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좌측 전대뇌동맥 영역의 뇌경색 후 발생한 초피질성 혼합 실어증 1예
심미섭,이연수,김은희,이인숙,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
We present a case of transcortical mixed aphasia (TMA) presumably caused by left anterior cerebral artery infarction. A 53-year-old, right-handed woman suddenly developed speech disturbance and abnormal behavior. Her spontaneous speech was remarkably reduced to almost mutistic state and objective naming, comprehension, reading and writing were severely impaired. However, repetition of phonemes and sentences were fully preserved. She showed echolalia and completion phenomenon, which prompted us to make a diagnosis of TMA. Although the lesion was confined to extrasylvian area on MRI, SPECT demonstrated diminished blood flow left perisylvian cortices suggestive of functional isolation of speech area. In spite of her echolalic repetition, she couldn't repeat affective prosody, presumably, because of the left anterior corpus callosal lesion. Treatment with bromocriptine, a dopamine agonist helped her recovery of behavioral changes, namely abulia or akinetic mutism consisitent with mesial frontal syndrome.
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Clinical Experience of Rigid Bronchoscopy in Single Center
Kim, Hyun-Jin,Kim, Sei-Won,Lee, Hye-Yeon,Kang, Hyeon-Hui,Kang, Ji-Young,Kim, Ju-Sang,Kim, Myung-Sook,Kim, Seung-Soo,Kim, Jin-Woo,Yun, Hyeong-Gyu,Kim, Chi-Hong,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Cho, Kwang The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.6
Background: The aim of this study was to analyze clinical situations requiring rigid bronchoscopy and evaluate usefulness of rigid bronchoscopic intervention in benign or malignant airway disorders. Methods: We retrospectively reviewed 29 patients who underwent rigid bronchoscopy from November 2007 to February 2011 at St. Paul's Hospital, The Catholic University of Korea School of Medicine. Results: Of the 29 patients, the most frequent underlying etiology was benign stenosis of trachea (n=20). Of those 20 patients, 16 had post-intubation tracheal stenosis (PITS), 2 had tracheal stenosis due to inhalation burn (IBTS) and other 2 had obstructive fibrinous tracheal pseudomembrane (OFTP). Other etiologies were airway malignancy (n=6), endobronchial stenosis due to tuberculosis (n=2), and foreign body (n=1). For treatment, silicone stent insertion was done in 16 cases of PITS and IBTS and mechanical removal was performed in 2 cases of OFTP. In 6 cases of malignant airway obstruction mechanical debulking was performed and silicone stents were inserted additionally in 2 cases. Balloon dilatation and electrocautery were used in 2 cases of endobronchial stenosis due to tuberculosis. In all cases of stent, airway obstructive symptom improved immediately. Granulation tissue formation was the most common complication. Conclusion: Tracheal stenosis was most common indication and silicone stenting was most common procedure of rigid bronchoscopy in our center. Rigid bronchoscopic procedures, at least tracheal silicone stenting, should be included in pulmonary medicine fellowship programs because it is a very effective and indispensable method to relieve critical airway obstruction which needs training to learn.
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Effects of β-Lapachone on Gastric Secretion
Yun-Bae Kim, Dongsun Park, In Geun Cho, Yun-Hui Yang, Jangbeen Kyung, Dajeong Kim, Ehn-Kyoung Choi, Tae Hwan Kwak3, Sang Ku Yoo 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.3
The effects of β-lapachone on gastric secretion were investigated. The pylorus of male Sprague-Dawley rats was ligated and intraduodenally injected with β-lapachone, and the volume, pH, free HCl, and total acidity of gastric fluid were measured 6 hours after the operation. Treatment with β-lapachone resulted in dose-dependent inhibition of gastric secretion Gastric fluid was reduced to 42.9% of control level by 100 mg/kg of β-lapachone, leading to an increase of pH to 6.70 from 1.85 in the control group. In parallel with the increase of pH, at this dosage, free HCl and total acidity decreased to 16.7% and 12.0%, respectively, of control levels. β-Lapachone exhibited ED50 values of 72, 46, and 47 mg/kg for inhibition of gastric volume, free HCl, and total acidity, respectively, implying a superior efficacy on gastric acid to volume. In comparison, pantoprazole (30 mg/kg) reduced the volume, free HCl and total acidity of gastric fluid to 53.0%, 26.0%, and 25.0%, respectively, of control levels, resulting in an increase in pH to 6.36. In the current study, it was confirmed that β-lapachone at an appropriate dose (100 mg/kg) exerted a higher inhibitory effect on gastric secretion than pantoprazole (30 mg/kg), a well-known proton-pump inhibitor. Therefore, it is suggested that β-lapachone could be a candidate compound for prevention or treatment of gastric ulcers induced by diverse psychological and physical stimuli.
