고지방식이로 비만을 유도한 C57BL/6 마우스에서 SM17의 항산화 및 항비만 효과

김수현,김수지,김경조,이아름,노성수,이영철,Kim, Soo Hyun,Kim, Su Ji,Kim, Kyeong Jo,Lee, Ah Reum,Roh, Seong-Soo,Lee, Young Cheol 대한본초학회 2017 大韓本草學會誌 Vol.32 No.5

Objectives : Obesity is caused by the excess accumulation of fat in the body due to energy imbalance, and it causes various diseases. The aim of this study was to investigate an anti-obesity efficacy and an antioxidant activity of water from herbal mixture extract (SM17). Methods : The antioxidant activities were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals. To evaluated anti-obesity effect of SM17, we used a high fat diet fed mouse model. The SM17 (150 mg/kg body weight/day, p.o.) was treated every day for 6 weeks to C57BL/6 mice. Body weight and food intake were measured every day. The changes of reactive oxygen species (ROS), alanine aminotransferanse (ALT), aspartate aminotransferase (AST), triglycerids (TG) and total cholesterol (TC) in serum were analyzed after experiment. Also, expression of lipid metabolism related proteins were investigated by western blot analysis. Results : It was effective in antioxidant measurements, SM17 administration inhibited the biomarkers of lipid metaboism in serum and tissues. The administration of SM17 showed a significant reduction of body and tissue weight. Morever, it decreased ROS, ALT, AST, TG and TC in serum, compared with those of the obese mice. Adipogenesis-related protein expressions increased in obese mice compared to normal mice. However, SM17 group exhibited the down-expression of these proteins. Conclusion : A SM17 aqueous extract has a great effect on the stimulation (AMPK) activation, and may have a benefit to reduce a fatty acid metabolism through inhibition of lipid accumulation.

헤모필루스 인플루엔자 기관염이 확인되면서 진단된 혈관륜 1례

김수현,정윤숙,오성희,김남수,김혁,Kim, Su Hyun,Chung, Yoon Sook,Oh, Sung Hee,Kim, Nam Su,Kim, Hyuck 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.2

저자들은 출생 후 호흡기 증상이 지속되어 오던 여아가 respiratory syncytial virus와 b형 헤모필루스 인플루엔자균에 의한 하기도 감염에 이환되면서 생후 4개월에 혈관륜으로 진단된 1예를 보고하는 바이다. 환아는 출생 후 협착음과 천명음 등의 잦은 호흡기 증상을 보였고, 3개월에 호흡 곤란을 주소로 입원하였으며 respiratory syncytial virus에 의한 세기관지염으로 치료받고 호전되었다. 퇴원 후 증상이 다시 악화되어 재입원 하였으며 b형 헤모필루스 인플루엔자균에 의한 기관염 및 폐렴이 확인되었고, 치료를 위해 기관내 튜브에 도관 삽입을 시도하였을 때 하부 기도에서 저항감이 감지되어 기도 부위의 해부학적 기형을 의심하게 되었다. 3차원 흉부 단층 촬영에서 이중 대동맥궁으로 인한 혈관륜이 확인되었고, 교정 수술을 시행한 후 좋은 경과를 보이고 있다. Vascular ring, originating from abnormal regression of the aortic arch during fetal life, can cause prolonged and recurrent respiratory symptoms and dysphagia when the diagnosis is delayed. We report a 4 month old girl with vascular ring, who had been treated for persistent respiratory symptoms including stridor, wheezing, and dyspnea soon after birth. Initially her respiratory symptoms were thought to be due to bronchiolitis, for which respiratory syncytial virus was confirmed by immunofluorescent staining. Her clinical course was again complicated with tracheitis and pneumonia due to Haemophilus influenzae type b. The possibility of anatomical anomaly was investigated when it was felt to be difficult to insert a suction catheter deep down through a endotracheal tube which was placed for adequate ventilatory management. A three-dimensional chest CT revealed a vascular ring consisting of a double aortic arch. For 5 months following surgery, her respiratory symptoms have slowly been improving. She developed another episode of pneumonia which was milder than the one which occurred before the surgery.

