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심재식,노인화,서경용,오주환,민지영,박창민,고일영 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.9
Objective: To assess the rubella specific immune status of a group of Korean pregnant women. Methods: Between June 1995 and May 1996, the seroprevalence of rubella was determined in the study group that consistss of 132 pregnant women who had visited Korea Veterans Hospital in Seoul for prenatal care. We checked the rubella specific IgG and IgM antibody titer of the womens sera by ELISA. We also asked the past history of the rubella infection, rubella vaccination, parity, womens age and gestational age. Results: A total of 19(14.39%) pregnant women were found to be susceptible to rubella infection and the seropositive rate was 85.61% in them. And mean IgG antibody titer was 53.40 IU/ml. And, IgM positive rate was 0.81%, negative rate was 99.19% and mean titer was 2.97 aU/ml. Among them there were no one who had taken vaccination and no one suffered from rubella infection. And, there were no statistically significant differences of IgG positive rate according to age, gestational age and parity. Conclusion: With such a high susceptibel density of pregnant women in comparison to developed countries, the vaccination against rubella should be enforced more actively in order to prevent possible outbreaks of the congenital rubella syndrome.
변형된 Williams 회음 질성형수술로 교정된 선천성 질결손증 환자 치험 1 례
심재식,진영수,최희경,윤덕용,오주환 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.6
Congenital absence of the uterus and vagina, Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, is a rare disorder that results from the agenesis of both mullerlian ducts or from the failure of the mullerian ducts to establish a proper communication with that part of the vagina formed from the urogenital sinus. Until recently, treatment for the patient with vaginal sgenesis has centered on the creation of a functional vagina. Many ingenious procedures have been devised for its correction; some are simple, some are complicated. We feel the procedure of choice is the simplest, least dangerous one which will give good results in the individual patient. Our experience, particularly with the modified Williams vulvovaginoplasty technique, is given and the literatures were reviewed briefly.
심상덕,김종훈,김완영,이진용,최두석,황도영 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.8
저자들은 표현형이 외견상 정상여성이고 일측에 색상생식선이 있었고 반대쪽에 생식아세포종 및 난소정상피종을 동반하였던 가족적으로 유전된 3 증례 및 양측에 색상생식선이 있었던 1예를 포함한 4예의 46, XY 순수생식선이형성증을 경험하였기에 이에 간단한 문헌고찰과 함께 보고하는 바이다. Four cases of 46,XY pure gonadal dysgenesis,which were confirmed by the findings of gonads at laparoscopy, are described. The first three cases are siblings. All the patients and a normal male (46, XY) karyotype in the cytogenetic studies. Patient 1, aged 22, had a hypoplastic uterus, normal tubes, and bilateral streak gonads. Patient 2, aged 29, had a hypoplastic uterus, normal tubes, right streak gonad harboring gonadoblastoma and left gonadoblastoma overgrown dysgerminoma. Patient 3, aged 19, had a cord-like uterus, hypoplastic tubes, and right streak gonad and left goand harboring gonadoblastoma. Patient 4, aged 26, had a cord-like uterus, normal tubes, and bilateral streak goands. Gonadal streaks were extirpated in all the patients and total abdominal hysterectomy was also performed due to the malignant potential of the gonadoblastoma in patient 2.
Endothelin의 수축반응 및 억제제의 효과에 관한 연구
심재현,박윤관,정용구,정흥섭,서중근,이훈갑,주정화,이기찬 대한신경외과학회 1991 Journal of Korean neurosurgical society Vol.20 No.9
An endothelium-derived 21-residue vasoconstrictive peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors. We have studied the vasoconstrictor properties of endothelin in porcine external carotid artery strips and compared the maximal contractile response with other vasoactive compounds such as KCl and prostaglandin F₂α. Endothelin typically produced an intense, sustained increase in vascular tone over a dose range similar to seen with other vasoconstrictor substances such as KCl and prostaglandin F₂α. Cumulative addition of the peptide to the tissue bath caused dose-dependent contraction. The contractile response to each addition of the peptide was typically gradual and sustained. And during the washing procedure, it was observed that the contractile response to endothelin was resistant to drug removal. The dose of endothelin that produced a half-maximal contraction for porcine external carotid artery was 10^(-8.3)M. The response was inhibited to the several antagonists of glyceryl trinitrate, nitroprusside, verapamil, nimodipine, nifedipine, acetylcholine, prostagladin I₂.