광간섭단층촬영으로 분류된 미만성 당뇨황반부종의 위험인자

김도형,김상훈,김현웅,윤일한,Do Hyung Kim,M,D,Sang Hoon Kim,M,D,Hyun Woong Kim,M,D,Ill Han Yoon M,D 대한안과학회 2006 대한안과학회지 Vol.47 No.4

Purpose: Recently diffuse diabetic macular edema has been morphologically classified by optical coherence tomography. This study was conducted to examine the difference of risk factors of the classified types of diffuse macular edema. Methods: The subjects included 93 people who were diagnosed with non-insulin dependent diabetes. We diagnosed the presence of diabetic macular edema with slit lamp fundus examination and used OCT for the classification of diffuse macular edema. We examined the differences in epidemiological risk factors in non-diabetic macular edema patients after diabetic macular edema patients were examined with fluorescein angiography to confirm diffuse macular edema. Results: Diabetic macular edema was classified into 4 types using OCT. Compared with patients without macular edema, sponge-like macular edema - related epidemiological risk factors included diabetic nephropathy, cystoid macular edema was related to HbA1c, serous macular detachment was related to treatment of diabetes by insulin, and posterior hyaloid raction was related to diastolic blood hypertension. Conclusions: In the present study, differences in epidemiological risk factors were related to the occurrence of a type of diffuse macular edema.

소형 정보가전 기기용 QPlus-P 윈도우 매니저 개발

김도형,강우철,정영준,김성우,Kim, Do-Hyung,Kang, Woo-Cheol,Jung, Young-Jun,Kim, Seung-Woo 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.1

본 논문에서는 한국전자통신연구원에서 개발한 정보가전용 실시간 운영체제 Qplus-P에 기반을 둔 소형 정보가전 기기용 윈도우 매니저 개발에 대해 기술한다. 기존의 공개된 소형 정보가전 기기용 윈도우 매니저들은 데스크탑용으로 개발된 것을 임베디드 시스템에 맞도록 변경하여 소형 정보가전 기기에 부적합한 기능들도 포함하고 있고, 한글을 제대로 지원하지 않는 문제점이 있었다. QPlus-P 윈도우 매니저는 공개 소스로 개발되고 있는 소형 정보가전 기기용 윈도우 매니저 매치박스에 한글 처리 기능을 추가하고, 다중 윈도우 환경에서 자동적으로 한/영 모드를 전환해주는 새로운 한글 입력기 아미키를 제공한다. 그리고, 한글을 지원하는 웹 브라우저, 메일 클라이언트, MP3 재생기 등과 같은 기본응용 프로그램들을 제공한다. Qplus-P 윈도우 매니저는 공개소스에 한팔 지원 기능을 추가하고, 타겟 시스템에 이식함으로써 개발되었다. This paper describes the development of a window manager based on the real time operating system, Qplus-p, for small internet appliance. Current window managers for small internet appliance are originally developed for desktop environment and then modified for embedded systems. So they have inadequate functions for small internet appliances and do not perfectly support Hangul. The Qplus-P window manager adds the Hangul processing function to Matchbox window manager, a royalty-free window manager for small Internet appliance and provides a new Hangul input method called Amikey. Input mode can be changed automatically from Hangul mode to English mode and vice versa by Amikey. In addition, Qplus-P window manager provides Hangul supported basic applications such as web browser, e-mail client, MP3 player. We developed the window manager by porting open sources to target system after adding Hangul supported functions to them.

실시간 운영체제 Qplus-P용 그래픽 윈도우 라이브러리 구현

김도형,김선자,김성우,Kim, Do-Hyung,Kim, Sun-Ja,Kim, Seung-Woo 한국정보처리학회 2003 정보처리학회논문지 A Vol.10 No.5

