실험계획법을 이용한 나노 결정 소석회 합성

김진성,김정우,이희수,김용남,신현규,김환,Kim, Jin-Seong,Kim, Jung-Woo,Lee, Hee-Soo,Kim, Yong-Nam,Shin, Hyun-Gyoo,Kim, Hwan 한국결정성장학회 2008 한국결정성장학회지 Vol.18 No.4

본 연구에서는 균일침전법으로 합성된 $CaCO_3$를 하소한 후 수화시키는 방법을 이용하여 소석회를 제조하였다. 소석회를 제조하기 위하여, 염화칼슘$(CaCl_2)$과 우레아(Urea)가 출발 물질로 사용되었으며 염화칼슘 수용액과 우레아 수용액을 혼합하여 가열하는 동안 반응용기 내에서 탄산칼슘이 합성되었다. 침전물들을 여과하고 증류수와 에탄올로 수 차례 세척하였으며 건조시켰다. 소석회는 하소된 탄산칼슘의 수화과정을 통하여 합성되었다. 최적의 합성조건을 선정하는데 있어 실험의 잡음인자를 최소화하고 결과를 통계적으로 추론할 수 있는 실험계획법(다구치 실험계획법)을 이용하였다. 제조된 탄산칼슘을 $1000^{\circ}C$에서 30분 동안 하소시킨 후 에탄올 및 옥살산이 첨가된 증류수로 수화시킴으로써 결정입자 크기가 약 50 nm인 소석회를 제조할 수 있었다. Nano-crystalline slaked lime was synthesized using design of experiment. In order to synthesize slaked lime, calcium chloride $(CaCl_2)$ and urea were used as starting materials. Calcium chloride solution and urea solution were mixed and heated in vessel that calcium carbonate was precipitated during heating. Precipitates were filtered, washed several times using D.I.water and ethanol and finally dried in oven. Slaked lime $(Ca(OH)_2)$ has been fabricated by the hydration of calcined $CaCO_3$. Design of experiment (Taguchi method) was used to optimize parameter, to minimize noise factors of experiment and to statistically analyze the results. Slaked lime having about 50 nm in optimized crystallite size could be obtained by calcination of $CaCO_3$ at $1000^{\circ}C$ for 0.5 h and hydration with D.I water containing ethanol and oxalic acid.

OpenCL을 이용한 돈사 감시 응용의 효율적인 태스크 분배

김진성,최윤창,김재학,정연우,정용화,박대희,김학재,Kim, Jinseong,Choi, Younchang,Kim, Jaehak,Chung, Yeonwoo,Chung, Yongwha,Park, Daihee,Kim, Hakjae 한국정보처리학회 2017 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.6 No.10

Pig monitoring applications consisting of many tasks can take advantage of inherent data parallelism and enable parallel processing using performance accelerators. In this paper, we propose a task distribution method for pig monitoring applications into a heterogenous computing platform consisting of a multicore-CPU and a manycore-GPU. That is, a parallel program written in OpenCL is developed, and then the most suitable processor is determined based on the measured execution time of each task. The proposed method is simple but very effective, and can be applied to parallelize other applications consisting of many tasks on a heterogeneous computing platform consisting of a CPU and a GPU. Experimental results show that the performance of the proposed task distribution method on three different heterogeneous computing platforms can improve the performance of the typical GPU-only method where every tasks are executed on a deviceGPU by a factor of 1.5, 8.7 and 2.7, respectively. 다수의 태스크로 구성된 돈사 감시 응용은 내재된 데이터 병렬성을 활용하고 성능가속기를 사용하여 병렬 처리가 가능하다. 본 논문에서는 멀티코어 CPU와 매니코어 GPU로 구성된 이기종 컴퓨팅 플랫폼에서 돈사 감시 응용 수행 시 태스크 분배 방법을 제안한다. 즉, 각 태스크별로 OpenCL을 이용한 병렬 프로그램을 작성한 뒤, deviceCPU와 deviceGPU 각각에서 수행시켜 측정된 수행시간을 기준으로 가장 적합한 처리기를 결정한다. 제안 방법은 간단하지만 매우 효과적이고, CPU와 GPU로 구성된 이기종 컴퓨팅 플랫폼에서 다수의 태스크로 구성된 다른 응용을 병렬화하는 경우에도 적용될 수 있다. 실험 결과, 상이한 이기종 컴퓨팅 플랫폼에서 최적의 태스크 분배로 수행한 경우 가 전체 태스크들을 deviceGPU에서 수행한 GPU-only 방법에 비교하여 각각 2.7배, 8.7배, 2.7배 성능 개선이 되었음을 확인하였다.