Tcf3 Function Is Required for the Inhibition of Oligodendroglial Fate Specification in the Spinal Cord of Zebrafish Embryos

김수현,정아영,Dohyun Kim,Young-Seop Kim,Hyung-Seok Kim,Hyung-Wook Kwon,Tae-Lin Huh,박해철 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.4

The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial fate specification is mediated in-dependently of canonical Wnt signaling. Altogether, these results show a novel function for Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord.

새로운 n형 고분자인 DFPP 기반의 MEH-PPV/DFPP Blend 소자의 광전특성

김수현,문지선,이재우,이석,김선호,변영태,김동영,이창진,김유진,정영철,이긍원,Kim, Su-Hyun,Moon, Ji-Sun,Lee, Jae-Woo,Lee, Seok,Kim, Sun-Ho,Byun, Young-Tae,Kim, Dong-Young,Lee, Chang-Jin,Kim, Eu-Gene,Chung, Young-Chul,Rie, Kung-Won 한국광학회 2006 한국광학회지 Vol.17 No.5

Optical characteristics in polymer films of MEH-PPV/DFPP blends were for the first time investigated. DFPP (N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide) used here was a novel n-type polymer, which had good stability in air and solubility in common solvents. For a 1:9 DFPP:MEH-PPV blend, highly efficient quenching of photoluminescence (PL) was observed. In addition, the photocurrent responses of these MEH-PPV/DFPP photovoltaic cells were measured. When the light intensity was $50mW/cm^2$, short-circuit photocurrent densities were two times higher than those of single layer MEH-PPV devices. MEH-PPV/DFPP 혼합물의 고분자 박막에서 광학적 특성들이 최초로 조사되었다. 여기서 사용된 BFPP(N, N'-diperfluorophenyl-3,4,9,10-perylenetetracarboxylic diimide)는 새로운 n형 고분자인데 공기 중에서 안정성이 우수하고 일반 용매에서 잘 용해되었다. 1:19 DFPP:MEH-PPV 혼합물의 경우 매우 효율적인 형광소멸이 관측되었다. 더불어 이 MEH-PPV/DFPP 광전 셀의 광전류 응답특성들이 측정되었다. 빛의 세기가 $50mW/cm^2$일 때 단락전류 밀도는 단일 층의 MEH-PPV 소자들보다 2배 이상 되었다.

