노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

생후 6일째(P6) 쥐와 성체 쥐의 해마체에서 시냅스의 발달과 프로테아좀 활성에 관한 연구

이찬혁,김형태,서혜명 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-

유비퀴틴-프로테아좀 시스템(ubiquitin-proteasome system: UPS) 은 세포내에서 비정상적인 단백질을 분해하는 기능을 담당하며, 그기능의 상실은 생체의 비정상적인 발달단계나 여러 퇴행성 신경질환의 병리학적 진행을 이해하는데 중요한 것으로 생각된다, 본 연구에서는 생후 6일째의 쥐(P6) 와 성체 쥐 뇌의 해마체에서 시냅스의 발달을 대표할수 있는 nerve growth factor(NGF)와 synaptophysin 의 발현 정도를 측정하고 더불어 프로테아조 활성의 차이를 알아보고자 하였다, 먼저 우리는 P6쥐 의 해마체에서 성체 쥐에 비하여 NGF의 발현이 1.3배 증가된 것을 확인하였고, 또한synaptophysin의 양이 특이적으로 감소된 것을 볼수 있었다, 흥미롭게도 P6쥐의 해마체에서 성체 쥐와 비교하여 유의성 있게 높은 프로테아좀 활성을 관찰 할수 있었다, 이와 같은 연구를 통하여 쥐 뇌의 발달 과정에 있어서 프로테아좀 활성의 조절은 시냅스의 발달과 밀접하게 연관되어 있다고 추정된다. Dysfunction of ubiquitin-proteasome system (UPS)has been proposed or implicated in the pathological processing of several neurodegenerative diseases and abnormalities in development . To address th differences of UPS in the sysnaptic development we determined the proteasome activities in the hippocampus of postnatal day 6 (P6) and adult rats. Using ELISA and western blot we found that the hippocampal NGF expression level is 1.3 times higher and synaptophysin level is significantly lower in P6 compared to adult Interestingly P6 rats in development showed 3~5 times higher hippocampal proteasome activities compared to adults. These results suggest that ubiquitin-proteasome are potentially related to synaptic divelopment.

감마선 조사 육류, 가금류에서 저장전과 후의 조사선량에 따른 DNA fragmentation의 변화

이혜진,김상미,박유경,양재승,강명희 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.2

The changes in DNA damage were investigated during storage after irradiation. Beef, pork and chicken were irradiated at 1.0, 3.0 and 5.0 kGy and stored for 6 months at 20℃. The comet assay was applied to the sample muscles at the beginning of irradiation and at the end of storage. Muscles were isolated, sliced, and the suspended cells were embedded in an agarose layer. After lysis of the cells, they were electrophoresed for 2 min. and then stained. DNA fragmentation in tissues caused by irradiition was quantified as tail length and taii moment (tail length x % DNA in tail) by comet image analyzing system. Right after irradiation, the differences in tail length between unirradiated and irradiated muscles were significant(p<0.05) in beef, pork and chicken. With increasing the irradiation doses, statistically significant longer extension of the DNA from the nucleus toward anode was observed. Similarly even 6 months after irradiation, all the irradiated muscles significantly showed longer taii length than the unirradiated controls. The results represented as tail moment showed similar tendency to those of tail length, but the latter parameter was more sensitive than the former. These results indicate that the comet assay could be one of the simple methods of detecting irradiated muscles. Moreover, this method suggest that using comet assay, we were able to detect DNA damage differences even after 6 months after irradiation.

갈색거저리(Tenebrio molitor)複眼에 관한 微細構造的 硏究

이혜원,정문진,문명진 단국대학교 1997 論文集 Vol.31 No.-

Tenebrio molitor, adult beetle has one pair of comound eye not ocelli in head. This eye is dumbbell shape through dorsal to ventral direction in side of head. The compound eye is composed of about 300 ommatidia. An ommatidium consist of a lens, 4 Semper cells, 2 primary pigment cells, 90 secondary pigment cells, and 8 retinula cells. Light enters from the top and passes through the lens and Semper cells. The lens is biconvex type and lamellated. And then the Semper cells were observed below the lens. The cytoplasm of the primary pigment cells(PG1) is more electron density than Semper cells. Electron dense of pigment granules distributes along the proximal region of the cell. Secondary pigment cells(PG2) is peripherally located each ommatidium. The columnar secondary pigment cells have 2 different types pigment granules. One type(PG1) is electron dense and 0.6 ㎛ in diameter and another type(PG2) is less electron dense and 1.4 ㎛ in diameter. Retina is located under the Semper cells and is composed of 8 retinular cells. Among the 8 retinular cells 2 cells lie central area and the rest 6 cells is located peripheral region. It is morphological feature that rhabdom is formed by the partial fusion of 6 rhabdomeres and fully fusion of 2 rhabdomeres in Tenebrio molitor.

부분차원 기반의 고차원 클러스터링 알고리즘

이혜명,김진호,박영배 명지대학교 산업기술연구소 2001 産業技術硏究所論文集 Vol.20 No.-

Although many clustering algorithms for datamining are developed, most approaches are not designed for a clustering of high-dimensional data. Therefore, the performance of existing algorithms degenerates rapidly with increasing dimension because of especially the inherent sparsity of the data points. The subspace clustering technique by incremental projection. The incremental projection uses data distribution-dependent partitioning for optimal partitioning of data set. It makes better quality of the cluster by ensuring the efficiency and the effectiveness.