디지털 TV, 인터넷 셋탑박스, 인터넷 전화기 등과 같은 정보가전 제품이 속속 등장하면서 이들 제품의 기능을 제어하는데 필수적인 실시간 운영체제 시장이 크게 성장하고 있다. 한국전자통신연구원에서는 소형의 휴대 정보 단말에서부터 디지털 셋탑박스 및 홈 서버까지 다양한 종류의 정보가전 기기에 공통으로 사용될 수 있는 확장 가능한 표준 실시간 운영체제 Qplus-P를 개발하였다. 본 논문에서는 정보가전용 실시간 운영체제 Qplus-P에 탑재되는 그래픽 윈도우 라이브러리의 구현에 대해 기술한다. Qplus-P 그래픽 윈도우 라이브러리는 공개소스인 tiny-X 그래픽 서버에 한글 처리 기능, 화면 회전 기능, 터치스크린 입력 기능, 그래픽 가속 기능 등을 추가하였다. Qplus-P 그래픽 윈도우 라이브러리는 현재 arm 프로세서를 사용하는 아이팩 3600 PDA, 삼성 S3C2400 보드, 자우루스 PDA와 x86 프로세서를 사용하는 홈서버에 탑재되었으며, Qplus-P타겟 빌더에 통합된 형태로 제공된다. As the Internet appliances like digital TV, Internet set-top boxes, and Internet phone, are showing up in the market, the economics of real-time operating system (RTOS), which is an essential for controlling those devices, is expanding faster than ever before. ETRI has developed describes RTOS called Qplus-P, targeting various platforms ranging from PDA to Internet set-top box and home server. This paper describes the implementation of graphic window library for Qplus-P. The Qplus-P graphic window library was implemented using tiny-X graphic server and gtk graphic toolkit, which are open source software. To port this library to various aliances, hangul processing, screen rotation, touch screen, and graphic acceleration functions are added to the tiny-X graphic server of the implementd graphic window library. Currently, Qplus-P graphic window is running on ARM-based appliances such as iPaq PDA, Samsung S3C2400 board, Zaurus PDA, and on Home Server that uses x86 processor. Qplus-P graphic library is provided as a of Qplus-P target builder.

백굴채(Chelidonium majus) 추출물의 Fischer 344/N 랫드를 이용한 90일간 반복 경구투여 독성시험

김도형,장호송,김광호,강상철,김학수,길기현,공광한,안태환,배진숙,고현규,김갑호,박찬구,이현걸,송시환,한충택,Kim, Do-Hyung,Zhang, Hu-Song,Kim, Kwang-Ho,Kang, Sang-Chul,Kim, Hak-Soo,Gil, Ki-Hyun,Kong, Kwang-Han,Ahn, Tae-Hwan,Bae, Jin-Sook,Go, Hyeon-K 대한수의학회 2009 大韓獸醫學會誌 Vol.49 No.1

This study was performed to evaluate repeated-dose oral toxicities of Chelidonium majus extract in Fischer 344/N rats. Chelidonium majus extract was administered orally to rats at dose levels of 0, 25, 74, 222, 666 and 2,000 mg/kg/day. Each group consisted of 10 rats of each gender. The Chelidonium majus extract was given once a day, 5 times a week, for 90 day repeatedly. This study was conducted in accordance with the Protocol of Korea National Toxicology Program (issued by National Institute of Toxicological Research) and The Standards of Toxicity Study for Medicinal Products (issued by Korea Food and Drug Administration). In the present study, There were no toxicologically significant changes in mortality, clinical signs, body weight gains, ophthalmoscopy, urine analysis, hematology, serum biochemistry, necropsy findings, organ weights, histopathology, estrus cycle and sperm examination of all animals treated with Chelidonium majus extract. These results suggest that the oral no observed adverse-effect level of the test item, Chelidonium majus extract, in rats is higher than 2,000 mg/kg/day in both genders. The target organs were not established.

옥수수 가공방법 및 두께가 in situ 건물 분해율과 in vitro 메탄 발생에 미치는 영향

김도형,이창현,우양원,김종남,조광현,장선식,김경훈,Kim, Do Hyung,Lee, Chang Hyun,Woo, Yang Won,Rajaraman, Bharanidharan,Kim, Jong Nam,Cho, Kwang Hyeon,Jang, Sun Sik,Kim, Kyoung Hoon 한국초지조사료학회 2017 한국초지조사료학회지 Vol.37 No.4

