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( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Gut microbial dysbiosis is associated with the development of nonalcoholic fatty liver disease (NAFLD). Antibiotics can alter the composition of the gut microbiota. However, the association of antibiotic use with the risk of NAFLD has not been clarified in a population at usual risk. We investigated the association of the duration of antibiotic use in different phases of adulthood with the risk of NAFLD. Methods: This study included 68,644 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 2005). Participants were followed prospectively through 2015. In the 2005 questionnaire, women were asked to indicate the cumulative amount of antibiotic use at age 20-39 years (young adulthood) or 40-49 years (middle adulthood). Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over a total of 534,644 person-years, we documented 1,944 incident cases of NAFLD. Compared to women with no antibiotic use during young adulthood, use of long-term antibiotics for ≥2 months was associated with significantly increased risk of incident NAFLD (multivariable aHR 1.48, 95% CI 1.03- 2.11). In analyses focused on middle adulthood, compared to women who did not use antibiotics during middle adulthood, those with both short-term (<2 months) and long-term (≥2 months) antibiotics use had significantly increased risk of incident NAFLD (multivariable aHRs, 1.32 [95% CI 1.01-1.72] and 1.83 [95% CI 1.37-2.45], respectively). Conclusions: In conclusion, long-term antibiotic use in both young and middle adulthood was associated with a significantly increased risk of developing incident NAFLD. These findings support the potential role of the gut microbiota in the pathogenesis of NAFLD.
( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Xiao Luo ),( Xuehong Zhang ),( Andrew T. Chan ),( Tracey G. Simon ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Previous studies have suggested consumption of red meat might be associated with an increased risk of developing nonalcoholic fatty liver disease (NAFLD). However, large-scale, prospective data regarding red meat consumption in relation to the incidence of NAFLD are lacking, nor is it known whether this association is mediated by obesity. Methods: This prospective cohort study included 77,795 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who provided detailed, validated information regarding diet, including consumption of red meat, every 4 years, through 2015. Lifestyle factors, clinical comorbidities and body mass index (BMI), were updated biennially. Cox proportional hazard models were used to estimate multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). Results: Over 1,444,637 person years of follow-up, we documented 3,130 cases of incident NAFLD. Women consuming ≥2 servings of red meat per day had a 56% higher risk of developing incident NAFLD compared to women consuming ≤1 serving per week (95% CI, 1.26-1.93), after multivariable adjustment. Similarly, significant and positive associations were observed for both unprocessed and processed red meat (both P-trend< 0.0001). However, after further adjustment for BMI, all associations for red meat, including unprocessed and processed red meat, were attenuated and not statistically significant (all P-trend >0.05). BMI was estimated to mediate 66% (95% CI, 41.9%-83.9%; P<0.0001) of the association between red meat consumption and NAFLD risk. Conclusions: Red meat consumption, including both unprocessed and processed red meat, was associated with significantly increased risk of developing NAFLD. This association was mediated largely by obesity.
( Mi Na Kim ),( Chun-han Lo ),( Kathleen E. Corey ),( Mingyang Song ),( Tracey G. Simon ),( Andrew T. Chan ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Obesity is established as a major risk factor for the development of nonalcoholic fatty liver disease (NAFLD). However, the influence of changes in adiposity over the life course on NAFLD risk remains poorly understood. Methods: This study included 110,054 women in the Nurses’ Health Study II cohort without NAFLD at baseline (in 1995), who were followed prospectively through 2015. Early adulthood weight change was defined as the difference between early adulthood weight (at age 18 years) and the weight reported in the current questionnaire cycle. We used a group-based modeling approach to identify five trajectories of body shape from age 5 years up to 50. Results: We documented 3,798 incident cases of NAFLD over 20 years of follow-up (1,842,560 person-years). An elevated early adulthood body mass index (BMI) and weight gain since early adulthood were significantly and positively associated with the risk of incident NAFLD (all P trend <0.0001). Compared to women who maintained stable weight (+/-2 kg), women with ≥20 kg of early adulthood weight gain had the multivariable adjusted hazard ratio (aHR) of 6.96 (95% confidence interval [CI], 5.27-9.18), and this remained significant after further adjusting for updated BMI (P trend <0.0001). Compared to women with a medium-stable body shape trajectory, the multivariable aHRs for NAFLD risk were, 2.84 (95% CI, 2.50-3.22) for lean-marked increase, 2.60 (95% CI, 2.27-2.98) for medium-moderate increase, and 3.39 (95% CI, 2.95-3.89) for medium-marked increase. Conclusions: Both early adulthood weight gain and lifetime body shape trajectory were significantly and independently associated with excess risk of developing NAFLD. Maintaining both lean and stable weight throughout life may offer the greatest benefit for the prevention of NAFLD.
