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증례(證例) : 한방 치료로 호전된 수족구병(手足口病) 소아환자 1례에 대한 보고
주정현 ( Jung Hyun Joo ),박수완 ( Su Wan Park ),( So Yeon Lim ),곽민아 ( Min A Kwak ),우극청 ( Keh Ching Yu ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.4
Objectives: This case study was made to evaluate and observe the treatment for Hand-foot-and mouth disease in children by korean traditional medicine. Methods: Cheonggisanhapsodokum, Takrisodokyeum ointment and cupping therapy were applied for treating patient`s chief symptoms. Results: The patient was 2-years-old baby boy who had blisters on hands, feet and hips by hand-foot-and-mouth disease. He also had pyrexy. After the patient was treated with korean traditional medicine these clinical symptom was improved. Conclusions: Based on the clinical results, korean traditional medicine is believed to be effective for treating hand-foot-and-mouth disease and further studies should be conducted to provide more valuable information.
성장클리닉에 내원한 소아의 골연령과 체성분 및 신체 계측치의 상관성에 대한 연구
이유진,윤혜진,곽민아,백정한,Lee, Yu-Jin,Yun, Hye-Jin,Kwak, Min-A,Baek, Jung-Han 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.2
Objectives : The purpose of this study was to examine relationships between bone age and body composition to make efficient clinical reviews on children's growth. Methods : 157 of children in age of 3 years to 16 years old were participated in this study(88 of boys and 69 of girls). They visited the department of pediatrics, OO university oriental hospital and were measured their body composition and bone age. Results : 1. An age and bone age, height, weight, and body mass index were positively correlated, and also a bone age and height, weight, and body mass index were positively correlated. 2. The level of soft lean mass, body fat mass, and MPH were increased in boys in higher height percentile. Children's predicted adult height was higher in children in higher height percentile. 3. The level of body fat mass was increased as weight percentile increased. Bone age, MPH was increased as weight percentile increased, especially in case of boys. In girl's case, the level of soft lean mass, their predicted adult height, the difference between children's bone age and their actual age was increased as weight percentile increased. Conclusions : Measuring bone age and body composition is the effective way to estimate children's growth and development in future.
증례(證例) : 베체트장염 환자 한방처치 후 경과보고 1례
권해원 ( Hae Won Kwon ),곽민아 ( Min A Kwak ),이자영 ( Ja Young Lee ) 대구한의대학교 제한동의학술원 2011 東西醫學 Vol.36 No.4
Objectives : This study was designed to evaluate the effect of traditional korean medicine on intestinal Bechet`s Disease. Methods : The patient in this case was 52-year-old. The Chief complains were right abdomen pain, dyspepsia, diarrhea, ulcer. She was treated by acupuncure, moxibustion and heral medicine. Results : After the treatments, right abdomen pain, dyspepsia, diarrhea, ulcers decreased. Conclusions : This clnical case indicate that traditional Korean medicine is effective in treatment of the intestinal Bechet`s disease.
장풍(腸風)으로 변증한 궤양성 대장염 환자의 당귀화혈산가미방(當歸和血散加味方) 및 가미전씨백출산(加味錢氏白朮散) 치험 1례
허일진,조동희,손지영,곽민아,김대준,변준석,박경,Hur, Jin-Il,Cho, Dong-Hee,Son, Ji-Young,Kwak, Min-A,Kim, Dae-Jun,Byun, Joon-Seok,Park, Kyung 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.2
This study is designed to evaluate the effects of an oriental herbal medication namely Danggwihwahyeolsan-gamibang and Gami-Jeonssibaekchulsan, on ulcerative colitis. Subject: A patient diagnosed ulcerative colitis who're not improved through western medication. Methods: The Clinical data was analyzed on a pastient with ulcerative clitis due to Changpung(腸風) resulted from Hanyeolchakjab(寒熱錯雜), whose symptoms were combined diarrhea, abdominal pain et al. The patient visited at the internal medicine department of Daegu Haany University affiliated Daegu Oriental Hospital on May 18. 2007 to June 25. 2007. The improvement of symptoms were checked by Seo Colitis Activity Index(AI).
역류성(逆流性) 식도염(食道炎)에 대한 이진탕가미방(二陳湯加味方) 구성(構成) 개별(個別) 한약재의 효과(效果)
이상태,곽민아,Lee, Sang-Tae,Kwak, Min-A 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.2
Objectives : The object of this study was to observe the protective effects of 8 types of individual herbal components of Yijintang-gamibang, on the reflux esophagitis (RE) in rats as compared with omeprazole. Methods : Each 100 mg/kg individual herbal component was orally pretreated, at 1 hr before and 6 hrs after pylorus and forestomach ligation, the changes on the esophageal lesion areas, gastric volumes, acid and pepsin outputs, antioxidant effects, esophageal total hexose and sialic acid contents were observed with changes on the esophageal histopathology. The results were compared with an omeprazole 10 mg/kg treated group. Results : Pylorus and forestomach ligation-induced RE were inhibited by treatment of all 8 herbal components and omeprazole except for Pinella Rhizoma and Massa Meicata Fermentata, in order of Atractylodis Rhizoma, Citri Pericarpium, omeprazole, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium, as compared with RE control. Pinella Rhizoma and Massa Meicata Fermentata did not show any favorable protective effects against RE nor antioxidant effects in the present study. Conclusions : The main active herbal components showing favorable protective effects on RE of Yijintang-gamibang mediated by antioxidant effects, were Atractylodis Rhizoma, Citri Pericarpium, Glycyrrhizae Radix, Hordei Fructus Germiniatus, Holelen and Citri Pericarpium. Furthermore Atractylodis Rhizoma and Citri Pericarpium showed more favorable protective effects as compared with omeprazole, therefore, it is expected that Atractylodis Rhizoma and Citri Pericarpium have potential as new alternatives or safe therapeutics against RE.