본 연구에서는 옥수수의 가공방법 및 옥수수의 두께의 차이가 반추위 in situ 소화율 및 in vitro 반추위 발효와 메탄 발생에 미치는 영향에 대하여 알아보고자 실시하였다. Micronized corn(2.5 mm thickness) 처리구는 다른 처리구들에 비하여 in situ 48시간 건물 분해율이 모든 배양시간대에서 높게(P<0.05) 나타났다. 반면, steam flaked corn(3.3 mm thickness) 처리구는 모든 배양시간대에서 가장 낮은(P<0.05) in situ 건물 분해율을 보였다. 반추위 내에서 미생물에 의해 분해되는 b fraction은 이와 상반되는 결과인 steam flaked corn(3.1 mm thickness)과 steam flaked corn(3.3 mm thickness) 처리구에서 높게(P<0.05) 나타났다. b fraction이 반추위를 통과하는 속도인 건물 분해상수 k값은 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 (P<0.05) 나타났고 steam flaked corn(3.3 mm thickness) 처리구에서 가장 낮게 (P<0.05) 나타났다. 반추위내 시간당 통과속도를 0.05로 적용한 유효 건물 분해도는 건물 분해상수와 유사하게 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 (P<0.05), steam flaked corn(3.3 mm thickness) 처리구에서 가장 낮게(P<0.05) 나타났다. In vitro 반추위 48시간 건물 소실율은 micronized corn(2.5 mm thickness) 처리구에서 가장 높은 경향을(P=0.088) 보인 반면 steam flaked corn 처리구들 사이에서는 두께에 따른 건물 소실율의 상관관계는 나타나지 않았다. 총 가스발생량 및 메탄 발생량에 있어서도 건물 소실율과 같은 결과인 micronized corn(2.5 mm thickness) 처리구에서 가장 높게 나타났으며(P=0.001), 총 휘발성지방산은 steam flaked corn(2.9 mm thickness)의 처리구에서 가장 높게 나타났으나(P=0.015) 나머지 처리구들에서는 유의적인 차이를 보이지 않았다. aectate: propionate의 비율 또한 steam flaked corn(2.9 mm thickness)의 처리구에서 가장 높게, micronized corn(2.5 mm thickness) 처리구에서 가장 낮게 나타났다(P=0.008). 본 연구의 결과를 종합하면 steam flaked corn 처리구들에서 in vitro 휘발성지방산 농도에 있어 in situ 반추위내 건물 분해상수와 유효 건물 분해도의 결과와 비교하여 상관관계가 나타나지 않은 결과로 유추해 보면 옥수수 가공방법에 의한 두께의 차이는 반추위 메탄 발생량에 영향을 미치지 않은 것으로 판단된다. This study was conducted with two ruminally cannulated Holstein steers to examine the effect of micronized and steam flaked corn on ruminal fermentation characteristics. The in situ dry matter degradability after 48 h incubation was the highest (P<0.05) at micronized corn (2.5 mm thickness) compared with steam flaked corn treatments. The steam flacked corn (3.3 mm thickness) was degraded lower (P<0.05) than the 2.9 and 3.1 mm thickness of steam flacked corn. Effective dry matter degradability and the rate of constant were the highest (P<0.05) at micronized corn (2.5 mm thickness) compared with steam flaked corns as well. The in vitro dry matter degradability after 48 h incubation was tended to higher (P=0.088) at micronized corn (2.5 mm thickness) than steam flaked corns, whereas there is no significantly difference between steam flaked corn treatments. Total volatile fatty acid concentration was higher at steam flaked corn (2.9 mm thickness) than micronized corn (2.5 mm thickness) and steam flaked corn (3.1 and 3.3 mm thickness). The acetate : propionate ratio was the highest (P=0.008) at steam flaked corn (2.9 mm thickness) and the lowest (P=0.008) at micronized corn (2.5 mm thickness). Total gas and methane production after 48h ruminal incubation was the highest (P=0.001) at micronized corn (2.5 mm thickness) compared with steam flaked corns. According to these results, the thickness of steam flaked corn as resulted corn processing is believed to do not affect methane production. However, further study is needed to better understand the present results to verify the correlation between corn processing method and their thickness on methane production using the same thickness corns by difference processing methods.

소형민수헬기 능동진동제어시스템 개발

김남조(Nam-Jo Kim),곽동일(Dong-Il Kwak),강우람(Woo-Ram Kang),황유상(Yoo-Sang Hwang),김도형(Do-Hyung Kim),김찬동(Chan-Dong Kim),이기진(Ki-Jin Lee),소희섭(Hee-Soup So) 한국항공우주학회 2022 韓國航空宇宙學會誌 Vol.50 No.3