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김정희 ( Kim Jeong Hui ),김준식 ( Kim Jun Sig ),어완규 ( Eo Wan Gyu ),김영일 ( Kim Yeong Il ),김선희 ( Kim Seon Hui ),김시영 ( Kim Si Yeong ),윤휘중 ( Yun Hwi Jung ),조경삼 ( Jo Gyeong Sam ) 대한내과학회 1993 대한내과학회지 Vol.44 No.4
연구배경 : 항원수용체유전자 재배열 현상의 분석은 림프구의 항원수용체인 B세포의 Immunoglobulin (Ig) 유전자와 T 세포의 T-cell receptor(TcR) 유전자가 림프구의 분화초기에 재배열되는 것을 이용한 방법으로 주로 림프종양의 확인과 분류에 이용되었다. 그러나 림프 종양과는 감별해야하는 급성골수성백혈병(AML)에서 Ig 혹은 TcR 유전자 재배열이 보고되고 있으며 그 의의는 확실치 않다. 방법 : AML 환자 25명의 진단당시의 골수세포에서 DNA를 분리하여 IgH 유전자 재배열 및 TcRβ 유전자 재배열을 Southern blot 방법으로 검사하였다. 세가지 제한효소(EcoRⅠ, BamHⅠ, HindⅢ)와 두가지 소식자(J_(H), Cβ)가 사용되었다. 결과 : 1) AML 환자 25명중 TcRβ 유전자 재배열이 2예에서 있었고(8%), IgH 유전자 재배열은 한예도 없었다. 2) 면역표지검사가 시행되었던 13명중 B 림프계표지인 CD19 양성인 환자가 3명, T 림프계표지인 CD2양성인 환자가 2명이었는데 모두 재배열이 없었다. TcRβ 유전자 재배열을 보였던 2명의 환자에서는 면역표지검사가 시행되지 않았다. 3) TcRβ 유전자 재배열을 보였던 2명은 각각 항암 화학요법후 14개월간 관해유지상태인 환자와 치료전 사망했던 환자였다. 결론 : 일부 AML에서 TcRβ 유전자재배열현상이 발견되었고, 항원수용체 유전자 재배열과 면역발현형이나 예후와는 연관이 없을 것으로 사료되며, 임상적인 이용을 위해서는 향후 좀더 광범위한 연구가 진행되어야 할 것이다. Background: Detection of the immunoglobulin (Ig) and the T cell receptor (TcR) gene rearrangements are useful markers for determining lineage and clonality in lymphoid malignancy. Antigen receptor gene rearrangements have also found in some patients with acute myeloid leukemia (AML). The significance of these rearrangements remains unclear. Methods: Ig heavy chain (IgH) gene and TcR beta chain(TcRβ) gene rearrangements were examined in leukemic cells from 25 patients with AML by Southern blot analysis. DNA was extracted from bone marrow aspirates. Three different enzymes (EcoRⅠ, BamHⅠ, HindⅢ) and two different probes(J_(H), Cβ) were used. Results: 1) TcRβ gene rearrangements were demonstrated in 2 of 25 cases(8%). But IgH gene rearrangement was not detected at all. 2) Antigen receptor gene rearrangement pattern of three cases with B cell antigen, CD19(+) and two cases with T cell antigen, CD2(+) were germline. Immunophenotyping was not performed in two cases with TcRβ gene rearrangement. 3) Of the patients with TcRβ gene rearrangement, one is alive in complete remission state after chemotherapy, and the other patient died before therapy. Conclusion: TcRβ gene rearrangement was demonstrated in some patients with AML. Antigen receptor gene rearrangment did not correlate with specific immunophenotype and prognosis. The clinical implication of antigen receptor gene rearrangement study need further study.
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Clinical Experience of Rigid Bronchoscopy in Single Center
( Hyun Jin Kim ),( Sei Won Kim ),( Hye Yeon Lee ),( Hyeon Hui Kang ),( Ji Young Kang ),( Ju Sang Kim ),( Myung Sook Kim ),( Seung Soo Kim ),( Jin Woo Kim ),( Hyeong Gyu Yun ),( Chi Hong Kim ),( Kwan H 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.6
Background: The aim of this study was to analyze clinical situations requiring rigid bronchoscopy and evaluate usefulness of rigid bronchoscopic intervention in benign or malignant airway disorders. Methods: We retrospectively reviewed 29 patients who underwent rigid bronchoscopy from November 2007 to February 2011 at St. Paul``s Hospital, The Catholic University of Korea School of Medicine. Results: Of the 29 patients, the most frequent underlying etiology was benign stenosis of trachea (n=20). Of those 20 patients, 16 had post-intubation tracheal stenosis (PITS), 2 had tracheal stenosis due to inhalation burn (IBTS) and other 2 had obstructive fibrinous tracheal pseudomembrane (OFTP). Other etiologies were airway malignancy (n=6), endobronchial stenosis due to tuberculosis (n=2), and foreign body (n=1). For treatment, silicone stent insertion was done in 16 cases of PITS and IBTS and mechanical removal was performed in 2 cases of OFTP. In 6 cases of malignant airway obstruction mechanical debulking was performed and silicone stents were inserted additionally in 2 cases. Balloon dilatation and electrocautery were used in 2 cases of endobronchial stenosis due to tuberculosis. In all cases of stent, airway obstructive symptom improved immediately. Granulation tissue formation was the most common complication. Conclusion: Tracheal stenosis was most common indication and silicone stenting was most common procedure of rigid bronchoscopy in our center. Rigid bronchoscopic procedures, at least tracheal silicone stenting, should be included in pulmonary medicine fellowship programs because it is a very effective and indispensable method to relieve critical airway obstruction which needs training to learn.