Design and fabrication of the MMIC frequency doubler for 29 GHz local oscillator application

김진성,이성대,이복형,김성찬,설우석,임병옥,김삼동,박현창,박형무,이진구,Kim, Jin-Sung,Lee, Seong-Dae,Lee, Bok-Hyoung,Kim, Sung-Chan,Sul, Woo-Suk,Lim, Byeong-Ok,Kim, Sam-Dong,Park, Hyun-Chang,Park, Hyung-Moo,Rhee, Jin-Koo The Institute of Electronics and Information Engin 2001 電子工學會論文誌-TC (Telecommunications) Vol.38 No.11

밀리미터파 대역에서 안정적이고 경제적인 local oscillator (LO) 신호를 생성하기 위한 주파수 체배기를 설계 및 제작하였다. 주파수 체배기는 14.5 GHz를 입력받아 29 GHz를 생성하도록 설계되었으며, 측정 결과 14.5 GHz에서 S11이 -9.2 dB, 29 GHz에서 S22가 -18.6 dB 로 입력 측은 14.5 GHz에, 출력 측은 29GHz에 매칭이 되었다. 변환손실의 경우 14.5 GHz에서 입력전력 6 dBm일 때 최소 값인 18.2 dB를 보였으며, 출력 단에서의 주파수 스펙트럼 특성은 14.5 GHz에서 15.2dB의 값을 나타내었다. 또한 입력신호의 isolation특성은 10.5 GHz에서 18.5GHz까지 주파수 범위에서 30 dB이상의 값을 보였다. 제작된 MMIC(Microwave monolithic integrated circuits) 주파수 체배기의 칩 사이즈는 $1.5{\times}2.2\;mm^2$이다. We demonstrate the MMIC (monolithic microwave integrated circuit) frequency doublers generating stable and low-cost 29 GHz local oscillator signals from 14.5 GHz input signals. These devices were designed and fabricated by using the M MIC integration process of $0.1\;{\mu}m$ gate-length PHEMTs (pseudomorphic high electron mobility transistors) and passive components. The measurements showed S11 or -9.2 dB at 145 GHz, S22 of -18.6 dG at 29 GHz and a minimum conversion loss of 18.2 dB at 14.5 GHz with an input power or 6 dBm. Fundamental signal of 14.5 GHz were suppressed below 15.2 dBe compared to the second harmonic signal at the output port, and the isolation characteristics of fundamental signal between the input and the output port were maintained above :i0 dB in the frequency range 10.5 GHz to 18.5 GHz. The chip size of the fabricated MMIC frequency doubler is $1.5{\times}2.2\;mm^2$.