헬기의 능동진동제어시스템(AVCS)은 주로터로부터 발생되는 진동을 제어하며, 수동형 진동저감장치 대비 저중량으로 우수한 진동저감 성능을 발휘한다. 본 논문에서는 FxLMS 알고리즘을 기반으로 타코미터 및 가속도 센서 신호를 통해 연산된 제어명령을 하중발생기(CFG)로 전달하여 소형 민수헬기의 진동을 제어하는 소프트웨어 개발 및 검증 내용을 제시하였다. DO-178C /DO-331 표준에 따라 모델 기반 설계 기법을 통해 진동제어 소프트웨어를 개발하였으며, PILS 및 HILS 환경에서 실시간 작동 성능을 평가하였다. 특히, PILS 환경에서는 LDRA 기반 검증 커버리지를 통해 소프트웨어의 신뢰성을 향상시켰다. AVCS를 소형민수헬기에 적용하기 위해 지상/비행시험을 통해 대상 헬기 동적응답특성 모델을 획득하였다. 이를 기반으로 시스템 최적화 분석 및 비행시험을 통해 최적 성능을 발휘하는 AVCS 형상을 결정하고, STC 인증을 획득하였다. Active vibration control system(AVCS) for helicopter enables to control the vibration generated from the main rotor and has the superb vibration reduction performance with low weight compared passive vibration reduction device. In this paper, FxLMS algorithm-based vibration control software of the light civil helicopter tansmits the control command calculated using the signals of the tachometer and accelerometers to the circular force generator(CFG) is developed and verified. According to the RTCA DO-178C/DO-331, the vibration control software is developed through the model based design technique, and real-time operation performance is evaluated in PILS(processor in-the loop simulation) and HILS(hardware in-the loop simulation) environments. In particular, the reliability of the software is improved through the LDRA-based verification coverage in the PIL environments. In order to AVCS to light civil helicopter(LCH), the dynamic response characteristic model is obtained through the ground/flight tests. AVCS configuration which exhibits the optimal performance is determined using system optimization analysis and flight test and obtain STC certification.

염류집적 농경지 탈염을 위한 전기역학적 처리공정의 비용산출

김도형,최정희,조성웅,백기태,Kim, Do-Hyung,Choi, Jeong-Hee,Jo, Sung-Ung,Baek, Ki-Tae 한국지하수토양환경학회 2012 지하수토양환경 Vol.17 No.4

In this study, cost analysis of electrokinetic (EK) restoration process for desalination of saline agricultural land was performed for field application based on a pilot scale field application. For reasonable cost analysis, EK process was classified into three major parts: system design, installation and operation. Cost of system installation consists of materials and installation for electrode/electric wire, power supply and data monitoring, drainage system, etc. Operation cost was calculated based on electrical consumption and water charges for EK process. Total cost for EK process was 2,943,013 won for $1000m^2$ in greenhouse area. Cost for system installation was 2,553,786 won, that is, 87% of total cost, while cost for system operation was 389,229 won, that is, 13% of total cost.

백내장 수정체 상피세포의 변형성장인자 발현

김도형,양재욱,박세광,김성두,허준,윤일한,최인학,Do-Hyung Kim,Jae-Wook Yang,Seh-Kwang Park,Sung-Doo Kim,Jun Hur,Ill-Han Yoon,In-Hak Choi 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: Transforming growth factor (TGF)-β is recognized as being associated with cataractogenesis. We quantitated the mRNA expression of TGF-β isoforms in cataractous crystalline lens to determine the effect of the isoforms on cataractogenesis. Methods: With lens epithelial cells from thirty eyes in thirty patients, the mRNA expressions of TGF-β1, β2 and β3 were quantitated by real-time SYBR Green polymerase chain reaction and the results were compared according to cataract type and presence of diabetes mellitus. Results: Each isoform mRNA of TGF-β was expressed: TGF-β3 in all 30 eyes, TGF-β1 in 29 eyes (96.7%), with the exception being one diabetic senile cataract, and TGF-β2 in 9 eyes. The amount of TGF-β1 mRNA expression was significantly lower in the diabetic cataracts than in the non-diabetic cataracts (P=0.056). Conclusions: TGF-β was associated with cataractogenesis. It is significant that the expression of TGF-β2 mRNA was decreased in all cataracts. The decrease of TGF-β1 mRNA expression was more meaningful in the diabetic cataracts than in the non-diabetic cataracts.

