the Wiener-Hopf C*-algebra W(G, M) of a partially ordered group G with the positive cone M has the uniqueness property, then (G, M) is weakly unperforated. We also prove that the Wiener-Hopf C*-algebra W(Z, M) of subsemigroup M generating the integer group Z is isomorphic to the Toeplitz algebra, but W(Z, M) does not have the uniqueness property except the case M = N.

Fuzzy stability of a cubic-quartic functional equation: a fixed point approach

장선영,박춘길,신동윤 대한수학회 2011 대한수학회보 Vol.48 No.3

Using the fixed point method, we prove the generalized Hyers-Ulam stability of the following cubic-quartic functional equation (0. 1)f(2x+y) + f(2x-y) = 3f(x+y) + f(-x-y) + 3 f(x-y) + f(y-x) + 18f(x) + 6f(-x) - 3f(y) - 3f(-y) in fuzzy Banach spaces.

대학에서의 팀기반 학습 설계모형 개발연구

장선영(張善英),이정주(李挺株) 서울대학교 교육연구소 2015 아시아교육연구 Vol.16 No.1

본 연구의 목적은 대학에서의 팀기반 학습을 위한 설계모형을 개발하는데 있다. 연구의 목적을 달성하기 위해 본 연구는 크게 3단계로 진행되었다. 먼저 팀기반 학습 및 설계모형과 관련된 문헌분석 결과를 기반으로 1차모형을 개발하였다. 1차 모형에 대한 개선점을 확인하기 위해 4인의 전문가 검토와 초보 교수설계자 3인의 모형에 대한 사용성 평가를 실시하였다. 마지막으로, 전문가 검토 및 사용성 평가 결과를 반영하여 최종모형을 개발하였다. 개발된 모형은 팀기반 학습 설계 적합성 분석, 학습자 분석, 팀 구성, 환경분석, 환경 설계, 과제설계, 과제 개발, 평가도구 개발, 수업전략 개발, 평가 체제 개발, 강의계획서 개발, 형성평가 실시, 팀기반 학습 실행, 총괄평가 실행 단계로 구성된다. 그리고 모형의 각 단계에 대한 설계활동 및 지침을 제시함으로써 대학에서 팀기반학습을 설계하고 실행하고자 하는 교수자에게 실제적인 정보를 제공하였다. 최종 모형은 7인의 전문가 타당화를 거쳐 타당성을 검증받았으며, 마지막으로 본 연구에 대한 논의점과 시사점이 제안되었다. The purpose of this study is to develop and validate a Team-based learning(TBL) design model in higher education. The TBL design model was developed through the following procedures; 1) developing the 1st TBL design model in higher education based on the results of literature review, 2) getting the expert review on the first TBL design model, 3) getting test for use by four practicing instructional designers, and 4) getting model validation by seven experts. The developed TBL design model consists of "judgement of appropriateness of TBL in university class", "learner analysis", "team building", "learning-environment analysis", "learning -environment design", "task design", "task development", "evaluation tool development", "formative evaluation", "TBL instructional strategies design", "evaluation-system determination", "syllabus development", TBL implementation", and "summative evaluation". The TBL design model in higher education, as a result of this study, includes specific guideline of each step of this model. The model was validated by seven experts. The results as follows: All of the CVI were over 0.8, and IRA was near 0.9. These results confirm that the TBL design model was both reliable and valid. The suggested model in this study is expected to be used to design scaffoldings in online learning environments.

