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돼지 관상동맥 스텐트 재협착에 대한 Endothelin 수용체 차단제 국소 전달요법의 효과
김진우(Jin Woo Kim),강정채(Jung Chaee Kang),박창수(Chang Soo Park),김완(Wan Kim),정명호(Myung Ho Jeong),김용록(Yong Rok Kim),조장현(Jang Hyun Cho),김주한(Ju Han Kim),김성희(Sung Hee Kim),배열,안영근(Young Keun Ahn),박주형(Joo Hyung Pa 대한내과학회 1999 대한내과학회지 Vol.56 No.6
N/A Objectives : Coronary stent is one of the most effective currently available devices in the treatment of coronary artery diseases. But, coronary stent restenosis is one of major limitations in clinical stenting. Local drug delivery may be a new strategy for the prevention of stent restenosis. Endothelin receptor blocker is known to have vasodilatory and antiproliferative activities. To investigate the effects of local endothelin receptor blocker delivery on stent restenosis, local delivery was performed in the porcine model of coronary stent restenosis. Methods : Stent overdilation injury alone was performed in the control porcine coronary arteries (n=4, group A) and local delivery of endothelin receptor blocker prior to stenting was performed in the porcine coronary artery (n=9, group B). Endothelin receptor blocker (TAK-044, Takeda, Japan) was delivered at a rate of 1 ml/min (50 mg/10 ml) using the Dispatch Catheter. Follow-up quantitative coronary angiogram (QCA) and immunohistopathologic assessment were performed 4 weeks after stenting. Results : 1) On QCA, percent diameter stenosis was significantly higher in Group A than in Group B (29.4±6.1 % vs. 14.5±11.6%, p<0.05). 2) Area stenosis was higher in Group A than in Group B (63.5±23.2 % vs. 40.9±13.3 %) measured by histopathologic method (p<0.05). 3) Neointimal area was higher in Group A than in Group B (3.53±1.9 mm2 vs. 1.75±0.8 mm2, p=0.03). 4) By immunocytochemistry, proliferating cell nuclear antigen index was higher in Group A compared with Group B (46.8±5.2 % vs. 31.1±3.7 %, p<0.05). Conclusion : Local delivery of endothelin receptor blocker is effective in the prevention of stent restenosis in a porcine model, which may be related with the partial inhibition of cell proliferation of neointimal cells.
AAO Template를 이용한 Au/TiO<sub>2</sub> 나노섬유 제조 및 응용에 관한 연구
엄선미,박상선,김영덕,김용록,설용건,Eom, Seon-Mi,Park, Sang-Sun,Kim, Young-Deok,Kim, Yong-Rok,Shul, Yong-Gun 한국전기화학회 2009 한국전기화학회지 Vol.12 No.1
본 연구에서는 불순물이 포함된 Al 기판으로부터 두 단계의 양극산화 (anodization) 법에 의해 균일한 나노기공을 갖는 AAO(Anodic Aluminum Oxide)을 제조하였다. 생성된 AAO템플릿 위에 Deposition-Precipitation(DP)방법을 사용하여 수직으로 형성된 $TiO_2$ 나노섬유에 Au를 첨가시켜 2 wt.% $Au/TiO_2$ 나노섬유룰 제조하였다. 두 단계의 양극산화를 통해 규칙적으로 배열된 AAO 기공 형상과 기판 위에 수직으로 배향된 $TiO_2$ 나노섬유의 형상을 SEM을 통해 확인하였다. 또한 $Au/TiO_2$ 나노섬유의 특성은 XRD와 Raman 분석을 통하여 $TiO_2$의 아나타제(anatase)와 루타일(rutile) 결정구조와 $TiO_2$ 나노섬유에 담지된 Au의 존재를 확인하였다. 또한 일산화탄소(CO) 산화반응을 통해 AAO(Anodic Aluminum Oxide)기판 위에 형성된 $TiO_2$와 2 wt% $Au/TiO_2$ 나노섬유의 광촉매적 활성을 비교하였다. In this study, highly ordered AAO (Anodic Aluminum Oxide) with nanopores was prepared by commercial grade Al substrate containing 3.5 wt.% impurities through two step anodizing method. Nanopores of prepared AAO arrays were used as templates for preparing nanofiber. $TiO_2$ was deposited by using DP (deposition-precipitation) method into AAO pores to grow nanofiber. Au particles were loaded on this $TiO_2$ nanofiber which was grown vertically. Prepared 2 wt.% $Au/TiO_2$ nanofiber was characterized by XRD, SEM and Raman. The crystal structure was analyzed by the XRD. SEM was used to observe pore size and pore wall thickness. Photocatalytic activity of co-oxidation was compared with $TiO_2$ and $Au/TiO_2$ nanofiber on AAO arrays.
김규홍,김용록,김용배,이성한,최재시 연세대학교 자연과학연구소 1982 學術論文集 Vol.9 No.-
0.1, o.8 및 1.2mol% CdO-La_2O_3 계의 전기전도도를 500∼900℃ 및 10^-7∼10^-1atm의 산소분압하에서 측정하였다. 일정한 산소분압하에서 logσ vs. 1/T 도시는 직선관계를 보여 주었고 직선의 기울기에서 구한 활성화에너지는 0.96∼0.97eV이다. 500∼900℃ 영역에서 logσ vs. log Po_2 도시결과는 직선 관계를 나타내었으며 전기전도도의 산소분압 의존성은 σ∞Po_2^¼이다. CdO-La_2O_3계의 결함구조는 V_la^´´´과 Vo¨의 혼합형으로 사료되며, 전기전도도의 온도의존성과 산소분압의존성으로부터 혼합형의 결함구조 반응식을 규명하였다. CkO-La_2O_3계의 전기전도메카니즘을 결함구조 반응식으로부터 규명하였다. Electrical conductivity of CdO-La_2O_3 system containing 0.1, 0.8, and 1.2 mol% of CdO were measured from 500 to 900℃ at an oxygen partial pressures of 10^-7 to 10^-1 atm. Plots of log σ vs. 1/T at constant Po_2 are found to be linear and the activation energy appears to be 0.96-0.97eV. The log σ vs. log Po_2 are found to be linear at oxygen pressures (Po_2's) of 10^-7 to 10^-1 atm and at 500∼900℃. The conductivity dependence on Po_2 at the above temperature range is given by σ∞Po_2^¼. The defect structure in this system are believed to be complex, i.e., V_la^´´´ and Vo¨. The interpretations of conductivity dependence on temperature and Po_2 are presented and conduction mechanism is proposed to explain the data.
김영진,김완,이숭,김윤미,명재일,강헌석,백종철,김용록 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.4
Primary adenocarcinoma of the duodenum is a rare disease, representing 0.35% of all gastrointestinal neoplasm and 0.042% of all malignant neoplasm. Since Ham-burger described the first duodenal caricinoma in 1746, the incidence has shown an increasing tendency. Compared with upper gastrointestinal contrast studies, the gastroduodenoscopy has gained an increasing popularity as an invesitigative tool in recent years. But the diagnosis is usually made at a very late stage because the symptoms are often non-specific, which contributes to delayed diagonsiss and poorer prognosis. We have experienced two cases of the primary carcinoma of the duodenal bulb and one case of carcinoma of the second portion, which were diagnosed by biopsy with gastrofiberoscopic endoscopy and operative finding. So we report three csses with a brief review of literature.