염류집적 농경지 제염기술에 대한 경제성분석 - 작물생산량을 기준으로

김도형,최정희,김이열,남창모,백기태,Kim, Do-Hyung,Choi, Jeong-Hee,Kim, Lee-Yul,Nam, Chang-Mo,Baek, Ki-Tae 한국지하수토양환경학회 2012 지하수토양환경 Vol.17 No.5

In this study, economic analysis of five desalination technologies for saline agricultural land was carried out. The analysis was comprehensively evaluated by calculating changes in crop production and benefit/cost (B/C) ratio. The analysis of crop production was in the order of tomato > cucumber > a (musk) melon > watermelon > cabbage, and economical efficiency for desalination technology was in the order of soil exchange > soil addition > electrokinetics > under-drainage > subsoil reversal. In cost benefit analysis, B/C ratio was in the order of under-drainage > soil exchange > electrokinetics > soil addition > subsoil reversal, and all desalination technologies used in this study have the ratio higher than 1, which means economical efficiency was high. Based on the net production considering B/C ratio, the general economic analysis was exactly order from that of crop production analysis. As a result, economical efficiency of soil exchange was highest, and economical efficiency of soil addition and electrokinetic was relatively higher than others.

저온 민감성 바실러스 서브틸리스 돌연변이 균주에서 glycine betaine의 저온 내성에 미치는 영향에 대한 연구

김도형,이상수,Kim, Do Hyung,Lee, Sang Soo 한국미생물학회 2018 미생물학회지 Vol.54 No.3

높은 염분 농도에서 glycine betaine은 Bacillus subtilis 안으로 유입되어 세포 생장이 지속될 수 있게 한다. 뿐만 아니라 최근 연구 결과에 따르면 저온에서도 glycine betaine이 세포 생장을 지속시키는 것으로 알려져 있다. 저온에서 Bacillus subtilis의 생장을 저해시키는 세포 대사 활동으로는 세포막 운송과 단백질 합성을 들 수 있다. 세포막 구조와 관련하여 저온에서 세포막 운송에 영향을 주는 유전자들로는 bkdR과 des가 있고, 단백질 합성 과정에서 RNA helicase 유전자인 ydbR과 yqfR들은 저온 민감성을 보인다. 따라서 Bacillus subtilis 저온 민감성 유전자 결손 세포들에 대한 glycine betaine의 효과를 조사하여 저온에서의 glycine betaine 생리적 기능에 대해 알아보고자 하였다. 이 결과 glycine betaine의 존재 유무에 따라 야생형 Bacillus subtilis와 ydbR과 yqfR 결손 균주의 저온생장에 큰 차이를 보였다($T_d$차이 190~686 min). 반면에 bkdR이나 des 결손균주의 경우에는 glycine betaine 존재 유무에 따라 차이를 보이지 않았다. Glycine betaine의 전구체인 choline으로 대치하여도 저온에서의 생장은 같은 결과를 보였다. Glycine betaine의 영향이 세포막 구조와 관련이 있는 유전자 bkdR과 des 결손균주에 미치는 영향이 적은 것을 알아보기 위해 세포막에 영향을 주는 세제의 효과를 조사하였다. Triton X-100과 N-lauryl sarcosine 세제에 의해 bkdR 결손 균주가 야생형에 비해 더 영향 받는 것을 확인하였고 이는 bkdR 결손이 저온에서 막 구조를 변형하여 glycine betaine의 투과에 영향을 미치는 것으로 보인다. At high salt concentration, glycine betaine is transported into Bacillus subtilis and growing rate of the cell is not suppressed. Also according to recent studies, cell growth is maintained normal growth rate at low temperature. Low temperature results in a stress response of Bacillus subtilis that is characterized by strong repression of major metabolic activities such as translation machinery and membrane transport. In this regards, genes showing cold sensitive phenotype are cold-induced DEAD box RNA helicases (ydbR, yqfR) and fatty acid desaturases (bkdR, des). Therefore to understand the effect of glycine betaine on cold growth of Bacillus subtilis, we investigated the effect of glycine betaine on growth rate of these deletion mutants showing cold sensitive phenotype. Glycine betaine strongly stimulated growth of wild type Bacillus subtilis JH642 and deletion mutants of ydbR and yqfR at $20^{\circ}C$ (190~686 min $T_d$ difference). On the other hands, glycine betaine does not show growth promoting effects on deletion mutants of bkdR, and des at cold conditions. Same cold protectant growth results were shown with the precursor choline instead of glycine betaine. We investigated the effects of detergents on the cell membrane in bkdR and des deficient strains associated with cell membrane. It was identified that bkdR deficient strain shows retarded growth with detergent such as Triton X-100 or N-lauryl sarcosine compared with wild type cell. Thus, it is possible that deletion mutation of bkdR modifies membrane structure and effects on transport of glycine betaine.