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      • KCI등재
      • KCI등재

        약콩, 비트 추출물의 자외선에 의한 망막 상피세포와 마우스의 눈 손상 조절 효능

        김하림,김솔,김상준,정승일,김선영 한국생약학회 2020 생약학회지 Vol.51 No.2

        Ultraviolet (UV)-induced damage plays a major role in ocular diseases, such as cataracts and retinal degeneration. UV irradiation can generate free radicals including reactive oxygen species (ROS), which are known to cause lipid peroxidation of cellular membranes. It has also been shown that UV can damage DNA directly and induce apoptosis. Rhynchosia volubilis Loureiro (the small black bean or yak-kong, RV) and Beta bulgaris (beet, BB) are used as health supplements. In this study, we explored the protective effects of RV and BB against UVA-induced damage in human pigment epithelial (ARPE-19) cells and in mice. RV and BB mixture and their effective constituents (cyanidin, delphidin, petunidin glycosides) improved cell viability and suppressed intracelluar ROS generation. Phosphorylation of p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK), Erk1/2 was analyzed by immunoblotting. RV and BB mixture inhibited UVA-induced phosphorylation of p38 MAPK, JNK, Erk1/2 in APRE-19 cells. RV and BB treatment also showed protective effects on ocular damage in UVA-irradiated mice by increasing the levels of endogenous antioxidants such as superoxide dismutase and glutathione. RV and BB have the potential to be used in a range of ocular diseases and conditions, based on in vitro and in vivo study.

      • KCI등재

        5·4운동 전후 중국의 세계주의의 확산과 민족주의의 재구성

        김하림 중국근현대사학회 2019 중국근현대사연구 Vol.83 No.-

        This article investigates the rise of cosmopolitanism during the era of May Fourth Movement in China, under the perspective that intellectual trends and features of the movement were closely connected for explicating the historical trend of the contemporary intellectual thinking of China. The article attempts to take a fresh look at the practice on the May Fourth from the context of intellectual history, about how the basically transnational thinking of cosmopolitanism competed with the nationalism which was particularly influential under the semi-colonial circumstance of China, and about how it worked as a recognizing momentum for remodeling the contents of Chinese nationalism. It carries out a two-fold analysis for further concrete investigation: first, defining the characteristic of Chinese cosmopolitanism so called post-war discourse it analyzes a diversified intellectual context during the formation of the discourse. Second, evaluating the significance and limitation of cosmopolitanism in building the relationship between (the remodeling of) China, (the remodeling of) the World, and Asia. There are three major points that is emphasized in the article: first of all, cosmopolitan thinking during the May Fourth era of China played a critical role as a universal discourse like de facto zeitgeist, so much so that it continuously competed with nationalism and that it consequently supplied a momentum for rethinking nationalism. Second, the rise of cosmopolitanism before and after the May Fourth era was a reflection of the intellectual agenda of post-war discourse, a transition in history of civilization. Third, strongly reflected in the Chinese prospect of cosmopolitanism were the critical view against the western-dominant modern world and the willingness to participate in the post-war world order in a more leading manner. Fourth, the principle of self-determination which drove the May Fourth Movement was rather perceived as realizing public good of the world than as a self-expansion of nationalism of one nation-state, and it necessitated the core process of remodeling China based on the practice of democracy. Fifth, although it was paramount for evidencing the vision of cosmopolitanism, the perception of Asia was significantly lacking in Chinese understanding of cosmopolitanism.

      • KCI등재

        Multicentric Breast Cancer of the Axillary and Pectoral Breasts: A Case Report and Literature Review

        김하림,고은영,한부경,김지연,채병주,이현우 한국유방암학회 2022 Journal of breast cancer Vol.25 No.5

        Multicentric cancer of the pectoral and ectopic breasts is extremely rare, and diagnosing this malignancy remains challenging because axillary breast cancer is easily misdiagnosed as lymph node metastasis. Moreover, there are no established treatment guidelines for this disease. We present our experience with a multicentric breast cancer patient who showed different responses to neoadjuvant chemotherapy (NAC) and underwent surgical treatments that differed from those in previous studies. In our case, the preoperative imaging of both lesions and subsequent core needle biopsy of each lesion were crucial, as these procedures confirm the diagnosis and help decide the chemotherapy regimen based on the subtype. After NAC, the patient underwent right breast-conserving surgery, sentinel lymph node biopsy (SLNB), and excision of accessory breast tissue in the right axilla. SLNB should be the initial step in staging multicentric breast cancer, unless imaging scan shows evidence of lymph node metastasis.

