심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

한국인에게서 그레이브스병 약물치료의 적정기간

이형숙,이동훈,정희선,이종우,김정은,신승수,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1

연구배경: 그레이브스병의 치료에는 항갑상선제, 수술 및 방사성 요오드법이 선택되어 사용되고 있다. 이중 항갑상선제는 가장 많이 선호되고 있으나 낮은 관해율과 높은 재발율로 장기간 치료기간이 요구된다. 저자들은 그레이브스병 환자에게서, 선택되는 치료법의 선호도와 각 치료법의 관해율을 조사하고자 본 연구를 시행하였다. 또한 본 연구에서는 항갑선제 치료의 적정기간을 평가하고자 하였다. 방법: 아주대학교병원에 내원한 환자 중 1년 이상 추적관찰이 가능한 205명의 그레이브스병 환자를 대상으로 조사하였다. 항갑상제군, 수술군 및 방사성 요오드군은 각각 170명, 29명 그리고 6명이었다. ROC curve를 이용하여 약물치료의 예후예측인자를 분석하였다. 결과: 1) 그레이브스병 환자의 치료 방법의 선택은 항갑상선제군, 수술군 및 방사성 요오드군 각각 170명(83.0%), 29명(14.1%) 그리고 6명(2.9%)으로 항갑상선제 치료가 가장 선호되었다. 2) 그레이브스병의 관해율은 항갑상선제군, 수술군 및 방사성 요오드군에서 각각 60.0%(102/170명), 96.5%(28/29명) 그리고 83.0%(5/6명)으로 수술군이 가장 높았다. 3) ROC curve의 AUC는 치료기간과 진단시 TBII가 각각 0.709 및 0.648이었고 적절한 약물투여 추적 관찰기간은 26개월이었다. 결론: 그레이브스병의 일차 치료법으로는 항갑상선제가 선호되고 있으나 수술 및 방사성 요오드 치료군에 비해 상대적으로 낮은 관해율을 보였다. 따라서 항갑상선제 치료로 26개월 이상 관해가 되지 않을 경우에는 치료 방법의 변경을 고려하는 것이 관해율을 높이는데 도움이 될 것으로 생각된다. Background: Graves' disease in an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment. Subjects & Methods : The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve. Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis. Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted (J Kor Soc Endocrinol 18:24∼31, 2003).

Production and Characterization of a Thermo-alkalotolerant Cyclodextrin Glucanotransferase from Thermo-alkalophilic Bacillus cereus B-13

Seo, Seung-Bo,Kim, Jae-Ho,Lee, Dae-Hyoung,Lee, Jong-Soo 배재대학교 자연과학연구소 2005 自然科學論文集 Vol.16 No.1

내열성의 cyclomaltodextrin glucanotransferase (CGTase)를 이용하여 열에 안정한 싸이클린 텍스트린 (CD)을 생산하기 위하여 매우 높은 CGTase 활성을 보이는 고열성이며 호알카리성인 B-13 세균을 분리하여 형태적, 생리학적 특성과 16S 리보솜 RNA 서열분석 등을 통하여 Bacillus cereus B-13으로 동정하였다. Bacillus cereus B-13을 2% 가용성 전분, 1% 효모 추출물, 1% Na_(2)CO_(3) 등을 함유하는 SYC 배지 (pH 8.5)에 접종하여 50℃에서 24시간 배양하였을 때 최고의 CGTase 활성(130 U/ml)을 보였다. 또한 부분 정제된 CGTase의 작용 최적 온도와 pH는 각각 65℃, pH 8.5-9.0 이었고 80℃이하와 pH 5.0-10.0에서 안정하였다. 1% 가용성 전분을 부분 정제한 CGTase와 작용 시켰을 때 49%의 CD 수율을 보였다. To produce a thermostable cyclodextrin by using thermotolerant cyclomaltodextrin glucanotransferase(CGTase), a thermophilic and alkalophilic bacterium isolate, designated B-13 showing the highest CGTase activity was isolated from natural sources and identified as Bacillus cereus B-13 based on the morphological and physiological characteristics, and 16S rRNA sequence. The maximal CGTase activity (130 U/ml) was obtained when Bacillus cereus B-13 was cultured in SYC medium containing 2.0% soluble starch, 1.0% yeast extracts, 1% corn steep liquor and 1% Na_(2)CO_(3) (pH 8.5) at 50℃ for 24 h and about 80% of maximal activity was also showed in the culture broth of 60℃ for 18 h . Optimum reaction temperature and pH of the partial purified CGTase for soluble starch were 65℃ and pH 8.5-9.0, respectively. The partial purified CGTase were also stable below 80℃ and pH 5.0-10.0. When 1% soluble starch was digested with the partial purified CGTase, the yield of cyclodextrin was 49%.

특수건강진단의 건강관리구분과 그 개선방안에 관한 연구

이승한,이원철,김형아,장성실 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

The findings of special medical examinations are not infrequently summarized in the form of health classification. This procedure seems valuable for the protection of workers' health from personal health as well as public health point of view, because health classification of workers provides occupational health workers with birds eye view informations in terms of medical, placement and educational procedures, which are to be followed after medical examinations. In this study, the authors have reviews the existing systems of special medical examinations and health classifications in different countries and those recommended by international organizations for the purpose of improving the current system in Korea. The important issues covered in this review in relation to health classification of workers included the categories of diseases, the examination and laboratory tests, the criteria for health level classification and the health instructions to be given at each health levels. It was found that the current health classification system in Korea could be featured as follows: 1. Special medical examinations are always carried out in combination with general medical examinations, contributing to the detection of risk factors of occupational diseases. 2. The selection of examinees is always made on the basis of work environment monitoring, often resulting in the underdetection of exposed workers. 3. Even if the test items are properly selected according to the principles of occupational medicine, further review is required in the light of recent advances in the pathogenesis as well as early changes of occupational diseases and epidemiologic principles. 4. The criteria for the classification of health levels are to be reviewed on the basis of clinical eqidemiology. 5. The health instructions covered only medical and placement aspects, failing to introduce the concept of health promotion.