착한기업 이미지가 구매에 영향을 미치는가?: 착한기업 이미지와 구매의도 간의 관계에 미치는 기업-소비자 동일시 매개효과 중심으로

김수현(Kim, Soo Hyun),최은정(Choi, Eun Jung) 한국소비문화학회 2017 소비문화연구 Vol.20 No.2

최근 우리 사회 전체에 사회적 가치를 창출하고 공유하는 ‘착한소비’에 대한 관심이 높아졌다. 기업의 사회적 책임활동(CSR)과 공유가치창출(CSV)의 정의에 대한 논쟁과 함께 착한기업에 대한 관심 또한 높아졌으나, 실제 착한기업 이미지에 대한 학술적 연구는 전무 하다시피 하다. 따라서 본 연구 목표는 첫째, 착한기업 이미지의 세부 구성차원을 밝히고, 둘째, 착한기업 이미지와 기업에 대한 태도, 구매 의도와 같은 마케팅 관점의 성과 변수와의 역학관계를 밝히고자 했다. 이를 위해 본 연구는 연구1과 연구2를 진행하였다. 일반 소비자 대상의 서베이를 통해 수집된 자료를 분석한 결과, 연구1에서는 김수현과 최은정(2014)의 착한기업 이미지의 탐색적 정성연구 결과를 기반으로 소비자 관점에서 착한기업 이미지를 구성하는 하위 세부 구성 요소로써 (1) 윤리성, (2) 소통관계 성, (3) 시장경쟁력, (4) 혁신리더쉽, (5) 진정성 및 자발성을 밝혀냈다. 연구2에서는 파악된 착한기업 이미지의 세부 구성요소가 구매의도 및 기업에 대한 태도에 어떤 영향을 미치는가를 분석하였다. 그 결과 착한기업의 이미지 중 ‘윤리성’과 ‘혁신리더십’을 제외한 ‘소통관계성’, ‘시장경쟁력’, ‘진정성 및 자발성’ 요인이 기업-소비자 동일시에 긍정적인 영향을 미쳤다. 그리고 기업-소비자 동일시는 착한기업에 대한 태도와 구매 의도에 긍정적인 영향을 미쳤다. 마지막으로 대안모델들을 개발하여 추가 분석 통해 기업-소비자 동일시의 매개효과 여부를 진단하였다. 본 연구모델과 대안모델을 비교한 결과, 착한기업 이미지는 기업성과에 직접적 효과는 없었으며 기업-소비자 동일 시를 통해 간접적으로 착한기업에 대한 태도 및 구매의도를 증대시키는 것으로 파악되었다. 착한기업 이미지가 기업 태도 및 구매의도에 미치는 정의 관계에서 기업-소비자 동일시가 중요한 매개변수로써 작동하는 역학관계를 밝혀낸 것이다. 본 연구는 소비자 관점의 착한기업 이미지에 대한 매우 초기 연구로써, 착한기업의 이미지 세부 구성요소를 밝히고, 이들과 마케팅 성과들과의 역학적 관계를 밝혔다는 점에서 이론적 공헌이 크다. 이를 기반으로본 연구는 기업들의 CSR, CSV 활동에 시사점을 제공하였다. Recently, as the interest in creating social values which share all over our society increases. Good companies have taken an attention in the situation debating CSV and CSR, but there exist little academic research about good company images from an academic research perspective. Therefore, the purposes of this study are firstly to explore sub-constructs of good company image, and secondly to find a mechanism among sub-constructs of good company image and marketing performance like company attitude, and purchase intention. This study did Research 1 and Research 2 by analyzing data obtained from general consumers. Based on Kim and Choi (2014)’s exploratory qualitative research about good company image, Research 1 found subconstructs of good company image: (1)ethnic; (2)communication and relationship; (3) economics; (4) innovation and vision clarity; and (5) authenticity and voluntary Research 2 examined how these sub-constructs of good company image affect attitude toward company and purchase intention. It also found that except ‘ethic’ among these images about good company, ‘communication and relationship,’ ‘economics,’ and ‘authenticity and voluntary’ positively affected companyconsumer identification. Also, company-consumer identification affected attitude toward good companies and the purchase intention positively. Lastly, this study confirmed the mediating effect of company-consumer identification on between good company images and attitude toward company and purchase intention by developing substitute models and additional analysis. According to the comparison between the original research model and these substitute models,the good company image did not improve consumers’ attitude toward good companies and purchase intention directly. Instead, company-consumer identification mediated the positive relationship between good company images and marketing performance. That is, this research found the mechanism mediating by company-consumer identification between the positive relationship between good company images and the marketing performances. This research is an exploratory study uncovering sub-constructs of images about good company. It provides a theoretical contribution in that this research found the mechanism between these sub-constructs and company marketing performances. Based on the results, this study provides some managerial implications about CSR and CSV activities.

