Anti-angiogenic activity of macrolactin A and its succinyl derivative is mediated through inhibition of class I PI3K activity and its signaling

강유라,Sushil Chandra Regmi,김미영,김동희,김정애,Suhrid Banskota,Jaya Gautam 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.2

In the current study, macrolactin compounds,macrolactinA(MA) and 7-O-succinyl macrolactinA(SMA),were investigated for their anti-angiogenic activities andaction mechanism. MA and SMA inhibited in vitro andin vivo angiogenesis induced by three different classes of proangiogenicfactors, VEGF, IL-8, and TNF-a. SMA exhibitedstronger anti-angiogenic activity than MA, and such antiangiogenicactivity of SMA was consistently observed inMDA-MB-231 human breast cancer cell-inoculated CAMassay showing dose-dependent suppression of tumor growthand tumor-induced angiogenesis. In an in vitro PI3K competitiveactivity assay, SMA induced concentration-dependentinhibition of class I PI3K isoforms, p110a, p110b,p110d, and p110c. In addition, non-receptor tyrosine kinasec-Src, which is involved in the activation of PI3K heterodimer,was suppressed byMAand SMA.Correspondingly,MAand SMA significantly inhibited the stimulus-induced phosphorylationof Akt, mTOR, p70S6K, and ribosomal S6 inhuman umbilical vein endothelial cells (HUVECs). At thesame time, the stimulus-induced production of reactiveoxygen species (ROS) and activation of NF-jB were significantlysuppressed by MA and SMA. Moreover, the macrolactinssuppressed NF-jB-regulated HSP90 proteinexpression, which stabilizes phosphorylated Akt andNADPH oxidase. Suppression of NF-jB in macrolactintreatedHUVECs with concurrent inhibition of rS6 indicatesthat MAs effectively block angiogenesis through down-regulationof genes related to angiogenesis at both transcriptionaland translational levels. Taken together, the results demonstratethat anti-angiogenic effect ofMAandSMAis mediatedthrough inhibition of PI3K/Akt andNADPHoxidase-derivedROS/NF-jB signaling pathways. These results further indicatethat MA and SMA may be applicable for treatment ofvarious diseases associated with angiogenesis.

Epicatechin Prevents Methamphetamine-Induced Neuronal Cell Death via Inhibition of ER Stress

강유라,이지하,서영호,장정희,Young Ho Seo,이수연,정길생,박병덕 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.2

Methamphetamine (METH) acts strongly on the nervous system and damages neurons and is known to cause neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Flavonoids, polyphenolic compounds present in green tea, red wine and several fruits exhibit antioxidant properties that protect neurons from oxidative damage and promote neuronal survival. Especially, epicatechin (EC) is a powerful flavonoid with antibacterial, antiviral, antitumor and antimutagenic effects as well as antioxidant effects. We therefore investigated whether EC could prevent METH-induced neurotoxicity using HT22 hippocampal neuronal cells. EC reduced METH-induced cell death of HT22 cells. In addition, we observed that EC abrogated the activation of ERK, p38 and inhibited the expression of CHOP and DR4. EC also reduced METH-induced ROS accumulation and MMP. These results suggest that EC may protect HT22 hippocampal neurons against METH-induced cell death by reducing ER stress and mitochondrial damage.

지하공간정보 통합 활용을 위한 DB 표준화 방안 연구

강유라,강인준,석철호,장용구 대한토목학회 2012 대한토목학회 학술대회 Vol.2012 No.10

칼로스와 삼광미를 이용하여 제조한 냉동 비빔밥의 품질 특성 평가

강유라,이상준,김경섭,장윤혁 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

KTX의 자유석제도 운용에 관한 연구

강유신(Kang Yu-Shin),김우제(Kim Woo-Je),홍순흠(Hong Soon-Heum) 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-

With the opening of the KTX(Korean Train Express) in April 2004, Express Train service started in KNR(Korean National Railroad). Each KTX train consists of 18 passenger compartments in total, such as of 4 first class car and 14 standard class car. And 2 compartments of standard class are serviced as a unreserved seat only. The Unreserved seat system of the KTX is convenient to the customer who wants to take a train without making a reservation. This study was designed to analyze the unreserved seat system of the KTX which is currently used, and to investigate the necessary conditions for gaining in public favor by developing the system.

국유철도 재산관리 기반체계 구축방안 연구

강유신(Kang Yu- Shin),추준섭(Choo Jun-Sup),김종태(Kim Jong-Tae) 한국철도학회 2008 한국철도학회 학술발표대회논문집 Vol.- No.-

This study examined the existing issues and current status of how to best approach the establishment of railroad asset of the corporation in the long run. It also explored some preventative measures for further problems. Based on the law of state property and related railroad statutes, the research referred to basic plans for railroad management of Korea Rail Network Authority, the outcome of file research, handbook of asset management, guidelines and policy of Ministry of Finance and Economy for state property management, recommendations of the Board of Audit and Inspection and fact-finding research of state property (miscellaneous properties). The findings are making a few suggestions on the service of the Korea Rail Network Authority and Korail.