만성 B형 간질환 환자의 정신사회적 측면

김진성,Kim, Jin-Sung 한국정신신체의학회 2000 정신신체의학 Vol.8 No.1

연구목적 : 저자는 만성 B형 간질환 환자의 정신과학적 측면과 사회학적 측면을 관찰해 보고자 본 연구를 실시하였다. 방법 : 저자는 1966년부터 1999년까지의 Medline database에 등록된 B형 간질환에 관한 모든 문헌들을 고찰하였다. 결과 : 만성 B형 간질환 환자와 관계되는 정신과학적 측면은 섬망, 전반적인 의학적 상태에 기인하는 정신병(특히 조증), 불안, 우울, 적응장애, 알코올 남용과 의존, 및 약물남용과 의존 등이다. 만성 B형 간질환 환자와 관계되는 사회학적 측면은 간염보균자로서의 낙인문제, 감염과 연관된 죄책감, 증가된 가족들의 부담에 대한 죄책감, 대인관계의 소외와 철수, 성장애, 직업상실 및 의료진의 치료 거부등이다. 결론 : 만성 경과를 거치는 B형 간염환자의 여러 가지 정신과학적 사회학적 문제로 볼 때, 적절한 조기의 교육적 상담 개업이 필요하다고 하겠다. 적절한 교육적 상담 개입은 간염으로부터 간경화 간암으로의 진행과정에 B형 간염환자의 치료의 순응도를 높이고 나아가 악화의 과정을 예방할 수 있다. Objectives : The author wanted to summarize the psychiatric and social aspects of the patients with hepatitis B virus infection. Methods : The author reviewed all pertinent citations in the Medline database from 1966 to 1999. Results : Psychiatric problems in this population include delirium, psychotic disorder due to general medical condition(especially mania), anxiety, depression, adjustment disorder, alcohol abuse/dependence, and drug abuse/dependence. Social aspects of the patients with hepatitis B viral infection relate to the stigma of being a carrier, guilty feeling about infection, guilty feeling about increased family burden, impacts of having hepatitis on interpersonal relations, sexual difficulties, and job loss with increased financial burden, and health care worker's refusal. Conclusions : Appropriate early educational counseling interventions regarding the expected course and psychosocial intervention should be tailored to the sociocultural needs of special populations. Those interventions will increase compliance of treatment and prevent progression to hepatocellalar carcinoma from hepatitis.

익기양음해독탕의 항암 및 항전이효과에 관한 연구

김진성,윤상협,류봉하,류기원,윤성우,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Yoon, Seoung-Woo 대한암한의학회 2003 大韓癌韓醫學會誌 Vol.9 No.1

Objective : Ikiyangeumhaedoc-tang(IYHT) has an effect of nourishing Yin(陰) and Jin(津), and has been used to cancer patient effectively. In order to prove the anticancer's and antimetastic effect of IYHT experimentally, studies were done. Methods : We evaluated the cytotoxic activity on HT-1080 cells as well as inhibitory effect on activity of DNA topoisomerase Ⅰ, cell adhesion, cell invasion and proliferation of HUVEC cells induced by bFGF and measured the expression of mRNA(uPA, MMP2, TIMP2), p-ERK protein, recovery effect of gap junctional intercellular communication by $H_{2}O_2$ and survival time of ICR mice bearing sacoma-180. Results : IYHT showed the inhibitory effect on DNA topoisomerase Ⅰ in the concentration of $100{\mu}g/ml,\;500{\mu}g/ml$ and the dosage-dependent inhibitory effect on the adhesion of HT-1080. The concentration of 1mg/ml of IYHT inhibited 15% of adhesion compared with control. IYHT decreased the expression of uPA, but not in MMP2, TIMP2 by RT-PCR and inhibited the expression of p-ERK effectively in the concentration of more than $500{\mu}g/ml.$ IYHT recovered the inhibited gap junctional intercellular communication by $H_{2}O_2$ to the level of 60% of normal control in the concentration of $400{\mu}g/ml$ but, did not extended the mean survival time of sarcoma 180-bearing mouse. Conclusions : It was concluded that IYHT could be applied usefully for prevention and treatment of human cancer, And also experimental study for the evaluation of molecular biological study and antimetastatic research would be recommended in the near future.