한국 미생물 자원의 개발연구 : 특히 유용 미생물주(균주)의 분리와 응용에 관한 연구 The Research on the Isolation and Application of Utilizable Microorganisms Related to Jeonju Materials

이주식,백승화,이오형 Natural Science Research Institute JEONJU UNIVERSI 1987 전주대학교 자연과학연구소 학술논문집 Vol.2 No.2

The isolated strains of microbes from some hay, water of lake, marketing milk and Tachju brewing in Jeonju area. Were as follows Isolated 10 strains of Bacillus group, 2 strainins of Chlorella group, 2 strains of Lactobacillus group, 2 strains of Saccharomyces grpup and other microbes and determinated 4 strains in the 20 strains and application of utlizable microorganisms studies on the strains or pure cultual materials. Microbiological and biochemical examined for each organism. Its Bacillus species, Lactobacillus species, Chlorella species and Saccharomyces species were as follows. Bacillus species in Bacillus subtilis natto like strain. In addition, some of these strains were prepared to show different responses to the biotin added medium. Therefore our primary purpose was to examine the possible effects of glutamic acid, biotin and boiling soybean extract on the growth or sporulation of one these strains. It is a novel finding that biothin and soybean extrat affects on its sporulation. Glulamic acid was required for both its growth and sporulation. Chlorella species is Chlorella ellipsoidea like strain. The optimum cultural conditions and composition of the medium for wild Chlorella ellipsoidea were studies as follow. The addition than in control in concentration of the nitrogen sources high presented the effective result in the increasing order of meat extract, peptone amino, acid. Lactobacillus species is Lactobacillus casei like. Lactobacillus casei was isolated relatively high temperature and high salt contend and mesothermophilic condition. In addition, among, J-1, J-2, J-3 strains isolated together from above samples, J-2 was prominant in producing typical curd within 20 hours. Saccharomyces species is Saccharomyces cerevisiae like. When Sacchromyces cerevisiae like was used as a sole yeast source, this was dominated soon after it. But in this case Hansennula, Candida, Pichia, Torulopsis etc. were alse found out. This fact indicates that many kinds of yeast species were related with the alcohol fermentation. Biochemical studies on Cell-bound a-amylase in Bacillus subtilis like. Extracelluiar and Cell-bound a-amylase were purified separately and some of their biochemical properties examined. The amount of extracellular a-amylase produced by bacteria is known to very greatly with growth conditions. Extracellular a-amylase activity was more inhibited than cell bound a-amylase by metal ions tested.

자살에 대한 태도(Ⅱ) : 대학생을 중심으로 among undergraduates

이미형,정승교 최신의학사 1991 最新醫學 Vol.34 No.8

정형회과영역에서의 Cefmetazole(Cefmetazon^(�)) 임상적 효과

이정웅,문형석,안상로,이준규,이광진,윤승호 최신의학사 1988 最新醫學 Vol.31 No.5

건 황색종의 가족력과 관상동맥질환을 갖는 이형집합 가족성 고 콜리스테롤혈증 1례

백승훈,형근영,김경년,조정구,이경근 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Familial hypercholesterolemia is a common autosomal dominant disorder with serious health consequences such as the coronary heart disease, in western area affecting approximately 1 in 500 persons in the heterozygous form, is caused by a mutation in the gene for the LDL(low density lipoprotein) receptor. A-45-years old male came to the hospital because of tendon xanthomas on both elbows, knees, and ankles. He also has retrosternal chest pain intermittently since 5 years ago. 4 kindreds of the patient have tendon xanthomas according to autosomal dominant inheritance. Serum levels of total cholesterol and triglyceride were 359 ㎎/dL, 103 ㎎/dL respectively. Lipoprotein electrophoresis showed type Ⅱa pattern. Treadmill exercise test revealed angina pectoris. The case of familial hypercholesterolemia who has familial inheritance of tendon xanthoma is rarely reported in Korea. We report this case with a review of the related literature

數種의 增量劑 粒度와 增量比率에 따른 尿素樹脂合板의 接着 特性

楊翰承,尹炯雲,李弼宇 서울대학교 농과대학 농업개발연구소 1993 서울대농학연구지 Vol.18 No.2

The purpose of this research was to evaluate and to examine the substitutional feasibility of paper sludge extender instead of wheat flour. As the extending materials, taro flour, paper sludge, wood flour and wheat were selected and dried at 103±2℃ during 24 hours in the drying oven and pulverized into three levels(-50∼+100, -100∼+200, -200∼mesh). The extenders were mixed with urea formaldehyde resin in the ratio of 10, 20 and 30%. After plywoods were manufactured by the above extended ratios, dry and wet shear strength were examined. The results obtained at this research were summarized as follows : 1) In 10% extionsion on -50∼+100 mesh particle size, paper sludge showed the highest dry and wet shear strength among the extenders. 2) As 20% extension, wheat showed the highest value. 3) the shear strength was affected by the particle size and extending ratios, and the shear strength extended by paper sludge powder was sensitively varied with particle sizes and extending ratios. 4) The shear strength extended by taro and wheat flour were less affected by the particle size of extender. Therefore, the particle size of extender would be considered along the extention ratios and extender types.