인삼양영탕(人蔘養榮湯)이 비소세포 폐암세포(NCI-H520) 이식 마우스에서 항암 및 면역 활성에 미치는 영향
송광규,곽민아,김종대,Song, Kwang-Kyu,Kwak, Min-A,Kim, Jong-Dae 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : The object of this study was to observe anticancer and related immunomodulatory effects of Insamyangyoung-tang extracts (ISYYTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of ISYYTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, which are intact control, tumor bearing control, 5-fluorouracil (FU) 30 mg/kg, ISYYTe 50 mg/kg, ISYYTe 100 mg/kg, ISYYTe 200 mg/kg, each of 8 mice per group were used in the present study. Changes on the body weight, tumor volume and weight, lymphatic organ (spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. Results : As results of ISYYTe 50, 100 and 200 mg/kg treatment, decreases in the tumor volumes and weights were detected. At histopathological observations, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of all three different dosages of ISYYTe. As results of tumor cell inoculation, marked decreases of spleen and popliteal lymph node weights, serum IFN-${\gamma}$, splenic TNF-${\alpha}$, IL-$1{\beta}$ and IL-10 contents and splenocytes were observed with histopathological atrophic changes of spleen and popliteal lymph nodes. Conclusions : Over 50 mg/kg of ISYYTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in ISYYTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, there are no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.
역류성식도염 유발 흰쥐에 대한 이진탕가미방(二陳湯加味方)의 효과
김희준,임소연,곽민아,김대준,변준석,Kim, Hee-Jun,Lim, So-Yeon,Kwak, Min-A,Kim, Dae-Jun,Byun, Joon-Seok 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.1
Purpose : The object of this study was to observe the suppressive effects of Yijintang-gamibang (YJGMB), Yijintang with Atractylodis Rhizoma, Massa Medicata Fermentata, Hordei Fructus Germiniatus, and Coptidis Rhizoma. YJGMB has been traditionally used in Korean medicine for treating various digestive diseases. We tested it on the rat reflux esophagitis (RE) induced by pylorus and forestomach ligation in rats as compared with omeprazole, a well-known proton pump inhibitor. Method : Three different dosages of YJGMB 200, 100 and 50mg/kg, were orally pretreated once a day for 28 days before pylorus and forestomach ligation. Seven groups, each of 8 rats per group were used in the study. Six hours after pylorus and forestomach ligation, changes of the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, invasive lesion percentages, fundic mucosa and total thicknesses were measured as histomorphometry. The results were compared with omeprazole, antioxidant and proton pump inhibitor, and 30 and 10mg/kg treated groups in which the effects on RE were already confirmed. Results : As results of pylorus and forestomach ligation, marked increases of esophageal and gastric mucosa lesion areas, gastric volumes, acid outputs, pepsin outputs were observed with histopathological changes of RE, such as hemorrhages, ulcerative lesions and edematous changes on the fundic mucosa. However, these pylorus and forestomach ligation-induced RE were dose-dependently inhibited by treatment of 200, 100 and 50mg/kg of YJGMB. YJGMB 200mg/kg showed similar protective effects as compared with 30mg/kg of omeprazole in the present study, and more favorable effects were observed in 50mg/kg of YJGMB treated rats as compared with omeprazole 10mg/kg in the present study. Conclusion : The results obtained in this study suggest that YJGMB has favorable protective effects on the RE induced by pylorus and forestomach ligation. Therefore, it is expected that YJGMB will also show favorable effects on RE corresponding well to the suggestion of traditional Korean medicine. However, more detailed mechanism studies should be conducted in future with the screening of the biological active chemical compounds in herbs.
간경변 환자의 근경련에 대한 전침 치료의 효과 무작위 대조군 연구
이창형,김병석,김경순,곽민아,김승모,Lee, Chang-hyeong,Kim, Byung-seok,Kim, Kyung-soon,Kwak, Min-a,Kim, Seung-mo 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4
Objectives: The purpose of this clinical trial was to examine the efficacy and safety of electroacupuncture on liver cirrhosis patients suffering from muscle cramps. Methods: Fourteen patients with liver cirrhosis who experienced muscle cramps at least once a week, regardless of cramp location, were enrolled and randomly allocated to an experimental group (n=12) or a control group (n=12). The experimental patients were treated with electroacupuncture at an electrical stimulation frequency of 100 Hz three times a week for four weeks (12 times in total). Muscle cramps were evaluated by a questionnaire that probed subjective symptoms. We analyzed the frequency of muscle cramps 3 times (at screening, 14 th visit, 15 th visit) during 8 weeks. Results: The number of patients with cramps occurring 'more than once a week' was reduced and the proportion of patients decreased in response to electroacupuncture. The number of patients with cramps occurring 'less than once every two weeks' increased and the proportion of patients also increased in response to eletroacupunture. Conclusions: The results of this study suggest that electroacupuncture treatment will be beneficial for improving muscle cramps in patients with liver cirrhosis. Electroacupuncture is considered a safe and efficacious treatment for patients with liver cirrhosis who complain of muscle cramps.