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Gastrointestinal stromal tumor with KIT mutation in neurofibromatosis type 1
Hwan Namgung 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.81 No.4
Multiple jejunalgastrointestinal stromal tumors (GISTs) were found in a 52-year-old woman with a history of neurofibromatosis type 1. These tumors were composed of interlacing fascicles of uniform spindle cells with eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for CD117, CD34 and negative for S-100, smooth muscle actin. Molecular analysis for activating mutations of KIT and PDGFRA was performed in two tumors. Contrary to sporadic GISTs, the NF1-associated GISTs are characterized by rare mutations of KIT or PDGFRA. But, one missense point mutation (Trp557Gly) was identified in KIT exon 11 of the extramural portion of the largest tumor in this case. The intramural portion of the largest tumor and the other tumor had wild type KIT and PDGFRA.
Adult intussusceptions: preoperative predictive factors for malignant lead point
Kil Hwan Kim,Hwan Namgung,Dong Guk Park 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.5
Purpose: Adult intussusception is uncommon, but an organic lesion is found to be the lead point in 75% to 90% of the cases. This study was designed to review our experience with adult intussusception and to determine if there are any preoperative predictive factors for a malignant lead point. Methods: Thirty-three patients over 15 years of age were diagnosed with intussusceptions through operative finding over a period of 20 years. We reviewed the medical records of these patients retrospectively, and preoperative predictive factors of malignant lead points were analyzed. Results: The preoperative diagnosis of intussusception had been made correctly in 86% of the cases, and computed tomography could find a lead point in 79%. A causative organic lesion was found in 29 patients (88%) pathologically; 16 cases (48%) were due to benign tumors, and 13 (39%) were due to malignant tumors. A malignant lead point was present in four of 21 enteric (20%) versus nine of 13 colonic intussusceptions (75%). The period from symptom appearance to hospital visit showed a more chronic nature in malignant neoplasm than in benign neoplasm (P = 0.006), and the location of causative organic lesion showed significant difference between benign and malignant groups (P = 0.003). Conclusion: Adult intussusceptions are commonly secondary to a pathologic lead point, and a computed tomography is an effective diagnostic tool for finding a lead point preoperatively. The chronic nature of the disease presentation and colonic location of the lead point may suggest a malignant neoplasm.
초등 도덕과 교육과정에서 덕의 본질과 역량의 특성을 반영한 도덕적 기능 재정립 방안
남궁환 ( Namgung Hwan ),이인재 ( Lee In Jae ) 한국초등도덕교육학회 2022 초등도덕교육 Vol.- No.77
현행 도덕과 교육과정에서 도덕적 기능은 덕과 역량 관련 이론적 기반이 약하고 추상적이어서, 교사와 학생들에게 구체적인 지침을 제공하지 못하고 있다. 따라서 초등 도덕과 교육에서 덕의 본질과 역량의 특성이 잘 반영된 도덕적 기능을 재정립하여, 2022 개정 도덕과 교육과정의 내용체계 정립을 위한 논의의 토대를 마련할 필요가 있다. 이를 위해 본 연구에서는 문헌 연구방법을 활용하여 덕과 역량, 그리고 기능에 대한 관련 이론과 선행 연구들을 분석했다. 또한 맥락-지향적이고 반성적 사고를 내재한 덕의 본질과 ‘무엇을 할 수 있는가?’에 대한 물음에 답할 수 있는 역량의 특징이 상호보완적으로 작동하는 도덕적 기능을 재정립할 수 있는 방안을 제시했다. In the current moral and curriculum, moral functions have a weak and abstract theoretical basis related to virtue and competence, so they cannot provide specific guidelines to teachers and students. Therefore, it is necessary to redefine the moral function that reflects the nature of virtue and competence in elementary morality and education, and lay the foundation for discussion to establish the content system of the 2022 revised moral curriculum. To this end, this study analyzed related theories and previous studies on virtue, competence, and function using literature research methods. In addition, a plan was proposed to re-establish and utilize a moral function in which the nature of virtue inherent in context-oriented and reflective thinking and the characteristics of the competence to answer the question of 'what can be done?' work complementarily.