보두(寶豆)의 수치법(修治法)에 따른 독성(毒性) 및 소화기계(消化器系)에 미치는 영향(影響)

김진성,윤상협,류봉하,류기원,조유경,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Cho, Yu-Kyung 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Objective : These experiments were designed to investigate the effects of Strychni Ignatii Semen on the gastrointestinal system and declining of toxicity. About experiments of acute toxicity, I investigated the quantity of Strychni $(C_{21}H_{22}N_2O_2)\;and\;LD_{50}$. In order to study the effects on gastrointestinal tract, I investigated the changes of gastric juice, discharging level of pepsin, inhibiting effects of ulceration, and transporting of intestine. Methods : Sample I : No making Strychni Ignatii Semen Sample II : Depositing for three days in water and then dry it. Sample III : Depositing for one hour in sesame oil and bum it. The results were as follows : 1. The average values of Strychnine decreased in Sample III. 2. The levels of $LD_{50}$ increased in Sample Ⅲ by about 70%. 3. In Sample III, inhibiting effects of ulceration and discharging level of pepsin were great. 4. In the level of gastric juice decreased in Sample I.II.III. 5. The transporting ability of large intestine elevated in Sample I.II.III. According to the results, making Strychni Ignatii Semen, especially Sample 3, toxicity decreased and has good effects on the gastrointestinal system.

종양의 예방과 치료를 위한 식이요법 -위암을 중심으로-

김진성,류봉하,박동원,류기원,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Gi-Won 대한암한의학회 1995 大韓癌韓醫學會誌 Vol.1 No.1

은화사간탕(銀花瀉肝湯)과 은화사간탕가녹용(銀花瀉肝湯加鹿茸)의 항암효과(抗癌效果)와 면역반응(免疫反應)에 관(關)한 연구(硏究)

김진성,류봉하,박동원,류기원,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Gi-Won 대한암한의학회 1997 大韓癌韓醫學會誌 Vol.3 No.1

This study was performed to investigate the effects of Eunwhasagantang and Eunwhasagantangganokyong on the viability of tumor cells in vitro(MTT assay), on antitumor effects after Sarcoma-180 cells transplantation into the peritoneal cavity or left groin, and on decreased immune responses in mice induced by methotrexate. The extracts of its herbal medicines were orally administered for 14 or 21 days. To evaluate the effects of the Eunwhasagantang and Eunwhasagantangganokyong many items such as 50% inhibitory concentration($IC_{50}$), mean survival days, tumor and body weight for antitumor effects, and delayed type hypersensitivity, hemagglutinin titer, hemolysin titer, rosette forming cells, natural killer cell activity, lymphocyte transformation, productivity of interleukin-2 and phagocytic activity for immune responses were measured in ICR mice. The results were obtained as follows; 1. $IC_{50}$ of Eunwhasagantang treated group was 0.000204mg/ml on SNU-396 and that of Eunwhasagantangganokyong treated group was 0.000103mg/ml on SNU-1, those results indicate that the medicine has high antitumor activity. 2. Mean survival times in Eunwhasagantang and Eunwhasagantangganokyong treated groups were slightly increased with no significance, as compared with the control group. 3. Tumor weight in Eunwhasagantang and Eunwhasagantangganokyong treated group was depressed, as compared with the control group(p<0.01). 4. Body weight in Eunwhasagantang and Eunwhasagantangganokyong treated group was significantly increased, as compared with the control group(p<0.05). 5. Delayed type hypersensitivity in Eunwhasagantang and Eunwhasagantang-ganokyong treated group was slightly decreased with no significance, as compared with the control group. 6. Hemagglutinin titer in Eunwhasagantang and Eunwhasagantangganokyong treated group was slightly increased with no significance, as compared with the control group. 7. Hemolysin titer only in Eunwhasagantang treated group was significantly increased, as compared with the control group(p<0.01). 8. Rosette forming cells only in Eunwhasagantangganokyong treated group was slightly increased with no significance, as compared with the control group. 9. In the NK cell activity, the ratio of effector cells and target cells of the Eunwhasagantang treated group was significantly increased(p<0.01) in case which the ratio was 100: 1, and that of the Eunwhasagantangganokyong treated group was significantly increased(P<.01, p<0.05) in case which the ratio was 100:1, 50:1, as compared with the control group. 10. Lymphocyte trasnformation in Eunwhasagantang and Eunwhasagantangganokyong treated group was significantly increased, as compared with the control group(p<0.01). 11. Interleukin-2 in Eunwhasagantang and Eunwhasagantangganokyong treated group was significantly increased, as compared with the control group(p<0.05, p<0.01). 12. Phagocytic activity in Eunwhasagantang and Eunwhasagantangganokyong treated group was significantly increased, as compared with the control group(p<0.05). According to the above results, it could be suggested that Eunwhasagantang and Eunwhasagantangganokyong have prominent antitumor effects, and enhance both cellular and humoral immunity.

