마이토마이신 C가 흰 쥐의 속눈썹 재성장에 미치는 영향

김체론,유웅선,김경현,서성욱,Che Ron Kim,Woong Sun Yoo,Kyeong Hyun Kim,Seong Wook Seo 대한안과학회 2011 대한안과학회지 Vol.52 No.12

Purpose: The aim of the present study was to determine the effects of mitomycin C (MMC) on eyelash regrowth in rats. Methods: Ten rats were subjected to bilateral eyelid epilation. One drop of 0.04% MMC solution and one drop of normal saline was then administered to the right and left eyelid, respectively. Three months post-epliation, the number of regrown eyelashes was counted, and a section of tissue from each eyelid was examined under light- and electron microscopies. Results: The number of regrown long eyelashes was 1.0 ± 0.81 on the right, and 12.5 ± 1.08 on the left. The rate of regrowth was 7.35 ± 5.55% on the right and 98.45 ± 3.27% on the left. Histological examination revealed no significant differences between the right and left eyelids, except for the absence of any hair shafts in the follicles on the right. However, electron microscopy revealed mitochondrial damage in the follicles of the right eyelid. These changes were not observed in tissue from the left eyelid. Conclusions: The application of 0.04% MMC inhibited the regrowth of normal eyelashes in rats following simple epilation. These results suggest that MMC may be a novel therapy for replacing invasive surgery in trichiasis with no malpositioning. J Korean Ophthalmol Soc 2011;52(12):1501-1506

Drechslera 균종에 의한 진균각막염 1예

김체론,서성욱,박종문,유지명,한용섭,김선주,김성재,Che Ron Kim,MD,Seong Wook Seo,MD,PhD,Jong Moon Park,MD,PhD,Ji Myung Yoo,MD,PhD,Yong Seop Han,MD,Sunjoo Kim,MD,PhD,Seong Jae Kim,MD 대한안과학회 2011 대한안과학회지 Vol.52 No.11

Purpose: To report a case of fungal keratitis caused by Drechslera species. Case summary: A 77-year-old man visited our clinic complaining of left ocular pain and decrease of visual acuity for 1 week On slit-lamp examination, epithelial defect and stromal infiltration on the corneal center with numerous inflammatory cells in the anterior chamber were found. There was no improvement after routine antibiotic treatment. A corneal biopsy and culture were performed on the corneal lesion. The KOH smear study reported hyphae, thus the patient was treated with 0.25% amphotericin B, 0.2% fluconazole and 5% natamycin eye drops. A clinical improvement was observed on the corneal lesion and Drechslera species was identified by the culture study. Conclusions: The authors report an experience of fungal keratitis caused by Drechslera species. J Korean Ophthalmol Soc 2011;52(11):1366-1369

가쪽눈구석에 발생한 저등급 악성 섬유성 조직구종 1예

김체론,김경현,유지명,서성욱,Che Ron Kim,Kyeong Hyun Kim,Ji Myung Yoo,Seong Wook Seo 대한안과학회 2010 대한안과학회지 Vol.51 No.8

Purpose: To report a case of malignant fibrous histiocytoma of the lateral canthal area that was diagnosed clinically as a benign epidermal inclusion cyst. Case summary: A 49 year-old man presented with a cutaneous mass involving the lateral canthal area. A 0.7-cm cystic lesion was freely movable and non-inflamed. After excisional biopsy, the results of immunohistochemical staining led to a final diagnosis of low-grade malignant fibrous histiocytoma. The specimen from excisional biopsy had margins positive for malignancy; the patient underwent a second procedure for complete resection, and that specimen had tumor-free margins. Conclusions: Fibrous histiocytoma is a rare disease but may occur in the eyelid. Therefore, when an eyelid tumor progresses rapidly, malignant fibrous histiocytoma should be considered as a diagnosis. J Korean Ophthalmol Soc 2010;51(8):1129-1132