      • KCI등재

        번스타인의 「새들 1권」에 나타난 움직임과 음악의 상관관계분석 및 교수방안

        김하림,유승지 한국무용교육학회 2018 韓國舞踊敎育學會誌 Vol.29 No.4

        Known as a pianist as well as a piano pedagogue and a composer, Bernstein, S. (1927~) composed various works for piano learners. Emphasizing especially the importance of understanding movements when it comes to musical expressions, he has created musical pieces based on live animals or insects. Most notable of all is Birds 1, which is his first suite for piano education that consists between 8 pieces of 1-2 pages. This particular piece was all composed based on impressions of birds’ movements and sounds using the modern composition techniques. The purpose of this research is to analyze the correlation between movements and music, and explore teaching methods which would be helpful for the effective learning of Birds. The results are as follows: In Birds 1, Bernstein, S. suggested 2-3 motives to express the characteristic movements and sounds of each bird, and employed techniques to develop and transform these motives. With the repeated or changed patterns of rhythm according to the unit and conversion of beats, the changes in the movements are naturally described. The phrase and form are separated depending on the developing patterns of the motives, resulting in changes in the atmosphere. With the registers, intervals, and harmony reflecting birds’ sounds or movements, the audience can imagine the kinds and sounds of different birds effectively. Furthermore, the continuous dissonance created from distinct use of atonality and bitonality. Birds 1 also implies the musical atmosphere effectively by employing descriptive directives that properly present the features of birds. Additionally, the piece delivers changes in musical nuance by the delicate use of dynamics and articulation. For the effective learning of this piece which describes the characteristics of birds by combining various musical elements, the researcher suggests three teaching methods: 1) learning by using images; 2) learning by using plastic animée; and 3) learning by creative activities in which movements and performance are combined. Through this study, it is expected that the piano teaching method through the understanding and application of movement becomes more active, and the piano work composed for education will be more actively used in the dance education field.

      • KCI등재

        체력증진을 목적으로 하는 집중적 운동 수행이 대학생의 자기통제력에 미치는 영향

        김하림,정경미,김윤명 한국인지행동치료학회 2018 인지행동치료 Vol.18 No.1

        본 연구에서는 체력증진을 목적으로 하는 집중적 운동 수행이 대학생의 자기통제 수준에 미치는 영향을 검증하고자 하였다. 연구 1에서는 집중적 운동을 통한 자기통제 수준의 향상을 충동성 감소의 차원에서 검증하기 위하여, 체력향상을 목적으로 집중적 운동을 실시한 학생들과(집중적 운동집단, n=199)들과 스포츠 활동 중심의 일반 교양체육 수업을 수강한 학생(대조집단, n=156)들을 대상으로 충동성을 측정하는 지연 디스카운팅 과제(delay discounting task)를 학기 전후로 실시하였다. 그 결과, 집중적 운동 집단의 충동성은 유의하게 감소한 반면, 대조집단의 충동성에서는 유의미한 변화가 관찰되지 않았다. 연구 2에서는 집중적 운동을 통한 자기통제 수준의 향상을 충동성 감소의 차원에서 재검증하고, 이러한 효과가 일상생활에서의 자기통제 행동의 증가로 일반화 되는지 확인하기 위하여, 연구 1과 다른 학기에 체력단련 수업을 수강한 학생(집중적 운동집단, n=193)들과 일반 교양체육 수업을 수강한 학생(대조집단, n=131)들을 대상으로 지연 디스카운팅 과제, 일반적 자기통제 행동 척도를 학기 전후로 실시하였다. 그 결과 충동성 감소는 연구1과 동일하게 집중적 운동 집단에서만 유의미한 것으로 나타났다. 그러나 일상생활에서의 자기통제 행동 변화에서는 집단 간 차이가 관찰되지 않아, 집중적인 운동 수행을 통한 충동성 감소의 일반화 효과는 확인되지 않았다. 이 같은 결과의 연구적, 임상적 함의와 함께 본 연구의 한계점 및 후속연구를 위한 제언을 논의하였다. Several studies have shown that repeatedly performing tasks that involve self-control could improve self-control strength. The purpose of this study was to test whether intensive physical exercise involving long-term health-related goals could enhance self-control among college students. Study 1 was conducted to investigate the effects of intensive exercise on self-control. Changes were measured using a delay discounting task(DDT), a behavioral task measuring impulsivity. College students who took the Intensive Physical Training(IPT) course(n=199) and a less intensive PE course involving a single sports activity (control, n=156) performed the computerized DDT at the beginning and end of the course. After administering the DDT, significant decreases in impulsivity were observed only in the IPT students. Study 2 was conducted to replicate the results of study 1 as well as explore whether increased self-control via exercise can be generalized to other behaviors. Students who participated in the IPT course(n=193) and the less intensive PE course(n=131) completed the DDT and general self-control behavior questionnaire at the beginning and end of the course. Results revealed that the impulsivity of only the IPT students decreased significantly, reaffirming the results of study 1. However, no generalization effects were found in other behaviors involving self-control. Clinical and research implications as well as limitations are also discussed.

      • KCI등재

        패션일러스트레이션의 창의적 표현방법 연구 : 창의적 발상기법을 중심으로 Focusing on Creative Idea Technique

        김하림,유영선 한국의류학회 2002 한국의류학회지 Vol.26 No.8

        The purpose of this study is to find out the creative visual expression in fashion illustration through the previous general theories on creativity. The creative visual expression, in fashion illustration works, can be summarized eight categories as follows. There are `maximization & minimization' to emphasize the illustrators' emotions and contemporary trends, proposed specially in body expression, inversion' seen as the forms of contra-perspective, upside-down, rearrangement of parts, diverted process, etc, 'Unusual uses' to add the effect of caricature, parody, and humor to the fashion illustration works, `extraordinary connection' seen as the shapes of various combination between animals, plants, stuff, and man, 'concealment & elimination' used frequently in creative visual expression includes a deformed human body, an abstracted human body, an extreme value contrast, simple colors, and dress in silhouette, `association' seen in various methods; comparing the similar shapes, describing a certain situation or details for analogizing the whole, `illusion' expressed in surreal, mysterious, and fairy depictions and `substitution' to imitate the composition and colors of masterpieces, copy the parts.

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