강박증 환자에서 신경 심리 검사를 통한 전두엽 기능에 관한 연구

안경흡,김명선,김연수,박은희,박선희,신민섭,류인균,권준수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 강박증 환자에서 비언어적 기억의 장애, 실행능력(executive function)의 장애, 시공간능력의 장애등의 신경 인지 기능의 장애 및 뇌 영상 연구에서 전두엽-기저핵 신경로의 기능장애가 있다는 결과들이 보고되어 왔다. 저자들은 전두엽의 기능을 반영하는 것으로 알려진 신경 심리 검사를 통하여 강박증 환자의 전두엽의 기능적 변화의 유무 및 기타 인지기능에 미치는 영향에 대해서 평가하고자 하였다. 방 법 : 서울대학교병원 강박증 클리닉에 내원한 32명의 강박증 환자군과 28명의 정상 대조군을 대상으로 강박증상의 중증도에 대한 평가와 함께 한국판 단축형 지능검사(Short-form of K-WAIS)와 주로 전두엽 기능을 평가하는데 민감한 것으로 알려진 신경 인지 기능 검사군(위스콘신 카드 분류 검사, Rey-Os-terrieth Complex Figure test, Controlled Oral Word Association test, 선로 잇기 검사, Luria-Nebraska 신경심리 바테리 중 언어학습능력검사)을 시행하였다. 이 검사들의 결과를 연령과 교육연수를 통제한 후에 ANCOVA로 분석하였다. 결 과 ; 강방증 환자군은 범주적 언어 유창성 점수(ANCOVA, F=15.07, df=58, p<0.001), Rey-Os-terrieth Complex Figure test의 즉각 회상 점수(ANCOVA, F=6.33, df=57, p<0.015), Rey-Os-terrieth Complex Figure test의 지연 화상 점수(ANCOVA, F=5.33, df=57, p<0.022)가 정상 대조군에 비하여 유의하게 저하되어 있었다. 결 론 : 이 결과는 강박증 환자들이 전두엽의 특징적인 기능으로 알려진 실행기능보다는 비언어적 기억능력의 장애 및 언어능력의 장애를 가지고 있음을 시사한다. Objective : Non-verbal memory deficits, impairments in executive function and deficits in visuospartial functions have been repeatedly reported in subjects with obsessive-compulsive disorder(OCD). The present study aimed to evaluate the frontal lobe function using neuropsychological test in subjects with OCD and normal control. Methods : A battery of neuropsychological test(Wisconsin Card Sorting test, Rey-Osterrieth Complex Figure test, Controlled Oral Word Association test, Trail Making test, Verbal Learning test) reflecting frontal lobe function was administrated to 32 OCD patients and 28 healthy comparison subjects. Result : There were no significant differences in age, years of education, or estimated IQ between the groups. Scores in category fluency, immediate recall and delayed recall of Rey-Osterrieth Complex Figure test in OCD subjects were significantly lower than those of healthy comparison subjects(ANCOVA, F=15.07, df=58, p<0.001 ;ANCOVA, F=6.33, df=57, p<0.015 ; ANCOVA, F=5.33, df=57, p<0.022, respectively). Conclusion : OCD patients had selective deficits in task involving non-verbal memory and categorical word fluency relative to healthy comparisons.

韓國의 階層別 所得分配 推移와 그 決定要因

安國臣,姜善代 중앙대학교 경제연구소 1990 經濟論文集 Vol.- No.4

Size distribution of income in Korea has been explained by two well-known "stylized facts." Firstly, size distribution of income in Korea is relatively equitable by international standards. Along with Taiwan, Korea is one of only a few developing countries whose distribution patterrn is known to be comparable to that of advanced countries such as the United States, France, and Italy. Secondly, Kuznets's U-shaped hypothesis can be applied to korea as its size distribution of income makes a downturn curve during the 1970s and it makes a upturn curve in the 1980s. The basic purpose of this paper is to demonstrate that the "stylized facts" about the size distribution of income in Korea are only hopeful estimates, distorting the real income distribution situation in Korea. It is shown that the size distribution of income is not as equitable as claims made by the "stylized facts" and that the size distribution of income has not improved but deteriorated in the 1980s, vitiating the Kuznets's hypothesis. The organization of this paper is as follows. In section Ⅱ, the data processing and estimation method are presented. In section Ⅲ, estimation of the size distribution of income in Korea for the period of 1970-1988 is given and compared with that of privious studies. In section Ⅳ, possible causes affecting the size distribution of income in Korea are analyzed. Concluding comments are in section Ⅴ.

流動層 燒却盧에서 段階的 燒却法에 의한 都市下水슬러지의 燒却

신용섭,안선국 慶星大學校 環境問題硏究所 1997 環境硏報 Vol.7 No.1

The characteristics of combustion and pollutant emission from a fluidized bed incinerator, in which waste activated sludge from municipal sewage treatment plant was burnt on the staged combustion modes, were investigated under the several operating conditions. The dried waste activated sludge with the moisture content of 4.5% and the heating value of about 4,200 kacal/kg dry solid was used in this study. With the variation of operating paramenters, such as bed temperature, superficial air velocity, and excess air ratio, temperature distributions in the incinerator and characteristics of ash drain rates and pollutant emission from the incinerator were measured. As the dried sludge had high volatile content, the maximum temperature appeared at upper region of fluidized bed surface in measured temperature distributions and the axial position of maximum temperature moved up with increase of superficial air velocity. The measured combustible contents of fly ash and bottom ash were lower than 3% and 0.4%, respectively. Thus, combustion efficiencies showed very high values of over 99.6% and were not severly affected by the variations of bed temperature and superficial air velocity. However, as the excess air ratio was increased, combustion efficiencies were decreased by the temperature drop in the freeboard region. The concentration of Co in exhausted gas was increased substantially with the increase of superficial air velocity which could reduce residence time of devolatilized gas in the freeboard. However, concentrations of SO₂and No?? were decreased slightly with the increase of superficial air velocity.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