반모가 수종의 인체 암세포에 미치는 영향

김진성,윤상협,류봉하,류기원,정명채,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Jung, Myung-Chai 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

Object : Objective: This study was conducted to investigate the anti-cancer effects of Mylabris phalerata (반모) in some kinds of cancer cells. Materials and Methods: Some kinds of cancer cells lines were treated. We used nine kinds of cancer cell lines, such as stomach cancer cells (Kato), lung cancer cells (Calu-1, NCI-H 1395), urinary bladder cancer cells (HS789T), bone cancer cells (Saos-2), brain cancer cells (SK-N-MC), liver cancer cells (Hep-G2), skin cancer cells (Mo-1) and prostate cancer cells (PC-3) with the water decoction of Mylabris phalerata. The histological changes of all cell lines in the media (RPMI-1640) containing the decoction of Mylabris phalerata were observed and we examined cell death assay by trypan blue exclusion testing was examined. Finally, the change of mitochondrial membrane potential was measurd and the inhibitory effect of Mylabris phalerata on cell increase was examined by analyzing the cell cycle. Results: In histologic change all cancer cell lines showed withdrawn and floating appearance that is typical in cellular impairment. Most of the cell lines showed over 50% death rate after 24 hours in trypan blue exclusion tests. Especially the stomach, urinary bladder. brain and liver cell lines showed over 30% death rate after 12 hours. All cell lines treated with Mylabris phalerata were less stained than the control group and the mitochondrial membrane potential in the Mylabris phalerata treated cell lines was markedly lower than that in the control group. The measurement of DNA quantity in all cell lines showed the disappearance of the peak and the thickened left axis, which suggests that all cellular DNA degraded. Conclusion: Mylabris phalerata had cytotoxicity on various kinds of cancer cell lines and the mechanism of that was the impairment of mitochondria by the breakdown of the mitochondrial cell membrane. We propose that this is in part attributable to the destruction of DNA in cancer cells.

영상유도 양성자치료를 위한 콘빔 CT 재구성 알고리즘: 기하학적 보정방법에 관한 연구

김진성,조민국,조영빈,윤한빈,김호경,윤명근,신동호,이세병,이레나,박성용,조관호,Kim, Jin-Sung,Cho, Min-Kook,Cho, Young-Bin,Youn, Han-Bean,Kim, Ho-Kyung,Yoon, Myoung-Geun,Shin, Dong-Ho,Lee, Se-Byeung,Lee, Re-Na,Park, Sung-Yong,Cho, Kwan- 한국의학물리학회 2008 의학물리 Vol.19 No.4

