비정형 기관지 유암종에 의한 이소성 ACTH 증후군 1례

이창훈,천남일,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 全南大醫大 2001 전남의대학술지 Vol.37 No.2

외측 미칩 갑상선에서 발생하여 다발성 전이로 발현된 유두상 갑상선암 1예

천남일,이창훈,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

유아용 조제 분유가 치태 pH에 미치는 영향에 관한 연구

정우진,이상훈,한세현 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

Infant formula in nursing bottle, with inappropriate feeding habits, is major factor associated with the development of nursing caries. Although each infant formula has different carbohydrate and protein composition, studies comparing cariogenic potential of many Korean-branded infant formulas are deficient. In addition, it is on the point of being difficult to evaluate the cariogenecity of milk due to development of many infant formulas. In this study, to evaluate the cariogenic potential of many infant formulas, after oral rinse with six Korean-branded infant formulas(three milk based formulas, one soy based formula and two specific formulas for infants with allergy to milk protein and with lactose intolerance) for ten adult volunteers(eight males and two females), plaque pH change was measured with In vivo/In vitro combination technique and results were as follows. 1. All six different kinds of Korean-branded commercial infant formulas dropped the plaque pH significantly(p<0.05) and at an hour after rinse, plaque pH was not recovered in most of subjects. 2. Soy based infant formula and casein-hydrolyzated infant formula containing no casein dropped the plaque pH significantly more than milk based infant formula containing casein(p<0.05). 3. In the milk protein of infant formulas, casein had more effect on buffering the pH change of the infant formula than whey protein and casein-hydrolyzated infant formula had a refuced effect of casein. 4. In infant formulas with similar protien composition, infant formula containing sucrose dropped plaque pH more than infant formula containing lactose, but there was no significant difference(p>0.05).

Interleukin-2가 Mouse 폐장의 폐포간 중격의 미세구조에 미치는 영향

황세진,김종우,정호삼,이규식 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1

Interleukin-2, a kind of lymphokine which is produced by activated T-lymphocytes during an immune response, is known to act not only as a growth factor for many cells of immune system but stimulates differentiation of cells of immune system. Although interleukin-2 is a useful agent for cancer immunotherapy and inhibiting agent of tumor cell metastasis, administration of interleukin-2 to cancer patient may cause various side effects such as pulmonary edema due to capillary leakage. In this experiment the author pursued the effects of interleukin-2 on ultrastructure of interalveolar septum in lung of mouse. Healthy male mice weighing about 20gm were used as experimental animals and divided into control group and experimental group. During the experiment water and foods were given ad libitum. Animals of control group were injected 0.2 ml of distilled water and animals of experimental grouup were injected 2 million units per kg body weight of interleukin-2 intraperitoneally Experimental animals were sacrified at 3 hours, 6 hours, 12 hours, 24 hours, 48 hours and 72 hours after administration and lung specimens were obtained. All specimens, which were prefixed in 2% glutaradehyde-2.5% paraformaldehyde and postfixed in osmium tetraoxide were dehydrated and embedded in Epon Araldite 502. Ultrathinsection about 600-800 in thickness, and uranyl acetate and lead citrate double stain were performed and all electron microscopic specimens were observed with JEM 100cx-II electron microscope. The results obtained were as follows: 1. The type I pneumocyte of interalveolar septum of lungs in interleukin-2 treated mice were swollen, separated from basal lamina. 2. Capillary endothelial cell of interalveolar septum of lungs in interleukin-2 treated mice were swollen, and pinocytic vesicles in endothelial cell were enlarged and increased in number. 3. Lamellar bodies of type II pneumocytes of interalveolar septum of lungs in interleukin-2 treated mice were enlarged, and vacuolized. 4. Mitochondria and microvilli of type II pneumocytes of interalveolar septum of lungs in interleukin-2 treated mice were decreased in number. It is consequently suggested that interleukin-2 induces intracellular edema of both the type I pneumocyte and the endothelial cell and damages to type II pneumocyte of interalveolar septum of lung in mice but alveolar epithelial cells and endothelial cells are recover as time goes by.