폐염간균에 대한 Quinolone계 약제의 항균작용에 미치는 Rifampin의 영향

류필열,정문태,신부안,정선식,안태휴 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2

Antimicrobial activities of nalidixic acid(NA),norfloxacin(NX), oxolinic acid(OA), pefloxacin(PX), pipemidic acid(PA), oxacillin, cefotaxime(CFT), cephaloridine, cefazoline, moxalactam(MX), gentamicin, amikacin(AK) and rifampin(RP) were compared by the agar dilution method against 31 strains of K. pneumoniae isolated from various clinical spectimens. And then combined activities of RP with each of the quinolones (NA, MX, OAA, PX, and PA) against the test strains were measured by checkerboard dilution and time-killing methods. The growth inhibitory activities of PX, NX, OA, MX and AK were exellent, and those of PA, NA, RP and CFT were moderate, while the other's being almost negligible. The bactericidal activity of PX was more active than that of the other quinolones. Increasing concentrations of the quinolones resulted in a parallel increment of killing rate. However, when levels of quinolones were excessive beyond the most effective bactericidal ones, the bactericidal activity was decreased. In the combined growth inhigitory tests of RP with quinolones by checkerboard agar dilution method, synergistic and additive effects were rarely observed, and antagonism was noticed among the combinations in the following order: RP-NA, 22 strains (71%); RP-PA, 21 strains (67.7%); RP-OA, 17 strains (54.8%); RP-PX, 15 strains (48.4%) and RP-NA, 14 strains (45.2%). In the combined bactericidal tests measured by time-killing method, RP was found to reduce the activities of all five quinolones tested. And the gradual increasing of RP dose was revealed to reduce progressively the bactericidal action of the quinolones. But when RP was added to quinolones after 1 hour of incubations, the bactericidal activities were not affected.

이차 전기영동을 이용한 프로테오믹 접근을 통한 정맥 압박이 혈장 프로테옴에 미치는 영향

양광익,박선아,오형근,정두신,박형국,성기범,안무영,홍세용 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

The human proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, are increasingly being used. Venous occlusion is commonly employed for stimulating tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-l) release from venous endothelial cells, and this has been regarded as a parameter of the individual fibrinolytic capacity of plasma. The present work involved a detailed investigation of the plasma proteome and fibrinolytic activity in normal subjects, with the aim of determining whether correlations exist between various parameters of the fibhnolytic system before and after venous occlusion. We analyzed fibhnolytic parameters and plasma proteome before and after 15-min periods of venous occlusion in the forearm in 10 healthy 3rd-decade volunteers. Proteome analysis was performed using two-dimensional gels. The tryptic digests of some proteins were confirmed by MALDI-TOF and the MS-Fit algorithm. The fibrinolytic response as measured by the absolute amount of t-PA after venous occlusion was increased by venous occlusion (5.5 vs 9.6 ng/㎗, p<0.05), as was PAI-l (46.8 vs 56.1 ng/㎗, p<0.05). However, two-dimensional electrophoresis finding was virtually nonspecific and inconsistent after venous occlusion in healthy male subjects. Venous occlusion does not influence plasma proteome in healthy males. Although the fibhnolytic response to venous occlusion is attributed to an increase in free tUPA antigen, this change is not correlated with plasma proteome.

β-Lactam 유도체의 N(1)-C(4) 위치에 한 개의 탄소를 도입한 입체 선택적 고리확장에 관한 연구

하진렬,오선주,김지아,신동수,안철진 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-

The base induced ring opening of β -1actam derivatives with LDA gave γ-lactam derivatives stereoselectively. The γ -1actam derivatives were formed stereoselectively depending on β-3 substituent of B-lactam derivatives.

ON INJECTIVE BCI-ALGEBRAS

Ahn, Sun-Shin The Honam Mathematical Society 2007 호남수학학술지 Vol.29 No.2

In this paper, we show that BCI-algebras P and Q are injective if and only if its direct sum P $\oplus$ Q is injective. Moreover, we obtain the equivalent conditions for a p-semisimple BCI-algebra to be p-injective.

A Hom Functor in BCK/BCI-Algebras

Ahn, Sun-Shin... et al KYUNGPOOK UNIVERSITY 2000 Kyungpook mathematical journal Vol.40 No.2

In this paper, we define a hom functor Hom(ㅡ, ㅡ) in BCK/BCI-algebras and discuss the exactness of Hom(_,_) in BCK/BCI-algebras, and obtain some properties of Hom(_ ,_).

ON QS-ALGEBRAS

Ahn, Sun Shin,Kim, Hee Sik 충청수학회 1999 충청수학회지 Vol.12 No.1

In this paper, we introduce a new notion, called an QS-algebra, which is related to the areas of BCI/BCK-algebras and discuss the G-part of QS-algebras.