Achromobacter Xylosoxidans에 의한 만성눈물주머니염 1예

김체론,김규남,김경현,유지명,서성욱,Che Ron Kim,Gyu Nam Kim,Kyeong Hyeon Kim,Ji Myong Yoo,Seong Wook Seo 대한안과학회 2011 대한안과학회지 Vol.52 No.8

Purpose: To report a case of chronic dacryocystitis caused by Achromobacter xylosoxidans. Case summary: A 73-year-old female was referred to our clinic for management of chronic dacryosyctitis from which she did not to recover despite empirical therapy. A. xylosoxidans was isolated from purulent discharge. Based on the results of susceptibility testing, therapy was changed to fortified ceftazidime eye-drop 6 times a day and intravenous tazocin 4.5 g/20 ml (piperacillin 2 g/tazobactam 0.25 g) 3 times a day. All symptoms were resolved after treatment with sensitive antibiotics and external dacryocystorhinostomy. Conclusions: To our knowledge, this is the first report of A. xylosoxidans dacryocystitis. A. xylosoxidans are rare but potential pathogens which cause dacryocystitis. The cultures and sensitivity test were collected and processed to detect the presence of unusual pathogens in a case with persistent infection despite conventional treatment. J Korean Ophthalmol Soc 2011;52(8):979-983

펜타캠을 이용한 유리체강내 주입술 후 전방인자 변화 분석

김병선,김체론,김성재,한용섭,서성욱,유지명,정인영,박종문 대한안과학회 2013 대한안과학회지 Vol.54 No.12

Purpose: To evaluate the changes of anterior chamber parameters and intraocular pressure (IOP) with Pentacam<SUP>® after intravitreal injection.<br /> Methods: A total of 76 eyes of 76 patients received an intravitreal injection of either triamcinolone acetonide (TA) or bevacizumab. Twelve patients were treated with an intravitreal injection of TA 0.1 ml, 16 patients were treated with an intravitreal injection of TA 0.05 ml, while the remaining 48 patients received a bevacizumab 0.05 ml injection. All patients underwent anterior chamber depth, anterior chamber angle, and anterior chamber volume evaluation with Pentacam<SUP>® before and 5 minutes after injection. Additionally, IOP measurements were taken 5 minutes before and 5 minutes, 30 minutes, 1 hour and 1 day after injection.<br /> Results: Anterior chamber depth, anterior chamber angle, anterior chamber volume, and IOP changes in patients receiving TA 0.1 ml were 0.4 ± 0.11 mm, 10.2 ± 4.1°, 33.7 ± 5.9 mm3 and 18.8 ± 12.1 mm Hg, respectively. Anterior chamber depth, anterior chamber angle, anterior chamber volume, and IOP changes in patients receiving TA 0.05 ml were -0.01 ± 0.05 mm, 2.4 ± 3.2°, 5.8 ± 9.5 mm3 and 4.8 ± 7.4 mm Hg, respectively. Anterior chamber depth, anterior chamber angle, anterior chamber volume, and IOP changes in patients receiving bevacizumab were 0.28 ± 0.99 mm, 0.8 ± 4.0°, 7.1 ± 9.6 mm3 and 5.4 ± 6.3 mm Hg, respectively. There was a significant difference between TA 0.1 ml and 0.05 ml. However, there was no significant difference between TA 0.05 ml and bevacizumab 0.05 ml.<br /> Conclusions: Because of similar anterior chamber parameters changes after 0.05 ml intravitreal injection with TA or bevacizumab, early period IOP increases due to intravitreal volume expansion. Intravitreal 0.05 ml injections do not require any other procedures for controlling IOP 30 minutes after injection.<br /> J Korean Ophthalmol Soc 2013;54(12):1824-1831

