백서에서 Depulpin®과 Formocresol에 대한 치수와 치근단 조직의 반응

문형인,김선호,황윤찬,오병주,황인남,김선헌,정선와,윤창,오원만 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.4

One fifth dilution of formocresol is usually for pulpotomy of the primary teeth and emergency pulpotomy of the permanent teeth. However, the use of formaldehyde has been subjected to criticism because it may be absorbed into the blood stream and become distributed systemically, it may also alter the pulp tissue rendering it immumologically active, and have carcinogenic potential. Recently Depulpin®(VoCo., Germany) gains popularity as a devitalizing agent during root canal therapy in spite of high concentration of 49% paraformaldehyde because it facilitate devitalization of pulp and make root canal therapy easier. But there have been not enough publications about the reaction of pulp and periapical tissue caused by Depulpin. This study was performed to evaluate the histological changes in pulp and periapical tissue of rats after pulpotomy using formocresol and Depulpin and to elucidate the toxic effects of these agents. Thirty six Sprague-Dawley rats were anesthetized by intraperitoneal injection of ketamine. Maxillary first molar teeth were used for pulpotomy with formocresol and Depulpin. Rats were sacrificed after 2 days, 4 days, 1 week, 2 weeks, 3 weeks and 4 weeks respectively. Specimens were histologically observed by light microscope changes in pulp and periapical tissue. The obtained results were as follows. 1. Formocresol group A zone of fixed tissue, in which odontoblasts could clearly be defined, was present directly underneath the pulpotomy dressing in almost all teeth of this group. This was followed by an area of necrotic tissue which resembled dried out fibrous tissue with no cellular detail except some pyknotic nuclei. In the specimens of after 2 days, 4 days, 1 week, 2 weeks in which vital tissue was present. it was separated from the fibrous area by a zone of inflammation. In the specimens of after 3 weeks and after 4 weeks, inflammatory infiltrate was in the periodontal ligament adjacent to the apical foramina of the teeth. 2. Depulpin® group The area of necrotic tissue which had no cells and fibers , was present adjacent to the dressing. This was followed by dried out fibrous tissue with no cellular details except some pyknotic nucleli. A short stump of vital pulp with odontoblasts was present at the end of the canal after 2 days. Inflammatory infiltrate was in the periodontal ligament after 4 days and after 1week. Severe root resorption and necrosis of periapical tissue opposite the root resorption site were defined after 2 weeks and after 3 weeks. Periapical lesion which consist of necrotic tissue surrounded by a fibrous connective wall. was found after 4 weeks. The results indicated that Depulpin can cause more adverse reaction to the dental pulp and periapical tissue than formocresol, and further studies are needed for its clinical use with safety.

전세수요에 관한 연구

황두현,김흥수,문선오 홍익대학교 경제연구소 1997 經濟硏究 Vol.12 No.-

생산성 향상을 위한 수작업 조립라인과 대안들의 비교 평가 시뮬레이션 사례연구

황선문 한국생산성학회 2003 生産性論集 Vol.17 No.3

The Standard Time method has often been applied for measuring work lead times in a manual assembly line. These work lead-times are grouped together to make workstations in the assembly line balanced. Although the work stations are balanced in a planning stage, the assembly line in an implementation stage is usually suffered from the unexpected unbalance between the work stations. This is caused by different skills among workers on the assembly line. The purpose of this research is to improve the balance of assembly line and increase the production output. An electronic company with manual assembly lines that has suffered serious line balancing problems has been chosen for this research. In this case study, ARENA is used as a simulation tool to compare and evaluate the current manual assembly line with two alternative plans. The first alternative plan was to focus on the line balancing using Standard Time. The second one was to focus on line balancing based not only on Standard Time but also on the individual worker s skill. Although the current system has not yet solved the line balancing problems, it has been used for a long time by a field manager as a trial and error method. Simulation results show that the second alternative plan is superior to the other two lines in terms of low work-in-process level and high production output. In addition, the results demonstrate that the worker s skill is one of the factors that have significant effect on grouping work stations in manual assembly lines.