IMRT, 양성자 치료와 같이 방사선 치료 기술이 발전할수록 치료 시 환자의 위치를 확인하고 그 정확성을 평가하는 기술의 중요성이 강조되고 있다. 현재 국립암센터 양성자치료센터에 설치되어 있는 양성자 치료기의 단순 X-선 영상시스템을 이용하여 콘빔 CT (cone-beam CT) 3차원 영상을 획득, 영상유도 방사선 치료의 가능성을 확인하고자 하였다. 양성자 치료기에 설치되어있는 X-선 영상시스템(SDD: 2,108 mm, SOD: 1,511 mm, Varian a277 x-ray tube & Varian Paxscan 4030: a-Si+DRZ screen)을 이용하여 양성자 갠트리를 $2^{\circ}$씩 회전시켜가면서 기하학적인 오차 측정을 위한 팬톰과 인체 팬톰 (Humanoid phantom, Rando, CA, USA)의 투사영상을 획득하였다. 현재 시스템적으로 연속적인 회전과 영상획득이 지원되지 않아서 영상획득 후 갠트리를 회전하는 방법으로 투사영상을 획득하였다. 기하학적 오차측정을 위한 팬텀과 두경부 팬텀에 대해서 $360^{\circ}$를 회전하며 180장의 투사영상($2,304{\times}3,200$, 14 bit with 127${\mu}m$ pixel pitch)을 관전압 85 kVp, 관전류 80 mA, 조사시간 0.5 s의 조건으로 촬영하였다. 콘빔 CT 영상재구성을 위해 Ram-Lak filter를 적용한 Feldkamp cone-beam 알고리즘을 사용하였으며, 획득한 180장의 투사영상을 사용하여 $0.4{\times}0.4{\times}0.4mm^3$의 voxel size를 가진 $512{\times}512{\times}512$ CT영상을 재구성하였다. 기하학적인 오차 측정방법을 통해 X-선 선원, 검출기와 갠트리의 기하학적 정보를 측정하였다. 측정된 결과에 의하면 검출기가 $0.25^{\circ}$ 회전된 오차를 보이는 것을 발견하였다. 기하학적 교정으로 재구성된 콘빔 CT 영상을 multi-planar view (axial, sagittal and coronal view) 및 3차원 영상으로 재구성하여 비교 평가 하였다. 현재 양성자치료기에 설치되어있는 단순 X-선 영상 시스템에서 기하학적 오차 측정을 위한 볼 팬텀을 이용하여 시스템의 오차를 측정하였다. 측정한 오차를 바탕으로 기하학적 교정을 통해서 두경부 및 복부 팬텀에 대한 3차원 영상인 콘빔 CT 영상들을 재구성하였다. 추후 연속적인 회전을 통한 영상획득이 가능하게 된다면, 보다 정확하고 신속한 영상재구성이 가능 하며 콘빔 CT가 영상유도 양성자 치료에 매우 유용할 것으로 사려된다. According to improved radiation therapy technology such as IMRT and proton therapy, the accuracy of patient alignment system is more emphasized and IGRT is dominated research field in radiation oncology. We proposed to study the feasibility of cone-beam CT system using simple x-ray imaging systems for image guided proton therapy at National Cancer Center. 180 projection views ($2,304{\times}3,200$, 14 bit with 127 ${\mu}m$ pixel pitch) for the geometrical calibration phantom and humanoid phantoms (skull, abdomen) were acquired with $2^{\circ}$ step angle using x-ray imaging system of proton therapy gantry room ($360^{\circ}$ for 1 rotation). The geometrical calibration was performed for misalignments between the x-ray source and the flat-panel detector, such as distances and slanted angle using available algorithm. With the geometrically calibrated projection view, Feldkamp cone-beam algorithm using Ram-Lak filter was implemented for CBCT reconstruction images for skull and abdomen phantom. The distance from x-ray source to the gantry isocenter, the distance from the flat panel to the isocenter were calculated as 1,517.5 mm, 591.12 mm and the rotated angle of flat panel detector around x-ray beam axis was considered as $0.25^{\circ}$. It was observed that the blurring artifacts, originated from the rotation of the detector, in the reconstructed toomographs were significantly reduced after the geometrical calibration. The demonstrated CBCT images for the skull and abdomen phantoms are very promising. We performed the geometrical calibration of the large gantry rotation system with simple x-ray imaging devices for CBCT reconstruction. The CBCT system for proton therapy will be used as a main patient alignment system for image guided proton therapy.