단말기 번들링과 혁신 유인에 대한 실증 사례

강유리 정보통신정책연구원 2008 정보통신정책 Vol.20 No.19

UCC 게시와 시청의 동기(Motivation)에 관한 연구

강유리,남형균,박철 한국경영정보학회 2007 한국경영정보학회 학술대회논문집 Vol.2007 No.-

본 연구는 최근 이슈가 되고 있는 UCC를 네티즌들이 올리는 동기와 내려보는 동기를 분석하였다. UCC생산자와 소비자의 동기를 파악하면 UCC서비스 사이트의 마케팅 전략과 UCC를 마케팅에 활용하고자 하는 기업들에게 시사점을 줄 수 있을 것이다. UCC를 시청하고 게시하는 동기에는 각각 사회적인 측면, 개인적인 측면, 정보추구 측면, 오락적인 측면, 경제적인 측면 등 이상 다섯 가지 동기로 분류되었고 이들의 특성에 대해 분석해 봄으로써 이런 동기가 UCC마케팅 전략에 어떻게 적용될 수 있는지 제시하였다.

고압열수추출법을 이용한 편백나무잎 추출물 활성성분의 효능 연구

강유리,김운중 한국인그리에학회 2021 한국인그리에학회지 Vol.3 No.1

In this study, in order to find out the active ingredients of the hot water extract of cypress leaves, extracting by ratio of ethanol was analyzed, and antioxidant and antibacterial activity were investigated. In the measurement of chromaticity, as the ratio of ethanol in the cypress leaf extract increased, the yellowness decreased and the redness tended to increase. GC-MS component analysis confirmed the sesquiterpene-based component. In the antioxidant experiment of cypress leaf extract, compared with ascorbic acid, a control group, ethanol extracts of 50% or more showed higher antioxidant activity. In addition, it showed antibacterial activity of over 80% against Staphylococcus aureus strain, a food poisoning-causing bacterium, under all extraction conditions, and among them, 100% ethanol extract showed high antibacterial activity of 99.9%.

TV홈쇼핑 반품에 영향을 미치는 요인

강유리(You-Rie KANG),문성환(Sung-Hwan MOON),박철(Cheol PARK) 전북대학교 산업경제연구소 2009 아태경상저널 Vol.1 No.1

현대 사회는 미디어의 형태가 다양한 정보사회로써 위성통신, 케이블TV, PC 등의 매체변화 역시 급속히 이루어지면서 홈쇼핑은 이런 정보 통신 기술의 발달과 함께 시장 환경의 변화와 컴퓨터 및 통신기술의 발달로 인한 소비자들의 생활패턴의 변화로 인해 상품판매와 구매수단의 상행위를 넘어선 정보화 산업의 하나이자 신 유통 형태로 자리잡고 있다. 그러나 다양한 매체를 통해 정보를 손쉽게 접할 수 있는 여건이 마련되면서 소비자들의 구매 행동이나 구매 방식, 욕구들이 다양화되어 가고 있고 또 진화되어 가고 있다. 특히 1990년대 중반 최초로 국내에 등장한 케이블 TV홈쇼핑은 유통시장의 대변혁을 일으키며 2003년까지 꾸준한 성장을 하였지만 그 뒤 홈쇼핑사들의 과열화된 경쟁과 대체 쇼핑 수단들이 등장하면서 그 성장률이 둔화되고 있는 실정이다. 케이블 TV 홈쇼핑에서의 매출 부진의 주된 이유 중 하나는 판매한 상품에 대한 반품의 횟수가 많아짐을 의미하고 있으므로 본 연구에서는 케이블 TV 홈쇼핑의 구매자들의 구매 특성 중 반품행동을 중심으로 TV홈쇼핑 시장의 특성과 현황은 물론, 반품에 유의한 영향을 미치는 요인을 분석하고자 한다. 반품에 영향을 미치는 요인으로는 성별, 거주지, 결제수단, 구매금액, 출연자, 내용, 제작 방식 등이었다. 특히 전반적으로는 20-30 대의 젊은 여성일수록, 고학력, 고소득일수록 반품 비율이 높았고 제품의 가격만 고려했을 경우에는 고가의 제품에 대한 반품 비율이 특히 높았다. 본 연구는 특정 A홈쇼핑사의 실제 구매 주문 데이터를 SPSS통계 패키지를 이용해 변수를 측정하였고 종속변수는 반품 여부로 선정하였고, 독립변수 전체를 투입하는 로지스틱 회귀분석을 통해 결과를 도출하였다. 통계 결과와 각 종 자료 조사 및 문헌연구 방법을 바탕으로 반품을 줄여나가는 방안 모색을 통해 국내 홈쇼핑 시장이 발전할 수 있는 방향성 또한 제시하고자 한다. As there are many new media like satellite communications, cable TV, PC coming up and spread out, the TV home-shopping also come up to be a new retail channel. But, because of these environment which can easily get information through various media, the behavior of consumer has been changing. Especially, as the industry competition overheating, the growth of TV home-shopping is getting slow after 2003. One of the reason of bad condition in sales might be returning goods from consumers. So, in this study, we analysis the influential factors of the return behavior in TV home-shopping. The influential factors of the return behavior were sex, residence, type of payment, type of model, amount of purchase, content, type of production and so on. In generally, 20-30age women who are becoming big income and high education are the highest return rate consumers and expensiveness goods return rate was high just consideration of the price. In this study, we measure the variables using real specific A home-shopping company order data and logistic regression analysis through SPSS program. Also, we suggest some strategies which lead to return rate get down for domestic home-shopping companies based on the result of analysis and various literature reviews or data.