다기능 작업자를 통한 생산성 향상 사례연구

황선문 전주대학교 공학기술종합연구소 1998 전주대학교 공학기술종합연구소 학술논문집 Vol.4 No.2

This study has been devoted to improve productivity through using multi-functional workers. In order to prove the power of using the multi-functional workers, two companies, were chosen for the research. Within these companies, Group Working(GW) cell was made on the shop floor and the multi-functional workers were trained from the single functional workers by on the job training method. Then, the production results from GW cells were recorded and analysed to find out the effectiveness of the cell. The productivity from the cells were much higher than the one using single functional workers. Through this research, on the job training was the appropriate training method to convert a single-function worker to the multi-functional worker. Furthermore, on the job training can be well matched within GW method. For the research, Action Research was used as the appropriate research methodology.

급성 포름알데히드 가스 흡입에 의한 흰쥐 후각상피의 형태학적 변화

백선용,전재기,문용석,황승영,노환중,고의경,왕수건 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

공장내 공장에 그룹워킹을 도입한 시뮬레이션 사례연구

황선문 전주대학교 공학기술종합연구소 2003 전주대학교 공학기술종합연구소 학술논문집 Vol.9 No.1

The purpose of this paper is to increase productivity for Plants Within Plants (PWP) worked for the outsourcing work from a big company. The big company supplies to PWP through informing production planning, rending a particular production line, suppling raw materials and helping variety of technical supports. PWP has to complete the process and returned the finished goods to the company, Thus, the production manager in PWP h limited options for increasing productivity, but organizing workers in a better way on the shop floor. The PWP m e was chosen for this research which is for the final process of making a body wash. Three alternatives were made as: firstly, reducing work stations and reducing balance delay; secondly, using group working method on the line; thirdly, an allowance time was added on the second alternative for compensating workers movements. A computer simulation method has been used for comparing and evaluating the current assembly line and three alternative plans. Simulation results have shown that the second one is superior to the other three lines in terms of low Work-In-Process(WIP) level and high production output. If the characteristics of Group working is considered by adding allowance rates, the third one is more realistic on the shop floor, and it shows also higher production output and low WIP level. In conclusion, applying Group Working within PWP production environment could be the solution for increasing productivity.

만성정신질환자의 직업재활 사례

황태연,한은선,이영문,강순정,정경선 용인정신의학연구소 1995 용인정신의학보 Vol.2 No.1

수작업 조립라인의 생산성 향상을 위한 대안들의 개발 및 비교 평가 시뮬레이션 사례연구

황선문 전주대학교 공학기술종합연구소 2003 전주대학교 공학기술종합연구소 학술논문집 Vol.9 No.1

A traditional method of organizing a manual assembly line is to use the Standard Time for the purpose of measuring work lead times and grouping these work lead times together in order to make work stations in the assembly line balanced. The work stations are usually balanced in a planning stage. However, due to the different skill levels of workers, the unexpected unbalance problems between work stations lime often been occurred The purpose of this research is to improve the balance of assembly line and increase the production output by using Group Working method An electronic company that has a manual assembly line and has suffered serious line balancing problems has been chosen for this research A computer simulation method has been used to compare and evaluate the current manual assembly line and three alternative plans. For the first alternative plan, only Standard Time was used to make the assembly line balanced Both Standard Time and the individual worker's skill were used for the second one. Finally, Group Working method was used for the third one. Simulation results have shown that the third alternative plan is superior to the other three lines in terms of low work-in-process level and high production output. In addition, the results demonstrated that the worker's skill and co-operation between them are the factors that have significant effect on grouping work stations in manual assembly line.

SSM을 이용한 중소기업 설비관리를 위한 정보화정책 결정에 관한 연구

황선문 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.2

This research is devoted to applying Soft System Methodology(SSM) for the in-formation policy decision making. In many cases, the information policy of the Medium-Small sized Enterprise is very important to knowledge based information management environment. However, the selecting of information policy alternatives is difficult in that the decision making process should include the real situation of the shop floor and the skill and knowledge of the information system operators. Furthermore, the elements of information policy are more qualitative than quantitative. In this case study, Soft System Methodology(SSM) has been applied for the decision making process of the information policy in order to choose the optimal alternative. According to the result, the information system chosen by SSM is proven to solve the complicated problems and has also concerned management environment of the case company.

