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문철 대한교통학회 2022 대한교통학회 학술대회지 Vol.86 No.-
자율주행 차량은 자체 센서만을 사용할 경우 인지 범위가 옆 차선 및 전 후방으로 제한되는 부분 인지(partial observation)의 한계가 발생하고, 자율주행 차량 단독으로 판단 및 경로를 계획을 수립하는 독립 드라이빙(independent driving)은 주변 차량과의 안전하고 효율적인 운행을 보장할 수 없다. 본 연구에서는 자율주행 차량의 부분 인지 및 독립 드라이빙의 한계로 발생할 수 있는 도로합류부, 교차로, 돌발교통상황 등에서, 인프라의 센싱 및 고도 상황인지 정보를 차량들에게 제공함으로써 자율주행 Lv.4/4+ 차량의 안전하고 유연한 운행을 지원하는 기술을 개발한다. 본 발표에서는 도로상황에 최적화된 인프라 센서 네트워크의 구축과 인프라 센서 네트워크에서 센싱된 데이터의 수집, 그래프 기반 객체간 관계 모델링과 그리드 기반 공간 정보 융복합 및 분석 등을 통한 초저지연 고신뢰 도로상황 인지 고도화 기술, 그리고 이를 통합한 스마트 도로상황 인지 노변 플랫폼 개발 및 구축하고 검증하기 위한 연구 계획을 소개한다.
성장호르몬이 단구 세포주 THP-1과 U937의 활성에 미치는 영향 평가
문철,유성률,김시현,성현경 한국보건기초의학회 2022 한국보건기초의학회지 Vol.15 No.2
Growth hormone (GH) is a peptide hormone secreted by the pituitary gland and stimulates cell proliferation and division to promote tissue growth. In addition, the development of the immune system and the regulation of the immune response have been reported. Along with the research results related to the inflammatory control function, a correlation between the severe symptoms of COVID-19 in the elderly and a decrease in the secretion of growth hormone has recently been suggested. Therefore, this research team studied the effect of growth hormone on the proliferation and inflammatory cytokine secretion of monocyte cell lines THP-1 and U937. As a result, it was confirmed that the proliferation of THP-1 and the secretion of TNF-α and IL-1β induced by LPS were decreased by growth hormone. On the other hand, the proliferation of U937 cell line was increased by growth hormone treatment, whereas the secretion of TNF-α and IL-1β was hardly affected. In the future, the analysis of the GH receptors expressed by the two cell lines and the study of the molecular mechanism of GH action are required. In addition, it is considered that the cell stimulation technique using Poly(I:C) needs to be established more accurately.
불멸화된 악성구상상피에 대한 Retinoic Acid의 세포활성 및 유전자 발현 연구
문철,민승기 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.1
cDNA microarray allows to monitor the expression of thousthand genes simultaneously and has been successfully to explore the gene expression of carcinoma and other diseases. To identify and monitor gene expression profile changes in oral tumorigenesis and exposure to medicine may shed light not only on the cause of these pathological changes, but also provide the opportunity to identify novel targets for disease detection and intervention. Retinoids and interferon are important regulators of human epithelial cell differentiation and have been used successfully in the clinical treatment of HPV-involved cervical cancer. However, there is only a limited information available concerning to the effect or role of retinoic acid in oral precancerous and cancer cells. We studied the effect of retinoic acid on normal human oral keratinocyte(NHOK), HPV-16 E6E7 immortalized human oral keratinocyte(IHOK), and two oral squamous cell line(HNSCC30, HNSCC31) according to the carcinogenesis stage. The RA effect was evaluated by MTT assay and microarray. Complementary DNA microarray including 400 genes was used to systematically characterize the variation in gene expression patterns of RA treated IHOK cells vs. control IHOK cells . The results were as follows: 1. RA has negative effect on growth for all NHOK, IHOK, HNSCC30 and HNSCC31 dependently on the concentration and cultivation time. 2. We identified 18 clones cDNA exhibiting more than 2 fold overexpression in RA treated IHOK probes relative to control probe, 21 cDNA s reveal more than 2 fold overexpression in control IHOK relating to the experimental cells. Pearson correlation coefficients for the set of selected spots from duplicated hybridization was 0.86. 3. Examination of gene expression that differs between RA treated IHOK and control IHOK cells apprear to be related to : cell cycle regulator, cell growth and apoptosis, cell adhesion, signal transduction and miscellanous. 4. Cell cycle regulator uprgulation is noted in MAD2, CDK9, Cdc20, Cdc2, CDK inhibitor 1A, and only HUS-1 is downregulated. 5. Cytochrome P450 and interleukin 1-alpha for cell growth and apoptosis factor was upregualted, and capase 8 & FADD apotosis regualtor gene was decreased expression, so we observed increased apoptosis mecahnism and resistance to apoptosis. 6. Cytokine upregulation in RA treated IHOK was noted in interIeukin 1 alpha, downregualtion was in interleukin 8, interleukin 10, interleukin 10 receptor, interleukin 3 receptor, interleukin 9 receptor, and interleukin 19 7. Signal transducers including JAK binding protein, STAT1, and Burkitt lymphoma receptor were upregulated with RA reated IHOK , suggesting the RA regulates the JAK/STAT signal-transduction pathway. In conclusion, we have demonstrated the high-throughput utility of cDNA array hybridization in parallel to the gene expression analysis to identify genes that are expressed differentially in RA treated with HPV16 immortalized keratinocytes. The differentially expressed genes identified here should be informative in oral epithelial cell carcinogenesis.
디지털 이동통신 단문서비스 메시지센터의 데이타베이스 구성
문철이(ChulYi Moon) 한국정보과학회 1996 한국정보과학회 학술발표논문집 Vol.23 No.2B
본 논문은 디지털 이동통신 시스템 단문서비스 메시지센터의 데이타베이스 구성에 관하여 논한다. 단문서비스는 단문단말기간 제한된 길이의 문자 메시지를 전달하는 텔리서비스이다. 단문서비스 메시지센터는 이동가입자간 또는 이동가입자와 유선통신망의 데이타 단말기간에 제한된 길이의 문자메시지를 축적교환방식으로 전달하기 위하여 데이타베이스를 필요로한다. 본 논문에서는 메시지센터 데이타베이스의 구성에 있어서 단문 서비스 자료의 분석을 통한 데이타베이스 스키마의 구성, 텔리서비스계층과 데이타베이스의 정합을 위한 질의접속부의 구조에 대하여 기술한다.