Correlation between TSH Receptor Antibody Assays and Clinical Manifestations of Graves’ Orbitopathy

장선영,신동엽,이은직,최영준,이상렬,윤진숙 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.4

Purpose: To investigate an association between the levels of serum thyroid-stimulating hormone (TSH)-receptor autoantibodies (TRAbs) and Graves’ orbitopathy (GO) activity/severity scores, and compare the performance of three different TRAb assays in assessing the clinical manifestations of GO. Materials and Methods: Cross-sectional study. Medical records of 155 patients diagnosed with GO between January 2008 and December 2010 were reviewed. GO activity was assessed by clinical activity score (CAS) and severity graded with the modified NOSPECS score by a single observer. Serum TRAb was measured by three different methods: 1st generation thyrotropin-binding inhibitor immunoglobulin (TBII) assay (TRAb1st); 3rd generation TBII assay (TRAb3rd); and biological quantitative assay of thyroid-stimulating immunoglobulin (TSI) using Mc4-CHO cells (Mc4-CHO TSI assay). Results were correlated with scores of activity/severity of thyroid eye disease. Results: All three assays (TRAb1st, TRAb3rd, and Mc4-CHO TSI) yielded results that were significantly positively correlated with CAS (β=0.21, 0.21, and 0.46, respectively; p<0.05) and proptosis (β=0.38, 0.34, and 0.33, respectively;p<0.05). Mc4-CHO TSI bioassay results were significantly positively correlated with all GO severity indices (soft tissue involvement, proptosis, extraocular muscle involvement, and total eye score; β=0.31, 0.33, 0.25, and 0.39, respectively;p<0.05). Conclusion: Mc4-CHO TSI bioassay was superior over the two TBIIs in assessing active inflammation and muscle restriction due to GO, whereas TBII assay would be sufficient for evaluation of patients with proptosis.

Pansori Othello: Othello with Korean Hyangga, Cheoyong ga

장선영 한국동서비교문학학회 2021 동서 비교문학저널 Vol.- No.55

This paper argues, first, that Im Youngwook’s Pansori Othello subverts the primacy of the West over the East presupposed in the theoretical foundation of interculturalism or postcolonialism, a predominant discourse in the investigations of Asian Shakespeare performances. Second, it contends that a proper understanding of Pansori Othello requires a close examination of the religions of Buddhism, Christianity, and Islam that set up the background of literary works, Cheoyong ga and Othello. Furthermore, I attest that, as Im’s performance is approached not with the discourse of cultural differences but with the interpretation of religion, we can grasp the universal potential for a better world both in literary works and in his production. This paper traces this universal potential, especially in Dan’s unique status as a female pansori singer, or kisaeng, in the Joseon dynasty, and then in the early 20th century, who performs both Cheoyong ga and Othello, connoting the ethical meaning of coexistence.

불명열 환자에서 동반된 급성 일과성 근시성 굴절력 변화 1예

장선영,이현준,정문선,김소영 대한안과학회 2009 대한안과학회지 Vol.50 No.8

Purpose: To report a case of acute transient myopic shift in a patient with fever of unknown origin. Case summary: A 31-year-old woman without a history of any ophthalmic problems presented with a sudden onset of bilateral blurred vision. She was admitted with the diagnosis of fever of unknown origin (FUO). Ophthalmic examination revealed a visual acuity of 0.06 in the right eye and 0.1 in the left eye. A myopic shift of 3.12 diopters (D) and 2.25D was noted in the right and left eyes, respectively. Retinal folds and choroidal thickening accompanied the myopic shift. On the third day after onset, visual acuity had decreased even more. Myopic shift increased to 4.87D in the right eye and 4.50D in the left eye. At the same time, the depth of the anterior chamber maximally decreased and the thickness of the lens was maximally increased. One week later, the myopic shift was normalized to emmetropia. The depth of the anterior chamber and the thickness of the lens also normalized as the fever subsided. 목적: 불명열 환자에서 동반된 급격한 근시성 굴절력 변화 1예를 경험하여 이를 보고하고자 한다. 증례요약: 안과적 과거력이 없는 31세 여자가 불명열로 치료하던 중 갑자기 발생한 양안의 시력저하를 주소로 안과에 의뢰되었다. 처음 검사에서 나안시력은 우안 0.06, 좌안 0.1이었으며 현성굴절검사에서 우안 -3.12Diopters(D), 좌안 -2.25D의 근시성 굴절이상을 보였다. 안저검사에서 망막 주름, 초음파 검사에서 맥락막 부종의 소견이 동반되었다. Pentacam과 A-scan을 이용하여 전방깊이, 수 정체 두께 및 안축장을 측정하였고 매 검사 시마다 추적 관찰했다. 증상 발생 3일째에 시력은 더욱 감소하였으며 우안-4.87D, 좌안 -4.50D로 근시성 굴절이상이 증가하였고 전방 깊이는 더욱 감소되었고 수정체 두께는 증가되었다. 증상 발생 1주일 후 내과적인 증상 이 호전되면서 굴절이상은 정시화되었고 전방 깊이 및 수정체의 두께도 정상화 되었으며 나안시력은 양안 1.0으로 호전되었다.

