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      • KCI등재

        악성흑색점흑색종 19예에 대한 임상 및 병리 조직학적 연구

        홍원진 ( Won Jin Hong ),장홍선 ( Hong Sun Jang ),이상희 ( Sang Hee Lee ),이상은 ( Sang Eun Lee ),정기양 ( Kee Yang Chung ),노미령 ( Mi Ryung Roh ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.10

        Background: Lentigo maligna melanoma (LMM) is a subtype of melanoma that typically develops on sun-damaged skin. LMM is estimated to comprise 4∼15% of melanomas, but the prevalence is known to be relatively lower in the Korean population than in the Caucasian population. Objective: To review the clinico-pathologic features and treatment outcomes of Korean patients with LMM. Methods: Nineteen patients diagnosed with LMM during 2003∼2015, in the Yonsei University Health System, were included in this study. The age and sex of the patients, lesion location, thickness (Breslow), stage, treatment methods, BRAF, NRAS, and KIT mutation status, and survival rates were analyzed. Results: Among the 19 Korean patients, 11 were male and 8 were female. The median age was 59.2 years. The most common site was the cheek (47.4%), followed by the scalp, eyelid, nose, forehead, lip, and neck. At the time of diagnosis, 13 patients were in localized stages (5 patients, stage 0; 3 patients, stage I; and 5 patients, stage II) and 6 patients were in advanced stages (3 patients, stage III; and 3 patients, stage IV). Patients in the localized stages showed better overall survival (OS) than those in the advanced stages (p=0.012). Nine patients were treated with a wide excision, and 6 using Mohs micrographic surgery. Three patients received high-dose interferon-α therapy; 6, chemotherapy; and 4, radiotherapy. Two patients in stage 0 were treated with topical ingenol mebutate. Two patients had BRAF V600E mutation; 1, NRAS G12R mutation; and 1, KIT mutation. Median OS of the patients was 40.8 months. Conclusion: Our analysis provides additional information about clinical characteristics, treatment, and prognosis of LMM in Korean patients. (Korean J Dermatol 2016;54(10):769∼775)

      • SCOPUSKCI등재

        비전문적 피부미용시술로 인한 합병증과 치료 방법의 고찰

        장홍선 ( Hong Sun Jang ),정기양 ( Kee Yang Chung ),오병호 ( Byung Ho Oh ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4

        Background: As the desire to maintain a youthful appearance escalates nationwide, the numbers of patients presentingwith complications subsequent to cosmetic treatments performed by non-professionals are increasing. Objective: The purpose of this study was to overview complications from cosmetic therapeutic attempts by nonprofessionals,and to discuss their management from a dermatologist’s point of view. Methods: During the period January 1st, 2011 to December 31st, 2013, a total of 24 patients who visited the SeveranceHospital at Yonsei University for complications that developed after cosmetic treatments by oriental doctors,non-medical personnel, and general practitioners were enrolled in this study. Patient clinical characteristics, pasthistory, diagnosis, biopsy results, and treatment information were collected. Results: The most common complication was a granulomatous foreign body reaction (n=15, 62.5%), followed byskin necrosis (n=8, 33.3%), and misdiagnosis and malpractice by non-professionals (n=5, 20.8%). Three patients hadmore than 2 complications combined. Patients with granulomatous foreign body reactions were usually managed withconservative treatments or excisions, while those with skin necrosis were managed with debridement and secondaryintention healing. Conclusion: As the number of cosmetic therapeutic attempts made by non-professionals increases, dermatologistsneed to understand the potential complications that can arise following these procedures, and should take an activerole in managing the patients.

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