청미래덩굴 잎 및 뿌리 추출물의 항산화, α-Glucosidase 억제 및 항염증 활성비교

김경곤,최면,강윤환,김대중,김태우 한국영양학회 2013 Journal of Nutrition and Health Vol.46 No.4

This study was conducted in order to compare the biological activities of leaf and root water extracts of Smilax china L. (SC) by measuring the total polyphenol and flavonoid contents, anti-oxidant activity, inhibitory effect on α-glucosidase, and anti-inflammatory gene expression. The total polyphenol and flavonoid contents of SC leaf (SCLE) and root (SCRE) water extracts were 127.93 mg GAE/g and 39.50 mg GAE/g and 41.99 mg QE/g and 1.25 mg QE/g, respectively. The anti-oxidative activities of SCLE and SCRE were measured using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity assay and reducing power assay. Both SCLE and SCRE scavenged radicals in a concentration-dependent manner, and SCLE showed stronger radical scavenging activity and reducing power than SCRE; however, both SCLE and SCRE exhibited lower activities than ascorbic acid. Compared to the anti-diabetic drug acarbose, which was used as a positive control, SCLE and SCRE exhibited low α-glucosidase inhibition activities; nevertheless, the activity of SCLE was 3.7 fold higher than that of SCRE. Finally, SCLE caused significantly decreased expression of the LPS-induced cytokines, iNOS, and COX-2 mRNA in RAW264.7 cells, indicating anti-inflammatory activity. These results indicate that SCLE might be a potential candidate as an anti-oxidant, anti-diabetic, and anti-inflammatory agent.

지역사회 바탕 의학교육 및 외래 진료 환경의 새로운 교육 방법인 Wave 모델에 대한 일차 진료의의 관심도

김경곤,강희철,김찬경,조희정,윤방부 한국의학교육학회 2005 Korean journal of medical education Vol.17 No.3

Purpose: In order to expand and improve community-based medical education(CBME), we attempted to delineate the characters of the primary care physicians interested in medical education and their opinions on the new medical teaching method for ambulatory care settings, Wave model. Methods: Through mailed questionnaires, we asked the Seoul members of the family physician association and the internal medicine physician association about their interest and opinions of CBME and the Wave model. Results: We received 186 replies from the total 1088 questionnaires(17.1%) sent out. Many of the primary care physicians(141/186; 75.8%) had no experience with CBME. However, 127 (68.7%) were interested in CBME and 121(65.4%) answered that they were interested in teaching students in their clinic. There were 128(69.2%) affirmative responses to the Wave model, which was much higher than that to the observation-centered method, 53(30.3%)(p<0.0001). Primary care physicians who have affirmative attitudes to adopting the Wave model would select this model as their CBME program(p<0.0001). Primary care physicians willing to teach students tend to be males(p=0.0085) and younger in age(p=0.0003), have examination rooms for student-patient contact(p<0.0001), and possess positive attitude to adopting the Wave model(p= 0.0018). Conclusion: There are many primary care physicians eager to participate in CBME. They view the Wave model as an effective teaching method. Factors associated with the desire to work as a preceptor include being male and younger in age. having examination rooms for student-patient contact, and possessing a positive attitude to adopting the Wave model.

Semitransparent Blue, Green, and Red Organic Solar Cells Using Color Filtering Electrodes

김경곤 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.1

건강기능식품과 대사증후군

김경곤 춘천바이오산업진흥원 2022 CBF 바이오경제 이슈포커스 Vol.2022 No.15

Lipid-lowering effects of Zanthoxylum schinifolium Siebold & Zucc. seed oil (ZSO) in hyperlipidemic rats and lipolytic effects in 3T3-L1 adipocytes

김경곤,김태우,강윤환,김대중,최면 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.5

On the basis of the antiatherosclerotic effect of Zanthoxylum schinifolium, the therapeutic potential of Zanthoxylum schinifolium seed oil (ZSO) was tested in terms of the blood lipid profile and obesity in rats. The lipolytic effects of ZSO were determined in adipocytes and the total body and liver weight were decreased in rats. Compared with the high-cholesterol high-fat (HCHF) group, the rats in the HCHF+ZSO group showed improved levels of hyperlipidemia indicators. Furthermore, western blot analysis confirmed that the improvement of hyperlipidemia indicators was induced by stimulation of lipoprotein lipase expression. Additional results indicated that the reduction in body weight was likely caused by phosphorylation of hormone-sensitive lipase (HSL) via the protein kinase A pathway, ultimately leading to lipolysis. In conclusion, the results of the in vivo experiment showed that ZSO improved the lipid profiles in the blood, lowering cardiovascular disease and arteriosclerosis and degrading cellular lipids by activating HSL.