감마선 조사된 감자, 마늘, 생강에서 조사선량과 저장기간에 따른 DNA fragmentation의 변화

이혜진,박유경,양재승,강명희 한국식생활문화학회 2004 韓國食生活文化學會誌 Vol.19 No.3

The changes in DNA damage were investigated during storage after irradiation. Potato, garlic were irradiated at 0.05, 0.07, 0.1 and 0.15 kGy and stored for 3 months. Ginger was irradiated at 0.01, 0.02, 0.03, 0.04 and 0.05 kGy and stored for 1 month. The comet assay was applied to the sample immediately after irradiation and at the end of storage. Samples were isolated, grounded and the suspended cells were embedded in an agarose layer. After lysis of the cells, they were electrophoresed for 1 min. and then stained. DNA fragmentation in seeds caused by irradiation was quantified as tail length and tail moment (tail length × % DNA in tail) by comet image analyzing system. Right after irradiation, the differences in tail length between unirradiated and irradiated samples were significant(p〈0.05) in potato, garlic and ginger. With increasing the irradiation doses, statistically significant longer extension of the DNA from the nucleus toward anode was observed. The results represented as tail moment showed similar tendency to those of tail length. Similarly in the stored samples, even 1 or 3 months after irradiation, all the irradiated samples significantly showed longer tail length than the unirradiated controls. These results indicate that the comet assay could be one of the simple methods of detecting irradiated samples. Moreover, the method could detect DNA damage even after 1 or 3 months after irradiation.

고양이에서 영양학적인 원인에 의해 발생한 속발성 부갑상선기능항진증 1례

이혜원,박성준,김명철,정성목 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 10 month-old Korean domestic shorthaired cat(male, 1.4kg)was admitted to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of astasia the onest of which was 3 month ago and all-meat diets. Physical examination revealed thin, growth retarded and lying in lateral recumbency. Radiograph showed abnormally radiolucent bones, thin cortices, kyphosis and lordosis of the spine and multiple fractures of the femurs. Result of serum biochemical test revealed mild hypocarcemia. Serum parathormone and 1, 25(OH)2-vitamin D3 levels were markedly elevated, whereas 25(OH)-vitamin D3 level was in normal range. Nutritional secondary hyperparathyroidism was diagnosed by history taking, physical examination, laboratory examination and radiography. Calcium gluconate with balanced commercial cat food was given. On 24 days later, improvements were found in clinical signs and radiographs.

Sequential Ordering Problem과 Job Shop Scheduling Problem에 적용 가능한 선행관계유지 유전 연산자의 비교

이혜리,이건명 충북대학교 컴퓨터 정보통신 연구소 1999 컴퓨터정보통신연구 Vol.7 No.2

본 논문에서는 Sequential Ordering Problem(SOP)와 Job-shop Scheduling Problem(JSP)라고 하는 선행관계 제약이 있는 조합 최적화 문제에 대해 유전자 알고리즘을 적용하는 것에 관심을 두고, 이러한 문제에 적용할 수 있는 유전 연산자를 비교 실험하고 성능을 분석한다. 기존의 연구에서 제안되었던 선행관계유지 교차연산자, 선행관계유지 순서기반 교차 연산자. 최대부분순서/임의삽입 연산자를 소개한 후에 TSP를 해결하기 위해서 제안되었던 간선 재결합 연산자를 선행제약이 있는 문제에 적용하기 위해 변형한 선행관계유지 간선 재결합 연산자와 POX에서 개체의 다양성을 고려한 다선택 선행관계유지 순서기반 교차연산자를 제안한다. SOP와 JSP에 제안된 유전자 알고리즘을 적용하기 위해서 변형한 GENITOR로 유전 연산자를 실험하고 그들의 수행시간과 실험 결과값을 비교한다. This paper is concerned with applying genetic algorithms to Sequential Ordering Problem(SOP) and Job-shop Scheduling Problem(JSP) focusing on the class of genetic operators applicable for combinational optimization problems, such as SOP and JSP with precedence constraints. It presents some existing genetic operators to generate chromosomes preserving the imposed precedence constraints : Precedence-preserving Crossover(PPX). Precedence-preserving Order-based Crossover (POX), Maximum Partial Order / Arbitrary Insertion(MPO/AI). It proposes two new precedence- preserving genetic operators : One is the Precedence-Preserving Edge Recombination(PPER) operator which is modified from the Edge Recombination operator in order to preserve the imposed precedence constraints. The other is a Multiple Selection Precedence-preserving Order-based Crossover(MSPOX) which is modified from POX operator to induce more diversity in the created child chromosomes. The genetic operators are compared and analyzed with respect to their obtained solution quality and running time.

림프절 생검으로 진단된 복강내 간질섬유형성 소원형 세포 종양 1예 보고

주명진,이광민,이혜경,정동규 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.5

개에서 발생한 만성 단독 비장 염전의 진단 및 치료 1례

이혜원,최호정,김명철,정성목 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 5-year-old German Shepherd dog(intact male, 27kg) was admitted to the Veterinary Medical Teaching Hospital of Chungnam National University with the history of anorexia and vomiting. On physical examination, he was depressed and had abdominal distention. A complete blood count indicated leukocytosis and anemia. Radiographic findings included a large soft tissue mass in the middle to caudal abdomen and loss of serosal detail. Ultrasonographs showed splenomegaly with mixed ethoic parenchyma, hyperechoic area around the splenic hilus, and loss of venous flow. Computed tomography revealed enlarged spleen with partially enhanced parenchyma. Chronic isolated splenic torsion was diagnosed and splenectomy was performed. Histopathologic examination revealed chronic passive congestion of the spleen. He was recovered normally after surgery without any complications.