고지방식이로 비만을 유도한 C57BL/6 마우스에서 SM17의 항산화 및 항비만 효과 : 정오표

김수현,김수지,김경조,이아름,노성수,이영철,Kim, Su-Hyeon,Kim, Su-Ji,Kim, Gyeong-Jo,Lee, A-Reum,No, Seong-Su,Lee, Yeong-Cheol 대한본초학회 2017 大韓本草學會誌 Vol.32 No.6

흉선에 생긴 carcinoid tumor;1례 보고

김수현,이정철,한승세,Kim, Su-Hyeon,Lee, Jeong-Cheol,Han, Seung-Se 대한흉부심장혈관외과학회 1992 Journal of Chest Surgery (J Chest Surg) Vol.25 No.11

Carcinoid tumors arising in the thymus are rare. Since Rosai and Higa in 1972 distinguished these neoplasms from thymomas, fewer than 100 cases have been reported in the world literature. The pathologic diagnosis of thymic carcinoids is been on findings from light microscopy, histochemical studies, and electron microscopy. About 50% of thymic carcinoids are seen with endocrinopathies. Recurrence and extrathoracic metastasis are characteristic of thymic carcinoids. Surgical extirpation of the tumor initially and of the subseguent recurrences in the most effective treatment today The role of adjuvant radiotherapy and chemotherapy is still uncertain. Herein we report a case of thymic carcinoid tumor in a 36-year old male with brief review of literatures.

의료용 섬유

김수현,김영하,안광덕(Soo Hyun Kim),Young Ha Kim,Kwang Duk Ahn 한국고분자학회 1996 고분자 과학과 기술 Vol.7 No.2

VOICE COIL ACTUATED (VCA) ENGINE MOUNT FOR VIBRATION REDUCTION IN AUTOMOBILE

김수현,Un Hwan Park,Jin Ho Kim 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.3

The purpose of this paper is to design and test the voice coil actuated (VCA) engine mount for vibration reduction in automobile. Due to the VCA engine mount generates a counter force to cancel the abnormal vibration generated when the variable cylinder is working, it is widely known one of the effective methods for reducing vibration delivered by the engine. To reduce the vibration efficiently, the VCA engine mount needs to have fast response, wide range of frequency and large excitation force. In this research, we present a VCA engine mount. Lumped parameter modeling and analysis of the VCA engine mount is performed to theoretical analysis. The dynamic performance of the VCA engine mount such as magnetic force, spring force, displacement and excitation force was verified by finite element analysis (FEA). After manufacturing a prototype, excitation force is experimentally investigated.

고전압맥동전류가 통각과민 백서의 통각역치 및 유해성 굴곡반사에 미치는 영향

김수현,문달주,최석주,정대인,이정우,정진규,김태열,Kim, Su-Hyon,Moon, Dal-Ju,Choi, Sug-Ju,Jung, Dae-In,Lee, Jung-Woo,Jeong, Jin-Gyu,Kim, Tae-Youl 대한물리치료학회 2006 대한물리치료학회지 Vol.18 No.2

Purpose: This study conducted quantitative sensory test and nociceptive flexion reflex(NFR) measurement to examine degree of pain depending on polarity of high voltage pulsed current(HVPC) of hyperalgesia site in hyperalgesia rat by local thermal injury. mechanical pain threshold, thermal pain threshold and root mean square of NFR were measured. Methods: This study was conducted with control group I of hyperalgesia rat at hind paw by thermal injury and experimental groups divided into cathodal HVPC group II, anodal HVPC group III and alternate HVPC group IV. It measured pain threshold and root mean square(RMS) of NFR and obtained the following results. Results: Mechanical pain threshold of hyperalgeisa site was significantly increased at groups II, III and IV applying HVPC group compared to control group, but there was no difference among HVPC groups. Thermal pain threshold of hyperalgesia site showed a significant increase in group II. Group III showed significant difference after 4 days of hyperalgesia. RMS of NFR at hyperalgeisa site was significantly reduced in group II after 2 days of hyperalgesia. Group III showed significant decrease after 5 and 6 days of hyperalgesia. Conclusion: Consequently it was found that application of HVPC of hyperalgesia site increased pain threshold at hyperalgesia site by mechanical stimuli and thermal stimuli. NFR by electrical stimuli was similar to pain threshold by mechanical stimuli. Effects by polarity of HVPC showed the greatest reduction of hyperalgesia when cathodal electrode was used.