기본형 간헐외사시에서 수술 전 단안차폐 후 사시각 측정의 의미

장선영,이자영,박성희,김소영 대한안과학회 2009 대한안과학회지 Vol.50 No.9

목적: 기본형 간헐외사시의 수술 전 1시간 단안차폐 후 사시각 측정의 의미를 알아보고자 하였다. 대상과 방법: 기본형 간헐외사시로 수술 받은 환아 중 수술 전 단안차폐검사를 시행한 29명을 대상으로 후향적으로 조사하였다(단안차 폐군). 1시간 단안차폐 후 원거리에서 사시각이 재 측정되었으며 사시각이 증가한 경우 측정된 사시각을 목표로 수술이 시행되었다. 수술 전 단안차폐검사를 하지 않았던 환아 중 대상군과 연령, 성별 및 융합상태가 유사한 29명의 환아를 대조군으로 하였으며 6개월 이상 추적관찰 하였을 때 수술 결과를 비교하였다. 결과: 단안차폐군 29명 중 15명(51.7%)에서 사시각의 증가가 관찰되었으며 융합상태가 나빴던 15명 중 4명(26.7%), 융합상태가 좋았던 14명 중 11명(78.6%)에서 사시각의 증가가 있었다(p<0.05). 수술 성공률은 단안차폐군 79.3%, 대조군 75.9%로 유의한 차이는 없었으나 융합 상태가 좋았던 환아의 수술 성공률은 각각 85.7%, 71.46%로 단안차폐군에서 수술 성공률이 높았으나 통계학적으로 유의하지는 않았다 (p=0.357). 결론: 융합상태가 좋은 기본형 간헐외사시에서 수술 전 단안차폐를 시행하는 것은 잠재되어 있는 사시각을 찾아주어 수술 후에 발생하는 부족교정을 예방하는데 도움을 줄 수 있을 것이다. Purpose: To assess the clinical potential of one‐hour monocular occlusion on preoperative alignment evaluation in basic intermittent exotropia. Methods: Twenty-nine patients with basic intermittent exotropia who were preoperatively examined for one‐hour monocular occlusion were selected (monocular occlusion group). Their records were reviewed retrospectively. The measured angle after one hour of monocular occlusion was used to determine the surgical target angle. The control group consisted of 29 patients whose age, sex and control state were similar to the monocular occlusion group. Measurement of the angle of strabismus was not done in the control group. Surgery was performed for the measured angle at six meters. The results of surgery were used to compare the groups relative to the control state. Results: Fifteen patients (51.7%) had an increase in the distance deviation after one hour of monocular occlusion. Of the patients with good control, 78.6% (11/14) had an increase in the angle of misalignment. Only 26.7% (4/15) of patients with poor control experienced a change in the angle deviation (p<0.05). In all, 79.3% of patients in the study group and 75.9% of those in the control group had a satisfactory surgical outcome. Among the patients with good control, 85.7% of patients who underwent surgery for increased angle had a satisfactory outcome, compared with 71.4% of patients who underwent surgery for initial angle (p=0.375). Conclusions: One-hour monocular occlusion might help to prevent undercorrection after surgical treatment by identifying the hidden deviation, especially in the patients whose control over the distance deviation was good.