포스터 발표 : 포스터 연제 ; 카드뮴 중독과 연관된 type 2 RTA를 동반한 성인형 Fanconi 증후군 1예
여미애 ( Yeo Mi Ae ),조진원 ( Jo Jin Won ),박규용 ( Park Gyu Yong ),구자룡 ( Gu Ja Lyong ),김근호 ( Kim Geun Ho ),전로원 ( Jeon Lo Won ),김형직 ( Kim Hyeong Jig ),채동완 ( Chae Dong Wan ),노정우 ( No Jeong U ),남은숙 ( Nam Eun Sug 대한신장학회 1999 춘계학술대회 초록집 Vol.18 No.2
췌담관질환이 있는 환자의 간흡충 진단에서 피내검사의 유용성 평가
주광로 ( Ju Gwang Lo ),이미숙 ( Lee Mi Sug ),윤태권 ( Yun Tae Gwon ),추연익 ( Chu Yeon Ig ),이진우 ( Lee Jin U ),조영철 ( Jo Yeong Cheol ),김대현 ( Kim Dae Hyeon ),김도하 ( Kim Do Ha ),박능화 ( Park Neung Hwa ),박재후 ( Park Jae H 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The diagnosis of clonorchiasis is based on demonstrating eggs in stool or bile. It is believed that bile examination is the most precise method for detecting eggs. We evaluated diagnostic usefulness of intradermal test (IDT) by comparing it with the result of bile examination. Methods: For 88 patients with pancreatobiliary diseases, we examined Clonorchis sinensis eggs in bile and performed IDT for clonorchiasis. The bile was obtained from endoscopic nasobiliary or percutaneous transhepatic biliary drainage tubes. Results: We calculated ROC curve to decide the cut-off value of IDT in determining diagnostic accuracy on the basis of bile examination. We chose a value of 40 mm2, which significantly improved the sensitivity, without reducing the specificity. With a cut-off value of 40 mm2, the sensitivity, specificity, positive and negative predictive values of IDT were 81.5%, 67.2%, 52.4%, and 89.1%, respectively. The value of IDT was not affected by age and showed no difference between benign and malignant diseases. However, in egg-positive patients, the mean value was lower in malignant diseases than in benign diseases. Conclusions: In patients with pancreatobiliary diseases, IDT with a cut-off value of 40 mm2 seems to be a valuable supplementary diagnostic test for clonorchiasis in view of its high sensitivity. (Korean J Gastroenterol 2003;42:232-236)
갑상선기능항진증으로 진단된 소양인(少陽人) 흉격열증(胸膈熱證) 환자의 사상방${/cdot}$양약 병용 투여에 의한 치험 1례(例)
이경로,임미경,송정모,김영원,Lee, Kyung-Lo,Lim, Mi-Kyung,Song, Jeong-Mo,Kim, Young-Won 사상체질의학회 2006 사상체질의학회지 Vol.18 No.3
1. Objectives The purpose of this case is to report that a Soyangin Heat sensation in the chest patient Diagnosed as Hyperthyroidism was treated with 'Yangkyuksanhwa-tang' and Antithyroid drugs in conjunction and then her symptom and thyroid function test results improved. 2. Methods We diagnosed her Hypetthyroidism on Soyangin Syndrome. So we treated her with 'Yangkyuksanhwa-tang' and Antithyroid drugs in combination. 3. Results This patient's symptom and thyroid function test results were improved 4. Conclusions By a combined treatment on a Soyangin Heat sensation in the chest patient Diagnosed as Hypetthyroidism, her symptom and thyroid function test results were improved. This case study showed an efficient results by giving Yangkyuksanhwa-tang in treatment of Soyangin Heat sensation in the chest patient.
Poster Presentations : Nutritional Assessment ; Application of Nottingham Nutritional Screening Tool
( Doo Sun Lee ),( So Young Ka ),( Hee Seung Song ),( Lo Mi Kim ),( Hye Eun Choi ),( Myung Ja Ahn ),( Sun Hee Han ),( Mi Jeong Kim ),( Jeong Eun Shin ),( Young Hee Yang ),( Hwan Namgung ) 한국정맥경장영양학회 2005 The 11th PENSA Congress Vol.2005 No.-
사상체질 진단을 위한 2단계 설문지(TS-QSCD)의 개발 연구
신동윤,김정호,최대성,임미경,이경로,송정모,김영원,Shin, Dong-Yoon,Kim, Jeong-Ho,Choi, Dae-Sung,Lim, Mi-Kyung,Lee, Kyung-Lo,Song, Jeong-Mo,Kim, Young-Won 사상체질의학회 2006 사상체질의학회지 Vol.18 No.1
1. Objectives The Sasang Constitution has been studied in many parts and one of the most common inquiries is the self-reporting questionnaire. But the established investigation has the problem that the respondents are not fully aware of the questionnaires and answer them. To settle this problem, it's been made new questionnaires through two steps. 2. Methods At first step, the testers ate classified into Yangin(陽人) and Eumin(陰人). And then, Taeyangin is distinguished from Soyangin likewise Taeumin is told from Soeumin. It's called 'The Two Step Questionnaire for the Sasang Constitution Diagnosis(TS-QSCD)'. This new method is tested by 160 testers and Woosuk university students whose constitution ate confirmed to make clear clinical uses 3. Results and Conclusions Questionnaire Sasang Constitution corresponds with The Real Sasang Constitution at the rate of 71.87%. Only 5.63% has shown an error at the first step. Every experimenters by constitutions, the 56 objects of 74 Taeumin are confirmed the same as it is. It has 84.85% accuracy. The 27 objects of 32 Soeumin come to the same thing and it has 69.23% accuracy. Similarly, the 32 objects of 42 Soyangin come to the same conclusion and 72.73% accuracy high As the result, in comparison to the Real Constitution with the Constitution by questionnaires, the accord comes out Kappa Indices 0.6427866. This result is comparatively high. Chi-square Test can be shown statistical meaning as well.