성상세포종양에서 VEGF발현과 혈관신생 및 세포자멸사와의 상관성

김두천,이민철,김세종,김두천,이민철,김세종 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

운동이 백서 스테로이드 근병증에 미치는 효과

박상준,이민철,김세종,박상준,이민철,김세종 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

Pirenzenpine이 흰 쥐의 위궤양 형성에 미치는 영향

설무종,김호빈,장세경,김종숙 중앙대부설한국의과학연구소 1985 한국의과학 Vol.17 No.4

等力性과 等長性 運動選手에 있어서 持續的 運動이 心臟의 形態 및 機能에 미치는 效果에 關한 硏究

陳世眞,裵鍾華,朴淳永 慶熙大學校 1990 論文集 Vol.19 No.-

To assess cardiac structure and function in sustained exercise of two different training modes, 32 subjects were studied. Matched 10 healthy Young men(Control group), 12 isotonic exercise athletes of 12 soccers(Group 1) and 10 isometric exercise weight lifters(Group 2) were evaluated by echocardiography at resting state and at maximal exercise state. The following results were obtained. 1. In isotonic exercise Group 1 of resting state, significantly increased left ventricular mass due to significantly increased diastolic left ventricular dimension and left ventricular dimension and left ventricular end-diastolic volume than controls of resting state. 2. In isometric exericise Group 2 of resting state, significantly increased left ventricular mass was due to not only increased diastolic left ventricular dimension and left ventricular end-diastolic volume but also increased septal wall thickness than controls of resting state. 3. Fractional shortening, ejection fraction, systolic velocity integral and peak acceleration were increased significantly in both isotonic and isometric exercise groups of resting state than controls of resting state. 4. Even though there were no changes in diastolic left ventricular dimenion and left ventricular end diastolic volume between isotonic and isometric exercise groups of resting state, systolic left ventricular dimension and left ventricular end-systolic volume were significantly decreased in isometric exercise group of resting state. Fractional shortening ejection fraction and peak acceleration were significantly increased in isomeric exercise group of resting state than isotonic exercise group of resting state. Moreover, the increment of septal wall thickness was greater in isometric exercise group of resting state than in isotonic exercise group of resting state. 5. In isotonic exercise group of maximal exercise state, left ventricular end-systolic volum and end-diastolic volume were significantly increased than controls of maximal exercise state. There were significant increases of diastolic left ventricular dimension and left ventricular end-diastolic volume in isometric exercise group of maximal exercise state than in controls of maximal exercise state, but there was no change of left ventricular end-systolic volume between those two groups. The left ventricular wall thcikness was mostly increased significantly in isometric exercise, group of maximal state than in controls of maximal exercise state. 6. Fractional shortening and ejection fraction were significantly increased in isometric exercise group of maximal exercise state than controls of maximal exercise state. 7. There were significant decrease of left ventricular dimensions and volumes, and significant increase of fractional shortening, ejection fraction and peak acceleration in isometric exercise group of maxmal exercise state than isotonic exercise group of maximal exercise state. In conclusion, isotonic exercise caused increased left ventricular dimension and increased myocardial contractility, whereas isometric exercise caused increased left ventricular dimension, wall thickening and myocardial contractility. At maximal exercise state, isotonic exercise showed more increased ventricular dimension with increased left ventricular wall thickness and myocardial contractility.

일부 생산직 근로자의 소음과 사회심리적 요인이 혈압에 미치는 영향

박종구,강명근,차봉석,고상열,장세진,고상백 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

This study was conducted to assess the effects of noise exposure and psychosocial factor on blood pressure in manufacturing workers. The study subjects are 414 workers(243 males, 171 females) employed at the noisy department. The mean age of low exposed group(<85dB) was 34.65±9.53 years, and that of high exposed group(≥85dB) was 36.37±11.15 years. The difference in mean age was not significant. The mean and distribution of working duration, smoking status, drinking status were not significantly different between two groups. The mean systolic blood pressure of the low exposed group was 120.01±12.06 mmHg, and that of high exposed group was 126.27±13.84mmHg. The mean diastolic blood pressure of the low exposed and the high exposed group were 77.18±10.83 mmHg, and 83.46±11.22mmHg respectively. These differences of blood pressure were statistically significant(p<0.05). The workers in noisy department have significantly less work environmental satisfaction, higher job demand, and higher social support. The mean values of psychosocial distress were higher in the workers of the noisy department, but the difference was not statistically significant. This study was to speculate whether the work environmental satisfaction and social support modify the association between the noise exposure level and the blood pressure. The result showed that work environmental satisfaction could not modify the association between the blood pressure and the noise exposure. Social support at work did not modify the association. Furthermore, we evaluated the high job strain from a combination of ratio of the high job strain group for hypertension in diastolic blood pressure were statistically significant, but not in systolic blood pressure. Hierarchical multiple regression analysis was used to determine whither the independent variables contributed to explaining the blood pressure. After controlling for possible confounders, we found that the noise exposure level was a correlated of the diastolic blood pressure. But no association between the noise exposure level and the systolic blood pressure. No significant result was found for psychosocial factor.