Bleomycin이 Mouse신사구체 및 근위요세관 상피세포의 미세구조에 미치는 영향

김진택,황세진,정호삼,이규식 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.2

Bleomycin, a glycopeptide antibiotic isolated from Streptomyces Verticillus, has been used as an anticancer drug active against human squamous cell carcinoma of skin and lung. It is well known that bleomycin inhibits DNA synthesis of tumor cell by scissoring DNA molecule and inhibiting DNA polymerase activity. Although bleomycin is very effective on various human cancers, it may damage certain normal cells to cause pulmonary and skin toxicity. In this experiment, the author pursued the effect of bleomycin on the mouse kidney, observing the ultrastructural changes in the proximal convoluted tubular epithelial cells and glomeruli. Healthy male mice(ICR strain) were used as experimental animals which were divided into two groups, the control and bleomycin treated groups. The bleomycin treated groups were subdivided into group of 3 times successive bleomycin treated and group of 7 times successive bleomycin treated. All experimental animals were given food and water ad libitum. The animals of bleomycin treated group were administered bleomycin 3 times and 7 times respectively, in a dose of 20 units per kg of body weight with 3 days interval. The experimental animals were sacrified in 24 hours after final administration of bleomycin. The specimens obtained from cortical region of left kidney were stained with uranyl acetate and lead citrate by the double contrast method and were observed with JEM 100cx-Ⅱ electron microscope. The results obtained were as follows: 1. In the epithelial cells of the proximal tubule the pinocytic vesicles were increased in number and also numerous autophagic vacuoles and the multivesicular bodies were found. 2. The deformed mitochondria and the dilated cisternae of rough endoplasmic reticulum were appeared in the epithelial cells of proximal renal tubule. 3. The basal infoldings were dilated and basement membrane were thickened and irregulary arranged at the basal portion of the epithelial cells of proximal tubule. 4. In the glomeruli the lamine densa of filterating membrane were irregulary arranged and thickened and many of the pedicles of podocytes were fusal together. It is consequently suggested that bleomycin damages both proximal convoluted tubular epithelial cells and glomeruli in mice kidney.

심한 척추변형(측만증 및 후만증)에 대한 척추 후방 절제술

석세일,김진혁,이상민,정의룡,이정희,김성수,정락용 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.1S

■ Purpose To report a technique of vertebral column resection through a single posterior approach and its first results in the treatment of severe spinal deformities. ■ Methods and materials Seventy spinal deformity patients treated by posterior vertebral column resection(PVCR) were reviewed. Minimum follow up was 2 years (2 - 3.3 years). There were 34 males and 36 females with a mean age of 27.4 years at the time of the operation. Etiologic diagnoses were adult scoliosis in 7, congenital kyphoscoliosis in 38, and post-infectious kyphosis in 25. The surgery consisted of temporary stabilization of the vertebral column with segmental pedicle screw fixation, resection of the vertebral column at the apex of the deformity via the posterior route followed by gradual deformity correction and global fusion. ■ Results The total number of resected vertebrae were 143; 76 in thoracic and 67 in lumbar. Mean operation time was 4 hours 31 minutes with average blood loss of 2333 ml. The deformity correction was 40o in the coronal plane and 5Oo in the sagiotal plane. Complications were encountered in 24 patients: 2 complete cord injuries in severe adult scoliosis and thoracic kyphosis patient who had significant preoperative cord compromise, 6 hematomas, 4 root injuries (all incomplete), 5 fixation failures, 2 infections and 5 hemopneumothoraxes. ■ Conclusions PVCR is an effective alternative for severe fixed spinal deformities. However, extreme caution must be taken in the patients with preoperative cord compromise who are the high risk of neurological complications.

