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강재명,우준희,류지소 대한의진균학회 2002 대한의진균학회지 Vol.7 No.1
Invasive aspergillosis remains a major cause of morbidity and mortality in immunocompromised patients, And there has been substantial increase in the number of cases documented at autopsy in all developed nations. There are probable many factors responsible for this substantial increase, but they include the following: greater numbers of transplantation patients; more aggressive chemotherapy for such conditions as myeloma, breast cancer, and certain lymphomas; more aggressive immunosuppressive regimens for patients with autoimmune disease; and the emergence of AIDS. The use of hepafiltration and, in particular, laminar air flow reduces the risk of invasive aspergillosis. The portal of entry for Aspergillus include the respiratory tract, damaged skin or other operative wounds, the cornea, and the ear. The majority of patients (80∼90%) have pulmonary disease, but some have other manifestations of disease, including aspergillus rhinosinusitis. Prognosis of invasive aspergillosis has in general relied on making a prompt diagnosis of infection, and early treatment. Unfortunately, the rapid diagnosis of invasive aspergillosis is difficult, as no rapid methods to establish definitely the diagnosis of infection are available in most clinical settings. An ELISA for detecting Aspergillus galactomannan is used to establish an early diagnosis in Western Europe. Invasive aspergillosis carries a nearly 100% mortality if untreated. There are currently two antifungal agents with activity against Aspergillus-amphotericin B and itraconazole. Several novel agents are under investigation, including Liposomal nystatin(Nyotran), Voriconazole, Posaconazole, Caspofungin. The most advanced azole is the voriconazole, which has shown good clinical efficacy and tolerability among immunocompromised patients with invasive aspergillosis. [Kor J med Mycol 7(1): 14-21]
성인 남자에서 발생한 Toxoplasmic Lymphadenitis 1예
박덕우,강재명,김인,박상현,김남중,김양수,우준희,류지소,김미나,유은실,남호우 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.1
성인에서 발생한 TL은 국내에서 매우 드문 질환이다. 저자들은 미국 여행 후 발생한 것으로 추정되고, 경과 관찰 후 임상적 호전을 보였던 TL 1례를 경험하였기에 보고하는 바이다. In Korea, Toxoplasmic lymphadenitis cases were reported infrequently and previous reports were considered to be due to the ingestion of raw pork and needle stick in the laboratory. A 38-year-old male was hospitalized because of cervical lymphadenopathy after traveling in the United States. Anti-Toxoplasma gondii antibodies (lg G/Ig M) were strongly positive by enzyme-linked fluorescence assay(ELFA), and the lymph node biopsy showed diffuse cortical and paracortical follicular hyperplasia and small clusters of epithelioid cells in the germinal centers. The lymphadenopathy subsided 4 Months later without medication of anti-parasitic agents. It is suggested to be a case of acute infection acquired during traveling in the United States.
全尙根,康才明 경희대학교 부설 식량자원개발연구소 1986 硏究論文集 Vol.7 No.-
The effects of the externally supplied carbohydrates and the growth substances on pollen germination rate and pollen tube development were investigated in Korean White Pine(Pinus koraiensis Sieb. et Zucc) Results obtained were as follows; 1. Sucrose treatment showed the highest pollen germination rate(90.76%) and raffinose treatment did the longest pollen tube length(184.58㎛), but sodium acetate and mannose prevented pollen germination. 2. In the media added IBA the highest pollen germination rate and the longest pollen tube length appeared 3. The optimum concentration of IBA treatment was 50 ppm for the pollen germination and tube development.
全尙根,康才明 慶熙大學校 1986 論文集 Vol.15 No.-
The effects of the externally supplied carbohydrates and the growth substances on pollen germination rate and pollen tube development were investigated in Korean White Pine(Pinus koraiensis Sieb. et Zucc.). Results obtained were as follows; 1. Sucrose treatment showed the highest pollen germination rate(90.76%) and raffinose treatment did the longest pollen tube length(184.58㎛), but sodium acetate and mannose prevented pollen germination. 2. In the media added IBA the highest pollen germination rate and the longest pollen tube length appeared. 3. The optimum concentration of IBA treatment was 50 ppm for the pollen germination and tube development.
성인원외폐렴의 원인미생물에대한 전향적 다기관 연구 : 성인원외폐렴의 원인으로 세균의 역할을 중심으로
우준희,강재명,김양수,신완식,류진홍,최정현,김양리,정희진,어수택,박춘식,정문현,정기석,이찬주,류지소 대한감염학회 2001 감염 Vol.33 No.1
Background : Communite-acquired peumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49% of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. Methods : A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. Results : Five hundred eighty eight cases of community-acquired peumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streprococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%), The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. Conclusion : In Korea, S.pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases. (Korean J Infect Dis 33:1∼7, 2001)