유전 알고리즘을 이용한 정방 비결합 제어기의 H₂설계

이종성,김세찬 부천대학 2001 論文集 Vol.22 No.-

본 논문에서는 다변수 제어시스템 설계시 효과적인 제어를 어렵게 만드는 요인중의 하나인 입력과 출력의 결합문제를 해결하기위해서 각 채널의 출력변수는 대응되는 입력 신호에 의해서만 독립적으로 조정되도록하는 비결합제어기를 설계하였다. 설계된 제어기는 비결합 조건뿐만아니라 제어계의 성능을 동시에 고려한 수 있는 2자유도 구조를 가지고 있다. 또한 제어기의 계산을 용이하게 하기위해서 플랜트를 표준모델로 확장시킨 후 전달 행렬을 이용하여 상태공간계수로 표현하였다. 이 경우 비결합제어기의 자유매개변수를 구하는데 있어서 지능형탐색방법의 일종인 유전알고리즘을 적용하였다. 일반적으로 유전알고리즘을 특정한 문제에 적용할 경우 그 문제가 가지고 있는 최적화 특징을 잘 파악하여 이 것을 이용하는 것이 유전알고리즘 적용의 성공여부를 결정하는 중요한 요인이된다. 따라서 본 연구에서는 유전알고리즘을 이용하여 고정차수의 정방 비결합제어기의 H₂설계시 효율적인 방법을 제시하였다. In this paper, the genetic algorithm is used to design a fixed order square decoupling controllers based on the Two-Degree-of-Freedom standard model. The proposed controller considers both the performance of controller and decoupling properties. A minimal set of assumptions for existence of the decoupling controller formula is describde in the state-space formulas. It is verified by an example.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

피로와 의료이용, 업무상 사고 및 질병결근

장세진,고상백,강동묵,김성아,정진주,이철갑,강명근,현숙정,조정진,차봉석,박종구 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Objectives: This study examined the relationship of fatigue to medical utilization, occupational accident and sickness absence. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project, 2002~2004). A total of 30,146 employees categorized within the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were recruited. A structured-questionnaire was used to assess the participants' sociodemo-graphics, job-related factors, health-related behaviors, personality trait, self=perceived fatigue (MFS) and the frequency of medical utilization, occupational accident and sickness absence. Data on medical utilization and occupational accident were confirmed from company health records. Chi-square test and logistic regression analysis were used to elucidate the relationship of self-perceived fatigue to medical utilization, occupational accident and sickness absence. Results: In logistic regression analyses, self-perceived fatigue was associated with medical utilization (outpatient), occupational accident and sickness absence although the strength of the associations was higher in the blue collar workers except for medical utilization. For medical utilization, the white collar worker's adjusted odds ratios of outpatient utilization for workers scoring in the third quartile and the highest quartile, compared to workers scoring in the lowest quartile were 1.50 (95% CI: 1.20-1.87) and 2.16 (95% CI: 1.69-2.75), respectively. The blue collar workers' adjusted odds ratios of outpatient utilization for workers scoring in the second (OR: 1.23, 95% CI: 1.06-1.43), third (OR: 1.42, 95% CI: 1.22-1.66) and highest quartile (OR:1.83, 95% CI: 1.55-2.17), respectively, compared to workers scoring in the lowest quartile were statistically significant. However, no associations were found between fatigue and inpatient utilization for either the white or blue collar workers. The blue collar workers' adjusted odds ratios of being injured for workers scoring in the second, third and highest quartile were 1.41 (95% CI: 1.00-2.00), 1.57 (95% CI: 1.10-2.22) and 2.41 (95% CI: 1.69-3.44), respectively, compared to those scoring in the lowest quartile, but, those of the white collar workers were not significant. There was more likely to an increased risk of sickness absence in workers scoring in the second, third and highest quartile compared to those scoring in the lowest quartile in both white and blue collar workers, but the magnitudes of risk were higher in the blue collar workers than the white collars workers. Conclusion: This result suggests that fatigue is a determinant predictor of medical utilization, occupational accident and sickness absence, and that the pattern of risks for the three outcomes differs according to the occupational type. Some limitations of this study and considerations for future study were also discussed.

런닝머신 프레임의 구조해석

이종선,김세환,이현곤 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

This study is object to structural analysis of running machine frame. The finite element model was developed to compute the stress, strain and natural frequency for running machine frame. For structural analysis using result from FEM Code. In other to structural analysis of running machine frame, many variables such as load condition, boundary condition and weight condition are considered.

뇌혈관질환과 심근경색증에 관련된 요인의 비교분석

박종구,김헌주,박금수,이성수,장세진,이은경 연세대학교 원주의과대학 1994 원주의대논문집 Vol.7 No.1