일산화탄소 및 고압산소의 폭로가 흰쥐의 제2형 폐포세포와 사구체에 미치는 영향에 관한 연구

백두진,정호삼,이계훈,황세진,전영호,전영희 한양대학교 의과대학 1997 한양의대 학술지 Vol.17 No.2

The present study was performed to investigate the ultrastructural changes of the type Ⅱ pneumocyte in the lung and that of the glomerulus in the kidney after carbon monoxide(CO) or hyperbaric oxygen (HBO) exposure. The male Sprague-Dawley rats, weighing about 200gm, were used as experimental animals. The animals were divided into CO exposure group, air exposure after CO exposure group, HBO exposure group and HBO exposure after CO exposure group. After single CO and HBO exposure (3790ppm), the specimen of lung and kidney were obtained. According to routine method, EM preparations were made and observed with electron microscope. The results obtained were as follows ; 1. Slight disruption of the mitochondrial membrane was observed in alveolar type Ⅱ pneumocyte, after single CO exposure. 2. In all experimental groups except CO exposure group, decrease in number and atropy of rough endoplasmic reticulum, disruption of double membrane and crista of mitochondria and vacuolar degeneration of lamellar bodies in alveolar type Ⅱ pneumocytes were observed. 3. In all experimental groups, fusion of the pedicles of podocytes, and obliterations of the endothelial fenestrations were observed. These results suggested that CO and HBO exposure may induced the ultrastructural damages in the alveolar type Ⅱ pneumocyte and the glomerulus.

후방 도달 척추 절제술을 이용한 강직성 요천추 변형의 치료

석세일,정의룡,이정희,김진혁,김성수,이지호,최원기,박용원 대한척추외과학회 2004 대한척추외과학회지 Vol.11 No.2

분절간 척추경 나사 고정과 척추전이법을 이용한 특발성 척추 측만증의 치료

석세일,김진혁,이상민,정의룡,김성수,이정희,박준석 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective : To report the clinical result of segmental pedicle screw fixation and translation technique in surgical correction of idiopathic scoliosis. Methods and materials : Ten idiopathic scoliosis. patients treated with segmental pedicle screw fixation and translation technique were analyzed retrospectively. The mean follow-up interval was 23.8months, with a minimum of 12 months. Eighteen structural curves were fused in one double curves(King type Ⅰ), seven double thoracic curve(King type Ⅴ) and two thoracolumbar curve. Deformity correction, apical vertebral rotation(AVR), apical vertebral translation(AVT), trunk balance, shoulder balance and complications were evaluated. Result : The structural curve was corrected from 47.4±10.6° to 20.3±5.9° at 1week after surgery and 55.6±14.1° at latest follow-up. AVR was corrected from 2.06±0.4 to 0.94±0.41 at 1week after surgery and latest follow-up. AVT was improved from 25±15.7㎜ to 11.5±7.3㎜ at 1week after surgery and 12.3±7.3㎜ at latest follow-up. There were no trunk imbalance(less than 10㎜ distance from C7 plumb line), no shoulder imbalance(less than 10㎜ shoulder height difference) and no screw related complications. Conclusions : The segmental pedicle screw fixation and translation technique is an effective method in treating for idiopathic scoliosis.

지속형 항응고성 살서제 중독에 기인한 뇌실질출형 1예

양충용,이진훈,이서울,정복희,노상균,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

저자들은 brodifacoum성분의 지속형 효과를 갖은 항응고제인 쿠마린계 살서제를 정확한 용량을 추정할 수는 없지만 다회의 약물 복용 17일 후 뇌실질출혈이 발생한 증례를 문헌 고찰과 함께 보고하는 바이다. 지금껏 쿠마린계의 지속형 항응고성 살서제의 약물 중독이 알려져 있다. 이러한 약물은 vitamin K₁ 2,3-epoxide 환원효소를 억제하여 vitamin K₁과 연속적으로 vitamin K₁ 의존성 응고인자 Ⅱ, Ⅶ, Ⅸ, Ⅹ의 합성을 억제하고 이로써 출혈 경향을 증가시킨다. 이 증례를 토대로 향후 출혈성 환자 특히 선행 질환이 없는 젊은 뇌실질출혈 환자에서 원인을 감별진단 함에 있어 환자의 약물 중독 가능성과 치료에 대한세심한 주의가 필요할 것으로 생각한다. Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.