신경매독과 연관되어 발생한 안매독의 임상 양상

조용운,김체론,한용섭,정인영,박종문,Yong Wun Cho,MD,Che Ron Kim,MD,Yong Seop Han,MD,PhD,In Young Chung,MD,PhD,Jong Moon Park,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report the manifestation of ocular syphilis combined with neurosyphilis in patients who present with uveitis clinically and are diagnosed initially by an ophthalmologist. Methods: This study is a retrospective, clinical investigation of seven male patients with ocular syphilis from a single tertiary center between 2009 and 2012. Results: The average age of the patients at onset was 44.4 years (range, 33-71 years). Posterior segment involvement was found in all patients. Two patients had papillitis. In serologic testing, all patients had positive responses to Venereal Disease Research Laboratory (VDRL), fluorescent treponemal antibody-absorption test (FTA-ABS) and Treponema pallidum hemagglutination (TPHA). In fluorescein angiography (FAG), retinal vascular and disc leakage was the most common finding. Cerebrospinal fluid (CSF) analysis was performed for six patients and demonstrated positive CSF FTA-ABS and CSF TPHA tests in all patients. CSF VDRL was reactive in 2 patients (33.3%). Conclusions: All patients with ocular syphilis were diagnosed with neurosyphilis based on the analysis of CSF with FTA-ABS and TPHA. Ophthalmologists play an important role in the early diagnosis and treatment of syphilis. J Korean Ophthalmol Soc 2014;55(4):602-607

3디옵터 이상의 차이를 보인 근시부등시 환자에서 굴절교정 정도에 따른 근시 진행 양상

김지혜,김체론,유지명 대한안과학회 2018 대한안과학회지 Vol.59 No.2

Purpose: To investigate the change of refractive error between the full-correction and under-correction treatment groups of myopic anisometropic patients. Methods: This study included 36 patients who had no amblyopia with myopic anisometropia > 3.00 diopters (D) and less than 6.00 D using the cycloplegic refraction test. The patients were divided into two groups involving the full-correction of both eyes(group 1) or full-correction on the less myopic eye and under-correction with -0.50 D of the more myopic eye (group 2). We monitored refractive changes every 6 months for 24 months. Results: At the first visit, the mean refractive error of the less myopic eye was -0.68 ± 0.54 D and that of the more myopic eye was-4.22 ± 0.77 D in group 1. The mean refractive error of the less myopic eye was -0.75 ± 0.58 D and that of the more myopic eye was -4.36 ± 0.73 D in group 2. There was no significant difference between the groups (p = 0.713 and p = 0.585, respectively). At 24 months, the mean refractive errors of group 1 were -1.27 ± 0.54 D and -4.88 ± 0.81 D, respectively, and that of group 2 were 1.38 ± 0.54 D and -5.59 ± 1.01 D, respectively. The mean refractive error of the less myopic eyes showed no significant difference between both groups (p = 0.555), but that of the more myopic eyes was significantly different (p = 0.027). Between both groups, the degree of anisometropia at 24 months was 3.61 ± 0.60 in group 1 and 4.20 ± 0.86 in group 2. Group 2 showed a significant difference and more severe anisometropic changes (p = 0.022). Conclusions: Full correction of myopic anisometropia without amblyopia is a better method for reducing the progression of anisometropia.