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( Jin Ah Kim ),( Chang Wook Kim ),( Ji Young Kim ),( Yun Hui Kim ),( Mi Ju Cheon ),( Hee Yeon Kim ),( Jung Myung Kim ),( Yoo Dong Won ),( Se Hyun Cho ),( Jong Young Choi ),( Seung Kew Yoon ),( Nam Ik 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Immune regulatory molecules such as forkhead box P3 (FoxP3), programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) on T cell are associated with antiviral effector T cell dysfunction, which influences on T cell exhaustion and persistent viral infection in patients with chronic hepatitis C (CHC) and chronic hepatitis B (CHB). These FoxP3, PD-1 and CTLA-4 are known to up-regulated in CHC and CHB but, there is few report about the phenotypic changes of these molecules during direct-acting antiviral (DAA) therapy, especially, Daclatasvir and asunaprevir (DCV+ASV) in genotype 1b CHC. We investigated the expression of FoxP3, PD-1 and CTLA-4 during 6 months DCV+ASV treatment in 19 patients with genotype 1b CHC. Methods: Nineteen patients with genotype 1b CHC under DCV+ASV treatment were enrolled for detection of intrinsic inhibitory molecules of T cell signals (PD-1, CTLA4) and extrinsic inhibitory molecule, FoxP3. Peripheral blood mononuclear cells (PBMC) were isolated from these subjects before treatment (T0), 1 month (T1), 3 month (T3), 6 month (T6) and 9 month (T9) during DCV+ASV treatment. The expressions of FoxP3, PD-1, CTLA-4, CD8, CD4 on T cells were monitored by flow cytometry. Results: T cells from patients with CHC before DCV+ASV treatment (T0) showed increased expression of FoxP3, PD-1 and CTLA-4 compared to healthy control. However, T cells from patients with CHC under DCV+ASV treatment showed decreased expression of PD1 and CTLA-4 at T6 compared to T0 significantly. Interestingly, the expression of Foxp3 was sustained at T6 through T0. Conclusions: In CHC, PD-1 and CTLA-4 as inhibitory T cell molecules were down-regulated during 6 months DCV+ASV therapy but, FoxP3 as regulatory T cell marker was sustained during DCV+ASV therapy. This phenomenon could be one of background mechanisms of post-DAA syndrome such as HCC development or reactivation of HBV coinfection after DAA therapy.
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Synthesis of a Low-Bandgap Fluorinated Donor–Acceptor Copolymer and Its Optoelectronic Application
Yun, Hui-Jun,Hwang, Moon Chan,Park, So Min,Kim, Ran,Chung, Dae Sung,Kim, Yun-Hi,Kwon, Soon-Ki American Chemical Society 2013 ACS APPLIED MATERIALS & INTERFACES Vol.5 No.13
<P>We demonstrate the synthesis of a new copolymer which is composed of dialkyl thienylated benzodithiophene and perfluororalkyl-carbonyl thienothiophene (DTBDT-TTFO) and the characterization of its optoelectronic properties. The introduction of thienyl groups enabled the extended delocalization of π electrons in the DTBDT-TTFO backbone and efficient intermolecular charge transport as proved by the fairly high field effect mobility of 0.02 cm<SUP>2</SUP>/(V s). The introduction of perfluororalkyl-carbonyl side chains resulted in a significant red-shift of DTBDT-TTFO in the absorption spectra and a decrease in the HOMO and LUMO levels. The resulting energy levels of DTBDT-TTFO were not satisfactory for solar cell applications, especially in terms of charge separation at the polymer/PCBM interfaces. Rather, the DTBDT-TTFO showed better energy level matching with the colloidal nanocrystals (NCs) of CdSe. A photodetector based on the bulkheterojunction of DTBDT-TTFO and CdSe NCs with coplanar device geometry resulted in a high photoconductive gain (responsivity higher than 1A/W under a low operating voltage of 1 V), possibly arising from electron trapping at CdSe NCs such that the hole can travel along the detector and its surrounding circuit. More importantly, the photodetector revealed a time constant of a few hundreds of microseconds, which means that the response speed of the photodetector is fast enough for lag-free imaging applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2013/aamick.2013.5.issue-13/am4007935/production/images/medium/am-2013-007935_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am4007935'>ACS Electronic Supporting Info</A></P>
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