휴대인터넷 시스템 셀 설계 방식에 관한 연구

김명민 ( Myoung Min Kim ),홍인기 ( Een Kee Hong ) 한국항행학회 2005 韓國航行學會論文誌 Vol.9 No.1

역상 고속액체크로마토그라프법을 이용한 혈장 및 뇨중 로바스타틴의 정량

최혜진(Hye Jin Choi),김명민(Myoung Min Kim),최경업(Kyung Eob Choi) 大韓藥學會 1998 약학회지 Vol.42 No.5

Lovastatin (LOVA), a fungal metabolite isolated from cultures of Aspergillus terreus, is a competitive HMG-CoA reductase inhibitor used for the treatment of primary hypercholesterolemia, and has also been shown to suppress growth in a variety of non-glioma tumor cell lines. A sensitive reversed-phase high-perfonnance liquid chromatographic method with ultraviolet (UV) absorbance detection has been developed to quantitate LOVA in human plasma and urine samples using liquid-liquid extraction procedure. Baseline separation of LOVA and internal standard, simvastatin was achieved on a Novapak C18 analytical column with a mobile phase containing 0.025M NaH2PO4: CAN (35:65, v/v%), adjusted pH to 4.5. The flow rate was set at 1.5ml/min, and the column effluent was monitored by a UV detection at 238nm. The limit of quantification was determined to be 0.5mcg/ml while extraction efficiency of LOVA ranged from 73.4-82.9% at LOVA concentrations of 0.5 to 10mcg/ml. Good linearity with correlation coefficients greater than 0.999 was obtained in the range of LOVA concentrations from 0.5 to 10mcg/ml. The accuracy and the precision were proven excellent with relative standard deviation (RSD, %) and relative error (RE, %) of less than 4.2 and 4.0, respectively. Intraday precision, evaluated at five LOVA concentrations (0.5, 1, 2, 5, 10mcg/ml) and expressed as RSD ranged from 0-1.82% while the interday precision at the same concentrations ranged from 0.7-10.5%. The analytical method described was then successfully employed for the determination of LOVA concentrations in plasma samples obtained during a phase II clinical trial using high doses of LOVA (30-40mg/kg/day). This method could be further utilized for the ongoing pharmacolkinetic studies and therapeutic drug monitoring of the high-dose LOVA therapy in adenocarcinoma patients.

흰쥐에서의 Fluoroquinolone계 항균제 농도와 광독성의 상관관계

최경업 ( Kyung Eob Choi ),정지은 ( Jee Eun Chung ),김명민 ( Myoung Min Kim ) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.4

건선에서의 전신 Bath-8-MOP-UVA의 치료효과

정찬우(Chan Woo Jeong),이일수(Eil Soo Lee),여운철(Un Cheol Yeo),박수홍(Soo Hong Park),김명민(Myoung Min Kim),복혜숙(Hae Sook Bok) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.6

Background:An alternative approach to oral PUVA therapy for psoriasis, psoralen bath plus UVA therapy(bath PUVA therapy) that avoids the adverse effects associated with oral PUVA therapy has increasingly been used during recent years. Objective:This study was performed to evaluate the efficacy and safety of bath-8-MOP-UVA therapy in the treatment of psoriasis. Methods:Twenty patients were enrolled in this study after determination of the minimal phototoxic doses(MPD). We evaluated the total treatment number, duration, final UVA dose and total cumulative UVA dose of bath-8-MOP-UVA therapy to reach grade 4 response and categorized each patient into clearing, improvement, or failure groups based on the therapeutic efficacy. We measured the PASI score at two week intervals. Blood samples were obtained from all twenty patients 2 hours after bath-8-MOP and plasma levels of 8-MOP were quantified by a reverse phase high performance liquid chromatography. Results:The following results were obtained from this study. 1. Phototoxicity testing with bath-8-MOP-UVA elicited mean MPD value of 3.5±1.3J/㎠. 2. The mean PASI score at 10 weeks was significantly decreased to 5.8±1.3 from baseline PASI score 20.1±4.3. 3. Among 20 patients, clearing was shown in 13 patients(65%), 6 patients(30%) were improved and 1 patients(5%) showed failure. 4. In clearing and improvement groups, the mean treatment number, duration, final dose of UVA and total cumulative UVA dose reaching grade 4 were 19.3±5.4, 49.9±13.5days, 5.2±1.3J/㎠ and 68.6±30.1J/㎠, respectively. 5. Five patients experienced side-effects. Two patients had intense tan, one withdrawing because of it and the other continued treatment. Three had pruritus that was controlled on oral antihistamines. Phototoxic or other classic adverse effects of oral PUVA therapy, such as nausea, vomiting and headaches, were not observed in any of our 20 patients. 6. All twenty patients had an undetectable plasma 8-MOP level. The lower limit of detection level was 20ng/㎖. Conclusion:Bath-8-MOP-UVA therapy for psoriasis is a very effective and safe alternative to oral PUVA therapy. (Korean J Dermatol 2000;38(6):756~761)

휴대인터넷 시스템 엔지니어링에 관한 연구

김명민,홍인기 경희-다반 ASIC 설계교육센터 2004 경희-다반 ASIC센터 논문집 Vol.5 No.-

ADSL, VDSL과 같은 초고속 유선 인터넷 기술의 박닥에 힘입어 유선 인터넷 사용자가 증가함에 따라 언제 어디서나 시간과 장소에 구애 받지 않는 휴대인터넷 서비스에 대한 요구가 점점 증대하고 있다. 이런 휴대인터넷의 성공적인 도입을 위한 셀 설계기술이 필요하고, 이를 위한 셀 크기나 가입자의 수에 따라 성능 평가를 바탕으로 한 셀 설계가 이루어져야 한다. 기존의 CDMA를 이용한 방식에서는 전력제어를 바탕으로 링크 설정의 여부에만 관심이 있었으나 휴대인터넷에서는 스케줄링 방식을 이용하여 시스템 성능이나 사용자 QoS를 더 고려한다.