PCzEHPV와 ALq3로 구성된 이종접합구조 소자의 발광 특성연구

김경곤,홍영래,진정일 한국고분자학회 1999 한국고분자학회 학술대회 연구논문 초록집 Vol.24 No.2

CzEH-PPV와 MEH-PPV의 발광층과 Alq₃의 전자전달층으로 구성된 이종접합구조 소자의 발광특성 연구

김경곤,홍영래,이동원,진정일 한국고분자학회 1999 한국고분자학회 학술대회 연구논문 초록집 Vol.24 No.1

캐모마일 물 추출물의 항염증 효능 검증

김경곤,김태우,김대중,최면 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

운동 후 발생한 횡문근융해증의 임상적 고찰

김경곤,김준형,김성민,전규락,김영욱,이호학,박상준,김윤권,김소연,김영중,조민구,이권전 대한내과학회 2002 대한내과학회지 Vol.63 No.6

Background : It is important to recognize rhabdomyolysis in clinical settings, because 10~30% of rhabdomyolysis patients develop acute renal failure as a complication and patients with such complication have risk of high mortality. Recently, there have been frequent reports about healthy people who developed rhabdomyolysis after heavy exercise, but few prospective studies on exercise-induced rhabdomyolysis have been reported. Methods : To evaluate the degree of muscle cell necrosis during the regular combat-police training, we examined the level of creatine kinase, plasma myoglobin and bone scan in 173 combat-police before the training and on fourth day after the training. Average ambient temperature and humidity during the study were 25℃ and 78%, respectively. Results : From the laboratory findings, 98 out of 173 combat-police were diagnosed as having rhabdomyolysis. Upon regressional analysis, an increase in amount of exercise correlated with the elevation of the levels of plasma creatine kinase and myoglobin. Among variables related to rhabdomyolysis only the levels of myoglobin, aspartate aminotransferase were significantly elevated. The level of plasma creatinine was elevated along with the elevation of plasma myoglobin. Bone scan not only provided detailed information on the location and degree of muscle cell damage, but also could be of diagnostic value in patients whose creatine kinase had been normalized. Conclusion : In people who developed rhabdomyolysis after heavy exercise, the level of plasma creatinine was elevated along with the elevation of plasma myoglobin. So early diagnosis of rhabdomyolysis and early detection of acute renal failure may be useful with monitoring of plasma myoglobin level.(Korean J Med 63:675-681, 2002) 목적 : 저자들은 전투 경찰에서 흔히 실시되는 훈련 후 횡문근융해증과의 연관성을 알아보고자 하였다. 방법 : 전투경찰 173명을 대상으로 6일간 평균 매일 8시간에 걸쳐 PT체조훈련이 시행하였고, 설문조사를 통해 개인당 훈련량을 조사하였다. 결과 : 검사 결과 173명 중 98명에서 횡문근융해증을 진단 할 수 있었다. 혈중 마이오글로빈은 훈련량이 증가함에 따라 상승하는 소견을 보였다. 시간 경과에 따른 진행 과정을 볼 때, CPK, AST, 혈중 마이오글로빈은 자연 치유되는 경향을 보여 주었으며, 다른 검사가 정상으로 되어도 골주사 검사는 병력이나 이학적 검사로는 알 수 없는 근육 손상의 정도나 위치를 알 수 있었으며 생화학 검사가 정상화된 환자에서도 횡문근융해증의 진단에 유용한 정보를 제공하였다.

비만의 약물 요법

김경곤 대한의사협회 2011 대한의사협회지 Vol.54 No.4

Due to its serious comorbidities and high prevalence, obesity is one of the heaviest burdens for public health. Although diet, exercise and behavioral modification are the first-line treatment for obesity, their outcomes are not satisfactory. The goal of this article is to review currently available anti-obesity drugs so that physicians may apply the principle of pharmacologic treatment for obesity to obese patients in the real clinical situation. Orlistat, phentermine, diethylpropion,mazindol, and phendimetrazine have been approved as anti-obesity drugs by Korea food and drug administration and administered to patients in Korea. Besides, several non-approved drugs, including fluoxetine, bupropion, topiramate and zonisamide, are being used for weight reduction. Among these drugs, orlistat has been studied most and is the only approved drug for long-term weight management. On the other hand, the rest of the approved drugs lack the evidence of safety issues on the long-term administration. Considering that the non-approved drugs have only a small body of clinical trial results for their efficacy and safety as anti-obesity drugs, it is not appropriate to use them as a first-line therapy in obesity. Because several new medicines and combination therapies are under investigations, more drug therapy options seem to be available in this field in coming years. Although the properly executed pharmacologic treatment is a good option for weight reduction, physicians should recognize that diet, exercise, and behavioral modification are essential to all obese patient and that pharmacologic treatment has several limitations until now.