한눈 고도근시가 있는 환아에서 양안 맥락막 두께 차이에 대한 후향적 연구

조용운,김체론,유웅선,유지명 대한안과학회 2015 대한안과학회지 Vol.56 No.10

Purpose: To compare the choroidal thickness of unaffected and affected eyes in children with unilateral high myopia when measured using enhanced depth imaging and to analyze the relationship among choroidal thickness and axial length, spherical equivalent and best corrected visual acuity (BCVA). Methods: Twenty children with high unilateral high myopia who received optical coherence tomography from December 2012 to May 2014 were retrospectively analyzed. Choroidal thickness was measured with a caliper at 500 μm apart from fovea superiorly and inferiorly, 2,500 μm apart nasally and at 2,500 μm apart temporally at 500 μm intervals. For statistical analyses, paired t-test was used for choroidal thickness and linear regression analysis for the relationship among choroidal thickness and axial length, spherical equivalent and BCVA. Results: The patients were 10.4 ± 3.5 years of age and the average BCVA of myopic eye was 0.38 ± 0.2. Mean spherical equivalent was -9.8 ± 1.9D. The choroidal thickness was significantly thinner in the myopic eye (102.5 ± 16.9 μm) than the fellow eye (282.9 ± 14.0 μm). The thickest choroid in the myopic eye was the temporal and the thinnest was the nasal area (p = 0.008). Choroidal thickness was significantly associated with axial length and spherical equivalent but not BCVA. Conclusions: Highly myopic eyes tend to have thinner choroidal thickness than the fellow eyes and choroidal thickness tends to be thicker temporally. Therefore, several anatomical changes in unilateral highly myopic children may exist. 목적: 한눈 고도근시를 가진 환아에서 빛간섭단층촬영기 Enhanced Depth Imaging (EDI) 방법으로 측정한 정상안과 근시안의 맥락막 두께를 비교하고, 맥락막 두께와 근시성 부등시의 정도, 안축장 및 최대교정시력과의 관계를 분석하였다. 대상과 방법: 2012년 12월부터 2014년 5월까지 한눈 고도근시를 가진 환아 중 빛간섭단층촬영을 시행한 20명의 맥락막 두께, 굴절력, 안축장, 최대교정시력을 후향적으로 분석하였다. 맥락막 두께는 한 관찰자가 중심와의 위쪽 아래쪽 500 μm 지점 및 코쪽 2,500 μm부터 귀쪽 2,500 μm까지 500 μm 간격으로 내장된 캘리퍼를 이용해 측정하였다. 통계적 분석을 위해 맥락막의 두께를 대응표본 t 검정을 통해 비교하였으며, 맥락막 두께와 근시성 부등시의 정도, 안축장 및 최대교정시력과의 관계는 선형회귀분석을 통해 비교하였다. 결과: 환자군의 평균 나이는 10.4 ± 3.5세였으며, 근시안의 평균 최대교정시력은 0.38 ± 0.2였고, 평균 구면렌즈 대응치는 -9.8 ± 1.9디옵터였다. 근시안 중심와의 맥락막 두께는 102.5 ± 16.9 μm로, 정상안 중심와의 맥락막 두께인 282.9 ± 14.0 μm보다 유의하게 얇았다. 근시안에서 맥락막이 가장 두꺼운 부분은 귀쪽이었고 가장 얇은 부분은 코쪽이었다(p=0.008). 맥락막 두께는 안축장, 근시성 부등시의 정도와는 통계적으로 유의한 관계가 있었으나 최대교정시력과는 통계적으로 유의한 관계가 없었다. 결론: 고도근시안의 경우 맥락막의 두께가 정상안에 비해 얇은 경향을 보이며, 맥락막 두께는 코쪽에서 귀쪽으로 두꺼워진다. 따라서한눈고도근시를 가진 소아 환아에서 해부학적인 변화의 가능성이 있을 것으로 생각된다.

내시경하 비강내 눈물주머니코안연결술 시행 후 수술용 장갑을 이용한 비강충전술의 효과

김상욱,장동엽,김체론,김규남,허현도,전시영,서성욱 대한이비인후과학회 부산,울산,경남 지부회 2012 임상이비인후과 Vol.23 No.2

To evaluate the surgical results of nasal pack covered with clean glove finger after endoscopic endonasal dacryocystorhinostomy (DCR). Materials and Methods:Seventy-five patients who underwent endoscopic endonasal DCR to treat nasolacrimal duct obstruction from 2007 to July 2011 were studied retrospectively. Female patients were 63 of 75 (84%). The patients were divided into two groups according to used packing materials after endoscoic endonasal DCR: 31 patients packed with Vaseline gauze were assigned to group 1, and the other 44 patients packed with nonabsorbable expandable nasal pack (IVALONⓇ) wrapped with surgical glove finger were assigned to group 2. Nasal pack was soaked with 2% lidocaine after inserted. Six months later, we evaluated the surgical success rate based on the patients’ symptoms and irrigation test results. Results : Success rates at 6 months after surgery were significantly higher in group 2 than in group 1 (group 1 : 54.8%, group 2 : 77.2%, p=0.036). Conclusion:Nasal pack wrapped with surgical glove finger after endoscopic endonasal DCR was increased functional success rate.