골관절염 환자에 있어서 경피 투여 후 피록시캄의 조직 분포

정원희,김명민,최경업,윤경호,하권익,민동선,최경업 大韓臨床藥理學會 1998 臨床藥理學會誌 Vol.6 No.1

Astromicin sulfate의 약동학 및 안전성 평가

정숙인,김연숙,오원섭,복혜숙,김명민,최경업,김연화,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.3

목적 : Astromicin은 aminoglycoside계 항생제와 유사한 화학구조와 특성을 지니고, 기존의 aminoglycoside와 유사하거나 향상된 임상효과 및 부작용을 지닌 것으로 알려져 있다. 저자들은 astromicin의 약동학적 특성을 분석하고, astromicin 투여 환자를 대상으로 한국인에서 그 임상적 및 세균학적 효과와 안전성을 평가하고자 하였다. 대상 및 방법 : 약동학적 지표는 정상성인 남자를 대상으로 astromicin 200㎎을 30분간 정주한 후 24시간까지 혈장 및 뇨 검체를 수집하여 one-compartment open model에 따라 분석하였다. 중증으 세균감염이 있는 18세 이상의 환자를 대상으로 병용 또는 단독 투여한 후 임상적 효과와 세균학적 효과를 판정하였고, 치료전과 후의 순음청력검사와 혈청 크레아티닌으로 이독성과 신독성을 평가하였다. 결과 : 정상 성인 남자 12명을 대상으로 약동학적 지표를 평가하였고, 최고혈장농도는 투여 종료시점(C_(0))에서 16.87±1.68㎍/mL였으며, 반감기는 1.86±0.43 시간 이었고, AUC_(0-12h)은 38.12±10.57㎍ㆍhr/mL, Vd는 0.18±0.02L/㎏, CL은 5.25±2.07L/hr였다. 이러한 약동학적 지표는 다른 aminoglycoside와 유사한 결과를 보였다. 59명의 환자를 대상으로 시행한 임상적 효과 분석에서는 단독요법을 시행한 50명 중 임상적 치유율 94%, 세균학적 치유율 100%를 보였고, 순음청력검사를 시행한 48례의 환자중 의미있는 청력감소 소견은 관찰되지 않았으며, 신독성 또한 전혀 나타나지 않았다. 결론 : Astromicin의 약동학적 지표는 다른 aminoglycoside의 약동학적 지표와 비슷한 양상을 보이므로 향후 astromicin의 약물농도 감시에 있어서 다른 aminoglycoside의 치료적 약물 농도 감시 방법과 유사한 방법을 적용할 수 있으리라 기대된다. 또한 임상적 치유율이 우수하면서 신독성이나 이독성이 적어 세균 감염 환자의 치료에 있어서 단독 또는 병합 요법으로 비교적 안전하게 사용할 수 있으리라 생각된다. Astromicin(Fortimicin®) has some characteristics in common with other aminioglycoside antibiotics, although it has a unique chemical structure, which is different from them. This study was performed to elucidate the pharmacokinetic (PK) parameters of astromicin following single-dose intravenous infusion of 200 mg and to evaluate clinical efficacy and safety of astromicin in Korean populations. PK parameters of astromicin were determined in 12 healthy volunteers (65.5±5.2㎏). The plasma and urine samples were collected up to 24hrs. PK variables were calculated by fitting individual concentration-time curves to a one-compartment open model. Plasma level at the end of infusion was 16.87?1.68 ㎍/mL and declined to 1.05±0.35 (㎍/mL 8hr later. The half-life was 1.86±0.43 hr. Apparent volume of distribution was 0.18±0.02 L/㎏g, and total body clearance was 5.25±2.07 L/hr. These values were similar to those of other aminioglycosides. Clinical efficacy and safety were eviuated in 59 patients with moderate to severe bacterial infections who needed parenteral antibiotics. Among 50 patients who recieved astromicin monotherapy, 49 (98%) had favorable clinical reponse and 28 (100%) had favorable bacteriological response. Serial audiograms revealed no change in all of 48 patients. No nephrotoxicity was observed in all patients. Conclusively, our data suggest that therapeutic drug monitoring of astromicin can be conducted in a similar fashion as other aminioglycosides and astromicin is a useful and safe antibiotic in the treatment of severe bacterial infections.

카르바마제핀 시럽(테그레톨^(TM))의 안정성 연구

박효정,최혜진,김명민,최경업 한국병원약사회 1996 병원약사회지 Vol.13 No.1

The stability of carbamazepine in 2% w/v syrup (Tegretol^(TM)) was investigated. Six Tegretol^(TM) syrup samples (Lot number:9083501) were selected randomly. The samples were then divided into 2 groups and stored as follows; Group I was stored at ambient room temperature and Group Ⅱ at 4℃ during 12 weeks. Physical stability was assessed by visual inspection and pH observation at designated time intervals (t=0, 1, 2, 3, 4, 8 and 12 weeks). Carbamazepine concentrations were determined periodically over 12 weeks by the fluorescence polarization immunoassay. No significant changes in appearance, pH and drug concentrations of Tegretol™ syrups were observed under the two different temperature conditions over the duration studied. In conclusion, pharmacists can safely dispense this preparation without considering the special storage conditions format least 12 weeks.