Bisthmus 제재와 항생제의 복합 투여가 Helicobactor pylori 박멸과 재발에 미치는 영향

김선주,황성규,박상흠,이문호 순천향대학교 1994 논문집 Vol.17 No.4

위점막내에 존재하는 Helicobacter pylori는 소화성 궤양의 발생과 재발에 중요한 인자로 인식되고 있으며, bisthmus, metronidazole, amoxicillin을 포함하는 3제 병합요법을 시행하면 H. pylori균의 박멸에 유효하고 소화성 궤양 재발 빈도를 낮출 수 있다고 한다. 그러나 3제 병합요법은 부작용 발생율이 높아 치료 실패의 주원인이 되고 있다. 이에 저자등은 H. pylori 양성인 소화성 궤양환자에서 H₂ 길항제 투여와 함께 3제 병합요법을 시행하였고, 또한 비교적 약제 부작용이 많은 metronidazole을 제외한 이제 병합 요법을 시행하여 H₂ 길항제 단독 투여한 대조군과 6개월간 추적하여 균의 박멸및 재발 여부를 비교 관찰하였다. 대조군은 Nizatidine을 8주간 투여하였으며 치료 1군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용), amoxicilline(500mg 하루 4회 복용) 투여하였다. 치료 2군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용)과 amoxicilline(500mg 하루 4회복용) metronidazole (250mg thrice a day)을 투여하였다. 치료 8주후 치료 1군은 53%에서, 치료 2군은 100%에서 균이 음전되었으나 대조군은 1예도 음전되지 않았다. 치료 2군의 13%에서 약물에 의한 부작용이 관찰되었다. 치료 6개월 추적 검사시 대조군은 모두 H. pylori 감염이 지속되었으며 치료 1군에서는 63%에서 재발하였으며, 치료 2군에서는 15%에서 재발하였다. 대조군에서는 소화성 궤양(위궤양 1명, 십이지장 궤양 4명)이 5명에서 재발하였으나 치료군에서는 재발이 없었다. H. pylori박멸된 환자에서의 항 H.pylori 항체(IgG)가는 치료 6개월에 치료전의 40%로 감소한 반면, 대조군의 항체가는 변화가 없었다. 이상의 결과로 H₂ 길항제(nizatidine)을 metronidazole 750mg/day, TDB 480mg/day, amoxicillin 2.0gm/day를 2주간 투여하면 약제에 의한 합병증이 비교적 적고, Helicobacter pylori 박멸과 재발 방지에 효과적이며 혈청 H. pylori 항체(IgG)의 추적 검사는 항 H. pylori 치료후 균박멸의 추적검사에 유용함을 알 수 있었다. It has recently been recognized that Helicobacter pylori is a important factor in the development and the recurrence of peptic ulcer diseases. Several studies has been shown that the eradication of Helicobacter pylori is associated with considerable reduction in the the rate of recurrence of peptic ulcer. Triple therapy including bisthmus, amoxicillin, metronidazole is known to be useful in the eradication of Helicobacter pylori, but relatively frequent side effects are a major problem. This study was performed to evaluate the clinical course and the efficacy of triple therapy with H₂ blocker and bisthmus plus amoxicillin therpy with H₂ blocker in the eradication and the recurrence of Helicobacter pylori at 8 weeks and 6 months of treatment. Forty five patients with peptic ulcer disease with a positive urease test of the gastric mucosa were enrolled and assigned to receive H₂ blocker (nizatidine 150mg twice a day) for 8 weeks(control group), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day for 2 weeks, nizatidine for 8 weeks (treatment group Ⅰ), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day, metronidazole 250mg thrice a day for 2 weeks, nizatidine for 8 weeks(treatment group Ⅱ). H. pylori was eradicated in 53% of treatment group Ⅰ, 100% of treatment group Ⅱ, none of control group after 8 weeks of treatment. Helicobacter pylori infection is recurred in 63% of of treatment group Ⅰ and 15% of treatment group Ⅱ. Side effects were recorded in 3 patients(2 patients on treatment group Ⅱ, 1 patient on treatment group Ⅰ), but it were minor side effects. No patients on treatment groups recurred peptic ulcer disease, while 5 patients on control group. Anti-H. pylori antibody IgG remained constant in bacteria positive control group, but in patients in whom H. pylori had been eradicated serum antibody titers fell significantly at 6 months of treatment. In conclusion, triple therapy including a low dose metronidazole with nizatidine is effective on the eradication of Helicobacter pylori infection and reduced the rate of side effects. Bisthmus and amoxicillin with nizatidine is not effective on the eradication and the recurrence of Helicobactor pylori infection. Serologic tests for H. pylori are reliable means of monitoring success of eradication of H. pylori.