사시수술 후 빛간섭단층촬영을 이용한 눈물띠의 변화 분석

김지혜(Ji Hye Kim),김체론(Che Ron Kim),김성재(Seong Jae Kim),정인영(In Young Chung),서성욱(Seong Wook Seo),유지명(Ji Myong Yoo) 대한안과학회 2016 대한안과학회지 Vol.57 No.12

목적: 소아에서 사시수술 후 안구표면인자의 변화와 빛간섭단층촬영(optical coherence tomography, OCT)을 이용한 눈물띠의 변화 및 인공눈물 사용유무에 따른 변화를 관찰하고자 하였다. 대상과 방법: 25프리즘디옵터 이상의 외사시로 양안에 외직근 후전술을 시행한 환자 총 30명을 대상으로 하였다. 대상자들은 수술 후 인공눈물을 좌안에만 점안하였다. 눈물막파괴시간검사, Schirmer 검사, 각막염색검사, 결막압흔세포검사, OCT를 이용한 눈물띠 높이, 넓이 검사를 수술 전과 수술 후에 시행하여 비교 분석하였다. 결과: 대상자들의 평균나이는 8.7세였다. 수술 후 8주에 눈물막파괴시간검사, 각막염색검사는 인공눈물 점안을 시행한 경우 12.3 ± 1.5초, 1.3 ± 0.4였으며, 인공눈물을 사용하지 않은 경우 9.5 ± 1.0초, 2.0 ± 0.7로 측정되었다(모두 p<0.000). OCT를 이용한 눈물띠 높이와 넓이 검사에서 수술 후 4주에 인공눈물 점안을 시행한 경우 290.2 ± 42.3 μm, 566.7 ± 48.2 pixels였으며, 인공눈물을 점안하지 않은 경우 246 ± 45.5 μm, 504.0 ± 29.7 pixels로 양안의 유의한 차이를 보였다(p=0.045, p=0.019). 결막압흔세포검사에서 인공눈물을 사용 유무에 따라 수술 후 8주째 유의한 술잔세포 수 차이가 있었다(p=0.033). 결론: 사시 수술 후 발생한 눈물막의 불안정성을 눈물막파괴시간검사, Schirmer 검사, 각막염색검사, 결막압흔세포검사, OCT를 이용하여 확인할 수 있다. 수술 후 인공눈물의 점안은 각결막의 빠른 치유와 눈물막의 안정성을 높여 수술 후 발생하는 안구건조증의 치료에 도움이 된다. Purpose: In this study, the changes in ocular surface parameters and tear meniscus after strabismus surgery when treated with or without artificial tears were evaluated using optical coherence tomography (OCT). Methods: The present study included 30 patients who received bilateral lateral rectus recession surgery for exotropia. The patients instilled artificial tear eye drops only in the left eye. Before and 2, 4, 8, and 12 weeks after surgery, tear film break-up time (BUT), Schirmer’s test, corneal staining test, tear meniscus height and area were measured using OCT and compared in both eyes. Before and 8 weeks after surgery, conjunctival compression cytology test was performed. Results: The mean patient age was 8.7 years. After 8 weeks, BUT and corneal staining scores were 12.3 ± 1.5 seconds and 1.3 ± 0.4 in patients treated with artificial tears and 9.5 ± 1.0 seconds and 2.0 ± 0.7 in patients not treated with artificial tears (both p < 0.000). Four weeks after surgery, tear meniscus height and area using OCT were 290.2 ± 42.3 μm and 566.7 ± 48.2 pixels in patients treated with artificial tears and 246 ± 45.5 μm and 504.0 ± 29.7 pixels in patients not treated with artificial tears (p = 0.045 and p = 0.019, respectively). Goblet cell count was significantly different between the eyes 8 weeks after surgery (p = 0.033). Conclusions: Instability of tear meniscus can be detected after strabismus surgery using BUT, Schirmer’s test, corneal staining test, tear meniscus height and area, and OCT. After surgery, artificial tears help treat dry eye symptoms by corneo-conjunctival wound healing mechanism and increasing tear meniscus stability.